ATE142878T1 - Verwendung der 3-indolbrenztraubensäure zur erniedrigung der glucocorticoidblutspiegel und zur vorbeugung cerebraler störungen - Google Patents

Verwendung der 3-indolbrenztraubensäure zur erniedrigung der glucocorticoidblutspiegel und zur vorbeugung cerebraler störungen

Info

Publication number: ATE142878T1
Authority: AT; Austria
Prior art keywords: acid; indolepyrugenic; blood levels; cerebral disorders; prevent cerebral
Prior art date: 1993-01-25

Application number

AT93830530T

Other languages

English (en)

Inventor

Vincenzo Politi

Mario Materazzi

Stazio Giovanni Di

Luca Giovanna De

Original Assignee

Polifarma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-25

Filing date

1993-12-29

Publication date

1996-10-15

1993-12-29 Application filed by Polifarma Spa filed Critical Polifarma Spa

1996-10-15 Application granted granted Critical

1996-10-15 Publication of ATE142878T1 publication Critical patent/ATE142878T1/de

Links

239000008280 blood Substances 0.000 title abstract 2
210000004369 blood Anatomy 0.000 title abstract 2
239000003862 glucocorticoid Substances 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
230000002490 cerebral effect Effects 0.000 title 1
RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical compound C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
210000004100 adrenal gland Anatomy 0.000 abstract 1
230000032683 aging Effects 0.000 abstract 1
208000029028 brain injury Diseases 0.000 abstract 1
230000035882 stress Effects 0.000 abstract 1
229940037128 systemic glucocorticoids Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Hematology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT93830530T 1993-01-25 1993-12-29 Verwendung der 3-indolbrenztraubensäure zur erniedrigung der glucocorticoidblutspiegel und zur vorbeugung cerebraler störungen ATE142878T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITRM930034A IT1261165B (it)	1993-01-25	1993-01-25	Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'.

Publications (1)

Publication Number	Publication Date
ATE142878T1 true ATE142878T1 (de)	1996-10-15

Family

ID=11401415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93830530T ATE142878T1 (de)	1993-01-25	1993-12-29	Verwendung der 3-indolbrenztraubensäure zur erniedrigung der glucocorticoidblutspiegel und zur vorbeugung cerebraler störungen

Country Status (7)

Country	Link
US (1)	US5447951A (de)
EP (1)	EP0608671B1 (de)
JP (1)	JP2562278B2 (de)
AT (1)	ATE142878T1 (de)
DE (1)	DE69304885T2 (de)
ES (1)	ES2093953T3 (de)
IT (1)	IT1261165B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1820756A (zh) *	2001-03-23	2006-08-23	科塞普特治疗公司	使用糖皮质激素受体特效拮抗剂治疗压力症的方法
US7371763B2 (en) *	2001-04-20	2008-05-13	Bayer Pharmaceuticals Corporation	Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
CN103860694A (zh) *	2014-02-14	2014-06-18	四川蜀源博业医药科技有限公司	一种鼻腔用离子敏感型原位凝胶剂及其制备方法和用途
JP7093961B2 (ja) *	2018-02-13	2022-07-01	国立大学法人金沢大学	ストレス低減薬剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1148618B (it) *	1982-10-11	1986-12-03	Polifarma Spa	Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
IT1184282B (it) *	1985-06-28	1987-10-22	Polifarma Spa	Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico
IT1206078B (it) *	1987-06-03	1989-04-14	Polifarma Spa	Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
IT1224546B (it) *	1988-09-29	1990-10-04	Polifarma Spa	Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative
IT1232167B (it) *	1989-08-08	1992-01-25	Polifarma Spa	Uso cosmetico di acido 3-indolpiruvico

1993
- 1993-01-25 IT ITRM930034A patent/IT1261165B/it active IP Right Grant
- 1993-12-29 EP EP93830530A patent/EP0608671B1/de not_active Expired - Lifetime
- 1993-12-29 AT AT93830530T patent/ATE142878T1/de active
- 1993-12-29 DE DE69304885T patent/DE69304885T2/de not_active Expired - Fee Related
- 1993-12-29 ES ES93830530T patent/ES2093953T3/es not_active Expired - Lifetime
1994
- 1994-01-10 US US08/179,203 patent/US5447951A/en not_active Expired - Lifetime
- 1994-01-24 JP JP6005893A patent/JP2562278B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH06234634A (ja)	1994-08-23
DE69304885D1 (de)	1996-10-24
EP0608671B1 (de)	1996-09-18
EP0608671A1 (de)	1994-08-03
ITRM930034A1 (it)	1994-07-25
IT1261165B (it)	1996-05-09
ES2093953T3 (es)	1997-01-01
JP2562278B2 (ja)	1996-12-11
ITRM930034A0 (it)	1993-01-25
DE69304885T2 (de)	1997-03-27
US5447951A (en)	1995-09-05

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