ATE154354T1 - Azabicyclische verbindungen, diese enthaltende pharmazeutische zubereitungen und ihre therapeutische verwendung - Google Patents

Azabicyclische verbindungen, diese enthaltende pharmazeutische zubereitungen und ihre therapeutische verwendung

Info

Publication number: ATE154354T1
Authority: AT; Austria
Prior art keywords: trifluoromethyl; independently represent; pharmaceutical preparations; therapeutic use; preparations containing
Prior art date: 1991-02-11

Application number

AT92200303T

Other languages

English (en)

Inventor

Raymond Baker

Christopher Swain

Eileen M Seward

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-11

Filing date

1992-02-04

Publication date

1997-06-15

1991-02-11 Priority claimed from GB919102809A external-priority patent/GB9102809D0/en

1991-04-09 Priority claimed from GB919107403A external-priority patent/GB9107403D0/en

1991-06-27 Priority claimed from GB919113892A external-priority patent/GB9113892D0/en

1991-07-05 Priority claimed from GB919114553A external-priority patent/GB9114553D0/en

1992-02-04 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1997-06-15 Application granted granted Critical

1997-06-15 Publication of ATE154354T1 publication Critical patent/ATE154354T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 abstract 1
102000003141 Tachykinin Human genes 0.000 abstract 1
241000534944 Thia Species 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
108060008037 tachykinin Proteins 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT92200303T 1991-02-11 1992-02-04 Azabicyclische verbindungen, diese enthaltende pharmazeutische zubereitungen und ihre therapeutische verwendung ATE154354T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB919102809A GB9102809D0 (en)	1991-02-11	1991-02-11	Therapeutic agents
GB919107403A GB9107403D0 (en)	1991-04-09	1991-04-09	Therapeutic agents
GB919113892A GB9113892D0 (en)	1991-06-27	1991-06-27	Therapeutic agents
GB919114553A GB9114553D0 (en)	1991-07-05	1991-07-05	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE154354T1 true ATE154354T1 (de)	1997-06-15

Family

ID=27450624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92200303T ATE154354T1 (de)	1991-02-11	1992-02-04	Azabicyclische verbindungen, diese enthaltende pharmazeutische zubereitungen und ihre therapeutische verwendung

Country Status (7)

Country	Link
US (1)	US5242930A (de)
EP (1)	EP0499313B1 (de)
JP (1)	JP2500279B2 (de)
AT (1)	ATE154354T1 (de)
CA (1)	CA2060949A1 (de)
DE (1)	DE69220258T2 (de)
IE (1)	IE920435A1 (de)

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US3796714A (en) *	1971-07-01	1974-03-12	Hercules Inc	Lactone and sultone adducts of bicyclic tertiary amines
US4013667A (en) *	1976-03-08	1977-03-22	G. D. Searle & Co.	2,2-Diaryl-3-(1-azabicyclo[2.2.2]oct-2-yl)propionamides and intermediates thereto
US4013668A (en) *	1976-03-10	1977-03-22	G. D. Searle & Co.	5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compounds
US4125531A (en) *	1977-04-18	1978-11-14	G. D. Searle & Co.	2-Substituted-1-azabicyclo[2.2.2]octanes
US4599344A (en) *	1984-10-31	1986-07-08	Schering A.G.	Quinuclidines and quinuclidinium salts as antiarrhythmic agents
GB2184047B (en) *	1985-03-27	1989-07-12	Potemkin Gennady Y	A tool for machining holes
WO1990005525A1 (en) *	1988-11-23	1990-05-31	Pfizer Inc.	Quinuclidine derivatives as substance p antagonists

1992
- 1992-02-04 US US07/830,822 patent/US5242930A/en not_active Expired - Lifetime
- 1992-02-04 AT AT92200303T patent/ATE154354T1/de not_active IP Right Cessation
- 1992-02-04 EP EP92200303A patent/EP0499313B1/de not_active Expired - Lifetime
- 1992-02-04 DE DE69220258T patent/DE69220258T2/de not_active Expired - Fee Related
- 1992-02-10 CA CA002060949A patent/CA2060949A1/en not_active Abandoned
- 1992-02-10 IE IE043592A patent/IE920435A1/en not_active Application Discontinuation
- 1992-02-12 JP JP4025068A patent/JP2500279B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69220258T2 (de)	1997-12-18
IE920435A1 (en)	1992-08-12
JP2500279B2 (ja)	1996-05-29
US5242930A (en)	1993-09-07
EP0499313B1 (de)	1997-06-11
DE69220258D1 (de)	1997-07-17
CA2060949A1 (en)	1992-08-12
EP0499313A1 (de)	1992-08-19
JPH0578354A (ja)	1993-03-30

Legal Events

Date	Code	Title	Description
1997-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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DE3862426D1 (de)	1991-05-23	2-selenomethyl-1,4-dihydropyridine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.