ATE130096T1 - Verfahren zur verstärkung des emissionssignals einer lumineszierenden verbindung. - Google Patents
Verfahren zur verstärkung des emissionssignals einer lumineszierenden verbindung.Info
- Publication number
- ATE130096T1 ATE130096T1 AT91913539T AT91913539T ATE130096T1 AT E130096 T1 ATE130096 T1 AT E130096T1 AT 91913539 T AT91913539 T AT 91913539T AT 91913539 T AT91913539 T AT 91913539T AT E130096 T1 ATE130096 T1 AT E130096T1
- Authority
- AT
- Austria
- Prior art keywords
- amplifying
- emission signal
- luminescent compound
- luminescent
- compound
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9008981A FR2664699B1 (fr) | 1990-07-13 | 1990-07-13 | Procede d'amplification du signal d'emission d'un compose luminescent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE130096T1 true ATE130096T1 (de) | 1995-11-15 |
Family
ID=9398708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91913539T ATE130096T1 (de) | 1990-07-13 | 1991-07-12 | Verfahren zur verstärkung des emissionssignals einer lumineszierenden verbindung. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5512493A (de) |
| EP (1) | EP0539477B1 (de) |
| JP (1) | JP3117459B2 (de) |
| AT (1) | ATE130096T1 (de) |
| AU (1) | AU8198091A (de) |
| DE (1) | DE69114499T2 (de) |
| DK (1) | DK0539477T3 (de) |
| ES (1) | ES2082217T3 (de) |
| FR (1) | FR2664699B1 (de) |
| GR (1) | GR3018429T3 (de) |
| WO (1) | WO1992001225A1 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736410A (en) | 1992-09-14 | 1998-04-07 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
| US6399397B1 (en) | 1992-09-14 | 2002-06-04 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
| US6159686A (en) | 1992-09-14 | 2000-12-12 | Sri International | Up-converting reporters for biological and other assays |
| US6238931B1 (en) * | 1993-09-24 | 2001-05-29 | Biosite Diagnostics, Inc. | Fluorescence energy transfer in particles |
| FR2735238B1 (fr) * | 1995-06-09 | 1997-09-05 | Cis Bio Int | Utilisation d'un complexe phycobiliproteine-peptide de liaison en tant que traceur fluorescent |
| FI963989L (fi) * | 1996-10-04 | 1998-04-05 | Wallac Oy | Homogeenisiä määritysmenetelmiä, jotka perustuvat luminesenssienergiasiirtoon |
| US7745142B2 (en) | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
| US7632651B2 (en) * | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US20050227294A1 (en) * | 1997-09-15 | 2005-10-13 | Molecular Devices Corporation | Molecular modification assays involving lipids |
| US7070921B2 (en) | 2000-04-28 | 2006-07-04 | Molecular Devices Corporation | Molecular modification assays |
| FR2769315B1 (fr) * | 1997-10-03 | 2001-06-08 | Cis Bio Int | Conjugues fluorescents de nucleosides ou de nucleotides, leur procede de preparation et leur utilisation |
| EP1078265A1 (de) | 1998-02-18 | 2001-02-28 | Dade Behring Inc. | Chemilumineszente verbindungen zur detektion einer mehrzahl von analyten |
| EP1925320A3 (de) | 1998-03-27 | 2008-09-03 | Prolume, Ltd. | Luciferasen, fluoreszierende Proteine, Nukleinsäuren zur Kodierung der Luciferasen und der fluoreszierenden Proteine sowie deren Verwendung zur Diagnose, zum Screening mit hohem Durchsatz und zur Behandlung neuartiger Probleme |
