ATE121412T1 - Tetraaza-makrocyclische verbindungen und verfahren zu deren herstellung. - Google Patents
Tetraaza-makrocyclische verbindungen und verfahren zu deren herstellung.Info
- Publication number
- ATE121412T1 ATE121412T1 AT90301477T AT90301477T ATE121412T1 AT E121412 T1 ATE121412 T1 AT E121412T1 AT 90301477 T AT90301477 T AT 90301477T AT 90301477 T AT90301477 T AT 90301477T AT E121412 T1 ATE121412 T1 AT E121412T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- integer
- zero
- hydrogen atom
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000002678 macrocyclic compounds Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898903023A GB8903023D0 (en) | 1989-02-10 | 1989-02-10 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE121412T1 true ATE121412T1 (de) | 1995-05-15 |
Family
ID=10651473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90301477T ATE121412T1 (de) | 1989-02-10 | 1990-02-12 | Tetraaza-makrocyclische verbindungen und verfahren zu deren herstellung. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0382582B1 (de) |
| JP (1) | JPH03504608A (de) |
| AT (1) | ATE121412T1 (de) |
| AU (1) | AU633877B2 (de) |
| CA (1) | CA2026322A1 (de) |
| DE (1) | DE69018662T2 (de) |
| GB (1) | GB8903023D0 (de) |
| WO (1) | WO1990009388A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5316757A (en) * | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
| US5342606A (en) * | 1984-10-18 | 1994-08-30 | Board Of Regents, The University Of Texas System | Polyazamacrocyclic compounds for complexation of metal ions |
| US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
| US5188816A (en) * | 1984-10-18 | 1993-02-23 | Board Of Regents, The University Of Texas System | Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS |
| US4937333A (en) * | 1989-08-04 | 1990-06-26 | The Dow Chemical Company | Method for purifying aminomethylenephosphonic acids for pharmaceutical use |
| US5236695A (en) * | 1989-11-27 | 1993-08-17 | Concat, Ltd. | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| ATE140869T1 (de) * | 1989-11-27 | 1996-08-15 | Concat Ltd | Qualitätssteigerung von mr-bildern von knochen und ähnlichem gewebe mittels paramagnetischer kationenkomplexe und polyphosphonatliganden |
| GB9008724D0 (en) * | 1990-04-18 | 1990-06-13 | Celltech Ltd | Chemical compounds |
| NZ237868A (en) * | 1990-04-18 | 1994-04-27 | Celltech Ltd | Paramagnetic metal complexes of 1,4,7,10-tetracyclododecane derivatives and their use as nmr imaging agents |
| US5684135A (en) * | 1990-04-18 | 1997-11-04 | Celltech Therapeutics Limited | Conjugate compounds containing aza-macro-cycles and processes for their preparation |
| AU648315B2 (en) * | 1990-06-18 | 1994-04-21 | Dow Chemical Company, The | The use of macrocyclic aminophosphonic acid complexes as imaging agents |
| DE4201179A1 (de) * | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung |
| US5310535A (en) * | 1992-04-24 | 1994-05-10 | The Dow Chemical Company | Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies |
| US5714604A (en) * | 1993-05-06 | 1998-02-03 | The Dow Chemical Company | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives |
| US5409689A (en) * | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| JP3356289B2 (ja) * | 1995-06-26 | 2002-12-16 | コンキャット リミティド | 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用 |
| US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| JP2003501488A (ja) | 1999-06-11 | 2003-01-14 | ネオルックス コーポレイション | 骨髄抑制のための高投与量放射性核種錯体 |
| US7094885B2 (en) | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| EP1390081A2 (de) | 2001-01-08 | 2004-02-25 | Neorx Corporation | Therapeutische und diagnostische verbindungen, zusammenstellungen und methoden |
| US11007283B2 (en) | 2016-04-13 | 2021-05-18 | Bracco Imaging S.P.A. | Contrast agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61226751A (ja) * | 1985-03-30 | 1986-10-08 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料用処理液及びその処理方法 |
-
1989
- 1989-02-10 GB GB898903023A patent/GB8903023D0/en active Pending
-
1990
- 1990-02-12 AT AT90301477T patent/ATE121412T1/de not_active IP Right Cessation
- 1990-02-12 WO PCT/GB1990/000231 patent/WO1990009388A1/en not_active Ceased
- 1990-02-12 EP EP90301477A patent/EP0382582B1/de not_active Expired - Lifetime
- 1990-02-12 CA CA002026322A patent/CA2026322A1/en not_active Abandoned
- 1990-02-12 JP JP2503007A patent/JPH03504608A/ja active Pending
- 1990-02-12 DE DE69018662T patent/DE69018662T2/de not_active Expired - Fee Related
- 1990-02-12 AU AU50436/90A patent/AU633877B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB8903023D0 (en) | 1989-03-30 |
| WO1990009388A1 (en) | 1990-08-23 |
| EP0382582B1 (de) | 1995-04-19 |
| AU633877B2 (en) | 1993-02-11 |
| DE69018662T2 (de) | 1996-01-18 |
| CA2026322A1 (en) | 1990-08-11 |
| JPH03504608A (ja) | 1991-10-09 |
| DE69018662D1 (de) | 1995-05-24 |
| AU5043690A (en) | 1990-09-05 |
| EP0382582A1 (de) | 1990-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |