ES2101858T3 - Derivados de geneserina como inhibidores de colinesterasa. - Google Patents

Derivados de geneserina como inhibidores de colinesterasa.

Info

Publication number
ES2101858T3
ES2101858T3 ES92916772T ES92916772T ES2101858T3 ES 2101858 T3 ES2101858 T3 ES 2101858T3 ES 92916772 T ES92916772 T ES 92916772T ES 92916772 T ES92916772 T ES 92916772T ES 2101858 T3 ES2101858 T3 ES 2101858T3
Authority
ES
Spain
Prior art keywords
geneserine
derivatives
cholinesterase inhibitors
cholinesterase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92916772T
Other languages
English (en)
Inventor
Paolo Chiesi
Canale Maurizio Del
Vittorino Servadio
Eleonora Ghidini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Application granted granted Critical
Publication of ES2101858T3 publication Critical patent/ES2101858T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPUESTOS DE FORMULA (I), EN DONDE R ES COMO SE DEFINE EN LA MEMORIA, TIENEN PROPIEDADES DE USO TERAPEUTICO, PARTICULARMENTE PARA EL TRATAMIENTO DE PATOLOGIAS NEUROLOGICAS.
ES92916772T 1991-08-09 1992-08-04 Derivados de geneserina como inhibidores de colinesterasa. Expired - Lifetime ES2101858T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912237A IT1251166B (it) 1991-08-09 1991-08-09 Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
ES2101858T3 true ES2101858T3 (es) 1997-07-16

Family

ID=11360556

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92916772T Expired - Lifetime ES2101858T3 (es) 1991-08-09 1992-08-04 Derivados de geneserina como inhibidores de colinesterasa.

Country Status (19)

Country Link
US (1) US5538968A (es)
EP (1) EP0599890B1 (es)
JP (1) JP3172185B2 (es)
KR (1) KR100225927B1 (es)
AT (1) ATE151426T1 (es)
AU (1) AU659865B2 (es)
CA (1) CA2115250A1 (es)
CZ (1) CZ281018B6 (es)
DE (1) DE69218949T2 (es)
DK (1) DK0599890T3 (es)
ES (1) ES2101858T3 (es)
FI (1) FI107532B (es)
GR (1) GR3023838T3 (es)
HU (1) HU222774B1 (es)
IT (1) IT1251166B (es)
NO (1) NO303175B1 (es)
NZ (1) NZ243869A (es)
WO (1) WO1993003041A1 (es)
ZA (1) ZA925903B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1273349B (it) * 1994-02-28 1997-07-08 Getters Spa Visualizzatore piatto ad emissione di campo contenente un getter e procedimento per il suo ottenimento
EA003192B1 (ru) * 1997-10-10 2003-02-27 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Способ получения аминокарбонильных производных генезеролина, обладающих селективной в отношении головного мозга антихолинэстеразной активностью
DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
CA2776023A1 (en) * 2001-01-12 2002-07-18 Fumapharm Ag Fumaric acid amides
DK1663197T3 (da) 2003-09-09 2008-01-07 Fumapharm Ag Anvendelse af fumarsyrederivater til behandling af hjerteinsuffiens og astma
US7897639B2 (en) * 2003-10-21 2011-03-01 Colucid Pharmaceuticals, Inc. Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
US8101782B2 (en) * 2007-02-02 2012-01-24 Colucid Pharmaceuticals, Inc. Compounds that inhibit cholinesterase
EP2653873B8 (en) 2007-02-08 2022-08-24 Biogen MA Inc. Compositions and uses for treating Multiple Sclerosis
HUE032251T2 (en) * 2007-02-08 2017-09-28 Biogen Ma Inc Neuroprotection in demyelinating diseases
WO2009011901A2 (en) * 2007-07-18 2009-01-22 Colucid Pharmaceuticals, Inc. Methods for promoting wakefulness
US8593728B2 (en) * 2009-02-19 2013-11-26 Toyota Motor Engineering & Manufacturing North America, Inc. Multilayer photonic structures
EP2533645B1 (en) 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
MX386935B (es) 2013-03-14 2025-03-04 Alkermes Pharma Ireland Ltd Profármacos de fumaratos y su uso en el tratamiento de diferentes enfermedades.
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
CA2904767C (en) 2013-03-15 2022-06-21 Agenebio, Inc. Methods and compositions for improving cognitive function
JP6337135B2 (ja) 2014-02-24 2018-06-06 アルカーメス ファーマ アイルランド リミテッド フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用
EA034167B8 (ru) 2015-05-22 2021-04-27 Эйджинбайо, Инк. Фармацевтические композиции леветирацетама пролонгированного высвобождения

