ATE122099T1 - Verfahren zur herstellung von c-terminalen alpha- amidierten peptiden. - Google Patents
Verfahren zur herstellung von c-terminalen alpha- amidierten peptiden.Info
- Publication number
- ATE122099T1 ATE122099T1 AT90901896T AT90901896T ATE122099T1 AT E122099 T1 ATE122099 T1 AT E122099T1 AT 90901896 T AT90901896 T AT 90901896T AT 90901896 T AT90901896 T AT 90901896T AT E122099 T1 ATE122099 T1 AT E122099T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide
- gly
- formula
- protein
- amino acid
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940059260 amidate Drugs 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 8
- 102000004169 proteins and genes Human genes 0.000 abstract 7
- 210000004899 c-terminal region Anatomy 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000003670 Carboxypeptidase B Human genes 0.000 abstract 1
- 108090000087 Carboxypeptidase B Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000005215 recombination Methods 0.000 abstract 1
- 230000006798 recombination Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/17—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced ascorbate as one donor, and incorporation of one atom of oxygen (1.14.17)
- C12Y114/17003—Peptidylglycine monooxygenase (1.14.17.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1005879A JP2535398B2 (ja) | 1989-01-17 | 1989-01-17 | アミド化ペプチドの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE122099T1 true ATE122099T1 (de) | 1995-05-15 |
Family
ID=11623192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90901896T ATE122099T1 (de) | 1989-01-17 | 1990-01-17 | Verfahren zur herstellung von c-terminalen alpha- amidierten peptiden. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0408764B1 (de) |
| JP (1) | JP2535398B2 (de) |
| KR (1) | KR960013618B1 (de) |
| AT (1) | ATE122099T1 (de) |
| AU (1) | AU630150B2 (de) |
| CA (1) | CA2025350C (de) |
| DE (1) | DE69019077T2 (de) |
| DK (1) | DK0408764T3 (de) |
| ES (1) | ES2072422T3 (de) |
| WO (1) | WO1990008194A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789234A (en) * | 1987-08-14 | 1998-08-04 | Unigene Laboratories, Inc. | Expression systems for amidating enzyme |
| DK67691D0 (da) * | 1991-03-01 | 1991-04-15 | Carlbiotech Ltd As | Enzymatisk fremgangsmaade til c-terminal modificering af peptider og mellemprodukter til brug ved fremgangsmaaden |
| JP3531947B2 (ja) * | 1991-08-19 | 2004-05-31 | 第一サントリーファーマ株式会社 | ペプチドの製造方法 |
| JPH0775593A (ja) * | 1993-09-08 | 1995-03-20 | Suntory Ltd | 蛋白質の製造方法 |
| AU4415796A (en) * | 1994-12-07 | 1996-06-26 | Bionebraska, Inc. | Production of c-terminal amidated peptides from recombinant protein constructs |
| CN1069699C (zh) * | 1997-04-16 | 2001-08-15 | 中国科学院上海生物化学研究所 | 一种活性重组酰胺化酶及其对多肽的酰胺化修饰应用 |
| CN1100789C (zh) * | 2000-01-13 | 2003-02-05 | 中国人民解放军第二军医大学 | 基因重组降钙素或降钙素类似物的制备方法 |
| ES2583259T3 (es) | 2009-12-01 | 2016-09-20 | Novo Nordisk A/S | Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH089639B2 (ja) * | 1982-05-20 | 1996-01-31 | サントリー株式会社 | Ｃ末端アミド化ペプチドの前駆体およびその製造法 |
| DE134631T1 (de) * | 1983-06-15 | 1985-12-05 | Roger Kingdom Craig | Peptide, pharmazeutische zusammensetzungen, gene, vektoren, wirtorganismen, verfahren zu deren herstellung und diagnostische reagenzien. |
| JPS6229997A (ja) * | 1985-04-08 | 1987-02-07 | Sankyo Co Ltd | Ｃ末端にプロリンアミドを有するペプチドの製法 |
| GB8523156D0 (en) * | 1985-09-19 | 1985-10-23 | Celltech Ltd | Polypeptide production |
| JPS62226998A (ja) * | 1986-03-28 | 1987-10-05 | Takara Shuzo Co Ltd | ヒトカルシトニン前駆体ペプチド及びその製造方法 |
| JPH0775541B2 (ja) * | 1986-06-07 | 1995-08-16 | 壽之 松尾 | Ｃ末端アミド化酵素及びその製造方法 |
| DK175535B1 (da) * | 1987-03-04 | 2004-11-29 | Daiichi Suntory Pharma Co Ltd | Fremgangsmåde til fremstilling af et fysiologisk aktivt cysteinholdigt peptid |
| JP2598050B2 (ja) * | 1987-07-17 | 1997-04-09 | サントリー株式会社 | Ｃ−末端α−アミド化酵素 |
-
1989
- 1989-01-17 JP JP1005879A patent/JP2535398B2/ja not_active Expired - Lifetime
-
1990
- 1990-01-17 DK DK90901896.2T patent/DK0408764T3/da active
- 1990-01-17 WO PCT/JP1990/000041 patent/WO1990008194A1/en not_active Ceased
- 1990-01-17 EP EP90901896A patent/EP0408764B1/de not_active Expired - Lifetime
- 1990-01-17 DE DE69019077T patent/DE69019077T2/de not_active Expired - Fee Related
- 1990-01-17 KR KR1019900702063A patent/KR960013618B1/ko not_active Expired - Fee Related
- 1990-01-17 AU AU49484/90A patent/AU630150B2/en not_active Ceased
- 1990-01-17 CA CA002025350A patent/CA2025350C/en not_active Expired - Lifetime
- 1990-01-17 ES ES90901896T patent/ES2072422T3/es not_active Expired - Lifetime
- 1990-01-17 AT AT90901896T patent/ATE122099T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2025350C (en) | 2000-08-01 |
| DE69019077D1 (de) | 1995-06-08 |
| EP0408764B1 (de) | 1995-05-03 |
| DE69019077T2 (de) | 1995-08-31 |
| WO1990008194A1 (en) | 1990-07-26 |
| KR910700351A (ko) | 1991-03-14 |
| EP0408764A1 (de) | 1991-01-23 |
| JPH02190193A (ja) | 1990-07-26 |
| JP2535398B2 (ja) | 1996-09-18 |
| CA2025350A1 (en) | 1990-07-18 |
| KR960013618B1 (ko) | 1996-10-09 |
| DK0408764T3 (da) | 1995-07-17 |
| AU630150B2 (en) | 1992-10-22 |
| AU4948490A (en) | 1990-08-13 |
| ES2072422T3 (es) | 1995-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |