ATE182588T1 - Verfahen zur herstellung von (s)(+)-4, 4'-(1- methyl-1,2-ethandiyl)-bis(2,6-piperazindion - Google Patents

Verfahen zur herstellung von (s)(+)-4, 4'-(1- methyl-1,2-ethandiyl)-bis(2,6-piperazindion

Info

Publication number: ATE182588T1
Authority: AT; Austria
Prior art keywords: pct; ethanediyl; bis; methyl; producing
Prior art date: 1991-10-25

Application number

AT92921725T

Other languages

English (en)

Inventor

Peter Lindsay Macdonald

Riccardo Stradi

Pierluigi Rossetto

Josephus Johannes Mar Holthuis

Original Assignee

Eurocetus Bv

Sicor Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-25

Filing date

1992-10-22

Publication date

1999-08-15

1992-10-22 Application filed by Eurocetus Bv, Sicor Ltd filed Critical Eurocetus Bv

1999-08-15 Application granted granted Critical

1999-08-15 Publication of ATE182588T1 publication Critical patent/ATE182588T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
CYJAWBVQRMVFEO-UHFFFAOYSA-N piperazine-2,6-dione Chemical compound O=C1CNCC(=O)N1 CYJAWBVQRMVFEO-UHFFFAOYSA-N 0.000 title 1
239000006227 byproduct Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
BMKDZUISNHGIBY-ZETCQYMHSA-N (+)-dexrazoxane Chemical compound C([C@H](C)N1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 BMKDZUISNHGIBY-ZETCQYMHSA-N 0.000 abstract 1
XNCSCQSQSGDGES-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]propyl-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)C(C)CN(CC(O)=O)CC(O)=O XNCSCQSQSGDGES-UHFFFAOYSA-N 0.000 abstract 1
BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92921725T 1991-10-25 1992-10-22 Verfahen zur herstellung von (s)(+)-4, 4'-(1- methyl-1,2-ethandiyl)-bis(2,6-piperazindion ATE182588T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB919122677A GB9122677D0 (en)	1991-10-25	1991-10-25	Process for preparing(s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)

Publications (1)

Publication Number	Publication Date
ATE182588T1 true ATE182588T1 (de)	1999-08-15

Family

ID=10703528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92921725T ATE182588T1 (de)	1991-10-25	1992-10-22	Verfahen zur herstellung von (s)(+)-4, 4'-(1- methyl-1,2-ethandiyl)-bis(2,6-piperazindion

Country Status (12)

Country	Link
US (1)	US5618936A (de)
EP (1)	EP0611369B1 (de)
AT (1)	ATE182588T1 (de)
AU (1)	AU2808892A (de)
DE (1)	DE69229677T2 (de)
DK (1)	DK0611369T3 (de)
ES (1)	ES2138978T3 (de)
GB (1)	GB9122677D0 (de)
GR (1)	GR3031588T3 (de)
MX (1)	MX9206138A (de)
PT (1)	PT101006B (de)
WO (1)	WO1993008172A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT504621B1 (de) *	2006-11-24	2014-08-15	Cyathus Exquirere Pharmaforschungsgmbh	Neues verfahren zur herstellung von 4,4'-(1-methyl -1,2-ethandiyl)-bis-(2,6-piperazindion)
CN100564363C (zh) *	2007-10-17	2009-12-02	江苏奥赛康药业有限公司	一种精制右丙亚胺的方法
WO2012081036A2 (en) *	2010-12-13	2012-06-21	Sequent Scientific Limited	A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione)
CN102675227B (zh) *	2012-06-05	2014-07-16	江苏奥赛康药业股份有限公司	一种高纯度右丙亚胺的制备方法
CN102952088B (zh) *	2012-06-26	2015-05-27	江苏奥赛康药业股份有限公司	右丙亚胺的制备方法
CZ304433B6 (cs) *	2013-03-07	2014-04-30	Ústav organické chemie a biochemie Akademie věd ČR, v. v. i.	Způsob výroby čistých bezvodých enantiomerů kyseliny 1,2-diaminopropan-N,N,N´,N´-tetraoctové
CN110804022B (zh) *	2019-11-06	2023-01-17	扬子江药业集团有限公司	一种右丙亚胺的制备方法
CN113636980B (zh) *	2020-05-11	2023-03-03	北京泰德制药股份有限公司	一种右丙亚胺的制备方法
CN114685383B (zh) *	2020-12-26	2023-09-08	四川汇宇制药股份有限公司	一种右雷佐生的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL273692A (de) *	1961-01-19	1900-01-01
GB1234935A (en) *	1967-07-03	1971-06-09	Nat Res Dev	Piperazine derivatives
US3941790A (en) *	1967-07-03	1976-03-02	National Research Development Corporation	Bis diketopiperazines
US4764614A (en) *	1987-03-23	1988-08-16	Monsanto Company	Process for preparing (S)(+)-4,4'(methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
US4963551A (en) *	1987-12-21	1990-10-16	Erbamont Inc.	Stable lyophilized form of (S)-(+)-bis-4,4'-(1-methyl-1,2-ethanediyl)2,6-piperazinedione and solutions thereof
US4963679A (en) *	1988-02-17	1990-10-16	Erbamont, Inc.	Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes
GB8916072D0 (en) *	1989-07-13	1989-08-31	Creighton Andrew M	Pharmaceutical compositions
GB9115596D0 (en) *	1991-07-12	1991-09-04	Creighton Andrew M	Pharmaceutical compositions

1991
- 1991-10-25 GB GB919122677A patent/GB9122677D0/en active Pending
1992
- 1992-10-22 EP EP92921725A patent/EP0611369B1/de not_active Expired - Lifetime
- 1992-10-22 US US08/211,876 patent/US5618936A/en not_active Expired - Lifetime
- 1992-10-22 DE DE69229677T patent/DE69229677T2/de not_active Expired - Lifetime
- 1992-10-22 DK DK92921725T patent/DK0611369T3/da active
- 1992-10-22 AU AU28088/92A patent/AU2808892A/en not_active Abandoned
- 1992-10-22 AT AT92921725T patent/ATE182588T1/de active
- 1992-10-22 WO PCT/GB1992/001942 patent/WO1993008172A1/en not_active Ceased
- 1992-10-22 ES ES92921725T patent/ES2138978T3/es not_active Expired - Lifetime
- 1992-10-23 MX MX9206138A patent/MX9206138A/es unknown
- 1992-10-23 PT PT101006A patent/PT101006B/pt not_active IP Right Cessation
1999
- 1999-10-21 GR GR990402682T patent/GR3031588T3/el unknown

Also Published As

Publication number	Publication date
GR3031588T3 (en)	2000-01-31
EP0611369B1 (de)	1999-07-28
DK0611369T3 (da)	2000-02-14
ES2138978T3 (es)	2000-02-01
DE69229677D1 (de)	1999-09-02
EP0611369A1 (de)	1994-08-24
MX9206138A (es)	1994-06-30
PT101006B (pt)	1999-07-30
PT101006A (pt)	1994-02-28
DE69229677T2 (de)	2000-02-24
US5618936A (en)	1997-04-08
WO1993008172A1 (en)	1993-04-29
GB9122677D0 (en)	1991-12-11
AU2808892A (en)	1993-05-21

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Legal Events

Date	Code	Title
2000-07-15	UEP	Publication of translation of european patent specification
2001-06-15	EEFA	Change of the company name
2002-08-15	EEIH	Change in the person of patent owner