ATE128983T1 - 17-spirofuran-3'-yliden steroide. - Google Patents

17-spirofuran-3'-yliden steroide.

Info

Publication number: ATE128983T1
Authority: AT; Austria
Prior art keywords: lower alkyl; spirofuran; hydrogen; yliden; steroids
Prior art date: 1991-12-20

Application number

AT92203923T

Other languages

English (en)

Inventor

Johannes Antonius Mar Hamersma

Everardus Otto Maria Orlemans

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-20

Filing date

1992-12-15

Publication date

1995-10-15

1992-12-15 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1995-10-15 Application granted granted Critical

1995-10-15 Publication of ATE128983T1 publication Critical patent/ATE128983T1/de

Links

150000003431 steroids Chemical class 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002252 acyl group Chemical group 0.000 abstract 2
230000000708 anti-progestin effect Effects 0.000 abstract 1
239000003418 antiprogestin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)

AT92203923T 1991-12-20 1992-12-15 17-spirofuran-3'-yliden steroide. ATE128983T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP91203366		1991-12-20

Publications (1)

Publication Number	Publication Date
ATE128983T1 true ATE128983T1 (de)	1995-10-15

Family

ID=8208088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92203923T ATE128983T1 (de)	1991-12-20	1992-12-15	17-spirofuran-3'-yliden steroide.

Country Status (16)

Country	Link
US (1)	US5292878A (de)
EP (1)	EP0549041B1 (de)
JP (1)	JP3462515B2 (de)
KR (1)	KR100287513B1 (de)
AT (1)	ATE128983T1 (de)
AU (1)	AU655858B2 (de)
CA (1)	CA2084431C (de)
DE (1)	DE69205405T2 (de)
DK (1)	DK0549041T3 (de)
ES (1)	ES2081040T3 (de)
FI (1)	FI104178B1 (de)
GR (1)	GR3018630T3 (de)
MX (1)	MX9207394A (de)
NO (1)	NO302525B1 (de)
NZ (1)	NZ245520A (de)
ZA (1)	ZA929315B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2100514C (en) *	1992-07-29	2005-03-29	Johannes A. M. Hamersma	17-spiromethylene steroids
TR200001334T2 (tr) *	1997-11-14	2000-09-21	Akzo Nobel N.V.	Progestojen-anti-progestojen rejimleri.
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
AU4093799A (en)	1998-05-22	1999-12-13	Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
US6262042B1 (en) *	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
SK15502001A3 (sk) *	1999-04-29	2002-03-05	Akzo Nobel N. V.	Použitie Org 33245
US6043235A (en) *	1999-07-21	2000-03-28	Research Triangle Institute	11β-aryl-17, 17-spirothiolane-substituted steroids
US7426602B2 (en) *	2004-01-08	2008-09-16	Topside Research, Llc	Switch for bus optimization
TW200531977A (en)	2004-03-25	2005-10-01	Akzo Nobel Nv	Progesterone receptor modulators
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
EP1945240B1 (de)	2005-09-16	2016-12-28	Raptor Pharmaceutical Inc	Zusammensetzungen mit rezeptor-assoziierten protein (rap) varianten, die für cr-haltige proteine spezifisch sind und ihre verwendungen
ATE453660T1 (de) *	2006-02-17	2010-01-15	Janssen Pharmaceutica Nv	17-phosphor-steroid-derivate als progesteron- rezeptormodulatoren
WO2007098381A2 (en) *	2006-02-17	2007-08-30	Janssen Pharmaceutica N.V.	11-phosphorous steroid derivatives useful as progesterone receptor modulators
AU2007327707B2 (en)	2006-10-24	2012-07-12	Allergan pharmaceuticals International Ltd.	Compositions and methods for suppressing endometrial proliferation
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
TR201908314T4 (tr)	2009-02-20	2019-06-21	2 Bbb Medicines B V	Glutatyon bazlı ilaç dağıtım sistemi.
US8673968B2 (en) *	2009-04-06	2014-03-18	Evestra, Inc.	Progesterone antagonists
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN101926806A (zh) *	2009-06-24	2010-12-29	天津金耀集团有限公司	一种17磷类雌甾化合物在制备紧急避孕药物中的应用
CN107260745A (zh)	2010-03-22	2017-10-20	利普生物药剂公司	用于抗孕酮的非毒性递送的组合物和方法
WO2011157443A1 (en)	2010-06-17	2011-12-22	N.V. Organon	(11b,17a)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one
US9096641B2 (en)	2013-06-05	2015-08-04	Evestra, Inc.	Imidazolyl progesterone antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0116974B1 (de) *	1983-02-18	1986-10-29	Schering Aktiengesellschaft	11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
FR2596395B1 (fr) *	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3761308D1 (de) *	1986-07-23	1990-02-08	Akzo Nv	18-phenylestrane-derivate.
IE60780B1 (en) *	1987-01-23	1994-08-10	Akzo Nv	New 11-aryl steroid derivatives
EP0289073B1 (de) *	1987-04-24	1991-11-27	Akzo N.V.	11-Arylestranderivate und 11-Arylpregnanderivate
ES2053714T3 (es) *	1987-12-12	1994-08-01	Akzo Nv	Proceso para la preparacion de 11-arilesteroides.

1992
- 1992-12-01 ZA ZA929315A patent/ZA929315B/xx unknown
- 1992-12-03 CA CA002084431A patent/CA2084431C/en not_active Expired - Fee Related
- 1992-12-11 AU AU30093/92A patent/AU655858B2/en not_active Ceased
- 1992-12-15 ES ES92203923T patent/ES2081040T3/es not_active Expired - Lifetime
- 1992-12-15 NO NO924857A patent/NO302525B1/no unknown
- 1992-12-15 AT AT92203923T patent/ATE128983T1/de not_active IP Right Cessation
- 1992-12-15 EP EP92203923A patent/EP0549041B1/de not_active Expired - Lifetime
- 1992-12-15 DE DE69205405T patent/DE69205405T2/de not_active Expired - Fee Related
- 1992-12-15 DK DK92203923.5T patent/DK0549041T3/da active
- 1992-12-17 KR KR1019920024581A patent/KR100287513B1/ko not_active Expired - Fee Related
- 1992-12-17 MX MX9207394A patent/MX9207394A/es not_active IP Right Cessation
- 1992-12-18 JP JP33883092A patent/JP3462515B2/ja not_active Expired - Fee Related
- 1992-12-18 FI FI925790A patent/FI104178B1/fi active
- 1992-12-18 NZ NZ245520A patent/NZ245520A/en unknown
- 1992-12-21 US US07/994,039 patent/US5292878A/en not_active Expired - Lifetime
1996
- 1996-01-10 GR GR960400050T patent/GR3018630T3/el unknown

Also Published As

Publication number	Publication date
NO924857D0 (no)	1992-12-15
CA2084431C (en)	2003-04-08
JP3462515B2 (ja)	2003-11-05
US5292878A (en)	1994-03-08
FI104178B (fi)	1999-11-30
EP0549041A1 (de)	1993-06-30
NZ245520A (en)	1995-02-24
MX9207394A (es)	1993-07-30
DK0549041T3 (da)	1996-01-29
FI104178B1 (fi)	1999-11-30
CA2084431A1 (en)	1993-06-21
EP0549041B1 (de)	1995-10-11
NO924857L (no)	1993-06-21
FI925790L (fi)	1993-06-21
HK1002033A1 (en)	1998-07-24
AU3009392A (en)	1993-06-24
JPH05255380A (ja)	1993-10-05
DE69205405T2 (de)	1996-05-09
AU655858B2 (en)	1995-01-12
NO302525B1 (no)	1998-03-16
FI925790A0 (fi)	1992-12-18
KR100287513B1 (ko)	2001-05-02
ES2081040T3 (es)	1996-02-16
GR3018630T3 (en)	1996-04-30
DE69205405D1 (de)	1995-11-16
ZA929315B (en)	1993-05-24

Legal Events

Date	Code	Title	Description
2009-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE128983T1 (de)	1995-10-15	17-spirofuran-3'-yliden steroide.
DE122012000012I1 (de)	2012-06-14	17-Substituierte steroide, verwendbar bei behandlung von krebs.
SE9100342D0 (sv)	1991-02-04	Novel steroid esters
FI955108A0 (fi)	1995-10-26	Steroideja, jotka sisältävät 17-spiromtyleenilaktoni- tai laktoliryhmän
ATE15047T1 (de)	1985-09-15	Galactopyranoside verbindungen, verfahren zu ihrer herstellung und ihre verwendung als antigene oder immunadsorbentien.
HU9202100D0 (en)	1992-10-28	New 16-methyl-pregna-1,4-diene-3,20-dione derivatives
ATE73136T1 (de)	1992-03-15	Verfahren zur herstellung von 6alpha, 9alphadifluor-11beta, 17alpha-dihydroxy-16alpha-methyl4-pregnen-3,20-dion und dessen derivate.
IL117497A (en)	1999-12-22	17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same
FI812777L (fi)	1982-03-14	Foerfarande foer framstaellning av nya cardenolid-bis-digitoxosider
JPS57108087A (en)	1982-07-05	(4,5)-4h-benzo(1,2-b)cycloheptafuran derivative, manufacture and use as medicine
ATE144779T1 (de)	1996-11-15	17-phenyl-substituierte steroide mit cardiotonischer wirksamkeit
ATE206699T1 (de)	2001-10-15	Uch-15-verbindungen