ATE138076T1 - Matritzenmetalloproteinasepeptide, ihre wirkung in diagnose und therapie - Google Patents

Matritzenmetalloproteinasepeptide, ihre wirkung in diagnose und therapie

Info

Publication number
ATE138076T1
ATE138076T1 AT90904575T AT90904575T ATE138076T1 AT E138076 T1 ATE138076 T1 AT E138076T1 AT 90904575 T AT90904575 T AT 90904575T AT 90904575 T AT90904575 T AT 90904575T AT E138076 T1 ATE138076 T1 AT E138076T1
Authority
AT
Austria
Prior art keywords
peptides
enzyme
metalloproteinase
inhibitors
metalloproteinases
Prior art date
Application number
AT90904575T
Other languages
English (en)
Inventor
Lance A Liotta
William Stetler-Stevenson
Henry C Krutzsch
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/317,407 external-priority patent/US5270447A/en
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE138076T1 publication Critical patent/ATE138076T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT90904575T 1989-03-01 1990-03-01 Matritzenmetalloproteinasepeptide, ihre wirkung in diagnose und therapie ATE138076T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/317,407 US5270447A (en) 1988-05-20 1989-03-01 Metalloproteinase peptides: role in diagnosis and therapy
US07/488,460 US5280106A (en) 1988-05-20 1990-02-26 Matrix metalloproteinase peptides: role in diagnosis and therapy

Publications (1)

Publication Number Publication Date
ATE138076T1 true ATE138076T1 (de) 1996-06-15

Family

ID=26980933

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90904575T ATE138076T1 (de) 1989-03-01 1990-03-01 Matritzenmetalloproteinasepeptide, ihre wirkung in diagnose und therapie

Country Status (9)

