ATE155137T1 - Prodrug von entzündungshemmenden 3-acyl-2- oxindol-1-carboxamiden - Google Patents

Prodrug von entzündungshemmenden 3-acyl-2- oxindol-1-carboxamiden

Info

Publication number
ATE155137T1
ATE155137T1 AT93923879T AT93923879T ATE155137T1 AT E155137 T1 ATE155137 T1 AT E155137T1 AT 93923879 T AT93923879 T AT 93923879T AT 93923879 T AT93923879 T AT 93923879T AT E155137 T1 ATE155137 T1 AT E155137T1
Authority
AT
Austria
Prior art keywords
oxindol
carboxamide
acyl
prodrug
inflammatory
Prior art date
Application number
AT93923879T
Other languages
English (en)
Inventor
Wayne E Barth
Kelvin Cooper
Edward F Kleinman
Lawrence A Reiter
Ralph P Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE155137T1 publication Critical patent/ATE155137T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT93923879T 1993-01-26 1993-10-20 Prodrug von entzündungshemmenden 3-acyl-2- oxindol-1-carboxamiden ATE155137T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/009,188 US5270331A (en) 1993-01-26 1993-01-26 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (1)

Publication Number Publication Date
ATE155137T1 true ATE155137T1 (de) 1997-07-15

Family

ID=21736103

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93923879T ATE155137T1 (de) 1993-01-26 1993-10-20 Prodrug von entzündungshemmenden 3-acyl-2- oxindol-1-carboxamiden

Country Status (35)

Country Link
US (1) US5270331A (de)
EP (1) EP0681580B1 (de)
JP (1) JP2703825B2 (de)
KR (1) KR0169827B1 (de)
CN (1) CN1052003C (de)
AP (1) AP443A (de)
AT (1) ATE155137T1 (de)
AU (1) AU678187B2 (de)
BR (1) BR9307768A (de)
CA (1) CA2152919C (de)
CZ (1) CZ281046B6 (de)
DE (1) DE69312093T2 (de)
DK (1) DK0681580T3 (de)
EG (1) EG20302A (de)
ES (1) ES2104187T3 (de)
FI (1) FI940365A7 (de)
GR (1) GR3024591T3 (de)
HR (1) HRP940034B1 (de)
HU (1) HUT69689A (de)
IL (1) IL108384A (de)
MA (1) MA23096A1 (de)
MX (1) MX9400677A (de)
MY (1) MY138629A (de)
NO (1) NO952949D0 (de)
NZ (1) NZ257278A (de)
OA (1) OA10563A (de)
PL (1) PL178857B1 (de)
RU (1) RU2124514C1 (de)
SI (1) SI9300567A (de)
SK (1) SK280929B6 (de)
TW (1) TW330935B (de)
UA (1) UA41348C2 (de)
WO (1) WO1994017061A1 (de)
YU (1) YU48796B (de)
ZA (1) ZA94463B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018194A1 (en) * 1993-02-09 1994-08-18 Pfizer Inc. Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as intiinflammatory agents
WO1997013767A1 (de) * 1995-10-09 1997-04-17 Chemisch Pharmazeutische Forschungsgesellschaft Mbh Heterocyclisch substituierte 1-indolcarboxamide als cyclooxygenase-2 inhibitoren
CA2320757A1 (en) * 1998-03-06 1999-09-10 Astrazeneca Ab New use
EP0984012A3 (de) * 1998-08-31 2001-01-10 Pfizer Products Inc. Stickstoffmonoxid freisetzende Oxindol-Prodrugs mit analgetischen und entzündungshemmenden Eigenschaften
AU2002325614A1 (en) * 2001-08-16 2003-03-03 Pharmacon-Forschung Und Beratung Gmbh Compounds containing lactic acid elements, method for the production and use thereof as pharmaceutically active substances
CN101628842A (zh) * 2009-08-27 2010-01-20 中国人民解放军防化指挥工程学院 烷氧羰基甲氧基作为羧基保护基

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
RO105052B1 (en) * 1987-02-02 1994-12-01 Pfizer Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide
MX18021A (es) * 1988-10-18 1993-11-01 Pfizer Pro-farmacos de la 3-acil-2-oxindol-1-carboxamidasanti-inflamatorias
ES2075055T3 (es) * 1988-10-18 1995-10-01 Pfizer Profarmacos de 3-acil-2-oxindol-1-carboxamidas antiinflamatorias.

Also Published As

Publication number Publication date
HU9400209D0 (en) 1994-05-30
CA2152919A1 (en) 1994-08-04
AU5359894A (en) 1994-08-15
JP2703825B2 (ja) 1998-01-26
PL178857B1 (pl) 2000-06-30
PL309989A1 (en) 1995-11-13
GR3024591T3 (en) 1997-12-31
RU2124514C1 (ru) 1999-01-10
AP443A (en) 1996-01-03
AU678187B2 (en) 1997-05-22
DE69312093D1 (de) 1997-08-14
YU48796B (sh) 2000-03-21
MY138629A (en) 2009-07-31
EP0681580B1 (de) 1997-07-09
FI940365L (fi) 1994-07-27
YU2994A (sh) 1997-01-08
NO952949L (no) 1995-07-25
MX9400677A (es) 1994-08-31
NZ257278A (en) 1996-09-25
ZA94463B (en) 1995-07-24
DK0681580T3 (da) 1997-08-18
HRP940034B1 (en) 2000-10-31
HRP940034A2 (en) 1996-08-31
AP9300583A0 (en) 1993-10-31
CZ181995A3 (en) 1996-06-12
CZ281046B6 (cs) 1996-06-12
OA10563A (en) 2002-06-05
CA2152919C (en) 1999-01-05
BR9307768A (pt) 1995-11-21
NO952949D0 (no) 1995-07-25
DE69312093T2 (de) 1997-10-30
IL108384A (en) 1998-12-27
ES2104187T3 (es) 1997-10-01
TW330935B (en) 1998-05-01
KR960700244A (ko) 1996-01-19
SK91295A3 (en) 1995-12-06
EG20302A (en) 1998-10-31
RU95117091A (ru) 1997-06-27
IL108384A0 (en) 1994-04-12
WO1994017061A1 (en) 1994-08-04
MA23096A1 (fr) 1994-10-01
US5270331A (en) 1993-12-14
SI9300567A (en) 1994-09-30
JPH08501316A (ja) 1996-02-13
FI940365A7 (fi) 1994-07-27
HUT69689A (en) 1995-09-28
CN1052003C (zh) 2000-05-03
SK280929B6 (sk) 2000-09-12
EP0681580A1 (de) 1995-11-15
FI940365A0 (fi) 1994-01-25
KR0169827B1 (en) 1999-01-15
CN1097740A (zh) 1995-01-25
UA41348C2 (uk) 2001-09-17

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee