DK0456817T3 - Fremgangsmåde til fremstilling af 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabino-furanosyl)adenin og nye mellemprodukter - Google Patents

Fremgangsmåde til fremstilling af 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabino-furanosyl)adenin og nye mellemprodukter

Info

Publication number: DK0456817T3
Authority: DK; Denmark
Prior art keywords: beta; adenine; preparation; furanosyl; arabino
Prior art date: 1989-12-04

Application number

DK91901479.5T

Other languages

English (en)

Inventor

Peter Blumbergs

Richard L Kalamas

Mohammed S Khan

Original Assignee

Ash Stevens Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-04

Filing date

1990-11-30

Publication date

1996-04-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23768933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0456817(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-11-30 Application filed by Ash Stevens Inc filed Critical Ash Stevens Inc

1996-04-29 Application granted granted Critical

1996-04-29 Publication of DK0456817T3 publication Critical patent/DK0456817T3/da

Links

238000000034 method Methods 0.000 title abstract 2
OLAYGHLOZNVHSE-JVYBIVSJSA-N 9-[(2r,3s,4r,5r)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-yl]purine-2,6-diamine Chemical compound C([C@H]1O[C@H]([C@H]([C@@H]1OCC=1C=CC=CC=1)OCC=1C=CC=CC=1)N1C=NC2=C(N)N=C(N=C21)N)OCC1=CC=CC=C1 OLAYGHLOZNVHSE-JVYBIVSJSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
IQJXEXWWKZGDAG-JAGXHNFQSA-N (2r,3s,4s,5r)-2-(2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC(F)=NC=C2N=C1 IQJXEXWWKZGDAG-JAGXHNFQSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
POKSXYSFFKXPCP-RIHHIRGMSA-N (2r,3s,4r,5r)-2-(6-amino-2-fluoropurin-9-yl)-3,4-dibenzyl-5-(1-hydroxy-2-phenylethyl)oxolane-3,4-diol Chemical compound OC([C@H]1O[C@H]([C@]([C@]1(CC=1C=CC=CC=1)O)(O)CC=1C=CC=CC=1)N1C=2N=C(F)N=C(C=2N=C1)N)CC1=CC=CC=C1 POKSXYSFFKXPCP-RIHHIRGMSA-N 0.000 abstract 1
PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK91901479.5T 1989-12-04 1990-11-30 Fremgangsmåde til fremstilling af 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabino-furanosyl)adenin og nye mellemprodukter DK0456817T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/445,446 US5110919A (en)	1989-12-04	1989-12-04	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates

Publications (1)

Publication Number	Publication Date
DK0456817T3 true DK0456817T3 (da)	1996-04-29

Family

ID=23768933

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91901479.5T DK0456817T3 (da)	1989-12-04	1990-11-30	Fremgangsmåde til fremstilling af 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabino-furanosyl)adenin og nye mellemprodukter

Country Status (9)

Country	Link
US (2)	US5110919A (da)
EP (1)	EP0456817B1 (da)
JP (2)	JPH07634B2 (da)
AT (1)	ATE133682T1 (da)
DE (2)	DE69025176T2 (da)
DK (1)	DK0456817T3 (da)
ES (1)	ES2038094T3 (da)
GR (2)	GR920300026T1 (da)
WO (1)	WO1991008215A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5110919A (en) *	1989-12-04	1992-05-05	Ash Stevens, Inc.	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CA2091732C (en) *	1992-07-08	1998-07-21	Anica Markovac	A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
US5602246A (en) *	1992-11-25	1997-02-11	Schering Aktiengesellschaft	Process for the preparation of fludarabine or fludarabine phosphate from guanosine
KR20050085937A (ko) *	1997-12-11	2005-08-29	쉐링 악티엔게젤샤프트	고순도의 플루다라빈 포스페이트
AU3851601A (en) *	2000-02-18	2001-08-27	Southern Res Inst	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h- purin-6-amine
DE10164510A1 (de) *	2001-12-20	2003-07-10	Schering Ag	Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
US7491725B2 (en)	2004-02-06	2009-02-17	Bristol-Myers Squibb Company	Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
US10669302B2 (en) *	2015-08-28	2020-06-02	Zhejianf Hisun Pharmaceutical Co., Ltd.	Crystal form of fludarabine phosphate, preparation method therefor, and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3008969A (en) *	1958-05-21	1961-11-14	American Cyanamid Co	4-substituted-7-carboalkoxyamino-coumarins
USRE29835E (en) *	1971-06-01	1978-11-14	Icn Pharmaceuticals	1,2,4-Triazole nucleosides
US4188378A (en) *	1978-01-04	1980-02-12	The United States Of America As Represented By The Department Of Health, Education And Welfare	Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US5110919A (en) *	1989-12-04	1992-05-05	Ash Stevens, Inc.	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates

1989
- 1989-12-04 US US07/445,446 patent/US5110919A/en not_active Expired - Lifetime
1990
- 1990-11-30 DE DE69025176T patent/DE69025176T2/de not_active Expired - Fee Related
- 1990-11-30 AT AT91901479T patent/ATE133682T1/de not_active IP Right Cessation
- 1990-11-30 JP JP3501945A patent/JPH07634B2/ja not_active Expired - Fee Related
- 1990-11-30 EP EP91901479A patent/EP0456817B1/en not_active Expired - Lifetime
- 1990-11-30 WO PCT/US1990/007004 patent/WO1991008215A1/en not_active Ceased
- 1990-11-30 DK DK91901479.5T patent/DK0456817T3/da active
- 1990-11-30 ES ES91901479T patent/ES2038094T3/es not_active Expired - Lifetime
- 1990-11-30 DE DE199191901479T patent/DE456817T1/de active Pending
1992
- 1992-04-30 US US07/876,412 patent/US5296589A/en not_active Expired - Fee Related
- 1992-08-26 GR GR92300026T patent/GR920300026T1/el unknown
1994
- 1994-06-30 JP JP6149934A patent/JPH07108912B2/ja not_active Expired - Fee Related
1996
- 1996-04-16 GR GR960401037T patent/GR3019656T3/el unknown

Also Published As

Publication number	Publication date
GR920300026T1 (en)	1992-08-26
ES2038094T3 (es)	1996-06-01
US5296589A (en)	1994-03-22
DE69025176T2 (de)	1996-05-30
WO1991008215A1 (en)	1991-06-13
JPH04504268A (ja)	1992-07-30
ATE133682T1 (de)	1996-02-15
JPH07634B2 (ja)	1995-01-11
EP0456817A4 (en)	1992-04-22
EP0456817A1 (en)	1991-11-21
DE69025176D1 (de)	1996-03-14
JPH07108912B2 (ja)	1995-11-22
ES2038094T1 (es)	1993-07-16
EP0456817B1 (en)	1996-01-31
DE456817T1 (de)	1992-04-09
US5110919A (en)	1992-05-05
GR3019656T3 (en)	1996-07-31
JPH07138280A (ja)	1995-05-30

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