ATE227709T1 - Benzimidazolderivate, ihre herstellung und verwendung als angiotensin ii-antagonisten - Google Patents

Benzimidazolderivate, ihre herstellung und verwendung als angiotensin ii-antagonisten

Info

Publication number
ATE227709T1
ATE227709T1 AT95118796T AT95118796T ATE227709T1 AT E227709 T1 ATE227709 T1 AT E227709T1 AT 95118796 T AT95118796 T AT 95118796T AT 95118796 T AT95118796 T AT 95118796T AT E227709 T1 ATE227709 T1 AT E227709T1
Authority
AT
Austria
Prior art keywords
anion
benzimidazole
substd
opt
angiotensin
Prior art date
Application number
AT95118796T
Other languages
English (en)
Inventor
Takehiko Naka
Kohei Nishikawa
Takeshi Kato
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27526589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE227709(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE227709T1 publication Critical patent/ATE227709T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95118796T 1990-04-27 1991-04-19 Benzimidazolderivate, ihre herstellung und verwendung als angiotensin ii-antagonisten ATE227709T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP11314890 1990-04-27
JP14194290 1990-05-30
JP20866290 1990-08-06
JP26457990 1990-10-01
JP41367990 1990-12-24

Publications (1)

Publication Number Publication Date
ATE227709T1 true ATE227709T1 (de) 2002-11-15

Family

ID=27526589

Family Applications (2)

Application Number Title Priority Date Filing Date
AT91106330T ATE146779T1 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, verfahren zu deren herstellung und anwendung
AT95118796T ATE227709T1 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, ihre herstellung und verwendung als angiotensin ii-antagonisten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT91106330T ATE146779T1 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, verfahren zu deren herstellung und anwendung

Country Status (22)

Country Link
US (4) US5196444A (de)
EP (2) EP0459136B1 (de)
JP (2) JP2514282B2 (de)
KR (1) KR100200541B1 (de)
CN (2) CN1048486C (de)
AT (2) ATE146779T1 (de)
CA (2) CA2040955C (de)
CY (1) CY2150B1 (de)
DE (3) DE19875004I2 (de)
DK (2) DK0459136T3 (de)
ES (2) ES2095266T3 (de)
FI (2) FI108434B (de)
GR (1) GR3022172T3 (de)
HK (1) HK1000803A1 (de)
HU (2) HU213266B (de)
IE (1) IE911317A1 (de)
LU (1) LU90224I2 (de)
LV (1) LV10258B (de)
NL (1) NL970044I2 (de)
NO (3) NO300923B1 (de)
NZ (1) NZ237949A (de)
PT (1) PT97451B (de)

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US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof

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LU90224I2 (fr) 1998-05-11
HU911347D0 (en) 1991-10-28
EP0459136A1 (de) 1991-12-04
NL970044I1 (nl) 1998-03-02
KR100200541B1 (ko) 1999-06-15
DE69123784T2 (de) 1997-04-17
EP0720982B1 (de) 2002-11-13
FI911936A0 (fi) 1991-04-22
CN1147515A (zh) 1997-04-16
FI982761L (fi) 1998-12-21
US5401764A (en) 1995-03-28
AU647469B2 (en) 1994-03-24
HK1000803A1 (en) 1998-05-01
NO970195D0 (no) 1997-01-16
CY2150B1 (en) 2002-08-23
JPH0899960A (ja) 1996-04-16
LV10258A (lv) 1994-10-20
EP0720982A1 (de) 1996-07-10
NO300923B1 (no) 1997-08-18
NO970195L (no) 1997-01-16
NL970044I2 (nl) 1998-06-02
JP2514282B2 (ja) 1996-07-10
LV10258B (en) 1995-04-20
DK0720982T3 (da) 2003-03-17
NO1998018I1 (no) 1998-06-25
US5196444A (en) 1993-03-23
DE69133149T2 (de) 2003-03-13
FI911936A7 (fi) 1991-10-28
CN1058966C (zh) 2000-11-29
PT97451A (pt) 1992-01-31
DE19875004I2 (de) 2002-03-28
FI108434B (fi) 2002-01-31
US5328919A (en) 1994-07-12
NZ237949A (en) 1995-07-26
ES2181742T3 (es) 2003-03-01
NO302752B1 (no) 1998-04-20
DK0459136T3 (da) 1997-04-01
ATE146779T1 (de) 1997-01-15
GR3022172T3 (en) 1997-03-31
KR910018359A (ko) 1991-11-30
CA2204290A1 (en) 1991-10-28
PT97451B (pt) 1997-01-31
FI114983B (fi) 2005-02-15
EP0459136B1 (de) 1996-12-27
CN1055927A (zh) 1991-11-06
AU7533191A (en) 1991-11-21
CA2040955A1 (en) 1991-10-28
ES2095266T3 (es) 1997-02-16
CN1048486C (zh) 2000-01-19
NO911586L (no) 1991-10-28
CA2040955C (en) 1998-02-03
DE69123784D1 (de) 1997-02-06
HU210871A9 (en) 1995-08-28
FI982761A0 (fi) 1998-12-21
CA2204290C (en) 2001-12-18
JPH04364171A (ja) 1992-12-16
NO911586D0 (no) 1991-04-22
JP2853611B2 (ja) 1999-02-03
HUT57736A (en) 1991-12-30
HU213266B (en) 1997-04-28
IE911317A1 (en) 1991-11-06
US5705517A (en) 1998-01-06
DE69133149D1 (de) 2002-12-19

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