ATE146779T1 - Benzimidazolderivate, verfahren zu deren herstellung und anwendung - Google Patents

Benzimidazolderivate, verfahren zu deren herstellung und anwendung

Info

Publication number
ATE146779T1
ATE146779T1 AT91106330T AT91106330T ATE146779T1 AT E146779 T1 ATE146779 T1 AT E146779T1 AT 91106330 T AT91106330 T AT 91106330T AT 91106330 T AT91106330 T AT 91106330T AT E146779 T1 ATE146779 T1 AT E146779T1
Authority
AT
Austria
Prior art keywords
anion
benzimidazole
substd
opt
production
Prior art date
Application number
AT91106330T
Other languages
English (en)
Inventor
Takehiko Naka
Kohei Nishikawa
Takeshi Kato
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27526589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE146779(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE146779T1 publication Critical patent/ATE146779T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT91106330T 1990-04-27 1991-04-19 Benzimidazolderivate, verfahren zu deren herstellung und anwendung ATE146779T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP11314890 1990-04-27
JP14194290 1990-05-30
JP20866290 1990-08-06
JP26457990 1990-10-01
JP41367990 1990-12-24

Publications (1)

Publication Number Publication Date
ATE146779T1 true ATE146779T1 (de) 1997-01-15

Family

ID=27526589

Family Applications (2)

Application Number Title Priority Date Filing Date
AT91106330T ATE146779T1 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, verfahren zu deren herstellung und anwendung
AT95118796T ATE227709T1 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, ihre herstellung und verwendung als angiotensin ii-antagonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT95118796T ATE227709T1 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, ihre herstellung und verwendung als angiotensin ii-antagonisten

Country Status (21)

Country Link
US (4) US5196444A (de)
EP (2) EP0720982B1 (de)
JP (2) JP2514282B2 (de)
KR (1) KR100200541B1 (de)
CN (2) CN1048486C (de)
AT (2) ATE146779T1 (de)
CA (2) CA2204290C (de)
CY (1) CY2150B1 (de)
DE (3) DE69133149T2 (de)
DK (2) DK0720982T3 (de)
ES (2) ES2095266T3 (de)
FI (2) FI108434B (de)
GR (1) GR3022172T3 (de)
HU (2) HU213266B (de)
IE (1) IE911317A1 (de)
LU (1) LU90224I2 (de)
LV (1) LV10258B (de)
NL (1) NL970044I2 (de)
NO (3) NO300923B1 (de)
NZ (1) NZ237949A (de)
PT (1) PT97451B (de)

Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223499A (en) * 1989-05-30 1993-06-29 Merck & Co., Inc. 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists
US5332744A (en) * 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
GB9027198D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
GB9027208D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
FR2673427B1 (fr) * 1991-03-01 1993-06-18 Sanofi Elf Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
TW274551B (de) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
GB9201789D0 (en) * 1992-01-28 1992-03-11 Fujisawa Pharmaceutical Co Heterocyclic derivatives
US5354759A (en) * 1991-09-12 1994-10-11 Fujisawa Pharmaceutical Co., Ltd. Angiotenin II antagonizing heterocyclic compounds
JP2682353B2 (ja) * 1991-11-20 1997-11-26 武田薬品工業株式会社 経口用医薬組成物およびその製造法
TW284688B (de) 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
DE4203872A1 (de) * 1992-02-11 1993-08-12 Thomae Gmbh Dr K Imidazo(1,2-a)pyridine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1993018030A1 (en) * 1992-03-03 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives as angiotensin ii antagonists
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
US5266583A (en) * 1992-09-01 1993-11-30 Merck & Co., Inc. Angitotensin II antagonist
DK154092D0 (da) * 1992-12-23 1992-12-23 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP2787539B2 (ja) * 1993-02-26 1998-08-20 松森　　昭 ウイルス性疾患の予防または治療剤
JP2003306432A (ja) * 1993-04-22 2003-10-28 Takeda Chem Ind Ltd 腎疾患の予防または治療剤
JP3810020B2 (ja) 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
CA2125251C (en) * 1993-06-07 2005-04-26 Yoshiyuki Inada A pharmaceutical composition for angiotensin ii-mediated diseases
US5721263A (en) * 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
JP3057471B2 (ja) * 1993-06-07 2000-06-26 武田薬品工業株式会社 アンジオテンシンｉｉ介在性諸疾患の予防または治療剤
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
US5391566A (en) * 1993-07-20 1995-02-21 Merck & Co., Inc. Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives
ZA945190B (en) * 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
US5824696A (en) * 1993-09-01 1998-10-20 Smithkline Beecham Corporation Medicaments
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
EP0668272B1 (de) * 1994-01-28 2000-07-12 Takeda Chemical Industries, Ltd. Ein Verfahren zur Herstellung von Tetrazolyl-Verbindungen
DE4408497A1 (de) * 1994-03-14 1995-09-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
ATE206050T1 (de) * 1994-03-16 2001-10-15 Sankyo Co Okulares hypotensium
AU677702B2 (en) * 1994-10-13 1997-05-01 Takeda Pharmaceutical Company Limited A prophylactic or therapeutic drug for renal diseases
SE9501881D0 (sv) * 1995-05-19 1995-05-19 Astra Ab New pharmacological use of AII-receptor antagonists
SE9502219D0 (sv) * 1995-06-19 1995-06-19 Astra Ab Novel medical use
DE69624253T2 (de) * 1995-10-06 2003-08-07 Novartis Ag, Basel Ati-rezeptorantagonisten zur verhinderung und behandlung des postischemischen nervenversagens und zum schutze ischemischer nieren
HUP9900625A3 (en) * 1995-12-28 2003-04-28 Fujisawa Pharmaceutical Co Benzimidazole derivatives, pharmaceutical compositions containing them and process for preparing the compounds
DE69718146T2 (de) 1996-02-29 2003-10-02 Novartis Ag, Basel At1 rezeptor antagonist zur anregung von apoptosis
RU2188013C2 (ru) * 1996-04-05 2002-08-27 Такеда Кемикал Индастриз, Лтд. Комбинация, содержащая соединение, имеющее ангиотензин ii антагонистическую активность
CN1221259C (zh) * 1996-07-15 2005-10-05 三共株式会社 Cs－866、氯沙坦和坎迪沙坦用于制备治疗动脉硬化的药物
US5771604A (en) * 1997-04-07 1998-06-30 Maytag Corporation Clothes dryer air inlet arrangement
US6177587B1 (en) * 1997-05-26 2001-01-23 Takeda Chemical Industries, Ltd. Production method of aminobenzene compound
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
DE69830069T3 (de) 1997-10-17 2012-02-09 Ark Therapeutics Ltd. Verwendung von hemmern des renin-angiotensin systems zur behandlung von hypoxie oder verringertem stoffwechsel
WO1999042451A1 (en) * 1998-02-23 1999-08-26 Kureha Chemical Industry Co., Ltd. Benzimidazole derivative
DE19820151A1 (de) * 1998-05-06 1999-11-11 Hexal Ag Transdermales therapeutisches System zur Anwendung von Candesartan
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
PL203730B1 (pl) 1998-07-15 2009-11-30 Teijin Ltd Pochodna tiobenzimidazolu, kompozycja farmaceutyczna i jej zastosowanie
ES2373556T3 (es) 1998-12-23 2012-02-06 Novartis Ag Comprimidos de valsartán.
US6465502B1 (en) 1998-12-23 2002-10-15 Novartis Ag Additional therapeutic use
CN101011390A (zh) 1999-01-26 2007-08-08 诺瓦提斯公司 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
GB0001662D0 (en) * 1999-02-06 2000-03-15 Zeneca Ltd Pharmaceutical compositions
DE60045211D1 (de) * 1999-02-19 2010-12-23 Takeda Pharmaceutical Präparationen zur perkutanen aufnahme von zusammnesetzungen die einen angiotensin-ii-rezeptorantagonismus aufweisen
US6211217B1 (en) 1999-03-16 2001-04-03 Novartis Ag Method for reducing pericardial fibrosis and adhesion formation
WO2000076489A2 (en) * 1999-06-10 2000-12-21 Warner-Lambert Company Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
US6972287B1 (en) 1999-06-10 2005-12-06 Pfizer Inc. Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
EP1867342A1 (de) * 1999-07-21 2007-12-19 Takeda Pharmaceutical Company Limited Wirkstoffe zum Lindern von Beschwerden infolge von zerebrovaskulären Erkrankungen und zum Hemmen deren Fortschreitens
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
SK2692002A3 (en) * 1999-08-30 2002-07-02 Aventis Pharma Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
EP1262180A4 (de) * 2000-02-18 2005-06-01 Takeda Pharmaceutical Tnf-alpha hemmer
SE0002353D0 (sv) * 2000-06-22 2000-06-22 Astrazeneca Ab New use
MXPA03001306A (es) * 2000-08-11 2003-10-15 Boehringer Ingelheim Pharma Compuestos heterociclicos utiles como inhibidores de las quinasas de tirosina.
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
CA2420844A1 (en) * 2000-08-30 2003-02-28 Sankyo Company, Limited Medicinal compositions for preventing or treating heart failure
US20040102502A1 (en) * 2000-10-25 2004-05-27 Toshifumi Watanabe Preventing/remedies for portal hypertension
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
ATE416784T1 (de) 2000-12-01 2008-12-15 Takeda Pharmaceutical Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
CA2453890A1 (en) * 2001-08-03 2003-02-20 Takeda Chemical Industries, Ltd. Crystal and process for producing the same
WO2003020315A1 (fr) * 2001-08-28 2003-03-13 Sankyo Company, Limited Compositions medicinales contenant un antagoniste du recepteur d'angiotensine ii
US7107198B2 (en) * 2001-11-02 2006-09-12 Sun Microsystems, Inc. Automatic generation of reduced-size circuit models including inductive interaction
CA2466659A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticancer agents
DE10205335A1 (de) * 2002-02-07 2003-08-21 Bdd Group Holding Ag Zug Deuterierte biphenylsubstituierte Benzimidazole sowie diese Verbindungen enthaltende Arzneimittel
EP1482896A4 (de) * 2002-03-01 2005-11-23 Merck & Co Inc Aminoalkylphosphonate und verwandte verbindungen als edg-rezeptor-agonisten
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
DE10335027A1 (de) 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Angiotensin II Rezeptor Antagonisten
WO2004083192A1 (en) * 2003-03-17 2004-09-30 Teva Pharmaceutical Industries Ltd. Polymorphis of valsartan
