ATE149483T1 - Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung - Google Patents

Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung

Info

Publication number: ATE149483T1
Authority: AT; Austria
Prior art keywords: crystals; solvent; isopropylcyclohexylcarbonyl; phenylalanine; trans
Prior art date: 1991-07-30

Application number

AT92306895T

Other languages

English (en)

Inventor

Michito Sumikawa

Yoshihito Koguchi

Takao Ohgane

Yasuo Irie

Satoji Takahashi

Original Assignee

Ajinomoto Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-30

Filing date

1992-07-29

Publication date

1997-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27169694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE149483(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-07-29 Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE149483T1 publication Critical patent/ATE149483T1/de

Links

239000013078 crystal Substances 0.000 title abstract 5
OELFLUMRDSZNSF-OFLPRAFFSA-N (2R)-2-[[oxo-(4-propan-2-ylcyclohexyl)methyl]amino]-3-phenylpropanoic acid Chemical compound C1CC(C(C)C)CCC1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-OFLPRAFFSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
239000002904 solvent Substances 0.000 abstract 3
238000002441 X-ray diffraction Methods 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
238000002329 infrared spectrum Methods 0.000 abstract 1
238000002844 melting Methods 0.000 abstract 1
230000008018 melting Effects 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT92306895T 1991-07-30 1992-07-29 Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung ATE149483T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP18969691		1991-07-30
JP19945391		1991-08-08
CA002114678A CA2114678C (en)	1991-07-30	1994-02-01	Crystals of n-(trans-4-isopropylcyclohexylcarbonyl)- d-phenylalanine and methods for preparing them

Publications (1)

Publication Number	Publication Date
ATE149483T1 true ATE149483T1 (de)	1997-03-15

Family

ID=27169694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92306895T ATE149483T1 (de)	1991-07-30	1992-07-29	Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung

Country Status (11)

Country	Link
US (1)	US5488150A (de)
EP (1)	EP0526171B1 (de)
JP (1)	JP2508949B2 (de)
AT (1)	ATE149483T1 (de)
BR (1)	BR1100807A (de)
CA (1)	CA2114678C (de)
DE (2)	DE10199058I2 (de)
DK (1)	DK0526171T3 (de)
ES (1)	ES2100291T3 (de)
LU (2)	LU90843I2 (de)
NL (1)	NL300063I2 (de)

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ATE503472T1 (de)	1996-11-15	2011-04-15	Ajinomoto Kk	Nateglinide-tablettenzubereitungen
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ATE368641T1 (de)	2000-10-18	2007-08-15	Ajinomoto Kk	Verfahren zur herstellung von nateglinidin- kristallen
CN1273442C (zh) *	2000-10-18	2006-09-06	味之素株式会社	酰基苯丙氨酸的制备方法
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AR035425A1 (es) *	2001-01-30	2004-05-26	Teijin Ltd	Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
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CA2478599A1 (en) *	2002-03-11	2003-09-18	Novartis Ag	Salts of nateglinide
US7411089B2 (en)	2002-04-15	2008-08-12	Ajinomoto Co., Inc.	Nateglinide crystals
JP4538842B2 (ja) *	2002-04-15	2010-09-08	味の素株式会社	新規ナテグリニド結晶
US7247746B2 (en) *	2002-04-15	2007-07-24	Novartis, Ag	Crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine
SK287644B6 (sk) *	2002-04-29	2011-05-06	Biocon Limited	Kryštalický N-(trans)-4-izopropylcyklohexylkarbonyl)-D- fenylalanín vo forme C a spôsob jeho prípravy
RU2324676C2 (ru) *	2002-04-29	2008-05-20	Байокон Лимитид	Кристаллический n-(транс-4-изопропилциклогексилкарбонил)-d-фенилаланин формы с для лечения сахарного диабета типа 2 и способ его получения
AU2003256454A1 (en) *	2002-07-03	2004-01-23	Teva Pharmaceutical Industries Ltd.	Process for preparing nateglinide and intermediates thereof
US6861553B2 (en) *	2002-07-03	2005-03-01	Teva Pharmaceuticals Industries Ltd.	Process for preparing nateglinide and intermediates thereof
US7534913B2 (en) *	2002-07-18	2009-05-19	Teva Pharmaceutica Industries Ltd.	Crystalline form of nateglinide
US7148376B2 (en) *	2002-07-18	2006-12-12	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US7420084B2 (en) *	2002-07-18	2008-09-02	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US20050075400A1 (en) *	2002-07-18	2005-04-07	Ronit Yahalomi	Polymorphic forms of nateglinide
US7358390B2 (en) *	2002-07-18	2008-04-15	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
WO2004020396A1 (en) *	2002-08-28	2004-03-11	Dr. Reddy's Laboratories Limited	Crystalline form of nateglinide and process for preparation thereof
US7449519B2 (en) *	2003-02-18	2008-11-11	Konishi Co., Ltd.	Curing resin, method for producing same and curing resin composition
HU227073B1 (hu) *	2003-07-10	2010-06-28	Richter Gedeon Nyrt	Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
US20060004102A1 (en) *	2004-05-07	2006-01-05	Shlomit Wizel	Polymorphic forms of nateglinide
US7425648B2 (en)	2005-01-03	2008-09-16	A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A.	Process for the preparation of nateglinide, preferably in B-form
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
PT1931350E (pt)	2005-09-14	2014-02-12	Takeda Pharmaceutical	Administração de inibidores de dipeptidil peptidase
CN101415668B (zh) *	2006-03-31	2013-06-19	味之素株式会社	羧酸酰氯化合物的制造方法
CN103951583B (zh) *	2006-12-06	2016-01-06	科内图斯医药公司	一种抑制剂的结晶形式
NZ596302A (en)	2009-05-15	2014-01-31	Novartis Ag	Aryl pyridine as aldosterone synthase inhibitors
JP5466759B2 (ja)	2009-05-28	2014-04-09	ノバルティスアーゲー	ネプリライシン阻害剤としての置換アミノ酪酸誘導体
SG176009A1 (en)	2009-05-28	2011-12-29	Novartis Ag	Substituted aminopropionic derivatives as neprilysin inhibitors
WO2011041293A1 (en)	2009-09-30	2011-04-07	Takeda Pharmaceutical Company Limited	Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
US8519134B2 (en)	2009-11-17	2013-08-27	Novartis Ag	Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
ES2472446T3 (es)	2009-11-30	2014-07-01	Novartis Ag	Derivados de imidazol como inhibidores de aldosterona sintasa
PL2531501T3 (pl)	2010-02-03	2014-05-30	Takeda Pharmaceuticals Co	Inhibitory kinazy 1 regulującej sygnał apoptotyczny
US8673974B2 (en)	2010-11-16	2014-03-18	Novartis Ag	Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en)	2010-11-16	2014-11-04	Novartis Ag	Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
UY35144A (es)	2012-11-20	2014-06-30	Novartis Ag	Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
TR201808541T4 (tr)	2013-02-14	2018-07-23	Novartis Ag	Nep (nötr endopeptidaz) inhibitörleri olarak ikame edilmiş bisfenil butanoik fosfonik asit türevleri.
HK1218252A1 (zh)	2013-07-25	2017-02-10	Novartis Ag	合成apelin多肽之生物结合物
KR20160031551A (ko)	2013-07-25	2016-03-22	노파르티스 아게	심부전의 치료를 위한 시클릭 폴리펩티드
MA41580A (fr)	2015-01-23	2017-11-29	Novartis Ag	Conjugués d'acides gras de l'apeline synthétique présentant une demi-vie améliorée
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CN109369443A (zh) *	2018-11-05	2019-02-22	扬子江药业集团江苏海慈生物药业有限公司	一种新的那格列奈h晶型的制备方法

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US196222A (en) *		1877-10-16		Improvement in belt-tighteners
JPS6354321A (ja) *	1985-03-27	1988-03-08	Ajinomoto Co Inc	血糖降下剤

1992
- 1992-07-29 ES ES92306895T patent/ES2100291T3/es not_active Expired - Lifetime
- 1992-07-29 JP JP4202686A patent/JP2508949B2/ja not_active Expired - Lifetime
- 1992-07-29 EP EP92306895A patent/EP0526171B1/de not_active Expired - Lifetime
- 1992-07-29 DE DE2001199058 patent/DE10199058I2/de active Active
- 1992-07-29 DK DK92306895.1T patent/DK0526171T3/da active
- 1992-07-29 AT AT92306895T patent/ATE149483T1/de active
- 1992-07-29 DE DE69217762T patent/DE69217762T2/de not_active Expired - Lifetime
1993
- 1993-12-14 US US08/166,144 patent/US5488150A/en not_active Expired - Lifetime
1994
- 1994-02-01 CA CA002114678A patent/CA2114678C/en not_active Expired - Lifetime
1997
- 1997-05-12 BR BR1100807-5A patent/BR1100807A/pt active IP Right Grant
2001
- 2001-09-28 NL NL300063C patent/NL300063I2/nl unknown
- 2001-09-28 LU LU90843C patent/LU90843I2/fr unknown
- 2001-10-03 LU LU90846C patent/LU90846I2/fr unknown

Also Published As

Publication number	Publication date
JPH05208943A (ja)	1993-08-20
US5488150A (en)	1996-01-30
EP0526171A3 (en)	1993-05-05
NL300063I2 (nl)	2002-02-01
DK0526171T3 (da)	1997-08-25
LU90846I2 (fr)	2002-02-04
EP0526171B1 (de)	1997-03-05
CA2114678C (en)	1999-04-27
EP0526171A2 (de)	1993-02-03
DE69217762D1 (de)	1997-04-10
DE69217762T2 (de)	1997-10-09
DE10199058I2 (de)	2006-04-27
DE10199058I1 (de)	2002-01-24
CA2114678A1 (en)	1995-08-02
LU90843I2 (fr)	2002-02-04
NL300063I1 (nl)	2001-12-01
ES2100291T3 (es)	1997-06-16
BR1100807A (pt)	1999-12-28
JP2508949B2 (ja)	1996-06-19

Publication	Publication Date	Title
ATE149483T1 (de)	1997-03-15	Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung
ATE147366T1 (de)	1997-01-15	Verfahren zur herstellung von überzugfilmen aus titanoxyd
DZ1792A1 (fr)	2002-02-17	Une nouvelle forme de composé.
ATE94195T1 (de)	1993-09-15	Verfahren zur herstellung von polyarylensulfidzusammensetzungen und damit hergestellter gegenstand.
ES2023509B3 (es)	1992-01-16	Producto granular (i).
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CS235488A2 (en)	1990-02-12	Method of new dihydropyridinamides production
ATE138654T1 (de)	1996-06-15	Verfahren zur herstellung von 1-carbamoyl- pyrazolen
BR9707004A (pt)	1999-07-20	Composto processo para preparar o mesmo composição farmacêutica utilização do composto e processos para tratamento de doenças do sistema endocinológico e para a manufatura de um medicamento
SE8700212D0 (sv)	1987-01-21	Forfarande for framstellning av hns ii
DE59103410D1 (de)	1994-12-08	Verfahren zur Herstellung von Gussstücken durch gerichtete oder einkristalline Erstarrung.
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DE69411660D1 (de)	1998-08-20	Vorrichtung zur Herstellung von Silizium-Einkristallen durch das Czochralski-Verfahren
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ATE154795T1 (de)	1997-07-15	Silbernitrat, hergestellt durch ein kontinuierliches verdampfungs- kristallisationsverfahren
AT341534B (de)	1978-02-10	Verfahren zur herstellung von neuen 5,6-diaryl-1,2,4-triazinverbindungen und ihren saureadditionssalzen