| FR2778744B1 (fr) | 1998-05-14 | 2000-06-23 | Cis Bio Int | Dosage immunologique de la chromogranine a humaine (cga) anticorps, reactifs et trousses utilisables pour ce dosage |
| US5998146A (en) * | 1998-07-17 | 1999-12-07 | Wallac Oy | Homogeneous luminescence assay method based on energy transfer |
| US6235479B1 (en) | 1999-04-13 | 2001-05-22 | Bio Merieux, Inc. | Methods and devices for performing analysis of a nucleic acid sample |
| US7109315B2 (en) | 2000-03-15 | 2006-09-19 | Bruce J. Bryan | Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items |
| FR2809817B1 (fr) | 2000-06-02 | 2003-08-15 | Cis Bio Int | Procede de detection de presence d'un liquide dans un melange |
| DE10153829A1 (de) | 2001-11-05 | 2003-05-28 | Bayer Ag | Assay basierend auf dotierten Nanoteilchen |
| EP1355159A1 (de) * | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verwendungen von Fragmenten der Carbamoylphosphat Synthetase 1 (CPS 1) für die Diagnose von Entzündungserkrankungen und Sepsis |
| EP1355158A1 (de) | 2002-04-19 | 2003-10-22 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur Diagnose von Entzündungserkrankungen und Infektionen unter Bestimmung des Phosphoproteins LASP-1 als Inflammationsmarker |
| WO2004039962A2 (en) * | 2002-10-30 | 2004-05-13 | Pointilliste, Inc. | Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides |
| WO2004071641A2 (en) * | 2003-02-10 | 2004-08-26 | Pointilliste, Inc. | Self-assembling arrays and uses thereof |
| US20050095648A1 (en) * | 2003-10-30 | 2005-05-05 | Mario Geysen | Method for designing linear epitopes and algorithm therefor and polypeptide epitopes |
| US20060018911A1 (en) * | 2004-01-12 | 2006-01-26 | Dana Ault-Riche | Design of therapeutics and therapeutics |
| US20060024722A1 (en) | 2004-07-30 | 2006-02-02 | Mark Fischer-Colbrie | Samples for detection of oncofetal fibronectin and uses thereof |
| DE102004045705A1 (de) * | 2004-09-21 | 2006-04-06 | B.R.A.H.M.S Ag | Verwendungen der Carbamoylphosphat Synthetase 1(CPS) als humoraler Biomarker für die Diagnose von Tumorerkrankungen und chronisch entzündlichen Darmerkrankungen |
| CA2581639C (en) * | 2004-09-30 | 2016-07-26 | Molecular Devices Corporation | Luminescent lanthanide complexes |
| DE102006021406B4 (de) | 2006-05-08 | 2008-08-07 | B.R.A.H.M.S Aktiengesellschaft | In vitro Verfahren zur Früherkennung von arznei- und suchtmittelinduzierten Leberschäden und zur Erkennung der bereits erreichten Stufe der Leberschädigung |
| DE102007009751A1 (de) | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| DE102007022367A1 (de) | 2007-05-07 | 2008-11-20 | B.R.A.H.M.S Ag | Verfahren zur Bestimmung von aminoterminalen pro-ANP bei übergewichtigen Patienten |
| WO2012037361A2 (en) | 2010-09-15 | 2012-03-22 | Endacea, Inc. | Methods of use and kit for measurement of lipopolysaccharide with a time resolved fluorescence based assay |
| US9653691B2 (en) * | 2012-12-12 | 2017-05-16 | Universal Display Corporation | Phosphorescence-sensitizing fluorescence material system |
| WO2016063304A1 (en) | 2014-10-21 | 2016-04-28 | Council Of Scientific & Industrial Research | Luminescent lanthanide complexes and method of preparation thereof |
| US10138267B2 (en) | 2015-04-06 | 2018-11-27 | Hunan Skyworld Biotechnologies Co. Ltd. | Bioconjugates of heterocyclic compounds |
