ES2038094T1 - Un procedimiento para la preparacion del compuesto 2,6-diamino-9-(2,3,5-trio-o-bencilbeta-d-arabinofuranosil)purina. - Google Patents

Un procedimiento para la preparacion del compuesto 2,6-diamino-9-(2,3,5-trio-o-bencilbeta-d-arabinofuranosil)purina.

Info

Publication number
ES2038094T1
ES2038094T1 ES199091901479T ES91901479T ES2038094T1 ES 2038094 T1 ES2038094 T1 ES 2038094T1 ES 199091901479 T ES199091901479 T ES 199091901479T ES 91901479 T ES91901479 T ES 91901479T ES 2038094 T1 ES2038094 T1 ES 2038094T1
Authority
ES
Spain
Prior art keywords
preparation
purine
bencilbeta
arabinofuranosil
trio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES199091901479T
Other languages
English (en)
Other versions
ES2038094T3 (es
Inventor
Peter Blumbergs
Mohammed S. Khan
Richard L. Kalamas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ASH Stevens Inc
Original Assignee
ASH Stevens Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23768933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2038094(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ASH Stevens Inc filed Critical ASH Stevens Inc
Publication of ES2038094T1 publication Critical patent/ES2038094T1/es
Application granted granted Critical
Publication of ES2038094T3 publication Critical patent/ES2038094T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA PREPARAR 2, 6-DIAMINO-9-(2, 3, 5-TRI-O-BENCIL -BETA-D-ARABINO-FURANOSIL PURINA (V) HACIENDO REACCIONAR 2, 6-DI (ALCOXIACETAMIDO)PURINA (II) CON 2, 3, 5-TRI-O-BENCIL-1-CLORO-ALFA-D -ARABINOFURANOSA (III) PARA PRODUCIR 2, 6-DI(ALCOXIACETAMIDO)-9-(2, 3, 5 -TRI-O-BENCIL-BETA-D-ARABINOFURANOSIL)PURINA (IV) Y LUEGO DESPROTEGER LAS POSICIONES 2, 6 PARA PRODUCIR LA 2, 6-DIAMINA (V). EL PROCESO PROPORCIONA PURINA (V) EN GRAN CANTIDAD. LA PURINA (V) ES UN INTERMEDIARIO EN LA PREPARACION DE 9-BETA-D-ARABINOFURANOSIL-2-FLUOROADENINA QUE ES UN AGENTE CITOTOXICO.
ES91901479T 1989-12-04 1990-11-30 Procedimiento para la preparacion de 2-amino-9-(2,3,5-tri-o-bencil-beta-d-arabinofuranosil)adenina y nuevos compuestos intermedios. Expired - Lifetime ES2038094T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/445,446 US5110919A (en) 1989-12-04 1989-12-04 Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates

Publications (2)

Publication Number Publication Date
ES2038094T1 true ES2038094T1 (es) 1993-07-16
ES2038094T3 ES2038094T3 (es) 1996-06-01

Family

ID=23768933

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901479T Expired - Lifetime ES2038094T3 (es) 1989-12-04 1990-11-30 Procedimiento para la preparacion de 2-amino-9-(2,3,5-tri-o-bencil-beta-d-arabinofuranosil)adenina y nuevos compuestos intermedios.

Country Status (9)

Country Link
US (2) US5110919A (es)
EP (1) EP0456817B1 (es)
JP (2) JPH07634B2 (es)
AT (1) ATE133682T1 (es)
DE (2) DE69025176T2 (es)
DK (1) DK0456817T3 (es)
ES (1) ES2038094T3 (es)
GR (2) GR920300026T1 (es)
WO (1) WO1991008215A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CA2091732C (en) * 1992-07-08 1998-07-21 Anica Markovac A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
US5602246A (en) * 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
JP4261051B2 (ja) * 1997-12-11 2009-04-30 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト リン酸フルダラビンのリチウム、ナトリウム、カリウム、カルシウム及びマグネシウム塩の製造方法、リン酸フルダラビンを製造するための精製方法及び少なくとも９９．５％の純度を有するリン酸フルダラビン
JP4555536B2 (ja) * 2000-02-18 2010-10-06 サザン・リサーチ・インスティテュート ２−クロロ−９−（２−デオキシ−２−フルオロ−β−Ｄ−アラビノフラノシル）−９Ｈ−プリン−６−アミンの合成方法
DE10164510A1 (de) * 2001-12-20 2003-07-10 Schering Ag Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
US10669302B2 (en) * 2015-08-28 2020-06-02 Zhejianf Hisun Pharmaceutical Co., Ltd. Crystal form of fludarabine phosphate, preparation method therefor, and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3008969A (en) * 1958-05-21 1961-11-14 American Cyanamid Co 4-substituted-7-carboalkoxyamino-coumarins
USRE29835E (en) * 1971-06-01 1978-11-14 Icn Pharmaceuticals 1,2,4-Triazole nucleosides
US4188378A (en) * 1978-01-04 1980-02-12 The United States Of America As Represented By The Department Of Health, Education And Welfare Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates

Also Published As

Publication number Publication date
DE69025176T2 (de) 1996-05-30
JPH04504268A (ja) 1992-07-30
JPH07108912B2 (ja) 1995-11-22
EP0456817A1 (en) 1991-11-21
JPH07634B2 (ja) 1995-01-11
GR920300026T1 (en) 1992-08-26
DK0456817T3 (da) 1996-04-29
US5110919A (en) 1992-05-05
US5296589A (en) 1994-03-22
WO1991008215A1 (en) 1991-06-13
JPH07138280A (ja) 1995-05-30
DE69025176D1 (de) 1996-03-14
EP0456817B1 (en) 1996-01-31
ATE133682T1 (de) 1996-02-15
DE456817T1 (de) 1992-04-09
GR3019656T3 (en) 1996-07-31
EP0456817A4 (en) 1992-04-22
ES2038094T3 (es) 1996-06-01

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