ATE140926T1 - Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden - Google Patents

Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden

Info

Publication number
ATE140926T1
ATE140926T1 AT89900774T AT89900774T ATE140926T1 AT E140926 T1 ATE140926 T1 AT E140926T1 AT 89900774 T AT89900774 T AT 89900774T AT 89900774 T AT89900774 T AT 89900774T AT E140926 T1 ATE140926 T1 AT E140926T1
Authority
AT
Austria
Prior art keywords
peptides
cell adhesion
stabilized cell
adhesion peptides
conformationally stabilized
Prior art date
Application number
AT89900774T
Other languages
English (en)
Inventor
Michael D Pierschbacher
Erkki I Ruoslahti
Original Assignee
Jolla Cancer Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22449259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE140926(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jolla Cancer Res Found filed Critical Jolla Cancer Res Found
Application granted granted Critical
Publication of ATE140926T1 publication Critical patent/ATE140926T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65HHANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H3/00Separating articles from piles
    • B65H3/02Separating articles from piles using friction forces between articles and separator
    • B65H3/06Rollers or like rotary separators
    • B65H3/063Rollers or like rotary separators separating from the bottom of pile
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65HHANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H2406/00Means using fluid
    • B65H2406/30Suction means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Polyamides (AREA)
AT89900774T 1987-12-10 1988-12-08 Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden ATE140926T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13139087A 1987-12-10 1987-12-10

Publications (1)

Publication Number Publication Date
ATE140926T1 true ATE140926T1 (de) 1996-08-15

Family

ID=22449259

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89900774T ATE140926T1 (de) 1987-12-10 1988-12-08 Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden

Country Status (8)

Country Link
US (2) US6020460A (de)
EP (2) EP0731110A1 (de)
JP (2) JP2547263B2 (de)
AT (1) ATE140926T1 (de)
AU (1) AU639409B2 (de)
CA (1) CA1341106C (de)
DE (1) DE3855458T2 (de)
WO (1) WO1989005150A1 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005150A1 (en) * 1987-12-10 1989-06-15 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
JP2945680B2 (ja) * 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US5686566A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5384309A (en) 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5061693A (en) * 1989-07-28 1991-10-29 Merck & Co., Inc. Fibrinogen receptor antagonists
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2021950A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
EP0410539A1 (de) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogenrezeptorantagonisten
US5120859A (en) * 1989-09-22 1992-06-09 Genentech, Inc. Chimeric amino acid analogues
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
WO1991011458A1 (en) * 1990-02-02 1991-08-08 Genentech, Inc. CYCLIC PEPTIDES CONTAINING Arg-Gly-Asp FLANKED BY PROLINE
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6017877A (en) * 1990-04-06 2000-01-25 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
DK0527798T3 (da) * 1990-04-06 1997-12-15 Jolla Cancer Res Found Fremgangsmåde og sammensætning til behandling af thrombose
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
DE69230525T2 (de) * 1991-02-08 2000-06-21 Diatide, Inc. Technetium-99m markierte Polypeptide zur Bildformung
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
AU666853B2 (en) * 1991-04-05 1996-02-29 Genentech Inc. Platelet aggregation inhibitors having high specificity for GP IIbIIIa
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5693636A (en) * 1991-06-28 1997-12-02 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
US5508020A (en) 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
DE69332203T2 (de) * 1992-10-02 2003-05-28 Diatide, Inc. Multimerische mehrzweckwirkstoffe gegen thrombose
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US6056940A (en) * 1993-04-08 2000-05-02 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
AU6770794A (en) * 1993-04-23 1994-11-21 Herbert J. Evans Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
JP3576554B2 (ja) * 1993-09-21 2004-10-13 協和醗酵工業株式会社 新規ペプチド
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5770565A (en) * 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
AU2958195A (en) * 1994-06-29 1996-01-25 Texas Biotechnology Corporation Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
EP0799189A4 (de) * 1994-12-13 1999-03-17 Smithkline Beecham Corp Bicyclische fibrinogen-antagonisten
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US6686444B2 (en) * 1996-08-22 2004-02-03 Children's Medical Center Corporation Osteopontin derived chemotactic peptides and methods of use
AP1224A (en) 1998-03-19 2003-11-14 Bristol Myers Squibb Co Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
US6428579B1 (en) 1998-07-01 2002-08-06 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
US6277824B1 (en) 1998-07-10 2001-08-21 Adherex Technologies Compounds and methods for modulating adhesion molecule function
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
JP2003502019A (ja) * 1999-04-16 2003-01-21 チルドレンズ メディカル センター コーポレーション 接着調節ペプチドおよび使用のための方法
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
KR101399175B1 (ko) * 2006-07-21 2014-06-19 푼다싸웅 지 앙빠루 아 뻬스끼자 두 에스따두 지 싸웅 파울루 - 에피아뻬에에씨뻬 항염증성 및 항알레르기성 시클릭 펩티드
WO2008045252A2 (en) 2006-10-04 2008-04-17 The Board Of Trustees Of The Leland Stanford Junior University Engineered integrin binding peptides
US8354274B2 (en) 2008-01-30 2013-01-15 Geron Corporation Synthetic surfaces for culturing cells in chemically defined media
TW201042038A (en) 2009-05-28 2010-12-01 Corning Inc Synthetic microcarriers for culturing cells
EP2459701A1 (de) 2009-07-28 2012-06-06 Corning Inc. Synthetische mikroträger für zellkulturen
EP2459704A1 (de) 2009-07-28 2012-06-06 Corning Inc. Substrat mit grossem oberflächenbereich für zellkuktur
EP2361968B1 (de) 2010-02-26 2014-11-19 Corning Incorporated Synthetische Polysaccharid-Mikroträger zur Kultivierung von Zellen
US8778888B2 (en) * 2009-11-06 2014-07-15 The Board Of Trustees Of The Leland Stanford Junior University Cystine knot peptides binding to alpha IIb beta 3 integrins and methods of use
US20110207216A1 (en) 2010-02-25 2011-08-25 Arthur Winston Martin Synthetic Peptide (Meth) Acrylate Microcarriers
MY161846A (en) 2010-07-09 2017-05-15 James Trinca Green Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin
US20120052579A1 (en) 2010-08-27 2012-03-01 Simon Kelly Shannon Peptide-modified microcarriers for cell culture
WO2012027218A2 (en) 2010-08-27 2012-03-01 Corning Incorporated Peptide-modified surfaces for cell culture
AU2012256403B2 (en) 2011-03-17 2016-10-20 Corning Incorporated Synthetic coating for cell culture
JP5916256B2 (ja) 2011-05-05 2016-05-11 コーニング インコーポレイテッド 細胞培養のための合成組成物および被覆
WO2013078250A2 (en) 2011-11-22 2013-05-30 The Board Of Trustees Of The Leland Stanford Junior University Cystine knot peptides that bind alpha-v-beta-6 integrin
BR112014019157B1 (pt) 2012-02-02 2022-02-22 Corning Incorporated Meio de ligação sintético para cultura de célula
US10533044B2 (en) 2014-01-06 2020-01-14 The General Hospital Corporation Integrin Antagonists