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2374908A1 (fr) * 1976-12-21 1978-07-21 Theranol Lab Medicament constitue par l'association optimale d'une substance vagomimetique, le salicylate d'amine-oxyde d'eserine, et d'une substance potentialisant la secretion gastrique, le chlorhydrate d'acide glutamique
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
IT1225462B (it) * 1987-04-03 1990-11-14 Mediolanum Farmaceutici Srl Sali organici di derivati della fisostigmina

Also Published As

Publication number Publication date
DE69218949D1 (de) 1997-05-15
KR100225927B1 (ko) 1999-10-15
IT1251166B (it) 1995-05-04
ITMI912237A0 (it) 1991-08-09
AU2387692A (en) 1993-03-02
DK0599890T3 (da) 1997-10-20
GR3023838T3 (en) 1997-09-30
HK1006714A1 (en) 1999-03-12
US5538968A (en) 1996-07-23
DE69218949T2 (de) 1997-09-18
NO940415L (no) 1994-04-06
ZA925903B (en) 1993-04-28
FI107532B (fi) 2001-08-31
HU222774B1 (hu) 2003-10-28
FI940573A0 (fi) 1994-02-08
EP0599890A1 (en) 1994-06-08
EP0599890B1 (en) 1997-04-09
CZ281018B6 (cs) 1996-05-15
ATE151426T1 (de) 1997-04-15
CA2115250A1 (en) 1993-02-18
JP3172185B2 (ja) 2001-06-04
NO303175B1 (no) 1998-06-08
FI940573L (fi) 1994-03-28
JPH06509572A (ja) 1994-10-27
CZ26294A3 (en) 1994-07-13
AU659865B2 (en) 1995-06-01
WO1993003041A1 (en) 1993-02-18
ITMI912237A1 (it) 1993-02-09
HU9400353D0 (en) 1994-06-28
NZ243869A (en) 1994-03-25
HUT70414A (en) 1995-10-30
NO940415D0 (no) 1994-02-08

Similar Documents

Publication Publication Date Title
ES2170252T3 (es) Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
ATE211743T1 (de) Substituierte 3-aminochinuclidine
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
ES2167377T3 (es) Derivados de piridina farmacologicamente activos y procedimientos para la preparacion de los mismos.
BR0109703A (pt) Derivados de piperazina
EA200300248A1 (ru) Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
SE0202463D0 (sv) Novel compounds
EA200300717A1 (ru) Гетероциклилиндазольные и -азаиндазольные соединения в качестве 5-гидрокситриптамин-6-лигандов
YU56492A (sh) Derivati hinuklidina
DK0682664T3 (da) Forbindelser med både potent calciumantagonist og antioxiderende aktivitet og anvendelse deraf som cytobeskyttende midler
DK0939627T3 (da) Pentaflourbenzensulfonamider og analoger
ES2150989T3 (es) Nuevos derivados de quinoxalinadiona, su preparacion y empleo en medicamentos.
ES2133324T3 (es) Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y metodos de uso.
DE69723863D1 (de) Chinoline und deren therapeutische verwendung
IT1251166B (it) Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono
TR199802060T2 (xx) Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�.
DE60115466D1 (de) Wirkstoffvorläufer von imidazopyridin-derivaten
YU30292A (sh) Nova aktivna jedinejnja
SE9902267D0 (sv) New compounds
ATE330958T1 (de) Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
ES2154311T3 (es) Quinoxalinas, procedimiento para su preparacion y su utilizacion.
PT861250E (pt) Derivados de amidina e de isotioureia como inibidores de oxido nitrico sintase
NO982863L (no) Nye forbindelser med analgetisk effekt
DK1294732T3 (da) Ruthenium (II)-forbindelser til anvendelse i cancerterapi
ES2156212T3 (es) Derivados de azabicicloheptano n-substituidos como neurolepticos, etc.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 599890

Country of ref document: ES