US7504516B2 (en) * 2003-03-27 2009-03-17 Hetero Drugs Limited Crystalline forms of candesartan cilexetil
SE0300988D0 (sv) * 2003-04-03 2003-04-03 Astrazeneca Ab New use
EP1556363A2 (de) * 2003-04-21 2005-07-27 Teva Pharmaceutical Industries Limited Verfahren zur herstellung von valsartan und zwischenprodukte davon
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0316546D0 (en) 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
ATE482950T1 (de) * 2003-08-27 2010-10-15 Zentiva Ks Verfahren zur entfernung der triphenylmethanschutzgruppe
WO2005030202A1 (en) * 2003-09-26 2005-04-07 Novartis Ag Use of angiotensin ii receptor antagonists for treating cerebrovascular disorders
GB0322552D0 (en) * 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
DE602004005488T2 (de) * 2003-10-16 2007-11-29 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von candesartan cilexetil
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US7829552B2 (en) 2003-11-19 2010-11-09 Metabasis Therapeutics, Inc. Phosphorus-containing thyromimetics
WO2005051928A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Process for production of tetrazolyl compounds
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
JP2005206603A (ja) * 2004-01-21 2005-08-04 Teva Pharmaceutical Industries Ltd カンデサルタンシレキセチルの調製
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
US7692023B2 (en) * 2004-02-11 2010-04-06 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
JP2007529459A (ja) 2004-03-17 2007-10-25 ノバルティス アクチエンゲゼルシャフト 治療に置けるレニン阻害剤の使用
AU2005249367A1 (en) * 2004-04-16 2005-12-15 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
US20050250827A1 (en) * 2004-05-05 2005-11-10 Etinger Marina Y Preparation of candesartan cilexetil in high purity
JP2005330277A (ja) * 2004-05-19 2005-12-02 Teva Pharmaceutical Industries Ltd カンデサルタンシレキセチル多形体
JP2009185060A (ja) * 2004-05-19 2009-08-20 Teva Pharmaceutical Industries Ltd カンデサルタンシレキセチル多形体
WO2005117591A2 (en) * 2004-05-28 2005-12-15 Andrx Labs Llc Novel pharmaceutical formulation containing a biguanide and an angiotensin antagonist
WO2005123720A1 (en) * 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof
KR20070055563A (ko) 2004-08-23 2007-05-30 와이어쓰 혈전증 및 심혈관 질병의 치료에 유용한 플라스미노겐활성화제 억제제 타입-1(ｐａｉ-1)의 조절제로서의옥사졸로-나프틸 산
BRPI0514549A (pt) 2004-08-23 2008-06-17 Wyeth Corp ácidos de pirrol-naftila como inibidores de pai-1
US7605172B2 (en) 2004-08-23 2009-10-20 Wyeth Thiazolo-naphthyl acids
BRPI0516128A (pt) 2004-10-08 2008-08-26 Novartis Ag uso de inibidores de renina para a prevenção ou tratamento de disfunção diastólica ou insuficiência cardìca diastólica
MX2007005129A (es) 2004-10-27 2007-09-11 Daiichi Sankyo Co Ltd Compuesto de benceno que tiene 2 o mas sustituyentes.
KR20070074576A (ko) * 2004-10-29 2007-07-12 코와 가부시키가이샤 사구체 질환 치료제
EP1655298A1 (de) * 2004-11-03 2006-05-10 LEK Pharmaceuticals d.d. Krystalline Polymorpheme Formen von Candesartan Cilexetil
WO2006050922A1 (en) * 2004-11-11 2006-05-18 Lek Pharmaceuticals D.D. Process for the synthesis of tetrazoles
MX2007005137A (es) * 2004-11-23 2007-06-22 Warner Lambert Co Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
DE102004060699A1 (de) * 2004-12-16 2006-06-22 Ratiopharm Gmbh Verfahren zur Herstellung von Candesartan
PT1833801E (pt) * 2004-12-22 2008-08-25 Algry Quimica S L Compostos intermediários para a preparação de antagonistas do receptor da angiotensina ii
CA2594332A1 (en) * 2005-01-06 2006-07-13 Elan Pharma International Ltd. Nanoparticulate candesartan formulations
CA2590894A1 (en) * 2005-01-14 2006-07-20 Teva Pharmaceutical Industries Ltd. Preparation of crude candesartan cilexetil
