IL108384A - Prodrugs of antiflammatory 3-Acyl-2-oxoindole-1-carboxamides and uses thereof - Google Patents

Prodrugs of antiflammatory 3-Acyl-2-oxoindole-1-carboxamides and uses thereof

Info

Publication number
IL108384A
IL108384A IL10838494A IL10838494A IL108384A IL 108384 A IL108384 A IL 108384A IL 10838494 A IL10838494 A IL 10838494A IL 10838494 A IL10838494 A IL 10838494A IL 108384 A IL108384 A IL 108384A
Authority
IL
Israel
Prior art keywords
alkyl
compound
chloro
optionally substituted
fluoro
Prior art date
Application number
IL10838494A
Other languages
English (en)
Other versions
IL108384A0 (en
Inventor
Wayne E Barth
Kelvin Cooper
Edward F Kleinman
Lawrence A Reiter
Ralph P Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL108384A0 publication Critical patent/IL108384A0/xx
Publication of IL108384A publication Critical patent/IL108384A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
IL10838494A 1993-01-26 1994-01-20 Prodrugs of antiflammatory 3-Acyl-2-oxoindole-1-carboxamides and uses thereof IL108384A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/009,188 US5270331A (en) 1993-01-26 1993-01-26 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (2)

Publication Number Publication Date
IL108384A0 IL108384A0 (en) 1994-04-12
IL108384A true IL108384A (en) 1998-12-27

Family

ID=21736103

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10838494A IL108384A (en) 1993-01-26 1994-01-20 Prodrugs of antiflammatory 3-Acyl-2-oxoindole-1-carboxamides and uses thereof

Country Status (35)

Country Link
US (1) US5270331A (de)
EP (1) EP0681580B1 (de)
JP (1) JP2703825B2 (de)
KR (1) KR0169827B1 (de)
CN (1) CN1052003C (de)
AP (1) AP443A (de)
AT (1) ATE155137T1 (de)
AU (1) AU678187B2 (de)
BR (1) BR9307768A (de)
CA (1) CA2152919C (de)
CZ (1) CZ181995A3 (de)
DE (1) DE69312093T2 (de)
DK (1) DK0681580T3 (de)
EG (1) EG20302A (de)
ES (1) ES2104187T3 (de)
FI (1) FI940365A7 (de)
GR (1) GR3024591T3 (de)
HR (1) HRP940034B1 (de)
HU (1) HUT69689A (de)
IL (1) IL108384A (de)
MA (1) MA23096A1 (de)
MX (1) MX9400677A (de)
MY (1) MY138629A (de)
NO (1) NO952949D0 (de)
NZ (1) NZ257278A (de)
OA (1) OA10563A (de)
PL (1) PL178857B1 (de)
RU (1) RU2124514C1 (de)
SI (1) SI9300567A (de)
SK (1) SK280929B6 (de)
TW (1) TW330935B (de)
UA (1) UA41348C2 (de)
WO (1) WO1994017061A1 (de)
YU (1) YU48796B (de)
ZA (1) ZA94463B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018194A1 (en) * 1993-02-09 1994-08-18 Pfizer Inc. Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as intiinflammatory agents
WO1997013767A1 (de) * 1995-10-09 1997-04-17 Chemisch Pharmazeutische Forschungsgesellschaft Mbh Heterocyclisch substituierte 1-indolcarboxamide als cyclooxygenase-2 inhibitoren
KR20010041625A (ko) * 1998-03-06 2001-05-25 아스트라제네카 악티에볼라그 신규 용도
EP0984012A3 (de) * 1998-08-31 2001-01-10 Pfizer Products Inc. Stickstoffmonoxid freisetzende Oxindol-Prodrugs mit analgetischen und entzündungshemmenden Eigenschaften
AU2002325614A1 (en) * 2001-08-16 2003-03-03 Pharmacon-Forschung Und Beratung Gmbh Compounds containing lactic acid elements, method for the production and use thereof as pharmaceutically active substances
CN101628842A (zh) * 2009-08-27 2010-01-20 中国人民解放军防化指挥工程学院 烷氧羰基甲氧基作为羧基保护基

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US5036099A (en) * 1987-02-02 1991-07-30 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
HU208421B (en) * 1988-10-18 1993-10-28 Pfizer Process for producing starting materials for producing 3-acyl-2-oxindol-carboxamides ofantiphlogistic activity
EP0365194B1 (de) * 1988-10-18 1995-08-02 Pfizer Inc. Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden

Also Published As

Publication number Publication date
MX9400677A (es) 1994-08-31
FI940365L (fi) 1994-07-27
GR3024591T3 (en) 1997-12-31
HRP940034A2 (en) 1996-08-31
DK0681580T3 (da) 1997-08-18
AU678187B2 (en) 1997-05-22
SK280929B6 (sk) 2000-09-12
KR0169827B1 (en) 1999-01-15
US5270331A (en) 1993-12-14
ES2104187T3 (es) 1997-10-01
CA2152919C (en) 1999-01-05
PL178857B1 (pl) 2000-06-30
BR9307768A (pt) 1995-11-21
EG20302A (en) 1998-10-31
TW330935B (en) 1998-05-01
JPH08501316A (ja) 1996-02-13
FI940365A0 (fi) 1994-01-25
RU95117091A (ru) 1997-06-27
HRP940034B1 (en) 2000-10-31
MA23096A1 (fr) 1994-10-01
YU2994A (sh) 1997-01-08
DE69312093D1 (de) 1997-08-14
EP0681580B1 (de) 1997-07-09
CA2152919A1 (en) 1994-08-04
EP0681580A1 (de) 1995-11-15
DE69312093T2 (de) 1997-10-30
JP2703825B2 (ja) 1998-01-26
AP443A (en) 1996-01-03
SI9300567A (en) 1994-09-30
SK91295A3 (en) 1995-12-06
CZ281046B6 (cs) 1996-06-12
WO1994017061A1 (en) 1994-08-04
PL309989A1 (en) 1995-11-13
CN1052003C (zh) 2000-05-03
NZ257278A (en) 1996-09-25
AP9300583A0 (en) 1993-10-31
IL108384A0 (en) 1994-04-12
UA41348C2 (uk) 2001-09-17
NO952949L (no) 1995-07-25
YU48796B (sh) 2000-03-21
CZ181995A3 (en) 1996-06-12
ATE155137T1 (de) 1997-07-15
HU9400209D0 (en) 1994-05-30
NO952949D0 (no) 1995-07-25
FI940365A7 (fi) 1994-07-27
HUT69689A (en) 1995-09-28
MY138629A (en) 2009-07-31
KR960700244A (ko) 1996-01-19
CN1097740A (zh) 1995-01-25
OA10563A (en) 2002-06-05
ZA94463B (en) 1995-07-24
AU5359894A (en) 1994-08-15
RU2124514C1 (ru) 1999-01-10

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