| CN119199150A (zh) | 2015-11-27 | 2024-12-27 | B.R.A.H.M.S 有限公司 | 作为对象的细胞外容量状态的标志物的MR-proADM |
| US9834808B2 (en) | 2016-01-21 | 2017-12-05 | SeLux Diagnostics, Inc. | Methods for rapid antibiotic susceptibility testing |
| EP3405585B1 (de) | 2016-01-21 | 2021-03-03 | Selux Diagnostics, Inc. | Verfahren für schnelltest auf antimikrobielle suszeptibilität |
| FR3051556A1 (fr) * | 2016-05-18 | 2017-11-24 | Biocytex | Utilisation de marqueurs fluorescents pour la detection de cible biologique dans un echantillon |
| JP7194673B2 (ja) | 2016-08-09 | 2022-12-22 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 臓器障害を示すマーカーとしてのヒストンおよび/またはproADM |
| CA3033094A1 (en) | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
| US12203124B2 (en) | 2016-12-23 | 2025-01-21 | SeLux Diagnostics, Inc. | Methods for improved rapid antimicrobial susceptibility testing |
| EP4220175A1 (de) | 2017-02-02 | 2023-08-02 | B.R.A.H.M.S GmbH | Proadm als marker zur anzeige eines unerwünschten ereignisses |
| US12385926B2 (en) | 2017-05-31 | 2025-08-12 | B.R.A.H.M.S Gmbh | MMP-8 as a marker for identifying infectious disease |
| EP4027145A1 (de) | 2017-09-13 | 2022-07-13 | B.R.A.H.M.S GmbH | Pro-adm zur therapieüberwachung von intensivpatienten |
| EP3682246A1 (de) | 2017-09-13 | 2020-07-22 | B.R.A.H.M.S GmbH | Verfahren zur leitung einer flüssigkeitstherapie auf basis von proadrenomedullin |
| EP3502691A1 (de) | 2017-12-20 | 2019-06-26 | B.R.A.H.M.S GmbH | Proadrenomedullin als indikator für nierenersatztherapie bei kritisch kranken patienten |
| EP3971572A1 (de) | 2017-09-13 | 2022-03-23 | B.R.A.H.M.S GmbH | Proadrenomedullin als marker für anormale thrombozytenspiegel |
| EP3682236A1 (de) | 2017-09-13 | 2020-07-22 | B.R.A.H.M.S GmbH | Proadrenomedullin als indikator für nierenersatztherapie bei kritisch kranken patienten |
| WO2019122089A1 (en) | 2017-12-20 | 2019-06-27 | B.R.A.H.M.S Gmbh | Antibiotic therapy guidance based on pro-adm |
| JP7444776B2 (ja) | 2017-12-20 | 2024-03-06 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 併存症を有する患者におけるプロカルシトニンに基づく抗生物質療法のガイダンス |
| EP3578989A1 (de) | 2018-06-06 | 2019-12-11 | B.R.A.H.M.S GmbH | Pro-adm zur prognose von traumabedingten komplikationen bei polytraumapatienten |
| EP3608673A1 (de) | 2018-08-08 | 2020-02-12 | B.R.A.H.M.S GmbH | Pro-adm zur prognose des risikos einer erkrankung, die einen krankenhausaufenthalt bei patienten mit symptomen einer infektionskrankheit erfordert |
| EP3918343B1 (de) | 2019-01-28 | 2025-06-11 | B.R.A.H.M.S GmbH | Verfahren zur vorhersage der behandlung bei patienten mit enuresis nocturna |
| EP3928099A1 (de) | 2019-02-21 | 2021-12-29 | B.R.A.H.M.S GmbH | Diagnose oder prognose postoperativer nebenwirkungen |
| EP3715851A1 (de) | 2019-03-29 | 2020-09-30 | B.R.A.H.M.S GmbH | Verschreibung von fernpatientenmanagement auf der basis von biomarkern |
| JP7575400B2 (ja) | 2019-03-29 | 2024-10-29 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | バイオマーカーに基づく遠隔患者管理の処方 |
| CA3152541A1 (en) | 2019-08-27 | 2021-03-04 | SeLux Diagnostics, Inc. | Systems and methods for performing antimicrobial susceptibility testing |
