ATE152123T1 - Regulierung der stellen-spezifischen rekombination durch stellen-spezifische fusionsproteine, die aus rekombinase und nuklearem rezeptor bestehen - Google Patents

Regulierung der stellen-spezifischen rekombination durch stellen-spezifische fusionsproteine, die aus rekombinase und nuklearem rezeptor bestehen

Info

Publication number
ATE152123T1
ATE152123T1 AT94921628T AT94921628T ATE152123T1 AT E152123 T1 ATE152123 T1 AT E152123T1 AT 94921628 T AT94921628 T AT 94921628T AT 94921628 T AT94921628 T AT 94921628T AT E152123 T1 ATE152123 T1 AT E152123T1
Authority
AT
Austria
Prior art keywords
site
recombinase
recombination
fusion proteins
regulation
Prior art date
Application number
AT94921628T
Other languages
English (en)
Inventor
Francis Stewart
Original Assignee
European Molecular Biology Lab Embl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by European Molecular Biology Lab Embl filed Critical European Molecular Biology Lab Embl
Application granted granted Critical
Publication of ATE152123T1 publication Critical patent/ATE152123T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT94921628T 1993-06-28 1994-06-28 Regulierung der stellen-spezifischen rekombination durch stellen-spezifische fusionsproteine, die aus rekombinase und nuklearem rezeptor bestehen ATE152123T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93110298A EP0632054A1 (de) 1993-06-28 1993-06-28 Regulation stellenspezifischer Rekombination mittels stellungsspezifischer Rekombinase/Kernrezeptor-Fusionsproteine

Publications (1)

Publication Number Publication Date
ATE152123T1 true ATE152123T1 (de) 1997-05-15

Family

ID=8213015

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94921628T ATE152123T1 (de) 1993-06-28 1994-06-28 Regulierung der stellen-spezifischen rekombination durch stellen-spezifische fusionsproteine, die aus rekombinase und nuklearem rezeptor bestehen

Country Status (9)

Country Link
US (1) US6040430A (de)
EP (2) EP0632054A1 (de)
JP (1) JP2986915B2 (de)
AT (1) ATE152123T1 (de)
AU (1) AU7227994A (de)
CA (1) CA2166198C (de)
DE (1) DE69402863T2 (de)
ES (1) ES2101552T3 (de)
WO (1) WO1995000555A1 (de)

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EP2322614A1 (de) * 1995-06-07 2011-05-18 Life Technologies Corporation Rekombinatorische Klonierung unter Verwendung genmanipulierter Rekombinationsorte
US6964861B1 (en) 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US6720140B1 (en) * 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
FR2749857B1 (fr) * 1996-06-12 1998-08-14 Centre Nat Rech Scient Generation de molecules replicatives in vivo
US5851808A (en) 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
EP1025217B1 (de) * 1997-10-24 2006-10-04 Invitrogen Corporation Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen
US20030124555A1 (en) * 2001-05-21 2003-07-03 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
CN101125873A (zh) * 1997-10-24 2008-02-20 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
US7102055B1 (en) 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
US5929301A (en) * 1997-11-18 1999-07-27 Pioneer Hi-Bred International Nucleic acid sequence encoding FLP recombinase
WO1999025821A1 (en) 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. Compositions and methods for genetic modification of plants
ES2256972T3 (es) 1997-11-18 2006-07-16 Pioneer Hi-Bred International, Inc. Metodo novedoso para la integracion de un adn foraneo dentro de genomas de eucariotas.
US6720475B1 (en) 1997-11-18 2004-04-13 Pioneer Hi-Bred International, Inc. Modified nucleic acid sequence encoding FLP recombinase
AU745238C (en) 1997-11-18 2003-02-27 Pioneer Hi-Bred International, Inc. Mobilization of viral genomes from T-DNA using site-specific recombination systems
EP1173460B1 (de) * 1999-03-02 2009-09-16 Life Technologies Corporation Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch
DE19956272B4 (de) * 1999-11-23 2004-09-16 Mpb Cologne Gmbh Molecular Plant & Protein Biotechnology Verfahren zur gesteuerten Nach-Ernte-Produktion von Proteinen in Wirtsorganismen
NZ539430A (en) 1999-12-10 2006-09-29 Invitrogen Corp Use of multiple recombination sites with unique specificity in recombinational cloning
EP1118668A1 (de) * 2000-01-07 2001-07-25 ARTEMIS Pharmaceuticals GmbH Übertragung von Rekombinasen zur induzierbaren Genveränderung
DE10024740A1 (de) * 2000-05-19 2001-11-29 Mpb Cologne Gmbh Molecular Pla Verfahren zur gesteuerten Eliminierung gewünschter DNA-Sequenzen in Wirtsorganismen
US7244560B2 (en) 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
DE10038573A1 (de) * 2000-08-03 2002-02-21 Mpb Cologne Gmbh Molecular Pla Verfahren zur Selektion auf Wirtszellen mit eliminierten DNA-Sequenzen
US7198924B2 (en) * 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
EP1322152A2 (de) * 2000-10-03 2003-07-02 ADEREGEM (Association pour le Développement de la Recherche en Génétique Moléculaire Transgene maus zur gezielten rekombination vermittelt durch verändertes cre-er
US7560622B2 (en) 2000-10-06 2009-07-14 Pioneer Hi-Bred International, Inc. Methods and compositions relating to the generation of partially transgenic organisms
JP2004531259A (ja) * 2001-04-19 2004-10-14 インヴィトロジェン コーポレーション 核酸分子の組換えクローニングのための組成物および方法
EP1264891A1 (de) * 2001-05-31 2002-12-11 Plant Research International B.V. Veränderung des Pflanzen Genoms durch induzierbaren, ortsspezifischen Rekombination von Transgenen
JP2005521400A (ja) 2002-03-29 2005-07-21 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 植物におけるラムダインテグラーゼ媒介型組換え
JP2005532829A (ja) * 2002-07-18 2005-11-04 インヴィトロジェン コーポレーション 組換え部位を含むウイルスベクター
WO2005028615A2 (en) * 2003-06-26 2005-03-31 Invitrogen Corporation Methods and compositions for detecting promoter activity and expressing fusion proteins
WO2005054438A2 (en) * 2003-12-01 2005-06-16 Invitrogen Corporation Nucleic acid molecules containing recombination sites and methods of using the same
US7935862B2 (en) 2003-12-02 2011-05-03 Syngenta Participations Ag Targeted integration and stacking of DNA through homologous recombination
JP4485475B2 (ja) * 2004-02-12 2010-06-23 独立行政法人科学技術振興機構 核内レセプターのアゴニスト・アンタゴニスト検出用プローブとそれを用いた核内レセプターに対するアゴニストおよびアンタゴニストのスクリーニング方法
WO2008008160A2 (en) * 2006-07-07 2008-01-17 Fred Hutchinson Cancer Research Center High efficiency flp site-specific recombination in mammalian cells using an optimized flp gene
JP6215196B2 (ja) 2011-05-31 2017-10-18 キージーン・エン・フェー 有害生物耐性植物
US20150059018A1 (en) 2011-10-19 2015-02-26 Keygene N.V. Methods and compositions for producing drimenol
WO2014142647A1 (en) 2013-03-14 2014-09-18 Wageningen Universiteit Fungals strains with improved citric acid and itaconic acid production
IL257831B2 (en) 2015-09-04 2025-11-01 Keygene Nv Diplosporic garden
WO2020239984A1 (en) 2019-05-29 2020-12-03 Keygene N.V. Gene for parthenogenesis
IL301700A (en) 2020-10-13 2023-05-01 Keygene Nv Modified promoter of a parthenogenesis gene

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EP0146050B1 (de) * 1983-12-16 1990-07-04 Denis M. Callewaert Stellenselektiver Plasminogenaktivator und Verfahren zu seiner Herstellung und Verwendung
WO1993015191A1 (en) * 1992-01-24 1993-08-05 Life Technologies, Inc. Modulation of enzyme activities in the in vivo cloning of dna
US5589362A (en) * 1993-06-14 1996-12-31 Basf Aktiengesellschaft Tetracycline regulated transcriptional modulators with altered DNA binding specificities

Also Published As

Publication number Publication date
EP0707599A1 (de) 1996-04-24
CA2166198A1 (en) 1995-01-05
ES2101552T3 (es) 1997-07-01
WO1995000555A1 (en) 1995-01-05
AU7227994A (en) 1995-01-17
EP0707599B1 (de) 1997-04-23
JPH08511681A (ja) 1996-12-10
DE69402863D1 (de) 1997-05-28
US6040430A (en) 2000-03-21
DE69402863T2 (de) 1997-07-31
EP0632054A1 (de) 1995-01-04
CA2166198C (en) 2002-01-08
JP2986915B2 (ja) 1999-12-06

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