ATE230801T1 - Verfahren zur detektion von zielnukleinsäure, verfahren zu ihrer quantifizierung und pyrylium- verbindungen zur chemilumineszenz-analyse - Google Patents
Verfahren zur detektion von zielnukleinsäure, verfahren zu ihrer quantifizierung und pyrylium- verbindungen zur chemilumineszenz-analyseInfo
- Publication number
- ATE230801T1 ATE230801T1 AT97307682T AT97307682T ATE230801T1 AT E230801 T1 ATE230801 T1 AT E230801T1 AT 97307682 T AT97307682 T AT 97307682T AT 97307682 T AT97307682 T AT 97307682T AT E230801 T1 ATE230801 T1 AT E230801T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- target nucleic
- quantifying
- detecting target
- pyrylium compounds
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 7
- 102000039446 nucleic acids Human genes 0.000 title abstract 7
- 108020004707 nucleic acids Proteins 0.000 title abstract 7
- WVIICGIFSIBFOG-UHFFFAOYSA-N pyrylium Chemical class C1=CC=[O+]C=C1 WVIICGIFSIBFOG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26281896 | 1996-10-03 | ||
| JP26282096 | 1996-10-03 | ||
| JP26281996 | 1996-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE230801T1 true ATE230801T1 (de) | 2003-01-15 |
Family
ID=27335174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97307682T ATE230801T1 (de) | 1996-10-03 | 1997-09-30 | Verfahren zur detektion von zielnukleinsäure, verfahren zu ihrer quantifizierung und pyrylium- verbindungen zur chemilumineszenz-analyse |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6297008B1 (de) |
| EP (1) | EP0837141B1 (de) |
| AT (1) | ATE230801T1 (de) |
| CA (1) | CA2217074C (de) |
| DE (1) | DE69718268D1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6123899A (en) * | 1998-10-15 | 2000-05-01 | Toyo Kohan Co. Ltd. | Supports for immobilizing dna or the like |
| EP1070709B1 (de) * | 1999-07-23 | 2004-12-01 | Canon Kabushiki Kaisha | Neue Pyrylium Verbindung, Verfahren zu ihrer Herstellung, Nucleinsäure-Färbemittel und markierte Nucleinsäure |
| EP3225632B1 (de) | 1999-11-30 | 2020-05-06 | Mayo Foundation for Medical Education and Research | An b7-h1, ein neuartiges immunregulierendes molekül bindende antikörper |
| ATE423222T1 (de) * | 2001-06-18 | 2009-03-15 | Eiken Chemical | Effizientes nachweisverfahren für doppelsträngige nukleinsäure |
| EP1434596B1 (de) * | 2001-10-09 | 2009-07-08 | Mayo Foundation For Medical Education And Research | Verwendung von agonistischen 4-1bb antikörpern zur erhöhung der immunantwort |
| DE10153818A1 (de) * | 2001-11-05 | 2003-05-15 | Chromeon Gmbh | Verfahren und Verbindungen zur Fluoreszenzmarkierung von Biomolekülen und Polymerpartikeln |
| ES2222825B1 (es) * | 2003-07-23 | 2005-12-16 | Universidad Politecnica De Valencia | Metodo para la deteccion de especies quimicas nucleofilicas. |
| JP4458327B2 (ja) * | 2003-08-28 | 2010-04-28 | キヤノン株式会社 | 標的物質の定量方法および該方法に用いるプローブ担体 |
| JP4541731B2 (ja) * | 2004-03-12 | 2010-09-08 | キヤノン株式会社 | 核酸検出方法 |
| JP4183256B2 (ja) * | 2004-08-04 | 2008-11-19 | キヤノン株式会社 | 核酸増幅反応産物の鎖分離方法、核酸増幅反応産物の検出方法 |
| JP2006094760A (ja) * | 2004-09-29 | 2006-04-13 | Canon Inc | 細胞のスクリーニング方法および口腔癌細胞検出方法 |
| WO2006042237A2 (en) | 2004-10-06 | 2006-04-20 | Mayo Foundation For Medical Education And Research | B7-h1 and methods of diagnosis, prognosis, and treatment of cancer |
| US7547775B2 (en) | 2004-12-31 | 2009-06-16 | Affymetrix, Inc. | Parallel preparation of high fidelity probes in an array format |