Country Link
US (3) US5280106A (de)
EP (1) EP0462182B1 (de)
JP (3) JP2736821B2 (de)
AT (1) ATE138076T1 (de)
AU (1) AU635007B2 (de)
DE (1) DE69027024T2 (de)
DK (1) DK0462182T3 (de)
ES (1) ES2088426T3 (de)
WO (1) WO1990010228A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5280106A (en) * 1988-05-20 1994-01-18 Liotta Lance A Matrix metalloproteinase peptides: role in diagnosis and therapy
EP0513388A4 (en) * 1990-11-30 1993-06-30 Asahi Glass Company Ltd. Peptide with activity of inhibiting cancer cell infiltration, composite thereof, and cancer metastasis inhibitor
US5837686A (en) * 1991-11-25 1998-11-17 Peptide Therapeutics Limited Peptides and antibodies for treatment of rheumatoid arthritis
EP0670737A4 (de) * 1992-03-26 1996-05-29 Gensia Inc In vivo peptidtherapie.
EP1002556A3 (de) * 1992-05-01 2001-01-10 British Biotech Pharmaceuticals Limited Verwendung von MMP Hemmer
EP0670849B1 (de) * 1992-10-29 2003-08-27 Bayer Corporation Diagnostischer test spezifisch für die latente matrix metalloproteinase no. 9
US5829174A (en) * 1994-04-08 1998-11-03 Sno-Way International, Inc. Articulated snowplow system
FI98961C (fi) * 1994-08-26 1997-09-10 Medix Biochemica Ab Oy Menetelmät ja määritysvälineet parodontaalisairauden aktiivisuuden ja/tai peri-implantiitin ja/tai niiden kohonneen riskin diagnosoimiseksi
US5759864A (en) * 1995-06-23 1998-06-02 Cedars Sinai Medical Center Methods for reducing background binding in antibody preparations
CA2252648C (en) * 1996-04-26 2009-11-03 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
US6811995B1 (en) * 1996-04-26 2004-11-02 Children's Medical Center Corporation Non-invasive enzyme screen for cancer
AU775537B2 (en) * 1996-04-26 2004-08-05 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
US5990293A (en) * 1996-09-05 1999-11-23 Celltech Therapeutics Limited Human metalloproteinase, variants thereof and DNA sequence coding therefor
AUPO573697A0 (en) * 1997-03-20 1997-04-10 Prince Henry's Institute Of Medical Research Diagnosis of endometrial cancer
AU4571099A (en) * 1998-06-16 2000-01-05 General Hospital Corporation, The Matrix metalloproteinase proenzyme activator
US20020151481A1 (en) * 2000-04-27 2002-10-17 Lawrence Weissbach MMP-2 propeptide for use as antiangiogenic or antitumor agent
US6767537B2 (en) 2000-05-26 2004-07-27 Phil Arnold Nicolay Composition and method for the treatment of sinusitis
US6600057B2 (en) 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
US7041787B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US7094754B2 (en) * 2001-08-16 2006-08-22 Kimberly-Clark Worldwide, Inc. Anti-aging and wound healing compounds
US7186693B2 (en) 2001-08-16 2007-03-06 Kimberly - Clark Worldwide, Inc. Metalloproteinase inhibitors for wound healing
US6906036B2 (en) * 2001-08-16 2005-06-14 Kimberly-Clark Worldwide, Inc. Anti-aging and wound healing compounds
US7071164B2 (en) * 2001-08-16 2006-07-04 Kimberly-Clark Worldwide, Inc. Anti-cancer and wound healing compounds
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
RU2346043C2 (ru) * 2002-01-23 2009-02-10 Маттиас Рат Синтетические пептиды и способ профилактического и лечебного применения при инвазии и метастазировании рака
US7148194B2 (en) * 2002-12-30 2006-12-12 Kimberly-Clark Worldwide, Inc. Method to increase fibronectin
US7189700B2 (en) * 2003-06-20 2007-03-13 Kimberly-Clark Worldwide, Inc. Anti-chrondrosarcoma compounds
US7405037B2 (en) * 2004-05-07 2008-07-29 Lonza Walkersville, Inc. Methods and tools for detecting collagen degradation
LT5328B (lt) 2004-08-23 2006-03-27 Matthias Rath Sintetiniai peptidai ir jų panaudojimas vėžio invazijos ir metastazių gydymui ir profilaktikai
JP5317954B2 (ja) 2006-03-16 2013-10-16 ボストン サイエンティフィック リミテッド 組織壁脱出症を治療するためのシステムおよび方法
US20070286813A1 (en) * 2006-06-09 2007-12-13 Toutounghi Camille Nasal formulation
KR101166387B1 (ko) 2007-03-17 2012-07-23 삼성전자주식회사 공기조화기의 실외기
US8481477B2 (en) 2010-01-12 2013-07-09 New York University Methods, agents and peptides for inducing an immune response to matrix metalloproteinase-2 expressing tumors
KR102504844B1 (ko) * 2019-02-01 2023-03-02 울산과학기술원 엔도트로핀 절단 효소의 저해제를 포함하는 엔도트로핀 활성 저해용 조성물 및 이의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486530A (en) * 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4677058A (en) * 1983-05-19 1987-06-30 Karl Tryggvason Detecting malignant cells with monoclonal antibodies specific to type IV collagenase enzyme
US4923818A (en) * 1987-09-04 1990-05-08 Washington University DNA clone of human type IV collagenase
US5280106A (en) * 1988-05-20 1994-01-18 Liotta Lance A Matrix metalloproteinase peptides: role in diagnosis and therapy

Also Published As

Publication number Publication date
AU635007B2 (en) 1993-03-11
JP2736821B2 (ja) 1998-04-02
EP0462182A1 (de) 1991-12-27
EP0462182A4 (en) 1992-08-12
JPH04501423A (ja) 1992-03-12
JP2001011093A (ja) 2001-01-16
DK0462182T3 (da) 1996-06-10
EP0462182B1 (de) 1996-05-15
WO1990010228A1 (en) 1990-09-07
AU5184090A (en) 1990-09-26
US5585356A (en) 1996-12-17
JPH09249700A (ja) 1997-09-22
DE69027024D1 (de) 1996-06-20
ES2088426T3 (es) 1996-08-16
US5280106A (en) 1994-01-18
DE69027024T2 (de) 1997-01-09
JP3252283B2 (ja) 2002-02-04
US5372809A (en) 1994-12-13

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