ATE105480T1 - Thrombin bindende substanz und verfahren zu ihrer herstellung. - Google Patents

Thrombin bindende substanz und verfahren zu ihrer herstellung.

Info

Publication number: ATE105480T1
Authority: AT; Austria
Prior art keywords: thrombin; binding substance; binding; conditions; production
Prior art date: 1988-08-29

Application number

AT8989115272T

Other languages

English (en)

Inventor

Nobuo Aoki

Shigeru Kimura

Masami Shiratsuchi

Original Assignee

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-29

Filing date

1989-08-18

Publication date

1994-05-15

1989-08-18 Application filed by Kowa Co filed Critical Kowa Co

1994-05-15 Application granted granted Critical

1994-05-15 Publication of ATE105480T1 publication Critical patent/ATE105480T1/de

Links

239000000126 substance Substances 0.000 title abstract 8
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
108090000190 Thrombin Proteins 0.000 abstract 9
229960004072 thrombin Drugs 0.000 abstract 9
206010053567 Coagulopathies Diseases 0.000 abstract 1
101800004937 Protein C Proteins 0.000 abstract 1
102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
101800001700 Saposin-D Proteins 0.000 abstract 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000035602 clotting Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
229960000856 protein c Drugs 0.000 abstract 1
229940083575 sodium dodecyl sulfate Drugs 0.000 abstract 1
235000019333 sodium laurylsulphate Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/834—Urine; urinary system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Zoology (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT8989115272T 1988-08-29 1989-08-18 Thrombin bindende substanz und verfahren zu ihrer herstellung. ATE105480T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP21413988		1988-08-29
JP11647189		1989-05-10
JP1202027A JPH0720997B2 (ja)	1988-08-29	1989-08-03	新規なトロンビン結合性物質及びその製法
EP89115272A EP0356836B1 (de)	1988-08-29	1989-08-18	Thrombin bindende Substanz und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
ATE105480T1 true ATE105480T1 (de)	1994-05-15

Family

ID=27313158

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT8989115272T ATE105480T1 (de)	1988-08-29	1989-08-18	Thrombin bindende substanz und verfahren zu ihrer herstellung.

Country Status (7)

Country	Link
US (1)	US5043425A (de)
EP (1)	EP0356836B1 (de)
JP (1)	JPH0720997B2 (de)
KR (2)	KR900003207A (de)
AT (1)	ATE105480T1 (de)
DE (1)	DE68915226T2 (de)
ES (1)	ES2056164T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5202421A (en) *	1988-12-27	1993-04-13	Mochida Pharmaceutical Co., Ltd.	Anticoagulant substance obtained from urine and process for the preparation thereof
US6063763A (en) *	1989-04-28	2000-05-16	Schering Aktiengesellschaft	Protease-resistant thrombomodulin analogs
JPH03259084A (ja) *	1990-03-06	1991-11-19	Kowa Co	トロンビン結合性物質の製造法
JP3180824B2 (ja) *	1991-08-30	2001-06-25	シスメックス株式会社	血液凝固試薬
US5716795A (en) *	1991-10-04	1998-02-10	Matschiner; John T.	Thrombomodulin-based coagulometric assay of the protein C system
US20050089543A1 (en) *	2001-02-01	2005-04-28	Weiser Mark J.	Animal scent based repellent and attractant compositions
WO2003061687A1 (fr) *	2002-01-18	2003-07-31	Asahi Kasei Pharma Corporation	Preparation a concentration elevee de thrombomoduline soluble
WO2008044631A1 (en) *	2006-10-06	2008-04-17	Asahi Kasei Pharma Corporation	Therapeutic and/or ameliorating agent for disseminated intravascular coagulation
ES2496596T3 (es)	2007-03-23	2014-09-19	Asahi Kasei Pharma Corporation	Método para producir trombomodulina soluble de gran pureza
JP2011178687A (ja) *	2010-02-26	2011-09-15	Kochi Univ	造血細胞移植に伴う疼痛の予防および／または治療剤
NZ602852A (en)	2010-04-30	2014-03-28	Asahi Kasei Pharma Corp	Highly-purified soluble thrombomodulin and method for producing same
DK2781221T3 (da)	2011-11-15	2020-06-02	Asahi Kasei Pharma Corp	Medicin til behandling og/eller forbedring af sepsis
IN2014DN10075A (de)	2012-05-31	2015-08-21	Univ Kinki
WO2020067389A1 (ja)	2018-09-28	2020-04-02	旭化成ファーマ株式会社	抗悪性腫瘍剤による末梢神経障害の症状軽減及び／又は発症抑制のための医薬
WO2020084853A1 (ja)	2018-10-22	2020-04-30	旭化成ファーマ株式会社	凝固異常を伴う敗血症の治療及び／又は改善のための医薬

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60199819A (ja) *	1984-03-23	1985-10-09	Kowa Co	トロンビン結合性物質およびその製法
WO1987000050A1 (fr) *	1985-06-28	1987-01-15	Asahi Kasei Kogyo Kabushiki Kaisha	Nouvelle substance physiologiquement active limitant la coagulation du sang
JPH0689014B2 (ja) *	1986-01-21	1994-11-09	興和株式会社	トロンビン結合性物質およびその製法
ES2065318T3 (es) *	1986-07-15	1995-02-16	Kowa Co	Sustancia que se une a trombina y procedimiento para su preparacion.
JP2738428B2 (ja) *	1987-01-08	1998-04-08	旭化成工業株式会社	トロンビンによるプロテインｃの活性化を促進する作用を有するペプチド
US4912207A (en) *	1987-05-06	1990-03-27	Washington University	DNA clone of human thrombomodulin and portions thereof

1989
- 1989-08-03 JP JP1202027A patent/JPH0720997B2/ja not_active Expired - Fee Related
- 1989-08-16 US US07/394,715 patent/US5043425A/en not_active Expired - Fee Related
- 1989-08-18 AT AT8989115272T patent/ATE105480T1/de not_active IP Right Cessation
- 1989-08-18 EP EP89115272A patent/EP0356836B1/de not_active Expired - Lifetime
- 1989-08-18 ES ES89115272T patent/ES2056164T3/es not_active Expired - Lifetime
- 1989-08-18 DE DE68915226T patent/DE68915226T2/de not_active Expired - Fee Related
- 1989-08-23 KR KR1019890012016A patent/KR900003207A/ko not_active Ceased
1994
- 1994-07-18 KR KR1019940017334A patent/KR940027658A/ko not_active Ceased

Also Published As

Publication number	Publication date
DE68915226T2 (de)	1995-01-05
JPH0386900A (ja)	1991-04-11
EP0356836B1 (de)	1994-05-11
US5043425A (en)	1991-08-27
DE68915226D1 (de)	1994-06-16
JPH0720997B2 (ja)	1995-03-08
EP0356836A3 (en)	1990-03-28
KR900003207A (ko)	1990-03-26
KR940027658A (ko)	1994-12-10
ES2056164T3 (es)	1994-10-01
EP0356836A2 (de)	1990-03-07

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Legal Events

Date	Code	Title	Description
1995-01-15	UEP	Publication of translation of european patent specification
1996-05-15	REN	Ceased due to non-payment of the annual fee