ATE518526T1 (de) * 2005-01-26 2011-08-15 Lek Pharmaceuticals Neue pharmazeutische zusammensetzung mit candesartan-cilexetil als lipophile kristalline substanz
DK1863801T3 (da) * 2005-03-30 2010-11-15 Takeda Pharmaceutical Benzimidazolderivat og anvendelse deraf
TW200719896A (en) * 2005-04-18 2007-06-01 Astrazeneca Ab Combination product
CN100400536C (zh) * 2005-04-30 2008-07-09 重庆圣华曦药业有限公司 坎地沙坦酯c-型晶体的制备方法
CA2599415C (en) * 2005-05-10 2011-07-19 Teva Pharmaceutical Industries Ltd. Stable micronized candesartan cilexetil and methods for preparing thereof
AR053517A1 (es) * 2005-06-06 2007-05-09 Medichem Sa Proceso para la preparacion de compuestos de tetrazolilo, uso de los mismos en el tratamiento de enfermedades circulatorias y formulaciones farmaceuticas que los contienen.
ES2264641B1 (es) * 2005-06-17 2008-03-01 Quimica Sintetica, S.A. Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios.
BRPI0613430A2 (pt) 2005-07-13 2011-01-11 Hoffmann La Roche compostos derivados de benzimidazol, uso dos mesmos, método para a preparação destes e composição farmacêutica
SI22127A (sl) * 2005-10-07 2007-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo kandesartan cileksetila
CZ299265B6 (cs) * 2005-10-20 2008-05-28 Zentiva, A. S. Zpusob výroby 1-(cyklohexyloxykarbonyloxy)ethyl-2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)bifenyl-4-yl]methyl]benzimidazol-7-karboxylátu (candesartan cilexetilu)
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN100344625C (zh) * 2005-12-22 2007-10-24 浙江天宇药业有限公司 一种制备坎地沙坦的方法
US7943780B2 (en) * 2006-02-15 2011-05-17 Matrix Laboratories Ltd. Process for the preparation of candesartan cilexetil
CN101024643A (zh) 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
WO2008035360A2 (en) * 2006-06-13 2008-03-27 Alembic Limited Novel crystalline forms of candesartan cilexetil, candesartan, tritylated candesartan and tritylated candesartan cilexetil
EP2049510A1 (de) * 2006-07-28 2009-04-22 Krka Tovarna Zdravil, D.D., Novo Mesto Verfahren zur herstellung von candesartandilexetil form i
JP5361188B2 (ja) 2006-08-10 2013-12-04 武田薬品工業株式会社 医薬組成物
WO2008067037A2 (en) 2006-10-05 2008-06-05 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EP1908469A1 (de) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II Rezeptor Antagonisten zur Behandlung von systemischen Krankheiten bei Katzen
US8143435B2 (en) * 2006-10-10 2012-03-27 Mylan Laboratories Ltd. One pot process for the preparation of candesartan
WO2008057802A2 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
ES2315141B1 (es) * 2006-11-23 2009-12-22 Quimica Sintetica, S.A Procedimiento para la preparacion de cardesartan cilexetilo en forma cristalina.
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
JP5290190B2 (ja) * 2006-12-06 2013-09-18 サルブリス・アセット・マネイジメント・カンパニー・リミテッド イミダゾール−５−カルボン酸誘導体の塩、製造方法及びその医薬組成物
CN101214242A (zh) 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
EP1952806A1 (de) 2007-02-01 2008-08-06 Helm AG Herstellungsverfahren für Candesartan-Adsorbate
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
EP1988091B1 (de) 2007-02-07 2015-06-10 Kyowa Hakko Kirin Co., Ltd. Trizyklische verbindungen
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
CA2679446C (en) 2007-03-01 2016-05-17 Probiodrug Ag New use of glutaminyl cyclase inhibitors
ES2351542T3 (es) * 2007-03-08 2011-02-07 Teva Pharmaceutical Industries Ltd. Composición farmacéutica que comprende candesartan cilexetilo.
WO2008123536A1 (en) * 2007-03-28 2008-10-16 Takeda Pharmaceutical Company Limited Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a ph control agent
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
SI22488A (sl) * 2007-04-24 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalni 1-(cikloheksiloksikarboniloksi)etil 1-((2'-cianobifenil-4-il)metil) - 2-etoksi-1h-benz(d)imidazol -7-karboksilat in proces za njegovo pripravo