| BR112022017489A2 (pt) | 2020-04-06 | 2022-10-18 | Brahms Gmbh | Pró adrenomedulina para prognóstico da progressão da doença na síndrome respiratória aguda grave (sars) |
| CN115136009A (zh) | 2020-04-09 | 2022-09-30 | B.R.A.H.M.S有限公司 | 用于呼吸道感染诊断的生物标志物 |
| AU2022405688A1 (en) | 2021-12-08 | 2024-06-06 | B.R.A.H.M.S Gmbh | Biomarkers for prognosis of early onset preeclampsia |
| AU2022410233A1 (en) | 2021-12-13 | 2024-06-06 | B.R.A.H.M.S Gmbh | Biomarkers for the prediction of preterm birth |
| CN120380346A (zh) | 2022-12-08 | 2025-07-25 | B.R.A.H.M.S有限公司 | 用于早发型先兆子痫预后的多个sFlt-1测量值 |
| WO2024235842A1 (en) | 2023-05-12 | 2024-11-21 | B.R.A.H.M.S Gmbh | Mid-regional pro-adrenomedullin immunoassay with monoclonal antibodies |
| AU2024360424A1 (en) | 2023-10-09 | 2026-04-09 | B.R.A.H.M.S Gmbh | Biomarkers for therapy management and/or prognosing disease progression, severity and/or outcome for respiratory virus infections |
| WO2026013199A1 (en) | 2024-07-12 | 2026-01-15 | Cezanne S.A.S. | Clinical immunoassay with early signal measurement |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4542104A (en) * | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
| FR2570703B1 (fr) * | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
| JPS61128169A (ja) * | 1984-11-27 | 1986-06-16 | Mitsubishi Chem Ind Ltd | 免疫分析法 |
| US4822733A (en) * | 1985-05-28 | 1989-04-18 | Amoco Corporation | Lifetime-resolved assay procedures |
| JP2802921B2 (ja) * | 1986-06-17 | 1998-09-24 | マイクロスキャン、インコーポレイテッド | 蛍光バックグラウンド消去および水溶性希土類金属キレートフルオロフォルを使用する均質蛍光アッセイ |
| FR2624862B1 (fr) * | 1987-12-18 | 1990-06-08 | Oris Ind | Cryptates de terres rares, procedes d'obtention, intermediaires de synthese et application a titre de marqueurs fluorescents |
| GB8820887D0 (en) * | 1988-09-06 | 1988-10-05 | Atomic Energy Authority Uk | Detecting selected species |
-
1990
- 1990-07-13 FR FR9008981A patent/FR2664699B1/fr not_active Expired - Fee Related
-
1991
- 1991-07-12 DE DE69114499T patent/DE69114499T2/de not_active Expired - Lifetime
- 1991-07-12 JP JP03512207A patent/JP3117459B2/ja not_active Expired - Fee Related
- 1991-07-12 EP EP91913539A patent/EP0539477B1/de not_active Expired - Lifetime
- 1991-07-12 DK DK91913539.2T patent/DK0539477T3/da active
- 1991-07-12 AU AU81980/91A patent/AU8198091A/en not_active Abandoned
- 1991-07-12 ES ES91913539T patent/ES2082217T3/es not_active Expired - Lifetime
- 1991-07-12 AT AT91913539T patent/ATE130096T1/de not_active IP Right Cessation
- 1991-07-12 WO PCT/FR1991/000567 patent/WO1992001225A1/fr not_active Ceased
-
1993
- 1993-05-26 US US08/068,843 patent/US5512493A/en not_active Expired - Lifetime
-
1995
- 1995-12-15 GR GR950403559T patent/GR3018429T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06500852A (ja) | 1994-01-27 |
| AU8198091A (en) | 1992-02-04 |
| DK0539477T3 (da) | 1995-12-11 |
| ES2082217T3 (es) | 1996-03-16 |
| FR2664699B1 (fr) | 1995-08-18 |
| US5512493A (en) | 1996-04-30 |
| DE69114499D1 (de) | 1995-12-14 |
| EP0539477A1 (de) | 1993-05-05 |
| DE69114499T2 (de) | 1996-03-28 |
| WO1992001225A1 (fr) | 1992-01-23 |
| JP3117459B2 (ja) | 2000-12-11 |
| FR2664699A1 (fr) | 1992-01-17 |
| GR3018429T3 (en) | 1996-03-31 |
| EP0539477B1 (de) | 1995-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |