ATE138381T1 - Verfahren zur herstellung von sterilen beta- lactam-antibiotika - Google Patents

Verfahren zur herstellung von sterilen beta- lactam-antibiotika

Info

Publication number: ATE138381T1
Authority: AT; Austria
Prior art keywords: lactam antibiotics; producing sterile; beta; solution; sodium
Prior art date: 1992-10-05

Application number

AT93115972T

Other languages

English (en)

Inventor

Giordano Bruno Corsi

Alberto Brandt

Loredana Cecchetelli

Original Assignee

Istituto Biochimico Italiano

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-05

Filing date

1993-10-04

Publication date

1996-06-15

1993-10-04 Application filed by Istituto Biochimico Italiano filed Critical Istituto Biochimico Italiano

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138381T1 publication Critical patent/ATE138381T1/de

Links

239000003782 beta lactam antibiotic agent Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000002132 β-lactam antibiotic Substances 0.000 title 1
229940124586 β-lactam antibiotics Drugs 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 2
229910052708 sodium Inorganic materials 0.000 abstract 2
239000011734 sodium Substances 0.000 abstract 2
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 abstract 1
KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
229960003022 amoxicillin Drugs 0.000 abstract 1
150000007942 carboxylates Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
239000002244 precipitate Substances 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/14—Preparation of salts
- C07D499/16—Preparation of salts of alkali or alkaline earth metals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT93115972T 1992-10-05 1993-10-04 Verfahren zur herstellung von sterilen beta- lactam-antibiotika ATE138381T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI922296A IT1255716B (it)	1992-10-05	1992-10-05	Procedimento per la preparazione di antibiotici beta-lattamici sterili

Publications (1)

Publication Number	Publication Date
ATE138381T1 true ATE138381T1 (de)	1996-06-15

Family

ID=11364060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93115972T ATE138381T1 (de)	1992-10-05	1993-10-04	Verfahren zur herstellung von sterilen beta- lactam-antibiotika

Country Status (13)

Country	Link
US (1)	US5559241A (de)
EP (1)	EP0596262B1 (de)
JP (1)	JPH072869A (de)
KR (1)	KR970010068B1 (de)
AT (1)	ATE138381T1 (de)
AU (1)	AU674021B2 (de)
DE (1)	DE69302793T2 (de)
DK (1)	DK0596262T3 (de)
ES (1)	ES2089667T3 (de)
GR (1)	GR3020834T3 (de)
IT (1)	IT1255716B (de)
NZ (1)	NZ248853A (de)
PH (1)	PH31252A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW347383B (en) *	1995-10-26	1998-12-11	Biochemie Gmbh	A process for the production of a crystalline sodium salt of amoxicillin in ethanol as solvent
US6073052A (en) *	1996-11-15	2000-06-06	Zelickson; Brian D.	Device and method for treatment of gastroesophageal reflux disease
NZ508179A (en) *	1998-06-01	2002-10-25	Smithkline Beecham Corp	Process for preparing crystalline salts of amoxycillin
IN191580B (de)	1999-12-17	2003-12-06	Ranbaxy Lab Ltd
ITMI20011718A1 (it) *	2001-08-03	2003-02-03	Istituto Biochimico Italiano	Processo per la preparazione del sale sodico dell'acido-6(d-(-)-alpha-(4-etil-2,3-diosso-1-piperazinocarbonilammino)fenilacetammido)penicill
ITMI20051630A1 (it) *	2005-09-02	2007-03-03	Acs Dobfar Spa	Formulazione farmaceutica sterile iniettabile contenente almeno due principi attivi
MX2012014758A (es) *	2010-06-16	2013-10-01	Vardhman Chemtech Ltd	Proceso mejorado para preparar amoxicilina sodica.
JP7322568B2 (ja) *	2019-07-25	2023-08-08	カシオ計算機株式会社	メモリシステム、制御方法及びプログラム

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE639104A (de) *	1962-11-02
GB1543317A (en) *	1976-08-04	1979-04-04	Beecham Group Ltd	Process for the preparation of sodium amoxycillin
US4387051A (en) *	1979-10-29	1983-06-07	Beecham Group Limited	β-Lactam antibiotics, their preparation and their use in pharmaceutical compositions
FR2503710B1 (fr) *	1981-04-10	1985-07-05	Bristol Myers Co	Procede de production du sel de sodium de l'amoxicilline
DE3474023D1 (en) *	1983-06-10	1988-10-20	Beecham Group Plc	Crystalline amoxycillin salt
ES8606871A1 (es) *	1985-10-21	1986-06-01	Antibioticos Sa	Un procedimiento de preparacion de amoxicilina sodica

1992
- 1992-10-05 IT ITMI922296A patent/IT1255716B/it active IP Right Grant
1993
- 1993-10-04 EP EP93115972A patent/EP0596262B1/de not_active Expired - Lifetime
- 1993-10-04 ES ES93115972T patent/ES2089667T3/es not_active Expired - Lifetime
- 1993-10-04 DK DK93115972.7T patent/DK0596262T3/da active
- 1993-10-04 DE DE69302793T patent/DE69302793T2/de not_active Expired - Fee Related
- 1993-10-04 NZ NZ248853A patent/NZ248853A/en not_active IP Right Cessation
- 1993-10-04 KR KR1019930020444A patent/KR970010068B1/ko not_active Expired - Fee Related
- 1993-10-04 AU AU48760/93A patent/AU674021B2/en not_active Ceased
- 1993-10-04 AT AT93115972T patent/ATE138381T1/de not_active IP Right Cessation
- 1993-10-05 PH PH47015A patent/PH31252A/en unknown
- 1993-10-05 JP JP5271238A patent/JPH072869A/ja active Pending
1995
- 1995-09-15 US US08/528,546 patent/US5559241A/en not_active Expired - Lifetime
1996
- 1996-08-21 GR GR960402196T patent/GR3020834T3/el unknown

Also Published As

Publication number	Publication date
EP0596262B1 (de)	1996-05-22
ITMI922296A1 (it)	1994-04-05
GR3020834T3 (en)	1996-11-30
NZ248853A (en)	1995-10-26
DK0596262T3 (da)	1996-10-07
AU674021B2 (en)	1996-12-05
EP0596262A1 (de)	1994-05-11
PH31252A (en)	1998-06-18
KR940009206A (ko)	1994-05-20
DE69302793D1 (de)	1996-06-27
ES2089667T3 (es)	1996-10-01
IT1255716B (it)	1995-11-10
AU4876093A (en)	1994-04-21
ITMI922296A0 (it)	1992-10-05
US5559241A (en)	1996-09-24
JPH072869A (ja)	1995-01-06
DE69302793T2 (de)	1997-01-23
KR970010068B1 (ko)	1997-06-20

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Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
2009-07-15	REN	Ceased due to non-payment of the annual fee