ATE70992T1 - Haertungsmittel fuer phasentrennungsmikroverkapselung. - Google Patents

Haertungsmittel fuer phasentrennungsmikroverkapselung.

Info

Publication number
ATE70992T1
ATE70992T1 AT88106617T AT88106617T ATE70992T1 AT E70992 T1 ATE70992 T1 AT E70992T1 AT 88106617 T AT88106617 T AT 88106617T AT 88106617 T AT88106617 T AT 88106617T AT E70992 T1 ATE70992 T1 AT E70992T1
Authority
AT
Austria
Prior art keywords
hardening agent
phase separation
separation microencapsulation
compositions
prior
Prior art date
Application number
AT88106617T
Other languages
English (en)
Inventor
James Ronald Lawter
Michael Gerard Lanzilotti
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE70992T1 publication Critical patent/ATE70992T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Packages (AREA)
  • Glass Compositions (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymerisation Methods In General (AREA)
AT88106617T 1987-05-26 1988-05-18 Haertungsmittel fuer phasentrennungsmikroverkapselung. ATE70992T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/054,372 US5000886A (en) 1987-05-26 1987-05-26 Silicone-hardened pharmaceutical microcapsules and process of making the same
EP88106617A EP0292710B1 (de) 1987-05-26 1988-05-18 Härtungsmittel für Phasentrennungsmikroverkapselung

Publications (1)

Publication Number Publication Date
ATE70992T1 true ATE70992T1 (de) 1992-01-15

Family

ID=21990585

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88106617T ATE70992T1 (de) 1987-05-26 1988-05-18 Haertungsmittel fuer phasentrennungsmikroverkapselung.

Country Status (19)

Country Link
US (1) US5000886A (de)
EP (1) EP0292710B1 (de)
JP (1) JP2712101B2 (de)
KR (1) KR970001209B1 (de)
AT (1) ATE70992T1 (de)
AU (1) AU618000B2 (de)
BR (1) BR1100810A (de)
CA (1) CA1330533C (de)
DE (1) DE3867313D1 (de)
DK (1) DK169119B1 (de)
ES (1) ES2038236T3 (de)
GR (1) GR3004186T3 (de)
HK (1) HK116493A (de)
IE (1) IE61338B1 (de)
IL (1) IL86274A (de)
NO (1) NO177984C (de)
NZ (1) NZ224722A (de)
PH (1) PH27019A (de)
ZA (1) ZA883737B (de)

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US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
US6217911B1 (en) * 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
USRE40786E1 (en) 1984-03-16 2009-06-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
US6024983A (en) * 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US5985354A (en) 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
US5143661A (en) * 1987-05-26 1992-09-01 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules
EP0374532B1 (de) * 1988-12-22 1994-09-21 American Cyanamid Company Durch Phasentrennung microinkapsulierte Arzneimittelzusammensetzung zur Verminderung der Zahnkrankheit
EP0374531B1 (de) * 1988-12-22 1994-05-04 American Cyanamid Company Verfahren zur Behandlung von Periodontitis durch protrahierte Wirkstoffabgabe von Arzneimitteln in der Zahnhöhle, Zusammensetzung davon und Vorrichtung zur Verabreichung
AU8303691A (en) 1991-04-24 1992-12-21 United States Of America, As Represented By The Secretary Of The Army, The Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
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DE4223169C1 (de) * 1992-07-10 1993-11-25 Ferring Arzneimittel Gmbh Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
DE4239244A1 (de) * 1992-11-21 1994-05-26 Basf Ag Retard-Form für pharmazeutische Wirkstoffe
US6939546B2 (en) 1993-05-21 2005-09-06 The United States Of America As Represented By The Secretary Of The Army Model for testing immunogenicity of peptides
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US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
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US8580307B2 (en) 2006-06-22 2013-11-12 Ethicon, Inc. High glass transition temperature absorbable microspheres
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Also Published As

Publication number Publication date
NO882277L (no) 1988-11-28
JPS63307813A (ja) 1988-12-15
EP0292710A2 (de) 1988-11-30
DE3867313D1 (de) 1992-02-13
KR880013553A (ko) 1988-12-21
AU1659288A (en) 1988-12-01
IL86274A0 (en) 1988-11-15
CA1330533C (en) 1994-07-05
US5000886A (en) 1991-03-19
HK116493A (en) 1993-11-05
BR1100810A (pt) 1999-10-13
KR970001209B1 (ko) 1997-02-04
EP0292710A3 (en) 1989-03-22
DK285088D0 (da) 1988-05-25
AU618000B2 (en) 1991-12-12
IE881565L (en) 1988-11-26
PH27019A (en) 1993-02-01
DK169119B1 (da) 1994-08-22
ZA883737B (en) 1989-02-22
IE61338B1 (en) 1994-11-02
JP2712101B2 (ja) 1998-02-10
DK285088A (da) 1988-11-27
IL86274A (en) 1992-03-29
NO177984B (no) 1995-09-25
NO177984C (no) 1996-01-03
GR3004186T3 (de) 1993-03-31
NZ224722A (en) 1990-04-26
EP0292710B1 (de) 1992-01-02
ES2038236T3 (es) 1993-07-16
NO882277D0 (no) 1988-05-25

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Legal Events

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EELA Cancelled due to lapse of time