ATE134633T1 - Thienoimidazolderivate, ihre herstellung und verwendung - Google Patents

Thienoimidazolderivate, ihre herstellung und verwendung

Info

Publication number
ATE134633T1
ATE134633T1 AT91118234T AT91118234T ATE134633T1 AT E134633 T1 ATE134633 T1 AT E134633T1 AT 91118234 T AT91118234 T AT 91118234T AT 91118234 T AT91118234 T AT 91118234T AT E134633 T1 ATE134633 T1 AT E134633T1
Authority
AT
Austria
Prior art keywords
group
diseases
ring
preparation
heart
Prior art date
Application number
AT91118234T
Other languages
English (en)
Inventor
Takehiko Naka
Yoshiyuki Inada
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE134633T1 publication Critical patent/ATE134633T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Lubricants (AREA)
AT91118234T 1990-10-30 1991-10-25 Thienoimidazolderivate, ihre herstellung und verwendung ATE134633T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29465590 1990-10-30
JP9208191 1991-04-23
JP15064391 1991-06-21

Publications (1)

Publication Number Publication Date
ATE134633T1 true ATE134633T1 (de) 1996-03-15

Family

ID=27306934

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91118234T ATE134633T1 (de) 1990-10-30 1991-10-25 Thienoimidazolderivate, ihre herstellung und verwendung

Country Status (13)

Country Link
US (1) US5463073A (de)
EP (1) EP0483683B1 (de)
KR (1) KR920008046A (de)
CN (1) CN1061973A (de)
AT (1) ATE134633T1 (de)
AU (1) AU636066B2 (de)
DE (1) DE69117431T2 (de)
FI (1) FI915099L (de)
HU (1) HUT62005A (de)
IE (1) IE913773A1 (de)
MX (1) MX9101768A (de)
NO (1) NO914236L (de)
PT (1) PT99357A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461040A1 (de) * 1990-06-08 1991-12-11 Roussel Uclaf Imidazolderivate, Verfahren zu deren Herstellung, Zwischenprodukte, deren Anwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen
TW274551B (de) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
EP0603712B1 (de) * 1992-12-22 2001-08-16 Takeda Chemical Industries, Ltd. Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP3810020B2 (ja) * 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
US5721263A (en) * 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
DE10341240A1 (de) 2003-09-08 2005-04-07 Aventis Pharma Deutschland Gmbh Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20070282099A1 (en) * 2006-06-02 2007-12-06 Steffen Zahn Heterocyclic fused imidazolone, dioxolone, imidazolethione and dioxolethione monomers
JPWO2008143262A1 (ja) 2007-05-21 2010-08-12 武田薬品工業株式会社 複素環化合物およびその用途
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (de) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituierte Benzimidazole als Angiotensin II-Hemmer
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
DE69013607T2 (de) * 1989-08-02 1995-03-02 Takeda Chemical Industries Ltd Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
EP0461040A1 (de) * 1990-06-08 1991-12-11 Roussel Uclaf Imidazolderivate, Verfahren zu deren Herstellung, Zwischenprodukte, deren Anwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
KR920008046A (ko) 1992-05-27
EP0483683A3 (en) 1992-06-03
HUT62005A (en) 1993-03-29
FI915099A0 (fi) 1992-08-11
EP0483683A2 (de) 1992-05-06
AU636066B2 (en) 1993-04-08
DE69117431T2 (de) 1996-06-13
PT99357A (pt) 1992-09-30
MX9101768A (es) 1992-06-05
DE69117431D1 (de) 1996-04-04
FI915099A7 (fi) 1992-08-11
IE913773A1 (en) 1992-05-22
HU913417D0 (en) 1992-01-28
NO914236D0 (no) 1991-10-29
CN1061973A (zh) 1992-06-17
FI915099L (fi) 1992-08-11
EP0483683B1 (de) 1996-02-28
NO914236L (no) 1992-05-04
US5463073A (en) 1995-10-31
AU8670791A (en) 1992-05-07

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties