SI9300567A - Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides - Google Patents

Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides Download PDF

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Publication number
SI9300567A
SI9300567A SI9300567A SI9300567A SI9300567A SI 9300567 A SI9300567 A SI 9300567A SI 9300567 A SI9300567 A SI 9300567A SI 9300567 A SI9300567 A SI 9300567A SI 9300567 A SI9300567 A SI 9300567A
Authority
SI
Slovenia
Prior art keywords
alkyl
chloro
oxo
evaporated
fluoro
Prior art date
Application number
SI9300567A
Other languages
English (en)
Slovenian (sl)
Inventor
E Wayne Barth
Kelvin Cooper
F Edward Kleinman
A Lawrence Reiter
P Ralph Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SI9300567A publication Critical patent/SI9300567A/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
SI9300567A 1993-01-26 1993-10-28 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides SI9300567A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/009,188 US5270331A (en) 1993-01-26 1993-01-26 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (1)

Publication Number Publication Date
SI9300567A true SI9300567A (en) 1994-09-30

Family

ID=21736103

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9300567A SI9300567A (en) 1993-01-26 1993-10-28 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Country Status (35)

Country Link
US (1) US5270331A (de)
EP (1) EP0681580B1 (de)
JP (1) JP2703825B2 (de)
KR (1) KR0169827B1 (de)
CN (1) CN1052003C (de)
AP (1) AP443A (de)
AT (1) ATE155137T1 (de)
AU (1) AU678187B2 (de)
BR (1) BR9307768A (de)
CA (1) CA2152919C (de)
CZ (1) CZ281046B6 (de)
DE (1) DE69312093T2 (de)
DK (1) DK0681580T3 (de)
EG (1) EG20302A (de)
ES (1) ES2104187T3 (de)
FI (1) FI940365A7 (de)
GR (1) GR3024591T3 (de)
HR (1) HRP940034B1 (de)
HU (1) HUT69689A (de)
IL (1) IL108384A (de)
MA (1) MA23096A1 (de)
MX (1) MX9400677A (de)
MY (1) MY138629A (de)
NO (1) NO952949L (de)
NZ (1) NZ257278A (de)
OA (1) OA10563A (de)
PL (1) PL178857B1 (de)
RU (1) RU2124514C1 (de)
SI (1) SI9300567A (de)
SK (1) SK280929B6 (de)
TW (1) TW330935B (de)
UA (1) UA41348C2 (de)
WO (1) WO1994017061A1 (de)
YU (1) YU48796B (de)
ZA (1) ZA94463B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607959A (en) * 1993-02-09 1997-03-04 Pfizer Inc. Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents
WO1997013767A1 (de) * 1995-10-09 1997-04-17 Chemisch Pharmazeutische Forschungsgesellschaft Mbh Heterocyclisch substituierte 1-indolcarboxamide als cyclooxygenase-2 inhibitoren
ATE249828T1 (de) * 1998-03-06 2003-10-15 Astrazeneca Ab Verwendung von isatin- und oxindolderivaten zur herstellung von arzeneimittel für die behandlung von mykobakteriellen erkrankungen
EP0984012A3 (de) * 1998-08-31 2001-01-10 Pfizer Products Inc. Stickstoffmonoxid freisetzende Oxindol-Prodrugs mit analgetischen und entzündungshemmenden Eigenschaften
AU2002325614A1 (en) * 2001-08-16 2003-03-03 Pharmacon-Forschung Und Beratung Gmbh Compounds containing lactic acid elements, method for the production and use thereof as pharmaceutically active substances
CN101628842A (zh) * 2009-08-27 2010-01-20 中国人民解放军防化指挥工程学院 烷氧羰基甲氧基作为羧基保护基

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
UA25898A1 (uk) * 1987-02-02 1999-02-26 Пфайзер Інк. Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду
EP0365194B1 (de) * 1988-10-18 1995-08-02 Pfizer Inc. Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden
US5118703A (en) * 1988-10-18 1992-06-02 Pfizer Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Also Published As

Publication number Publication date
EG20302A (en) 1998-10-31
MA23096A1 (fr) 1994-10-01
WO1994017061A1 (en) 1994-08-04
MY138629A (en) 2009-07-31
TW330935B (en) 1998-05-01
HRP940034B1 (en) 2000-10-31
DE69312093D1 (de) 1997-08-14
NO952949D0 (no) 1995-07-25
ZA94463B (en) 1995-07-24
DE69312093T2 (de) 1997-10-30
IL108384A (en) 1998-12-27
KR960700244A (ko) 1996-01-19
NO952949L (no) 1995-07-25
CN1052003C (zh) 2000-05-03
PL178857B1 (pl) 2000-06-30
YU2994A (sh) 1997-01-08
JP2703825B2 (ja) 1998-01-26
HRP940034A2 (en) 1996-08-31
SK280929B6 (sk) 2000-09-12
OA10563A (en) 2002-06-05
CZ181995A3 (en) 1996-06-12
HU9400209D0 (en) 1994-05-30
FI940365A0 (fi) 1994-01-25
ATE155137T1 (de) 1997-07-15
YU48796B (sh) 2000-03-21
US5270331A (en) 1993-12-14
UA41348C2 (uk) 2001-09-17
AP9300583A0 (en) 1993-10-31
KR0169827B1 (en) 1999-01-15
CZ281046B6 (cs) 1996-06-12
RU95117091A (ru) 1997-06-27
FI940365L (fi) 1994-07-27
NZ257278A (en) 1996-09-25
AU5359894A (en) 1994-08-15
MX9400677A (es) 1994-08-31
AP443A (en) 1996-01-03
DK0681580T3 (da) 1997-08-18
EP0681580B1 (de) 1997-07-09
EP0681580A1 (de) 1995-11-15
JPH08501316A (ja) 1996-02-13
GR3024591T3 (en) 1997-12-31
IL108384A0 (en) 1994-04-12
BR9307768A (pt) 1995-11-21
ES2104187T3 (es) 1997-10-01
FI940365A7 (fi) 1994-07-27
HUT69689A (en) 1995-09-28
CA2152919A1 (en) 1994-08-04
CN1097740A (zh) 1995-01-25
SK91295A3 (en) 1995-12-06
CA2152919C (en) 1999-01-05
AU678187B2 (en) 1997-05-22
RU2124514C1 (ru) 1999-01-10
PL309989A1 (en) 1995-11-13

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Effective date: 20070126