| US8338093B2 (en) | 2004-12-31 | 2012-12-25 | Affymetrix, Inc. | Primer array synthesis and validation |
| US8535914B2 (en) * | 2005-01-21 | 2013-09-17 | Canon Kabushiki Kaisha | Probe, probe set and information acquisition method using the same |
| US20080019905A9 (en) * | 2005-02-18 | 2008-01-24 | Strome Scott E | Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection |
| JP2007010413A (ja) * | 2005-06-29 | 2007-01-18 | Canon Inc | 核酸ハイブリッドの融点測定方法及びそのための装置 |
| US7642086B2 (en) * | 2005-08-09 | 2010-01-05 | Canon Kabushiki Kaisha | Labeled probe bound object, method for producing the same and method for using the same |
| JP5328019B2 (ja) * | 2005-10-21 | 2013-10-30 | レヴォ バイオロジクス インコーポレイテッド | 抗体依存性細胞障害活性を増強させた抗体、その調製法および使用法 |
| US20090011413A1 (en) * | 2005-12-14 | 2009-01-08 | Canon Kabushiki Kaisha | Method for screening colon cancer cells and gene set used for examination of colon cancer |
| WO2007082144A2 (en) * | 2006-01-05 | 2007-07-19 | Mayo Foundation For Medical Education And Research | B7-h1 and survivin in cancer |
| WO2007124361A2 (en) * | 2006-04-20 | 2007-11-01 | Mayo Foundation For Medical Education And Research | Soluble b7-h1 |
| US20110020325A1 (en) * | 2008-02-29 | 2011-01-27 | Kwon Eugene D | Methods for reducing granulomatous inflammation |
| EP2279003A4 (de) * | 2008-05-01 | 2013-04-03 | Gtc Biotherapeutics Inc | Anti-cd137-antikörper als mittel zur behandlung von entzündlichen erkrankungen |
| JP5676454B2 (ja) | 2008-09-25 | 2015-02-25 | ユニバーサル ディスプレイ コーポレイション | 有機セレン材料および有機発光デバイス内でのその使用 |
| JP5729904B2 (ja) | 2009-06-02 | 2015-06-03 | キヤノン株式会社 | 細胞から蛋白質、ｄｎａ、ｒｎａを調製する方法 |
| US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| EP3052131B1 (de) | 2013-10-01 | 2018-12-05 | Mayo Foundation for Medical Education and Research | Verfahren zur krebsbehandlung bei patienten mit erhöhtem bim-spiegel |
| US10302653B2 (en) | 2014-05-22 | 2019-05-28 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti B7-H1 antibodies |
| WO2016014148A1 (en) | 2014-07-23 | 2016-01-28 | Mayo Foundation For Medical Education And Research | Targeting dna-pkcs and b7-h1 to treat cancer |
| WO2017075045A2 (en) | 2015-10-30 | 2017-05-04 | Mayo Foundation For Medical Education And Research | Antibodies to b7-h1 |
| US12257286B2 (en) | 2018-10-31 | 2025-03-25 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| WO2020092839A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3786369A (en) | 1972-12-27 | 1974-01-15 | Eastman Kodak Co | Laser dye composition |
| US4341894A (en) | 1978-03-13 | 1982-07-27 | Eastman Kodak Company | Sensitizers for photoconductive compositions |
| US4555396A (en) | 1982-12-22 | 1985-11-26 | Eastman Kodak Company | Use of pyrylium and thiapyrylium compounds as biological stains |
| US4840784A (en) | 1982-12-22 | 1989-06-20 | Eastman Kodak Company | Use of pyrylium and thiapyrylium compounds as biological stains |
| US4820630A (en) | 1984-11-23 | 1989-04-11 | Digene Diagnostics, Incorporated | Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels |
| US4886744A (en) | 1985-04-25 | 1989-12-12 | Polaroid Corporation | Fluorescent conjugates and biological diagnostic assay system |
| US4794073A (en) | 1985-07-10 | 1988-12-27 | Molecular Diagnostics, Inc. | Detection of nucleic acid hybrids by prolonged chemiluminescence |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| CA1273552A (en) | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
