ATE128983T1 - 17-spirofuran-3'-yliden steroide. - Google Patents

17-spirofuran-3'-yliden steroide.

Info

Publication number: ATE128983T1
Authority: AT; Austria
Prior art keywords: lower alkyl; spirofuran; hydrogen; yliden; steroids
Prior art date: 1991-12-20

Application number

AT92203923T

Other languages

English (en)

Inventor

Johannes Antonius Mar Hamersma

Everardus Otto Maria Orlemans

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-20

Filing date

1992-12-15

Publication date

1995-10-15

1992-12-15 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1995-10-15 Application granted granted Critical

1995-10-15 Publication of ATE128983T1 publication Critical patent/ATE128983T1/de

Links

150000003431 steroids Chemical class 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002252 acyl group Chemical group 0.000 abstract 2
230000000708 anti-progestin effect Effects 0.000 abstract 1
239000003418 antiprogestin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)

AT92203923T 1991-12-20 1992-12-15 17-spirofuran-3'-yliden steroide. ATE128983T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP91203366		1991-12-20

Publications (1)

Publication Number	Publication Date
ATE128983T1 true ATE128983T1 (de)	1995-10-15

Family

ID=8208088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92203923T ATE128983T1 (de)	1991-12-20	1992-12-15	17-spirofuran-3'-yliden steroide.

Country Status (17)

Country	Link
US (1)	US5292878A (de)
EP (1)	EP0549041B1 (de)
JP (1)	JP3462515B2 (de)
KR (1)	KR100287513B1 (de)
AT (1)	ATE128983T1 (de)
AU (1)	AU655858B2 (de)
CA (1)	CA2084431C (de)
DE (1)	DE69205405T2 (de)
DK (1)	DK0549041T3 (de)
ES (1)	ES2081040T3 (de)
FI (1)	FI104178B (de)
GR (1)	GR3018630T3 (de)
HK (1)	HK1002033A1 (de)
MX (1)	MX9207394A (de)
NO (1)	NO302525B1 (de)
NZ (1)	NZ245520A (de)
ZA (1)	ZA929315B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2100514C (en) *	1992-07-29	2005-03-29	Johannes A. M. Hamersma	17-spiromethylene steroids
JP2001523639A (ja)	1997-11-14	2001-11-27	アクゾ・ノベル・エヌ・ベー	プロゲストゲン−抗プロゲストゲンレジメン
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
ATE473759T1 (de)	1998-05-22	2010-07-15	Univ Leland Stanford Junior	Bifunktionelle moleküle sowie darauf basierende therapien.
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) *	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
WO2000066129A2 (en) *	1999-04-29	2000-11-09	Akzo Nobel N.V.	Use of antiprogestagens in combined therapy
US6043235A (en) *	1999-07-21	2000-03-28	Research Triangle Institute	11β-aryl-17, 17-spirothiolane-substituted steroids
US7426602B2 (en) *	2004-01-08	2008-09-16	Topside Research, Llc	Switch for bus optimization
TW200531977A (en)	2004-03-25	2005-10-01	Akzo Nobel Nv	Progesterone receptor modulators
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
CN101415720B (zh)	2006-02-17	2011-10-05	詹森药业有限公司	用作孕酮受体调节剂的11-磷类固醇衍生物
SI1989218T1 (sl) *	2006-02-17	2010-04-30	Janssen Pharmaceutica Nv	17- fosforjevi steroidni derivati, koristni kot progesteronski receptorski modulatorji
ES2643318T3 (es)	2006-10-24	2017-11-22	Repros Therapeutics Inc.	Composiciones y métodos para suprimir la proliferación endometrial
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
EP2398500B1 (de)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Arzneiabgabesystem auf glutathion-basis
US8673968B2 (en) *	2009-04-06	2014-03-18	Evestra, Inc.	Progesterone antagonists
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
CN101926806A (zh) *	2009-06-24	2010-12-29	天津金耀集团有限公司	一种17磷类雌甾化合物在制备紧急避孕药物中的应用
BR112012023281A2 (pt)	2010-03-22	2016-05-17	Repros Therapeutics Inc	composto ou sal do mesmo, composição farmacêutica, métodos para produzir efeito antiprogestacional em paciente e para tratar condição dependente de progesterona e usos de composto ou sal do mesmo farmaceuticamente aceitável do mesmo e de composição
WO2011157443A1 (en)	2010-06-17	2011-12-22	N.V. Organon	(11b,17a)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one
US9096641B2 (en)	2013-06-05	2015-08-04	Evestra, Inc.	Imidazolyl progesterone antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0116974B1 (de) *	1983-02-18	1986-10-29	Schering Aktiengesellschaft	11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
FR2596395B1 (fr) *	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3761308D1 (de) *	1986-07-23	1990-02-08	Akzo Nv	18-phenylestrane-derivate.
IE60780B1 (en) *	1987-01-23	1994-08-10	Akzo Nv	New 11-aryl steroid derivatives
EP0289073B1 (de) *	1987-04-24	1991-11-27	Akzo N.V.	11-Arylestranderivate und 11-Arylpregnanderivate
ATE85342T1 (de) *	1987-12-12	1993-02-15	Akzo Nv	11-arylsteroid-derivate.

1992
- 1992-12-01 ZA ZA929315A patent/ZA929315B/xx unknown
- 1992-12-03 CA CA002084431A patent/CA2084431C/en not_active Expired - Fee Related
- 1992-12-11 AU AU30093/92A patent/AU655858B2/en not_active Ceased
- 1992-12-15 DE DE69205405T patent/DE69205405T2/de not_active Expired - Fee Related
- 1992-12-15 DK DK92203923.5T patent/DK0549041T3/da active
- 1992-12-15 AT AT92203923T patent/ATE128983T1/de not_active IP Right Cessation
- 1992-12-15 ES ES92203923T patent/ES2081040T3/es not_active Expired - Lifetime
- 1992-12-15 EP EP92203923A patent/EP0549041B1/de not_active Expired - Lifetime
- 1992-12-15 NO NO924857A patent/NO302525B1/no unknown
- 1992-12-17 KR KR1019920024581A patent/KR100287513B1/ko not_active Expired - Fee Related
- 1992-12-17 MX MX9207394A patent/MX9207394A/es not_active IP Right Cessation
- 1992-12-18 JP JP33883092A patent/JP3462515B2/ja not_active Expired - Fee Related
- 1992-12-18 FI FI925790A patent/FI104178B/fi active
- 1992-12-18 NZ NZ245520A patent/NZ245520A/en unknown
- 1992-12-21 US US07/994,039 patent/US5292878A/en not_active Expired - Lifetime
1996
- 1996-01-10 GR GR960400050T patent/GR3018630T3/el unknown
1998
- 1998-02-11 HK HK98101028A patent/HK1002033A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO302525B1 (no)	1998-03-16
JPH05255380A (ja)	1993-10-05
FI925790L (fi)	1993-06-21
NZ245520A (en)	1995-02-24
MX9207394A (es)	1993-07-30
FI104178B1 (fi)	1999-11-30
NO924857L (no)	1993-06-21
KR100287513B1 (ko)	2001-05-02
EP0549041A1 (de)	1993-06-30
NO924857D0 (no)	1992-12-15
AU655858B2 (en)	1995-01-12
CA2084431C (en)	2003-04-08
FI104178B (fi)	1999-11-30
US5292878A (en)	1994-03-08
AU3009392A (en)	1993-06-24
DK0549041T3 (da)	1996-01-29
CA2084431A1 (en)	1993-06-21
EP0549041B1 (de)	1995-10-11
DE69205405T2 (de)	1996-05-09
JP3462515B2 (ja)	2003-11-05
HK1002033A1 (en)	1998-07-24
GR3018630T3 (en)	1996-04-30
DE69205405D1 (de)	1995-11-16
ZA929315B (en)	1993-05-24
ES2081040T3 (es)	1996-02-16
FI925790A0 (fi)	1992-12-18

Legal Events

Date	Code	Title	Description
2009-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69205405D1 (de)	1995-11-16	17-Spirofuran-3'-Yliden Steroide.
NZ310850A (en)	1999-07-29	3 alpha hydroxy(17)-unsubstituted derivatives of androstane and 21 substituted derivatives of the pregnane series and medicaments
DE122012000012I1 (de)	2012-06-14	17-Substituierte steroide, verwendbar bei behandlung von krebs.
SE9100342D0 (sv)	1991-02-04	Novel steroid esters
FI80888B (fi)	1990-04-30	Foerfarande foer framstaellning av terapeutiskt verkande steroida karboxylsyraestrar.
TR199501327A2 (tr)	1996-06-21	17-spirometilen lakton veya laktol gruba sahip steroidler
ATE15047T1 (de)	1985-09-15	Galactopyranoside verbindungen, verfahren zu ihrer herstellung und ihre verwendung als antigene oder immunadsorbentien.
FI875244A0 (fi)	1987-11-27	Foerfarande foer framstaellning av 6 ,9 -difluor-11 ,17 -dihydroxi-16--metyl-4-pregnen-3,20-dion och dess derivat.
IL117497A (en)	1999-12-22	17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same
FI812777L (fi)	1982-03-14	Foerfarande foer framstaellning av nya cardenolid-bis-digitoxosider
JPS57108087A (en)	1982-07-05	(4,5)-4h-benzo(1,2-b)cycloheptafuran derivative, manufacture and use as medicine
ATE144779T1 (de)	1996-11-15	17-phenyl-substituierte steroide mit cardiotonischer wirksamkeit
ATE206699T1 (de)	2001-10-15	Uch-15-verbindungen