ATE254132T1 - Antivirale pyrimidin nucleoside derivate - Google Patents

Antivirale pyrimidin nucleoside derivate

Info

Publication number
ATE254132T1
ATE254132T1 AT01928079T AT01928079T ATE254132T1 AT E254132 T1 ATE254132 T1 AT E254132T1 AT 01928079 T AT01928079 T AT 01928079T AT 01928079 T AT01928079 T AT 01928079T AT E254132 T1 ATE254132 T1 AT E254132T1
Authority
AT
Austria
Prior art keywords
pyrimidine nucleoside
nucleoside derivatives
antiviral pyrimidine
antiviral
compounds
Prior art date
Application number
AT01928079T
Other languages
English (en)
Inventor
Christopher Mcguigan
Jan Balzarini
Clercq Erik De
Original Assignee
Univ Cardiff
Rega Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff, Rega Foundation filed Critical Univ Cardiff
Application granted granted Critical
Publication of ATE254132T1 publication Critical patent/ATE254132T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01928079T 2000-05-09 2001-05-08 Antivirale pyrimidin nucleoside derivate ATE254132T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0011203.7A GB0011203D0 (en) 2000-05-09 2000-05-09 Chemical compounds
PCT/GB2001/002004 WO2001085749A1 (en) 2000-05-09 2001-05-08 Anti-viral pyrimidine nucleoside analogues

Publications (1)

Publication Number Publication Date
ATE254132T1 true ATE254132T1 (de) 2003-11-15

Family

ID=9891276

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01928079T ATE254132T1 (de) 2000-05-09 2001-05-08 Antivirale pyrimidin nucleoside derivate

Country Status (14)

Country Link
US (1) US7019135B2 (de)
EP (1) EP1280813B1 (de)
JP (1) JP2003532735A (de)
AT (1) ATE254132T1 (de)
AU (1) AU780879B2 (de)
CA (1) CA2406633A1 (de)
DE (1) DE60101223T2 (de)
DK (1) DK1280813T3 (de)
ES (1) ES2210153T3 (de)
GB (1) GB0011203D0 (de)
NZ (1) NZ521877A (de)
PT (1) PT1280813E (de)
TR (1) TR200302313T4 (de)
WO (1) WO2001085749A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
IL137164A0 (en) 1998-01-23 2001-07-24 Newbiotics Inc Enzyme catalyzed therapeutic agents
MXPA02000762A (es) 1999-07-22 2002-08-20 Newbiotics Inc Metodos para tratar tumores resistentes a terapia.
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
GB0009486D0 (en) * 2000-04-17 2000-06-07 Univ Cardiff Chemical compounds
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
GB0609178D0 (en) 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
EP2691409B1 (de) 2011-03-31 2018-02-21 Idenix Pharmaceuticals LLC. Verbindungen und zusammensetzungen zur behandlung von virusinfektionen
GB201111779D0 (en) * 2011-07-08 2011-08-24 Univ Cardiff Chemical compounds
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
EP2768838A1 (de) 2011-10-14 2014-08-27 IDENIX Pharmaceuticals, Inc. Substituierte 3 ', 5 '-cyclophosphate von purin-nukleotid-verbindungen und pharmazeutische zusammensetzungen für die behandlung von virusinfektionen
GEP20176800B (en) 2012-05-22 2018-01-10 Idenix Pharmaceuticals Llk D-amino acid compounds for liver disease
WO2013177195A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphate prodrugs for hcv infection
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
WO2013174962A1 (en) 2012-05-25 2013-11-28 Janssen R&D Ireland Uracyl spirooxetane nucleosides
EP2900682A1 (de) 2012-09-27 2015-08-05 IDENIX Pharmaceuticals, Inc. Ester und malonate aus sate-prodrugs
CN111848711A (zh) 2012-10-08 2020-10-30 埃迪尼克斯医药有限责任公司 用于hcv感染的2′-氯核苷类似物
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9339541B2 (en) 2013-03-04 2016-05-17 Merck Sharp & Dohme Corp. Thiophosphate nucleosides for the treatment of HCV
EP2970358B1 (de) 2013-03-04 2021-06-30 Idenix Pharmaceuticals LLC 3'-deoxy-nukleoside zur behandlung von hcv
US20140271547A1 (en) 2013-03-13 2014-09-18 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
WO2014197578A1 (en) 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
EP3027636B1 (de) 2013-08-01 2022-01-05 Idenix Pharmaceuticals LLC D-amino acid phosphoramidate pronucleotide of halogenierte pyrimidine verbindungen für leber krankheiten
WO2015161137A1 (en) 2014-04-16 2015-10-22 Idenix Pharmaceuticals, Inc. 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62255499A (ja) * 1986-04-28 1987-11-07 Teijin Ltd 螢光性ヌクレオシド又はヌクレオチド
GB9708611D0 (en) * 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
GB9716231D0 (en) * 1997-07-31 1997-10-08 Amersham Int Ltd Base analogues

Also Published As

Publication number Publication date
US7019135B2 (en) 2006-03-28
EP1280813A1 (de) 2003-02-05
GB0011203D0 (en) 2000-06-28
DE60101223D1 (de) 2003-12-18
US20030176370A1 (en) 2003-09-18
NZ521877A (en) 2004-11-26
EP1280813B1 (de) 2003-11-12
WO2001085749A1 (en) 2001-11-15
TR200302313T4 (tr) 2004-01-21
ES2210153T3 (es) 2004-07-01
PT1280813E (pt) 2004-03-31
CA2406633A1 (en) 2001-11-15
AU5494501A (en) 2001-11-20
JP2003532735A (ja) 2003-11-05
DK1280813T3 (da) 2004-03-22
DE60101223T2 (de) 2004-09-02
AU780879B2 (en) 2005-04-21

Similar Documents

Publication Publication Date Title
ATE254132T1 (de) Antivirale pyrimidin nucleoside derivate
ATE245641T1 (de) Antivirale pyrimidinderivate
NO20035524D0 (no) 4'-substituerte nukleosider
ATE249219T1 (de) Antivirale verbindungen
DK1265889T3 (da) Lægemidler imod virussygdomme
MY128458A (en) Antiviral azaindole derivatives
JO2403B1 (en) Nickeloside derivatives antiviral
SG149067A1 (en) IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT
TR200101499T1 (tr) Azepinoindol türevleri, hazırlanmaları ve kullanımları.
DE69111232D1 (de) 5-benzyl barbitursäurederivate.
ATE231149T1 (de) (1,8)-naphthyridinderivate derivate mit antiviraler wirkung
GEP20074099B (en) 3-β-D-RIBOFURANO-SYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
BR0215392A (pt) Composições farmacêuticas compreendendo um inibidor de fosfodiesterase multifuncional e um inibidor de absorção de adenosina, bem como uso das mesmas
DE60031886D1 (de) Purinderivate
EP1422225A4 (de) Benzoisoselenazolderivate mit entzündungshemmender, antiviraler und antithrombotischer wirkung und deren verwendungen
TR200402534T4 (tr) Viral enfeksiyonların tedavisinde yararlı oksazinokuinolonlar.
WO2001098275A3 (en) 1-aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
MXPA04006041A (es) Antivirales de piridoquinoxalina.
CY1109592T1 (el) 5-υποκατεστημενα παραγωγα πυριμιδινης νουκλεοζιτικων αναλογων με κλειδωμα διαμορφωσης
EA200600046A1 (ru) Производные 6-[2-(фосфонометокси)алкокси]пиримидинов (варианты), способ их получения (варианты), фармацевтическая композиция на их основе и способ лечения вирусной инфекции
TR200000907T2 (tr) Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri.
WO2003002580A8 (en) 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity
DK1068209T3 (da) Fremgangsmåde til fremstilling af purinderivater og deres mellemprodukter
TR200102501T2 (tr) Antiviral nükleozid analoglar.
ATE251162T1 (de) Triazolo(4,5-d)pyrimidin-verbindungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1280813

Country of ref document: EP

REN Ceased due to non-payment of the annual fee