EP1985287A3 (de) 2007-04-25 2009-04-29 Teva Pharmaceutical Industries Ltd. Pharmazeutischer Hilfsstoffkomplex
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
TWI406850B (zh) 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
WO2009007986A1 (en) * 2007-07-11 2009-01-15 Alembic Limited An improved process for the preparation of candesartan cilexetil
JP2010538071A (ja) * 2007-09-07 2010-12-09 セラヴァンス， インコーポレーテッド 二重作用性降圧剤
CN101896470B (zh) * 2007-12-11 2013-04-10 施万制药 双重作用的苯并咪唑衍生物和其作为抗高血压药剂的用途
CA2716367C (en) 2008-02-20 2015-05-26 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
JP2011518884A (ja) 2008-04-29 2011-06-30 セラヴァンス， インコーポレーテッド 二重活性抗高血圧剤
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2303870A4 (de) * 2008-06-24 2011-07-20 Hetero Research Foundation Verfahren zur herstellung von candesartan-cilexetil
EP2321341B1 (de) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
WO2010011821A2 (en) * 2008-07-24 2010-01-28 Theravance, Inc. Dual-acting antihypertensive agents
CN101648918B (zh) * 2008-08-15 2013-01-09 联化科技股份有限公司 坎地沙坦酯的中间体化合物及其合成方法
ES2377552T3 (es) 2008-09-17 2012-03-28 Helm Ag Composiciones disueltas fácilmente y estables de candesartán cilexetilo preparadas con una granulación por vía húmeda
EP2352499A1 (de) * 2008-10-10 2011-08-10 Janssen Pharmaceutica, N.V. Kombinationstherapie mit angiotensinrezeptor-blockern und vasopressinrezeptorantagonisten
KR100995755B1 (ko) 2008-10-31 2010-11-19 일동제약주식회사 트리틸 칸데사르탄 실렉세틸의 개선된 제조방법
DE102008059206A1 (de) 2008-11-27 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
US9387249B2 (en) 2008-12-23 2016-07-12 Takeda Pharmaceutical Company Limited Methods of treating hypertension with at least one angiotensin II receptor blocker and chlorthalidone
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
WO2011005674A1 (en) 2009-07-07 2011-01-13 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
US8372984B2 (en) 2009-07-22 2013-02-12 Theravance, Inc. Dual-acting oxazole antihypertensive agents
BR112012008346B1 (pt) 2009-09-11 2021-12-21 Vivoryon Therapeutics N.V. Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
WO2011080684A1 (en) 2009-12-31 2011-07-07 Ranbaxy Laboratories Limited Process for the preparation of candesartan cilexetil
WO2011090929A1 (en) * 2010-01-19 2011-07-28 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
WO2011092666A1 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
CN101880241B (zh) * 2010-07-14 2013-04-17 浙江美诺华药物化学有限公司 一锅法制备2-(取代苯基)甲氨基-3-硝基苯甲酸甲酯的方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR101251741B1 (ko) * 2010-12-16 2013-04-05 동화약품주식회사 칸데사르탄실렉세틸의 개선된 제조방법
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
CN102198129B (zh) * 2011-03-22 2016-03-30 浙江华海药业股份有限公司 含有坎地沙坦酯和氢氯噻嗪的口服片剂
CN102206186A (zh) * 2011-04-18 2011-10-05 张家港市信谊化工有限公司 坎地沙坦环合物的制备方法
MX2014002163A (es) 2011-08-26 2014-09-25 Wockhardt Ltd Métodos para el tratamiento de desórdenes cardiovasculares.
WO2013041944A1 (en) 2011-09-19 2013-03-28 Ranbaxy Laboratories Limited Process for the preparation of micronized candesartan cilexetil
JP5850697B2 (ja) * 2011-10-18 2016-02-03 株式会社トクヤマ カンデサルタンシレキセチルの製造方法
WO2013090196A1 (en) 2011-12-15 2013-06-20 Takeda Pharmaceuticals U.S.A., Inc. Combinations of azilsartan and chlorthalidone for treating hypertension black patients
CN102391254B (zh) * 2011-12-16 2013-03-13 珠海润都制药股份有限公司 一种坎地沙坦的制备方法
CN103304543A (zh) * 2012-03-12 2013-09-18 邓俐丽 一种坎地沙坦酯的制备方法
CN102633816A (zh) * 2012-03-30 2012-08-15 李莎 头孢西丁酯化前体药物化合物及口服制剂
EP2844250B1 (de) 2012-05-01 2017-11-08 Translatum Medicus Inc. Verfahren zur behandlung und diagnose von erblindenden augenerkrankungen
EP2846777B1 (de) 2012-05-07 2016-10-26 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung einer pharmazeutischen dosierform mit nifedipin und candesartan-cilexetil
US20140134187A1 (en) 2012-06-25 2014-05-15 The Johns Hopkins University Therapeutic and diagnostic methods for autism spectrum disorders and other conditions
JP6218084B2 (ja) 2012-10-04 2017-10-25 国立研究開発法人国立循環器病研究センター 悪性腫瘍転移抑制用医薬
CN102952040A (zh) * 2012-11-20 2013-03-06 峨眉山天梁星制药有限公司 一种坎地沙坦酯中间体的硝基还原为氨基的方法
PL236001B1 (pl) 2012-12-21 2020-11-30 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Złożona kompozycja farmaceutyczna zawierająca kandesartan cyleksetylu oraz amlodypinę, sposób jej wytwarzania oraz jednostkowa postać dawkowania zawierająca tę kompozycję
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9339542B2 (en) * 2013-04-16 2016-05-17 John L Couvaras Hypertension reducing composition
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
EP3025711B1 (de) 2013-07-23 2020-11-18 Daiichi Sankyo Company, Limited Medikament zur vorbeugung oder behandlung von hypertonie
CN104098550A (zh) * 2014-07-17 2014-10-15 浙江华海药业股份有限公司 一种精制三苯甲基坎地沙坦的方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2016192099A1 (zh) * 2015-06-05 2016-12-08 浙江华海药业股份有限公司 一种制备三苯甲基坎地沙坦的方法
CZ2015687A3 (cs) 2015-10-02 2017-04-12 Zentiva, K.S. Farmaceutická kompozice obsahující kombinaci kandesartanu, amlodipinu a hydrochlorthiazidu
EP3219309A1 (de) 2016-03-17 2017-09-20 K.H.S. Pharma Holding GmbH Pharmazeutische zusammensetzung mit fixdosierungskombination von amlodipin, candesartan cilexetil und hydrochlorothiazid zur behandlung von bluthochdruck
CN108778334A (zh) 2016-03-24 2018-11-09 第三共株式会社 用于治疗肾脏疾病的药物
CN106432201B (zh) * 2016-09-14 2019-04-23 威海迪素制药有限公司 一种坎地沙坦酯结晶的制备方法
PL3648761T3 (pl) 2017-07-07 2024-07-22 Boehringer Ingelheim Vetmedica Gmbh Telmisartan do profilaktyki lub leczenia nadciśnienia u kotów
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CA3096838A1 (en) 2018-04-11 2019-10-17 Ohio State Innovation Foundation Methods and compositions for sustained release microparticles for ocular drug delivery
EP3907215A4 (de) 2019-01-02 2022-03-16 Linhai Huanan Chemical Co., Ltd. Syntheseverfahren für candesartan-cilexetil-zwischenprodukt
RS66416B1 (sr) 2019-01-18 2025-02-28 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene
CN110514758A (zh) * 2019-08-21 2019-11-29 天地恒一制药股份有限公司 一种坎地沙坦酯有关物质的检测方法
EP3984989A4 (de) * 2020-08-13 2023-11-22 Nanjing Heron Pharmaceutical Science and Technology Co., Ltd. Ibuprofenester-prodrug, pharmazeutische zusammensetzung sowie herstellungsverfahren und verwendung
US11655220B2 (en) 2020-10-22 2023-05-23 Hetero Labs Limited Process for the preparation of angiotensin II receptor blockers
EP4052695A1 (de) 2021-03-05 2022-09-07 Midas Pharma GmbH Stabile orale pharmazeutische zusammensetzungen mit fester dosis und sofortiger freisetzung mit amlodipin, atorvastatin und candesartan cilexetil
WO2023285646A1 (en) 2021-07-15 2023-01-19 Adamed Pharma S.A A pharmaceutical composition comprising amlodipine, candesartan cilexetil and hydrochlorothiazide for the treatment of hypertension
CN114149414B (zh) * 2021-12-23 2023-08-04 浙江永宁药业股份有限公司 一种利用微反应器连续流制备坎地沙坦的方法
EP4598528A1 (de) 2022-10-04 2025-08-13 Arsenil Zabirnyk Hemmung der verkalkung der aortenklappe
EP4374855A1 (de) 2022-11-22 2024-05-29 KRKA, D.D., Novo Mesto Pharmazeutische darreichungsform von candesartan und indapamid
TW202508455A (zh) 2023-05-24 2025-03-01 德商百靈佳殷格翰維美迪加股份有限公司 包含一或多種sglt-2抑制劑及替米沙坦(telmisartan)之非人類哺乳動物之腎臟疾病及/或高血壓之組合治療及/或預防
US20250195525A1 (en) 2023-12-15 2025-06-19 Boehringer Ingelheim Vetmedica Gmbh Angiotensin ii receptor antagonist for the prevention of systemic diseases in cats

