ATE162852T1 - Biosynthetisches verfahren zur herstellung von protein - Google Patents

Biosynthetisches verfahren zur herstellung von protein

Info

Publication number
ATE162852T1
ATE162852T1 AT92118598T AT92118598T ATE162852T1 AT E162852 T1 ATE162852 T1 AT E162852T1 AT 92118598 T AT92118598 T AT 92118598T AT 92118598 T AT92118598 T AT 92118598T AT E162852 T1 ATE162852 T1 AT E162852T1
Authority
AT
Austria
Prior art keywords
protein
epib
host
dna
auxiliary
Prior art date
Application number
AT92118598T
Other languages
English (en)
Inventor
Karl-Dieter Dr Entian
Friedrich Dr Goetz
Norbert Dr Schnell
Johannes Dr Augustin
Germar Dr Engelke
Ralf Dr Rosenstein
Cortina Dr Kaletta
Cora Dr Klein
Bernd Dr Wieland
Thomas Dr Kupke
Guenther Dr Jung
Roland Dr Kellner
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Application granted granted Critical
Publication of ATE162852T1 publication Critical patent/ATE162852T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Epoxy Compounds (AREA)
AT92118598T 1991-10-31 1992-10-30 Biosynthetisches verfahren zur herstellung von protein ATE162852T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78423491A 1991-10-31 1991-10-31

Publications (1)

Publication Number Publication Date
ATE162852T1 true ATE162852T1 (de) 1998-02-15

Family

ID=25131778

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92118598T ATE162852T1 (de) 1991-10-31 1992-10-30 Biosynthetisches verfahren zur herstellung von protein

Country Status (18)

Country Link
EP (1) EP0543195B1 (de)
JP (1) JP4117033B2 (de)
KR (1) KR100242268B1 (de)
AT (1) ATE162852T1 (de)
AU (1) AU661054B2 (de)
CA (1) CA2081704C (de)
CZ (2) CZ286727B6 (de)
DE (1) DE69224269T2 (de)
DK (1) DK0543195T3 (de)
ES (1) ES2112289T3 (de)
FI (1) FI104498B (de)
GR (1) GR3026465T3 (de)
HU (1) HU215548B (de)
IL (1) IL103603A (de)
MX (1) MX9206265A (de)
NO (1) NO307474B1 (de)
NZ (1) NZ244976A (de)
ZA (1) ZA928397B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639949A (en) * 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5662898A (en) * 1990-08-20 1997-09-02 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US6117670A (en) * 1994-06-08 2000-09-12 Novartis Finance Corporation Pyrrolnitrin biosynthesis genes and uses thereof
US6964760B2 (en) 1997-06-10 2005-11-15 University Of Florida Research Foundation Antimicrobial polypeptide, nucleic acid, and methods of use
US6475771B1 (en) 1997-06-10 2002-11-05 University Of Florida Research Foundation Antimicrobial polypeptides and methods of use
US5932469A (en) 1997-06-10 1999-08-03 University Of Florida Antimicrobial polypeptide, nucleic acid, and methods of use
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
DE10261782A1 (de) * 2002-12-19 2004-07-01 Dr. Petry Genmedics Gmbh Neue Gene und Genprodukte
DE602005009738D1 (de) 2004-12-07 2008-10-23 Applied Nanosystems Bv Verfahren zur herstellung und sekretion modifizierter peptide
CN117511763A (zh) * 2022-08-05 2024-02-06 天康制药股份有限公司 一种表皮葡萄球菌高密度发酵培养基及其发酵方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8811761D0 (en) * 1988-05-18 1988-06-22 Thomae Gmbh Dr K Biosynthetic process for preparation of chemical compounds

Also Published As

Publication number Publication date
IL103603A0 (en) 1993-03-15
JPH05292952A (ja) 1993-11-09
IL103603A (en) 1999-12-31
EP0543195A3 (en) 1994-06-08
HUT65492A (en) 1994-06-28
CZ326992A3 (en) 1993-09-15
KR930008147A (ko) 1993-05-21
CZ359396A3 (cs) 1999-03-17
NO307474B1 (no) 2000-04-10
NO924192L (no) 1993-05-03
GR3026465T3 (en) 1998-06-30
EP0543195A2 (de) 1993-05-26
CA2081704A1 (en) 1993-05-01
CZ286727B6 (cs) 2000-06-14
FI104498B (fi) 2000-02-15
FI924909L (fi) 1993-05-01
MX9206265A (es) 1994-05-31
ES2112289T3 (es) 1998-04-01
HU9203434D0 (en) 1993-01-28
DK0543195T3 (da) 1998-09-23
EP0543195B1 (de) 1998-01-28
CA2081704C (en) 2007-05-01
AU661054B2 (en) 1995-07-13
AU2745992A (en) 1993-05-27
JP4117033B2 (ja) 2008-07-09
DE69224269D1 (de) 1998-03-05
NO924192D0 (no) 1992-10-30
HU215548B (hu) 1999-01-28
FI924909A0 (fi) 1992-10-29
KR100242268B1 (ko) 2000-02-01
ZA928397B (en) 1994-05-02
DE69224269T2 (de) 1998-06-04
NZ244976A (en) 1995-07-26
CZ284861B6 (cs) 1999-03-17

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