MY138629A - Prodrugs of antiinflammatory 3-acyl-2- oxindole-1-carboxamides - Google Patents

Prodrugs of antiinflammatory 3-acyl-2- oxindole-1-carboxamides

Info

Publication number
MY138629A
MY138629A MYPI94000137A MYPI9400137A MY138629A MY 138629 A MY138629 A MY 138629A MY PI94000137 A MYPI94000137 A MY PI94000137A MY PI9400137 A MYPI9400137 A MY PI9400137A MY 138629 A MY138629 A MY 138629A
Authority
MY
Malaysia
Prior art keywords
antiinflammatory
oxindole
prodrugs
carboxamides
acyl
Prior art date
Application number
MYPI94000137A
Other languages
English (en)
Inventor
Wayne E Barth
Kelvin Cooper
Edward F Kleinman
Lawrence A Reiter
Ralph P Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MY138629A publication Critical patent/MY138629A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
MYPI94000137A 1993-01-26 1994-01-18 Prodrugs of antiinflammatory 3-acyl-2- oxindole-1-carboxamides MY138629A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/009,188 US5270331A (en) 1993-01-26 1993-01-26 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (1)

Publication Number Publication Date
MY138629A true MY138629A (en) 2009-07-31

Family

ID=21736103

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI94000137A MY138629A (en) 1993-01-26 1994-01-18 Prodrugs of antiinflammatory 3-acyl-2- oxindole-1-carboxamides

Country Status (35)

Country Link
US (1) US5270331A (de)
EP (1) EP0681580B1 (de)
JP (1) JP2703825B2 (de)
KR (1) KR0169827B1 (de)
CN (1) CN1052003C (de)
AP (1) AP443A (de)
AT (1) ATE155137T1 (de)
AU (1) AU678187B2 (de)
BR (1) BR9307768A (de)
CA (1) CA2152919C (de)
CZ (1) CZ181995A3 (de)
DE (1) DE69312093T2 (de)
DK (1) DK0681580T3 (de)
EG (1) EG20302A (de)
ES (1) ES2104187T3 (de)
FI (1) FI940365A7 (de)
GR (1) GR3024591T3 (de)
HR (1) HRP940034B1 (de)
HU (1) HUT69689A (de)
IL (1) IL108384A (de)
MA (1) MA23096A1 (de)
MX (1) MX9400677A (de)
MY (1) MY138629A (de)
NO (1) NO952949D0 (de)
NZ (1) NZ257278A (de)
OA (1) OA10563A (de)
PL (1) PL178857B1 (de)
RU (1) RU2124514C1 (de)
SI (1) SI9300567A (de)
SK (1) SK280929B6 (de)
TW (1) TW330935B (de)
UA (1) UA41348C2 (de)
WO (1) WO1994017061A1 (de)
YU (1) YU48796B (de)
ZA (1) ZA94463B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018194A1 (en) * 1993-02-09 1994-08-18 Pfizer Inc. Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as intiinflammatory agents
WO1997013767A1 (de) * 1995-10-09 1997-04-17 Chemisch Pharmazeutische Forschungsgesellschaft Mbh Heterocyclisch substituierte 1-indolcarboxamide als cyclooxygenase-2 inhibitoren
KR20010041625A (ko) * 1998-03-06 2001-05-25 아스트라제네카 악티에볼라그 신규 용도
EP0984012A3 (de) * 1998-08-31 2001-01-10 Pfizer Products Inc. Stickstoffmonoxid freisetzende Oxindol-Prodrugs mit analgetischen und entzündungshemmenden Eigenschaften
AU2002325614A1 (en) * 2001-08-16 2003-03-03 Pharmacon-Forschung Und Beratung Gmbh Compounds containing lactic acid elements, method for the production and use thereof as pharmaceutically active substances
CN101628842A (zh) * 2009-08-27 2010-01-20 中国人民解放军防化指挥工程学院 烷氧羰基甲氧基作为羧基保护基

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US5036099A (en) * 1987-02-02 1991-07-30 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
HU208421B (en) * 1988-10-18 1993-10-28 Pfizer Process for producing starting materials for producing 3-acyl-2-oxindol-carboxamides ofantiphlogistic activity
EP0365194B1 (de) * 1988-10-18 1995-08-02 Pfizer Inc. Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden

Also Published As

Publication number Publication date
MX9400677A (es) 1994-08-31
FI940365L (fi) 1994-07-27
GR3024591T3 (en) 1997-12-31
HRP940034A2 (en) 1996-08-31
DK0681580T3 (da) 1997-08-18
AU678187B2 (en) 1997-05-22
SK280929B6 (sk) 2000-09-12
KR0169827B1 (en) 1999-01-15
US5270331A (en) 1993-12-14
ES2104187T3 (es) 1997-10-01
CA2152919C (en) 1999-01-05
PL178857B1 (pl) 2000-06-30
BR9307768A (pt) 1995-11-21
EG20302A (en) 1998-10-31
TW330935B (en) 1998-05-01
JPH08501316A (ja) 1996-02-13
IL108384A (en) 1998-12-27
FI940365A0 (fi) 1994-01-25
RU95117091A (ru) 1997-06-27
HRP940034B1 (en) 2000-10-31
MA23096A1 (fr) 1994-10-01
YU2994A (sh) 1997-01-08
DE69312093D1 (de) 1997-08-14
EP0681580B1 (de) 1997-07-09
CA2152919A1 (en) 1994-08-04
EP0681580A1 (de) 1995-11-15
DE69312093T2 (de) 1997-10-30
JP2703825B2 (ja) 1998-01-26
AP443A (en) 1996-01-03
SI9300567A (en) 1994-09-30
SK91295A3 (en) 1995-12-06
CZ281046B6 (cs) 1996-06-12
WO1994017061A1 (en) 1994-08-04
PL309989A1 (en) 1995-11-13
CN1052003C (zh) 2000-05-03
NZ257278A (en) 1996-09-25
AP9300583A0 (en) 1993-10-31
IL108384A0 (en) 1994-04-12
UA41348C2 (uk) 2001-09-17
NO952949L (no) 1995-07-25
YU48796B (sh) 2000-03-21
CZ181995A3 (en) 1996-06-12
ATE155137T1 (de) 1997-07-15
HU9400209D0 (en) 1994-05-30
NO952949D0 (no) 1995-07-25
FI940365A7 (fi) 1994-07-27
HUT69689A (en) 1995-09-28
KR960700244A (ko) 1996-01-19
CN1097740A (zh) 1995-01-25
OA10563A (en) 2002-06-05
ZA94463B (en) 1995-07-24
AU5359894A (en) 1994-08-15
RU2124514C1 (ru) 1999-01-10

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