OA10563A - Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides - Google Patents

Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides Download PDF

Info

Publication number
OA10563A
OA10563A OA60692A OA60692A OA10563A OA 10563 A OA10563 A OA 10563A OA 60692 A OA60692 A OA 60692A OA 60692 A OA60692 A OA 60692A OA 10563 A OA10563 A OA 10563A
Authority
OA
OAPI
Prior art keywords
alkyl
compound
chloro
oxo
fluoro
Prior art date
Application number
OA60692A
Other languages
English (en)
Inventor
Wayne E Barth
Kelvin Cooper
Edward F Kleinman
Lawrence A Reiter
Ralph P Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of OA10563A publication Critical patent/OA10563A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
OA60692A 1993-01-26 1995-07-25 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides OA10563A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/009,188 US5270331A (en) 1993-01-26 1993-01-26 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (1)

Publication Number Publication Date
OA10563A true OA10563A (en) 2002-06-05

Family

ID=21736103

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60692A OA10563A (en) 1993-01-26 1995-07-25 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Country Status (35)

Country Link
US (1) US5270331A (de)
EP (1) EP0681580B1 (de)
JP (1) JP2703825B2 (de)
KR (1) KR0169827B1 (de)
CN (1) CN1052003C (de)
AP (1) AP443A (de)
AT (1) ATE155137T1 (de)
AU (1) AU678187B2 (de)
BR (1) BR9307768A (de)
CA (1) CA2152919C (de)
CZ (1) CZ181995A3 (de)
DE (1) DE69312093T2 (de)
DK (1) DK0681580T3 (de)
EG (1) EG20302A (de)
ES (1) ES2104187T3 (de)
FI (1) FI940365A7 (de)
GR (1) GR3024591T3 (de)
HR (1) HRP940034B1 (de)
HU (1) HUT69689A (de)
IL (1) IL108384A (de)
MA (1) MA23096A1 (de)
MX (1) MX9400677A (de)
MY (1) MY138629A (de)
NO (1) NO952949D0 (de)
NZ (1) NZ257278A (de)
OA (1) OA10563A (de)
PL (1) PL178857B1 (de)
RU (1) RU2124514C1 (de)
SI (1) SI9300567A (de)
SK (1) SK280929B6 (de)
TW (1) TW330935B (de)
UA (1) UA41348C2 (de)
WO (1) WO1994017061A1 (de)
YU (1) YU48796B (de)
ZA (1) ZA94463B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018194A1 (en) * 1993-02-09 1994-08-18 Pfizer Inc. Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as intiinflammatory agents
WO1997013767A1 (de) * 1995-10-09 1997-04-17 Chemisch Pharmazeutische Forschungsgesellschaft Mbh Heterocyclisch substituierte 1-indolcarboxamide als cyclooxygenase-2 inhibitoren
KR20010041625A (ko) * 1998-03-06 2001-05-25 아스트라제네카 악티에볼라그 신규 용도
EP0984012A3 (de) * 1998-08-31 2001-01-10 Pfizer Products Inc. Stickstoffmonoxid freisetzende Oxindol-Prodrugs mit analgetischen und entzündungshemmenden Eigenschaften
AU2002325614A1 (en) * 2001-08-16 2003-03-03 Pharmacon-Forschung Und Beratung Gmbh Compounds containing lactic acid elements, method for the production and use thereof as pharmaceutically active substances
CN101628842A (zh) * 2009-08-27 2010-01-20 中国人民解放军防化指挥工程学院 烷氧羰基甲氧基作为羧基保护基

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US5036099A (en) * 1987-02-02 1991-07-30 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
HU208421B (en) * 1988-10-18 1993-10-28 Pfizer Process for producing starting materials for producing 3-acyl-2-oxindol-carboxamides ofantiphlogistic activity
EP0365194B1 (de) * 1988-10-18 1995-08-02 Pfizer Inc. Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden

Also Published As

Publication number Publication date
MX9400677A (es) 1994-08-31
FI940365L (fi) 1994-07-27
GR3024591T3 (en) 1997-12-31
HRP940034A2 (en) 1996-08-31
DK0681580T3 (da) 1997-08-18
AU678187B2 (en) 1997-05-22
SK280929B6 (sk) 2000-09-12
KR0169827B1 (en) 1999-01-15
US5270331A (en) 1993-12-14
ES2104187T3 (es) 1997-10-01
CA2152919C (en) 1999-01-05
PL178857B1 (pl) 2000-06-30
BR9307768A (pt) 1995-11-21
EG20302A (en) 1998-10-31
TW330935B (en) 1998-05-01
JPH08501316A (ja) 1996-02-13
IL108384A (en) 1998-12-27
FI940365A0 (fi) 1994-01-25
RU95117091A (ru) 1997-06-27
HRP940034B1 (en) 2000-10-31
MA23096A1 (fr) 1994-10-01
YU2994A (sh) 1997-01-08
DE69312093D1 (de) 1997-08-14
EP0681580B1 (de) 1997-07-09
CA2152919A1 (en) 1994-08-04
EP0681580A1 (de) 1995-11-15
DE69312093T2 (de) 1997-10-30
JP2703825B2 (ja) 1998-01-26
AP443A (en) 1996-01-03
SI9300567A (en) 1994-09-30
SK91295A3 (en) 1995-12-06
CZ281046B6 (cs) 1996-06-12
WO1994017061A1 (en) 1994-08-04
PL309989A1 (en) 1995-11-13
CN1052003C (zh) 2000-05-03
NZ257278A (en) 1996-09-25
AP9300583A0 (en) 1993-10-31
IL108384A0 (en) 1994-04-12
UA41348C2 (uk) 2001-09-17
NO952949L (no) 1995-07-25
YU48796B (sh) 2000-03-21
CZ181995A3 (en) 1996-06-12
ATE155137T1 (de) 1997-07-15
HU9400209D0 (en) 1994-05-30
NO952949D0 (no) 1995-07-25
FI940365A7 (fi) 1994-07-27
HUT69689A (en) 1995-09-28
MY138629A (en) 2009-07-31
KR960700244A (ko) 1996-01-19
CN1097740A (zh) 1995-01-25
ZA94463B (en) 1995-07-24
AU5359894A (en) 1994-08-15
RU2124514C1 (ru) 1999-01-10

Similar Documents

Publication Publication Date Title
AP1288A (en) Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation.
TW203608B (de)
JP7165270B2 (ja) 網膜疾患用化合物
US20030130278A1 (en) Alkynylated fused ring pyrimidine compounds
JP2010248209A (ja) ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法
SK150398A3 (en) Indole derivatives useful as endothelin receptor antagonists
WO2023034946A1 (en) Indole compounds and uses thereof in the treatement of cystic fibrosis
TWI259085B (en) Piperazine derivatives having SST1 antagonistic activity
KR0130899B1 (ko) 인돌일피페리딘 화합물, 그 제조방법 및 그들을 함유하는 약학조성물
CN102131802A (zh) 用作凝血酶抑制剂的新型杂环甲酰胺
OA10563A (en) Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
CN108473532A (zh) 硼替佐米缀合物和其使用方法
FR2758329A1 (fr) Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
HU223476B1 (hu) Új intermedierek tiolok előállításához
JP2019510000A (ja) 新規トキシン及びその中間体の製造方法
EP1613610B1 (de) Benzo¬1,2,5 oxadiazole und benzo¬1,2,5 thiadiazole als histopathologische anfärbungsmittel, abbildungsmittel und biomarker
WO1998042710A1 (fr) Derives de dihydropyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique
EP0365194B1 (de) Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden
KR100552252B1 (ko) 4-치환된-3-할로게노-1,4-벤즈옥사제핀 유도체 및 이의 염의 제조방법
JPH02149589A (ja) 新規なアスパルテートトランスカルバミラーゼ抑制剤類
JPH11310568A (ja) ペンタン酸アミド類
JPH0436266A (ja) フェニルスルフィニルアルキルカルボン酸誘導体
JPH0436268A (ja) フェニルスルフィニルアルキルカルボン酸誘導体
JPH093080A (ja) 新規な骨親和性エストロゲン誘導体