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526896A (en) * 1978-12-26 1985-07-02 Riker Laboratories, Inc. Tetrazol-5-yl 2-nitro-3-phenylbenzofurans and antimicrobial use thereof
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
JPS5671073A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
US4775679A (en) * 1985-04-25 1988-10-04 Merck & Co., Inc. Certain heterocyclic-ethyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4764623A (en) * 1987-06-15 1988-08-16 American Home Products Corporation N-(1H-tetrazol-5-yl-alkylphenyl)polyfluoroalkanamides
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
US5250554A (en) * 1989-10-24 1993-10-05 Takeda Chemical Industries, Ltd. Benzimidazole derivatives useful as angiotensin II inhibitors
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof

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HU213266B (en) 1997-04-28
DE69123784D1 (de) 1997-02-06
EP0459136A1 (de) 1991-12-04
AU647469B2 (en) 1994-03-24
NO911586L (no) 1991-10-28
DE19875004I2 (de) 2002-03-28
EP0720982A1 (de) 1996-07-10
GR3022172T3 (en) 1997-03-31
AU7533191A (en) 1991-11-21
ES2181742T3 (es) 2003-03-01
US5705517A (en) 1998-01-06
PT97451A (pt) 1992-01-31
NO911586D0 (no) 1991-04-22
KR910018359A (ko) 1991-11-30
FI114983B (fi) 2005-02-15
FI108434B (fi) 2002-01-31
HU210871A9 (en) 1995-08-28
DE69123784T2 (de) 1997-04-17
EP0720982B1 (de) 2002-11-13
NL970044I1 (nl) 1998-03-02
ATE227709T1 (de) 2002-11-15
CY2150B1 (en) 2002-08-23
DK0720982T3 (da) 2003-03-17
JP2853611B2 (ja) 1999-02-03
CA2204290A1 (en) 1991-10-28
NZ237949A (en) 1995-07-26
JP2514282B2 (ja) 1996-07-10
FI911936A0 (fi) 1991-04-22
LU90224I2 (fr) 1998-05-11
KR100200541B1 (ko) 1999-06-15
US5328919A (en) 1994-07-12
IE911317A1 (en) 1991-11-06
CN1147515A (zh) 1997-04-16
US5401764A (en) 1995-03-28
CN1055927A (zh) 1991-11-06
HU911347D0 (en) 1991-10-28
NO300923B1 (no) 1997-08-18
NO970195D0 (no) 1997-01-16
FI911936A7 (fi) 1991-10-28
CA2040955C (en) 1998-02-03
NL970044I2 (nl) 1998-06-02
NO1998018I1 (no) 1998-06-25
FI982761L (fi) 1998-12-21
US5196444A (en) 1993-03-23
DE69133149D1 (de) 2002-12-19
LV10258A (lv) 1994-10-20
CA2204290C (en) 2001-12-18
EP0459136B1 (de) 1996-12-27
CN1048486C (zh) 2000-01-19

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