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1562732A (en) * 1976-02-10 1980-03-12 Allen & Hanburys Ltd Device for dispensing medicaments
US4517666A (en) * 1981-06-22 1985-05-14 Tokyo Shibaura Denki Kabushiki Kaisha Optical head
US4474311A (en) * 1981-07-31 1984-10-02 Nordson Corporation Thermoplastic melting and dispensing apparatus
ZA831854B (en) * 1982-03-26 1984-01-25 Biogen Nv Small peptides with the specificity of foot and mouth disease viral antigens
US4661111A (en) * 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4517686A (en) * 1982-08-04 1985-05-21 La Jolla Cancer Research Foundation Polypeptide
US5041380A (en) * 1982-08-04 1991-08-20 La Jolla Cancer Research Foundation Tetrapeptide
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4589881A (en) * 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
GB8301928D0 (en) * 1983-01-24 1983-02-23 Nicholson B H Process for producing polypeptides
JPS59177159A (ja) * 1983-03-28 1984-10-06 Yokohama Rubber Co Ltd:The 接着剤の塗工方法及びその装置
JPS6044074A (ja) * 1983-08-18 1985-03-08 Kikkoman Corp 接着剤の自動供給方法及び自動供給装置
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
JPS60257873A (ja) * 1984-06-04 1985-12-19 Kyoritsu Kikai Shoji Kk 接着剤自動供給装置
US4547489A (en) * 1984-06-11 1985-10-15 Ortho Pharmaceutical Corporation Conformationally restricted thymopentin-like compounds
US4789734A (en) * 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
DE3781263T2 (de) * 1986-12-15 1993-04-08 Inst Nat Sante Rech Med Peptid-derivate und deren verwendung in der therapie.
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
FR2622587B1 (fr) * 1987-10-30 1990-12-21 Inst Vaisseaux Sang Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
ES2060654T3 (es) * 1987-11-18 1994-12-01 Univ Temple Trigramina - un polipeptido inhibidor de la agregacion plaquetaria.
FR2623509B1 (fr) * 1987-11-19 1990-04-20 Centre Nat Rech Scient Proteine de 17 kd a action angiogenique, son procede d'isolement a partir de lait de mammiferes, compositions therapeutiques la contenant, procede de detection et/ou de dosage et reactifs immunologiques de detection et de dosage des angiogenines de mammiferes, de leurs homologues et de leurs fragments
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
WO1989005150A1 (en) * 1987-12-10 1989-06-15 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
WO1989007609A1 (en) * 1988-02-22 1989-08-24 The Upjohn Company Homoarginine-based peptides as platelet aggregation inhibitors
US5066592A (en) * 1988-03-08 1991-11-19 Temple University Of The Commonwealth System Of Higher Education Trigramin - a platelet aggregation inhibiting polypeptide
NZ228710A (en) * 1988-04-22 1992-10-28 Merck & Co Inc Modified "echistatin" and anti-clotting pharmaceutical composition
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
ATE144535T1 (de) * 1988-06-30 1996-11-15 Cor Therapeutics Inc Plättchen blockierende peptide
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
JP2945680B2 (ja) * 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
US5169836A (en) * 1988-11-10 1992-12-08 Trustees Of The University Of Penna. Inhibitors of platelet binding
DE3841753A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
DE3841763A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
DK0527798T3 (da) * 1990-04-06 1997-12-15 Jolla Cancer Res Found Fremgangsmåde og sammensætning til behandling af thrombose
DE69132332T2 (de) * 1990-04-06 2000-11-30 Genelabs Technologies, Inc. Hepatitis c-virus-epitope
US6589881B2 (en) * 2001-11-27 2003-07-08 United Microelectronics Corp. Method of forming dual damascene structure
US7228306B1 (en) * 2002-12-31 2007-06-05 Emc Corporation Population of discovery data

