ATE149483T1 - Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung - Google Patents

Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung

Info

Publication number: ATE149483T1
Authority: AT; Austria
Prior art keywords: crystals; solvent; isopropylcyclohexylcarbonyl; phenylalanine; trans
Prior art date: 1991-07-30

Application number

AT92306895T

Other languages

English (en)

Inventor

Michito Sumikawa

Yoshihito Koguchi

Takao Ohgane

Yasuo Irie

Satoji Takahashi

Original Assignee

Ajinomoto Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-30

Filing date

1992-07-29

Publication date

1997-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27169694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE149483(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-07-29 Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE149483T1 publication Critical patent/ATE149483T1/de

Links

239000013078 crystal Substances 0.000 title abstract 5
OELFLUMRDSZNSF-OFLPRAFFSA-N (2R)-2-[[oxo-(4-propan-2-ylcyclohexyl)methyl]amino]-3-phenylpropanoic acid Chemical compound C1CC(C(C)C)CCC1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-OFLPRAFFSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
239000002904 solvent Substances 0.000 abstract 3
238000002441 X-ray diffraction Methods 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
238000002329 infrared spectrum Methods 0.000 abstract 1
238000002844 melting Methods 0.000 abstract 1
230000008018 melting Effects 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT92306895T 1991-07-30 1992-07-29 Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung ATE149483T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP18969691		1991-07-30
JP19945391		1991-08-08
CA002114678A CA2114678C (en)	1991-07-30	1994-02-01	Crystals of n-(trans-4-isopropylcyclohexylcarbonyl)- d-phenylalanine and methods for preparing them

Publications (1)

Publication Number	Publication Date
ATE149483T1 true ATE149483T1 (de)	1997-03-15

Family

ID=27169694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92306895T ATE149483T1 (de)	1991-07-30	1992-07-29	Kristalle von n-(trans-4- isopropylcyclohexylcarbonyl)-d-phenylalanin und verfahren zu ihrer herstellung

Country Status (11)

Country	Link
US (1)	US5488150A (de)
EP (1)	EP0526171B1 (de)
JP (1)	JP2508949B2 (de)
AT (1)	ATE149483T1 (de)
BR (1)	BR1100807A (de)
CA (1)	CA2114678C (de)
DE (2)	DE10199058I2 (de)
DK (1)	DK0526171T3 (de)
ES (1)	ES2100291T3 (de)
LU (2)	LU90843I2 (de)
NL (1)	NL300063I2 (de)

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PT1586314E (pt)	1996-11-15	2011-07-01	Ajinomoto Kk	Composição de comprimidos de nateglinida
GB9713730D0 (en)	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds
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US6878749B2 (en) *	1999-09-17	2005-04-12	Novartis Ag	Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
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DK1248604T4 (da)	2000-01-21	2012-05-21	Novartis Ag	Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
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JP4114200B2 (ja) *	2000-10-18	2008-07-09	味の素株式会社	ナテグリニド結晶の製造方法
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DE60130014T2 (de) *	2000-10-24	2008-05-08	Ajinomoto Co., Inc.	Verfahren zur herstellung der b-form von nateglinid-kristallen
BR0114896A (pt) *	2000-10-24	2003-08-12	Ajinomoto Kk	Preparação contendo nateglinida, e, método para produzir a mesma
AR035425A1 (es) *	2001-01-30	2004-05-26	Teijin Ltd	Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
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JP2005519949A (ja) *	2002-03-11	2005-07-07	ノバルティスアクチエンゲゼルシャフト	ナテグリニドの塩
US7411089B2 (en)	2002-04-15	2008-08-12	Ajinomoto Co., Inc.	Nateglinide crystals
JP4615866B2 (ja) *	2002-04-15	2011-01-19	ノバルティスアーゲー	Ｎ−（トランス−４−イソプロピルシクロヘキシルカルボニル）−ｄ−フェニルアラニンの結晶形
EP1496048A4 (de)	2002-04-15	2006-08-02	Ajinomoto Kk	Neuer nateglinidkristall
RU2324676C2 (ru) *	2002-04-29	2008-05-20	Байокон Лимитид	Кристаллический n-(транс-4-изопропилциклогексилкарбонил)-d-фенилаланин формы с для лечения сахарного диабета типа 2 и способ его получения
CZ2004997A3 (cs) *	2002-04-29	2005-01-12	Biocon Limited	Nová forma N-(trans-4-isopropylcyklohexylkarbonyl)-D-fenylalaninu
US6861553B2 (en) *	2002-07-03	2005-03-01	Teva Pharmaceuticals Industries Ltd.	Process for preparing nateglinide and intermediates thereof
CN100384813C (zh) *	2002-07-03	2008-04-30	特瓦制药工业有限公司	制备那格列奈及其中间体的方法
US20050075400A1 (en) *	2002-07-18	2005-04-07	Ronit Yahalomi	Polymorphic forms of nateglinide
US7358390B2 (en) *	2002-07-18	2008-04-15	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US7148376B2 (en) *	2002-07-18	2006-12-12	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US7534913B2 (en) *	2002-07-18	2009-05-19	Teva Pharmaceutica Industries Ltd.	Crystalline form of nateglinide
US7420084B2 (en) *	2002-07-18	2008-09-02	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US20040077725A1 (en) *	2002-08-28	2004-04-22	Dr. Reddy's Laboratories Limited	Crystalline form of N-(trans-4-isopropylcyclohexane carbonyl)-D-phenylalanine and process for preparation thereof
US7449519B2 (en) *	2003-02-18	2008-11-11	Konishi Co., Ltd.	Curing resin, method for producing same and curing resin composition
HU227073B1 (hu)	2003-07-10	2010-06-28	Richter Gedeon Nyrt	Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
US20060004102A1 (en) *	2004-05-07	2006-01-05	Shlomit Wizel	Polymorphic forms of nateglinide
US7425648B2 (en)	2005-01-03	2008-09-16	A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A.	Process for the preparation of nateglinide, preferably in B-form
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
PL1931350T5 (pl)	2005-09-14	2021-11-15	Takeda Pharmaceutical Company Limited	Podanie inhibitorów dipeptydylo-peptydazy
WO2007119580A1 (ja) *	2006-03-31	2007-10-25	Ajinomoto Co., Inc.	カルボン酸クロリド化合物の製造方法
JP5495787B2 (ja) *	2006-12-06	2014-05-21	クオナトウスファーマシューティカルズ，インコーポレイテッド	（３Ｓ）−３−［Ｎ−（Ｎ’−（２−ｔｅｒｔ−ブチルフェニル）オキサミル）アラニニル］アミノ−５−（２’，３’，５’，６’−テトラフルオロフェノキシ）−４−オキソペンタン酸の結晶形態
BRPI1010600A2 (pt)	2009-05-15	2016-03-15	Novartis Ag	aril piridina como inibidores de aldosterona sintase
SG176010A1 (en)	2009-05-28	2011-12-29	Novartis Ag	Substituted aminobutyric derivatives as neprilysin inhibitors
JP5420761B2 (ja)	2009-05-28	2014-02-19	ノバルティスアーゲー	ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体
WO2011041293A1 (en)	2009-09-30	2011-04-07	Takeda Pharmaceutical Company Limited	Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
ES2663351T3 (es)	2009-11-17	2018-04-12	Novartis Ag	Derivados de aril-piridina como inhibidores de la aldosterona sintasa
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8575160B2 (en)	2009-11-30	2013-11-05	Novartis Ag	Imidazole derivatives as aldosterone synthase inhibitors
WO2011097079A1 (en)	2010-02-03	2011-08-11	Takeda Pharmaceutical Company Limited	Apoptosis signal-regulating kinase 1 inhibitors
US8673974B2 (en)	2010-11-16	2014-03-18	Novartis Ag	Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en)	2010-11-16	2014-11-04	Novartis Ag	Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
UY35144A (es)	2012-11-20	2014-06-30	Novartis Ag	Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
NZ710574A (en)	2013-02-14	2017-11-24	Novartis Ag	Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
BR112016001376A2 (pt)	2013-07-25	2017-10-24	Novartis Ag	bioconjugados de polipeptídeos de apelin sintéticos
US9266925B2 (en)	2013-07-25	2016-02-23	Novartis Ag	Cyclic polypeptides for the treatment of heart failure
CA2972871A1 (en)	2015-01-23	2016-07-28	Novartis Ag	Synthetic apelin fatty acid conjugates with improved half-life
UY38072A (es)	2018-02-07	2019-10-01	Novartis Ag	Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
CN109369443A (zh) *	2018-11-05	2019-02-22	扬子江药业集团江苏海慈生物药业有限公司	一种新的那格列奈h晶型的制备方法

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US196222A (en) *		1877-10-16		Improvement in belt-tighteners
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1992
- 1992-07-29 DE DE2001199058 patent/DE10199058I2/de active Active
- 1992-07-29 EP EP92306895A patent/EP0526171B1/de not_active Expired - Lifetime
- 1992-07-29 JP JP4202686A patent/JP2508949B2/ja not_active Expired - Lifetime
- 1992-07-29 DE DE69217762T patent/DE69217762T2/de not_active Expired - Lifetime
- 1992-07-29 ES ES92306895T patent/ES2100291T3/es not_active Expired - Lifetime
- 1992-07-29 DK DK92306895.1T patent/DK0526171T3/da active
- 1992-07-29 AT AT92306895T patent/ATE149483T1/de active
1993
- 1993-12-14 US US08/166,144 patent/US5488150A/en not_active Expired - Lifetime
1994
- 1994-02-01 CA CA002114678A patent/CA2114678C/en not_active Expired - Lifetime
1997
- 1997-05-12 BR BR1100807-5A patent/BR1100807A/pt active IP Right Grant
2001
- 2001-09-28 NL NL300063C patent/NL300063I2/nl unknown
- 2001-09-28 LU LU90843C patent/LU90843I2/fr unknown
- 2001-10-03 LU LU90846C patent/LU90846I2/fr unknown

Also Published As

Publication number	Publication date
JP2508949B2 (ja)	1996-06-19
DK0526171T3 (da)	1997-08-25
JPH05208943A (ja)	1993-08-20
LU90843I2 (fr)	2002-02-04
NL300063I1 (nl)	2001-12-01
LU90846I2 (fr)	2002-02-04
ES2100291T3 (es)	1997-06-16
DE10199058I2 (de)	2006-04-27
US5488150A (en)	1996-01-30
DE10199058I1 (de)	2002-01-24
DE69217762T2 (de)	1997-10-09
EP0526171A3 (en)	1993-05-05
NL300063I2 (nl)	2002-02-01
EP0526171B1 (de)	1997-03-05
BR1100807A (pt)	1999-12-28
CA2114678C (en)	1999-04-27
EP0526171A2 (de)	1993-02-03
DE69217762D1 (de)	1997-04-10
CA2114678A1 (en)	1995-08-02

Publication	Publication Date	Title
DE10199058I2 (de)	2006-04-27	Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
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ES2016975B3 (es)	1990-12-16	Compuestos quimicos.
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DE69012488D1 (de)	1994-10-20	Verfahren zur Herstellung von Diamant-Einkristallen durch chemische Dampfabscheidung.
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ATE125258T1 (de)	1995-08-15	Mono-n,n-dimethyl-4-aminopyridinium sn glycerol-3-phosphat, seine herstellung und verwendung bei der herstellung von phosphatidsäuren.