ATE151426T1 - Generserin-derivate als cholinesterase-hemmer - Google Patents

Generserin-derivate als cholinesterase-hemmer

Info

Publication number: ATE151426T1
Authority: AT; Austria
Prior art keywords: pct; group; sec; generserin; derivatives
Prior art date: 1991-08-09

Application number

AT92916772T

Other languages

English (en)

Inventor

Paolo Chiesi

Canale Maurizio Del

Vittorino Servadio

Eleonora Ghidini

Original Assignee

Chiesi Farma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-09

Filing date

1992-08-04

Publication date

1997-04-15

1992-08-04 Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa

1997-04-15 Application granted granted Critical

1997-04-15 Publication of ATE151426T1 publication Critical patent/ATE151426T1/de

Links

239000000544 cholinesterase inhibitor Substances 0.000 title abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000006755 (C2-C20) alkyl group Chemical group 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000004776 neurological deficiency Effects 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrane Compounds (AREA)
Saccharide Compounds (AREA)

AT92916772T 1991-08-09 1992-08-04 Generserin-derivate als cholinesterase-hemmer ATE151426T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI912237A IT1251166B (it)	1991-08-09	1991-08-09	Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number	Publication Date
ATE151426T1 true ATE151426T1 (de)	1997-04-15

Family

ID=11360556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92916772T ATE151426T1 (de)	1991-08-09	1992-08-04	Generserin-derivate als cholinesterase-hemmer

Country Status (19)

Country	Link
US (1)	US5538968A (de)
EP (1)	EP0599890B1 (de)
JP (1)	JP3172185B2 (de)
KR (1)	KR100225927B1 (de)
AT (1)	ATE151426T1 (de)
AU (1)	AU659865B2 (de)
CA (1)	CA2115250A1 (de)
CZ (1)	CZ281018B6 (de)
DE (1)	DE69218949T2 (de)
DK (1)	DK0599890T3 (de)
ES (1)	ES2101858T3 (de)
FI (1)	FI107532B (de)
GR (1)	GR3023838T3 (de)
HU (1)	HU222774B1 (de)
IT (1)	IT1251166B (de)
NO (1)	NO303175B1 (de)
NZ (1)	NZ243869A (de)
WO (1)	WO1993003041A1 (de)
ZA (1)	ZA925903B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1273349B (it) *	1994-02-28	1997-07-08	Getters Spa	Visualizzatore piatto ad emissione di campo contenente un getter e procedimento per il suo ottenimento
KR20010015714A (ko) *	1997-10-10	2001-02-26	파올로 키에시	선택적인 뇌 항콜린에스테라제활성을 가진 게네세롤린의아미노카보닐추출물의 제조방법
DE19853487A1 (de) *	1998-11-19	2000-05-25	Fumapharm Ag Muri	Verwendung von Dialkylfumaraten
DE10000577A1 (de)	2000-01-10	2001-07-26	Fumapharm Ag Muri	Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
US7157423B2 (en) *	2001-01-12	2007-01-02	Fumapharm Ag	Fumaric acid amides
DE10101307A1 (de) *	2001-01-12	2002-08-01	Fumapharm Ag Muri	Fumarsäurederivate als NF-kappaB-Inhibitor
CA2526586C (en)	2003-09-09	2010-03-16	Biogen International Gmbh	The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
US7795307B2 (en) *	2003-10-21	2010-09-14	Colucid Pharmaceuticals, Inc.	Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
JP2010518010A (ja) *	2007-02-02	2010-05-27	コルシド・ファーマシューティカルズ・インコーポレイテッド	コリンエステラーゼを阻害する化合物
EP2680010A1 (de)	2007-02-08	2014-01-01	Biogen Idec MA Inc.	Nrf2-screening-assays sowie entsprechende verfahren und zusammensetzungen
ES2599227T3 (es) *	2007-02-08	2017-01-31	Biogen Ma Inc.	Neuroprotección en enfermedades desmielinizantes
AU2008276459A1 (en) *	2007-07-18	2009-01-22	Colucid Pharmaceuticals, Inc.	Methods for promoting wakefulness
US8593728B2 (en) *	2009-02-19	2013-11-26	Toyota Motor Engineering & Manufacturing North America, Inc.	Multilayer photonic structures
AU2011215870B2 (en)	2010-02-09	2016-01-28	The Johns Hopkins University	Methods and compositions for improving cognitive function
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
US8669281B1 (en)	2013-03-14	2014-03-11	Alkermes Pharma Ireland Limited	Prodrugs of fumarates and their use in treating various diseases
KR102085557B1 (ko)	2013-03-14	2020-03-06	엘커메스 파마 아일랜드 리미티드	푸마레이트의 프로드럭 및 다양한 질환을 치료하는데 있어서의 이들의 용도
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
WO2014144663A1 (en)	2013-03-15	2014-09-18	The Johns Hopkins University	Methods and compositions for improving cognitive function
JP6337135B2 (ja)	2014-02-24	2018-06-06	アルカーメスファーマアイルランドリミテッド	フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用
WO2016191288A1 (en)	2015-05-22	2016-12-01	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2374908A1 (fr) *	1976-12-21	1978-07-21	Theranol Lab	Medicament constitue par l'association optimale d'une substance vagomimetique, le salicylate d'amine-oxyde d'eserine, et d'une substance potentialisant la secretion gastrique, le chlorhydrate d'acide glutamique
IT1199076B (it) *	1984-03-01	1988-12-30	Consiglio Nazionale Ricerche	Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
IT1225462B (it) *	1987-04-03	1990-11-14	Mediolanum Farmaceutici Srl	Sali organici di derivati della fisostigmina

1991
- 1991-08-09 IT ITMI912237A patent/IT1251166B/it active IP Right Grant
1992
- 1992-08-04 US US08/193,154 patent/US5538968A/en not_active Expired - Fee Related
- 1992-08-04 AT AT92916772T patent/ATE151426T1/de not_active IP Right Cessation
- 1992-08-04 EP EP92916772A patent/EP0599890B1/de not_active Expired - Lifetime
- 1992-08-04 DE DE69218949T patent/DE69218949T2/de not_active Expired - Fee Related
- 1992-08-04 CZ CZ94262A patent/CZ281018B6/cs not_active IP Right Cessation
- 1992-08-04 AU AU23876/92A patent/AU659865B2/en not_active Ceased
- 1992-08-04 ES ES92916772T patent/ES2101858T3/es not_active Expired - Lifetime
- 1992-08-04 WO PCT/EP1992/001762 patent/WO1993003041A1/en not_active Ceased
- 1992-08-04 DK DK92916772.4T patent/DK0599890T3/da active
- 1992-08-04 KR KR1019940700410A patent/KR100225927B1/ko not_active Expired - Fee Related
- 1992-08-04 HU HU9400353A patent/HU222774B1/hu not_active IP Right Cessation
- 1992-08-04 JP JP50327893A patent/JP3172185B2/ja not_active Expired - Fee Related
- 1992-08-04 CA CA002115250A patent/CA2115250A1/en not_active Abandoned
- 1992-08-06 ZA ZA925903A patent/ZA925903B/xx unknown
- 1992-08-06 NZ NZ243869A patent/NZ243869A/en unknown
1994
- 1994-02-08 FI FI940573A patent/FI107532B/fi active
- 1994-02-08 NO NO940415A patent/NO303175B1/no unknown
1997
- 1997-06-19 GR GR970401476T patent/GR3023838T3/el unknown

Also Published As

Publication number	Publication date
JP3172185B2 (ja)	2001-06-04
NO940415D0 (no)	1994-02-08
WO1993003041A1 (en)	1993-02-18
EP0599890B1 (de)	1997-04-09
NZ243869A (en)	1994-03-25
EP0599890A1 (de)	1994-06-08
GR3023838T3 (en)	1997-09-30
HK1006714A1 (en)	1999-03-12
CZ26294A3 (en)	1994-07-13
NO940415L (no)	1994-04-06
US5538968A (en)	1996-07-23
ZA925903B (en)	1993-04-28
DE69218949T2 (de)	1997-09-18
CZ281018B6 (cs)	1996-05-15
KR100225927B1 (ko)	1999-10-15
DK0599890T3 (da)	1997-10-20
FI940573A0 (fi)	1994-02-08
CA2115250A1 (en)	1993-02-18
FI940573L (fi)	1994-03-28
NO303175B1 (no)	1998-06-08
ES2101858T3 (es)	1997-07-16
FI107532B (fi)	2001-08-31
HUT70414A (en)	1995-10-30
ITMI912237A0 (it)	1991-08-09
AU2387692A (en)	1993-03-02
ITMI912237A1 (it)	1993-02-09
HU222774B1 (hu)	2003-10-28
DE69218949D1 (de)	1997-05-15
JPH06509572A (ja)	1994-10-27
AU659865B2 (en)	1995-06-01
IT1251166B (it)	1995-05-04
HU9400353D0 (en)	1994-06-28

Legal Events

Date	Code	Title	Description
1997-10-15	UEP	Publication of translation of european patent specification
2004-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE151426T1 (de)	1997-04-15	Generserin-derivate als cholinesterase-hemmer
LU91210I2 (fr)	2006-11-06	Emodepside & Praziquantel ainsi que leurs dérivés pharmaceutiqement acceptables (PROFENDER)
EP0720852A4 (de)	1997-07-23	Arzneimittel gegen nervöse erkrankungen
KR950700258A (ko)	1995-01-16	레티노이드 수용체(rar)에 결합하는 헤테로고리 탄산유도체(heterocyclic carbonic acid derivatives which bind to retinoid receptors(rar))
BR9206552A (pt)	1995-10-17	Composto, processo para a preparação do mesmo, composição inseticida ou acaricida e processo de combater pregas de insetos ou acarinas
DK295888A (da)	1988-06-07	Monoaminacridiner, farmaceutiske midler indeholdende disse samt anvendelse deraf til behandling af cholinerge neuronale mangeltilstande.
DE3869907D1 (de)	1992-05-14	Chinolincarbonsaeure-derivate.
BR0313846A (pt)	2005-09-27	Derivados de dioxano-2-alquilcarbamatos, sua preparação e sua aplicação em terapêutica
ATE184483T1 (de)	1999-10-15	Spirooxathiolan-quinuclidin-derivat zur behandlung des sjögren-syndroms
DK0514277T3 (da)	1995-05-01	3-aminopyradazinderivater med virkning på centralnervesystemet
NO924949D0 (no)	1992-12-21	Piperidylsubstituerte indoler
DE60002558D1 (de)	2003-06-12	Derivate der Phosphonsäure zur Inhibierung von Carboxypeptidase B
ATE128462T1 (de)	1995-10-15	Cyclische hydroxamsaeuren und ihre verwendung.
ATE43140T1 (de)	1989-06-15	Derivate von enzym-hemmender griseolsaeure und deren verwendung.
DE69123757D1 (de)	1997-01-30	Epoxysuccinamidsäurederivat
ES2043820T3 (es)	1994-01-01	Nuevas 1-1 alkil-1-sulfonil-2-alkoxicarbonilsulfenilhidrazinas que tienen actividad antineoplastica.
ATE92468T1 (de)	1993-08-15	Zimtsaeureamid-derivate.
DK0413278T3 (da)	1997-04-07	Anvendelse af xanthinderivater mod mavesår
ES2206296T3 (es)	2004-05-16	Derivados de tienopiranocarboxamida.
AR030879A1 (es)	2003-09-03	Uso de derivados del acido hidroperoxieicosatetraenoico luego de cirugia refractiva
KR920701154A (ko)	1992-08-11	비시클로락탐 유도체
BR9306170A (pt)	1998-01-13	Amidas de ácido isoxazolcarboxílico processo para sua produç o composiç es herbicidas e processo para o comtrole do crescimento vegetal indesejado
ATE152104T1 (de)	1997-05-15	1,2-dihydro-2-oxo-3-aminochinoxalin derivate, ihre verwendung als heilmittel