Also Published As

Publication number Publication date
DE3855458D1 (de) 1996-09-05
WO1989005150A1 (en) 1989-06-15
CA1341106C (en) 2000-10-03
JPH03501610A (ja) 1991-04-11
EP0394326B1 (de) 1996-07-31
DE3855458T2 (de) 1996-12-05
AU639409B2 (en) 1993-07-29
EP0394326A1 (de) 1990-10-31
US6020460A (en) 2000-02-01
JPH07165797A (ja) 1995-06-27
AU2817389A (en) 1989-07-05
US5880092A (en) 1999-03-09
JP2547263B2 (ja) 1996-10-23
EP0731110A1 (de) 1996-09-11
EP0394326A4 (en) 1991-03-13

Similar Documents

Publication Publication Date Title
ATE140926T1 (de) Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden
ATE45382T1 (de) Biosynthetisch hergestellter humannervenwachstumsfaktor, verfahren zu seiner herstellung, diesen faktor enthaltende zusammensetzungen, diesen faktor codierende dna- sequenz, vektoren, die diese sequenz enthalten und dadurch transformierte wirtszellen.
DE3880438D1 (de) Verfahren zur herstellung von aktivkohle.
DE3889361D1 (de) Verfahren zur Herstellung von organische Füllstoffe enthaltenden Polyolefinharzzusammensetzungen.
DE69016739D1 (de) Chirale Azabicycloheptanone und Verfahren zu ihrer Herstellung.
DE68925083D1 (de) Rekombinante DNS, diese rekombinante DNS enthaltender Mikroorganismus und Verfahren zur Herstellung von L-Aminosäure unter Verwendung dieses Mikroorganismus
DE69020143D1 (de) Verfahren zur verwendung und herstellung von peptiden.
ATE280240T1 (de) Enzymatische verfahren zur aüftrennüng von enantiomeren-mischungen nützlich als zwischenprodukte zur herstellung von taxanen
DE3783081D1 (de) Verfahren zur herstellung von bernsteinsaeure durch anaerobe fermentation.
DE60015371D1 (de) Verfahren zur herstellung von n-[(aliphatisch oder aromatisch)carbonyl]-2-aminoacetamid-verbindungen und deren cyclisierung
DE3682130D1 (de) Verfahren zur herstellung von ultrafeinen organischen verbindungen.
ATE226940T1 (de) Verfahren zur herstellung von d-threo-(r,r)- methylphenidat und recycling nicht erwünschter enantiomere durch epimerisierung
DE3862306D1 (de) Verfahren zur elektrochemischen herstellung von carbonsaeuren.
ATE132487T1 (de) Verfahren zur herstellung von substituierten piperidinen
ATE42553T1 (de) Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DE3875953D1 (de) Verfahren zur herstellung von organischen chemischen verbindungen.
DE3687006D1 (de) Verfahren zur herstellung von 2-alkoxy-n-(1-azabicyclo(2.2.2)octan-3-yl)aminobenzamiden.
DE3864512D1 (de) Verfahren zur herstellung von kandis mit gepressten gaszellen.
DE3854420D1 (de) Onkogen kodierendes polypeptid, das wachstumsfaktoraktivität besitzt, verfahren zu seiner herstellung und verwendung.
ATE205498T1 (de) Verfahren zur herstellung von kaliumclavulanat
DE3768784D1 (de) Verfahren zur herstellung von caprolactam.
DE3668164D1 (de) Verfahren zur herstellung von tertiaeren olefinen durch zersetzung von alkyl-tert.-alkylaethern.
DE3766648D1 (de) Katalytisches verfahren zur herstellung von silakohlenwasserstoffen.
ATA217886A (de) Verfahren zur herstellung von 6-(d-(-)-alpha-(4- ethyl-2,3-dioxo-1-piperazinocarbonylamino)- phenylazetamido)-penicillansaeure
ES2165358T3 (es) Utilizaciones de la proteinquinasa de neurofilamento/tau pk40.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee
RZN Patent revoked