| EP0232967B1 (de) | 1986-01-10 | 1993-04-28 | Amoco Corporation | Kompetitiver homogener Test |
| US4774250A (en) | 1987-04-02 | 1988-09-27 | Dana Farber Cancer Institute | Composition and method for treating differentiated carcinoma or melanoma cells with thiapyrylium dyes |
| JPH01153683A (ja) | 1987-11-06 | 1989-06-15 | Eastman Kodak Co | アミノ置換チオピリリウム化合物 |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| GB8805849D0 (en) | 1988-03-11 | 1988-04-13 | Efamol Holdings | Porphyrins & cancer treatment |
| US5162519A (en) | 1988-03-11 | 1992-11-10 | Efamol Holdings Plc | Porphyrins and cancer treatment |
| JPH0275958A (ja) | 1988-09-13 | 1990-03-15 | Kao Corp | Ｄｎａ検出法 |
| US5047419A (en) | 1988-10-24 | 1991-09-10 | Eastman Kodak Company | Photodynamic therapy of glioma or mammary carcinoma using seleno- or telluropyrylium salts |
| US4916127A (en) | 1988-10-24 | 1990-04-10 | Eastman Kodak Company | Mixed chalcogenide pyrylium salts of a Lewis base |
| US5229297A (en) | 1989-02-03 | 1993-07-20 | Eastman Kodak Company | Containment cuvette for PCR and method of use |
| GB8902689D0 (en) | 1989-02-07 | 1989-03-30 | Ici Plc | Assay method |
| CA2033692A1 (en) | 1990-01-25 | 1991-07-26 | Wilhelm Bannwarth | Energy transfer systems |
| US5102784A (en) | 1990-05-04 | 1992-04-07 | Oncor, Inc. | Restriction amplification assay |
| EP0487218B1 (de) | 1990-10-31 | 1997-12-29 | Tosoh Corporation | Verfahren zum Nachweis oder Quantifizierung von Zielnukleinsäuren |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| US5340716A (en) | 1991-06-20 | 1994-08-23 | Snytex (U.S.A.) Inc. | Assay method utilizing photoactivated chemiluminescent label |
| US6300058B1 (en) | 1992-01-29 | 2001-10-09 | Hitachi Chemical Research Center, Inc. | Method for measuring messenger RNA |
| JP3495752B2 (ja) | 1992-12-11 | 2004-02-09 | キヤノン株式会社 | 生標的個体の検出方法およびプローブ |
| JP3247001B2 (ja) | 1992-12-21 | 2002-01-15 | キヤノン株式会社 | ピリリウム化合物を用いた２本鎖核酸の検出方法、ピリリウム化合物を含有するプローブ及びそれを用いた標的核酸の検出方法、新規ピリリウム化合物 |
| US5808077A (en) * | 1993-06-30 | 1998-09-15 | Abbott Laboratories | Intercalators having affinity for DNA and methods of use |
| CA2126391C (en) | 1993-09-13 | 2002-01-08 | Nobuko Yamamoto | Determination of nucleic acid by pcr, measurement of number of microbial cells, genes, or gene-copies by pcr, and measuring-kit employed for the same |
| US5591578A (en) | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| DE69532255D1 (de) * | 1994-05-26 | 2004-01-22 | Canon Kk | Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung |
-
1997
- 1997-09-30 AT AT97307682T patent/ATE230801T1/de not_active IP Right Cessation
- 1997-09-30 DE DE69718268T patent/DE69718268D1/de not_active Expired - Lifetime
- 1997-09-30 EP EP97307682A patent/EP0837141B1/de not_active Expired - Lifetime
- 1997-10-01 CA CA002217074A patent/CA2217074C/en not_active Expired - Fee Related
- 1997-10-02 US US08/943,019 patent/US6297008B1/en not_active Expired - Fee Related
-
2001
- 2001-08-17 US US09/931,048 patent/US20020115079A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6297008B1 (en) | 2001-10-02 |
| CA2217074A1 (en) | 1998-04-03 |
| US20020115079A1 (en) | 2002-08-22 |
| EP0837141A3 (de) | 1998-05-06 |
| EP0837141B1 (de) | 2003-01-08 |
| CA2217074C (en) | 2007-12-18 |
| EP0837141A2 (de) | 1998-04-22 |
| DE69718268D1 (de) | 2003-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |