ATE133682T1 - Verfahren zur herstellung von 2-amino-9-(2,3,5- tri-0-benzyl-beta-d-arabinofuranosyl)adenin und neue zwischenprodukte - Google Patents

Verfahren zur herstellung von 2-amino-9-(2,3,5- tri-0-benzyl-beta-d-arabinofuranosyl)adenin und neue zwischenprodukte

Info

Publication number: ATE133682T1
Authority: AT; Austria
Prior art keywords: beta; arabinofuranosyl; adenine; tri; benzyl
Prior art date: 1989-12-04

Application number

AT91901479T

Other languages

English (en)

Inventor

Peter Blumbergs

Mohammed S Khan

Richard L Kalamas

Original Assignee

Ash Stevens Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-04

Filing date

1990-11-30

Publication date

1996-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23768933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE133682(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-11-30 Application filed by Ash Stevens Inc filed Critical Ash Stevens Inc

1996-02-15 Application granted granted Critical

1996-02-15 Publication of ATE133682T1 publication Critical patent/ATE133682T1/de

Links

GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 title 1
229930024421 Adenine Natural products 0.000 title 1
229960000643 adenine Drugs 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
IQJXEXWWKZGDAG-JAGXHNFQSA-N (2r,3s,4s,5r)-2-(2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC(F)=NC=C2N=C1 IQJXEXWWKZGDAG-JAGXHNFQSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
POKSXYSFFKXPCP-RIHHIRGMSA-N (2r,3s,4r,5r)-2-(6-amino-2-fluoropurin-9-yl)-3,4-dibenzyl-5-(1-hydroxy-2-phenylethyl)oxolane-3,4-diol Chemical compound OC([C@H]1O[C@H]([C@]([C@]1(CC=1C=CC=CC=1)O)(O)CC=1C=CC=CC=1)N1C=2N=C(F)N=C(C=2N=C1)N)CC1=CC=CC=C1 POKSXYSFFKXPCP-RIHHIRGMSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91901479T 1989-12-04 1990-11-30 Verfahren zur herstellung von 2-amino-9-(2,3,5- tri-0-benzyl-beta-d-arabinofuranosyl)adenin und neue zwischenprodukte ATE133682T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/445,446 US5110919A (en)	1989-12-04	1989-12-04	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates

Publications (1)

Publication Number	Publication Date
ATE133682T1 true ATE133682T1 (de)	1996-02-15

Family

ID=23768933

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91901479T ATE133682T1 (de)	1989-12-04	1990-11-30	Verfahren zur herstellung von 2-amino-9-(2,3,5- tri-0-benzyl-beta-d-arabinofuranosyl)adenin und neue zwischenprodukte

Country Status (9)

Country	Link
US (2)	US5110919A (de)
EP (1)	EP0456817B1 (de)
JP (2)	JPH07634B2 (de)
AT (1)	ATE133682T1 (de)
DE (2)	DE69025176T2 (de)
DK (1)	DK0456817T3 (de)
ES (1)	ES2038094T3 (de)
GR (2)	GR920300026T1 (de)
WO (1)	WO1991008215A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5110919A (en) *	1989-12-04	1992-05-05	Ash Stevens, Inc.	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CA2091732C (en) *	1992-07-08	1998-07-21	Anica Markovac	A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
US5602246A (en) *	1992-11-25	1997-02-11	Schering Aktiengesellschaft	Process for the preparation of fludarabine or fludarabine phosphate from guanosine
AU739574B2 (en) *	1997-12-11	2001-10-18	Alcafleu Management Gmbh & Co. Kg	Method for producing fludarabin phosphate lithium, sodium, potassium, calcium and magnesium salts, purification method for producing fludarabin phosphate and fludarabin phosphate which is at least 99.5 per cent pure
AU3851601A (en) *	2000-02-18	2001-08-27	Southern Res Inst	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h- purin-6-amine
DE10164510A1 (de) *	2001-12-20	2003-07-10	Schering Ag	Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
US7491725B2 (en)	2004-02-06	2009-02-17	Bristol-Myers Squibb Company	Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
WO2017036356A1 (zh) *	2015-08-28	2017-03-09	浙江海正药业股份有限公司	磷酸氟达拉滨的晶型及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3008969A (en) *	1958-05-21	1961-11-14	American Cyanamid Co	4-substituted-7-carboalkoxyamino-coumarins
USRE29835E (en) *	1971-06-01	1978-11-14	Icn Pharmaceuticals	1,2,4-Triazole nucleosides
US4188378A (en) *	1978-01-04	1980-02-12	The United States Of America As Represented By The Department Of Health, Education And Welfare	Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US5110919A (en) *	1989-12-04	1992-05-05	Ash Stevens, Inc.	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates

1989
- 1989-12-04 US US07/445,446 patent/US5110919A/en not_active Expired - Lifetime
1990
- 1990-11-30 DK DK91901479.5T patent/DK0456817T3/da active
- 1990-11-30 EP EP91901479A patent/EP0456817B1/de not_active Expired - Lifetime
- 1990-11-30 ES ES91901479T patent/ES2038094T3/es not_active Expired - Lifetime
- 1990-11-30 DE DE69025176T patent/DE69025176T2/de not_active Expired - Fee Related
- 1990-11-30 AT AT91901479T patent/ATE133682T1/de not_active IP Right Cessation
- 1990-11-30 JP JP3501945A patent/JPH07634B2/ja not_active Expired - Fee Related
- 1990-11-30 DE DE199191901479T patent/DE456817T1/de active Pending
- 1990-11-30 WO PCT/US1990/007004 patent/WO1991008215A1/en not_active Ceased
1992
- 1992-04-30 US US07/876,412 patent/US5296589A/en not_active Expired - Fee Related
- 1992-08-26 GR GR92300026T patent/GR920300026T1/el unknown
1994
- 1994-06-30 JP JP6149934A patent/JPH07108912B2/ja not_active Expired - Fee Related
1996
- 1996-04-16 GR GR960401037T patent/GR3019656T3/el unknown

Also Published As

Publication number	Publication date
JPH07108912B2 (ja)	1995-11-22
US5296589A (en)	1994-03-22
US5110919A (en)	1992-05-05
JPH07138280A (ja)	1995-05-30
JPH04504268A (ja)	1992-07-30
ES2038094T1 (es)	1993-07-16
GR3019656T3 (en)	1996-07-31
DK0456817T3 (da)	1996-04-29
GR920300026T1 (en)	1992-08-26
JPH07634B2 (ja)	1995-01-11
EP0456817B1 (de)	1996-01-31
DE456817T1 (de)	1992-04-09
EP0456817A1 (de)	1991-11-21
DE69025176T2 (de)	1996-05-30
WO1991008215A1 (en)	1991-06-13
EP0456817A4 (en)	1992-04-22
DE69025176D1 (de)	1996-03-14
ES2038094T3 (es)	1996-06-01

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Legal Events

Date	Code	Title	Description
1996-08-15	UEP	Publication of translation of european patent specification
2005-08-15	REN	Ceased due to non-payment of the annual fee