ATE164515T1 - Herstellung von liposomen und verfahren zur substanzverkapselung - Google Patents

Herstellung von liposomen und verfahren zur substanzverkapselung

Info

Publication number
ATE164515T1
ATE164515T1 AT95900452T AT95900452T ATE164515T1 AT E164515 T1 ATE164515 T1 AT E164515T1 AT 95900452 T AT95900452 T AT 95900452T AT 95900452 T AT95900452 T AT 95900452T AT E164515 T1 ATE164515 T1 AT E164515T1
Authority
AT
Austria
Prior art keywords
liposomes
lipid powder
liposome dispersion
dehydration
formation
Prior art date
Application number
AT95900452T
Other languages
English (en)
Inventor
David Sammuel Collins
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE164515T1 publication Critical patent/ATE164515T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95900452T 1993-11-05 1994-11-03 Herstellung von liposomen und verfahren zur substanzverkapselung ATE164515T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14809993A 1993-11-05 1993-11-05

Publications (1)

Publication Number Publication Date
ATE164515T1 true ATE164515T1 (de) 1998-04-15

Family

ID=22524272

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95900452T ATE164515T1 (de) 1993-11-05 1994-11-03 Herstellung von liposomen und verfahren zur substanzverkapselung

Country Status (10)

Country Link
US (2) US5567433A (de)
EP (1) EP0678017B1 (de)
JP (1) JPH08505882A (de)
AT (1) ATE164515T1 (de)
AU (1) AU683957B2 (de)
CA (1) CA2153251C (de)
DE (1) DE69409361T2 (de)
DK (1) DK0678017T3 (de)
ES (1) ES2115343T3 (de)
WO (1) WO1995012387A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994314A (en) * 1993-04-07 1999-11-30 Inhale Therapeutic Systems, Inc. Compositions and methods for nucleic acid delivery to the lung
US20020132787A1 (en) * 1993-04-07 2002-09-19 Mohammed Eljamal Compositions and methods for nucleic acid delivery to the lung
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5981501A (en) * 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
US7422902B1 (en) * 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AU3130597A (en) * 1996-05-16 1997-12-05 Duke University Tristetraprolin
EP0938298B1 (de) * 1996-09-13 2002-12-04 Lipoxen Technologies Limited Liposomenzusammensetzung
US7384923B2 (en) * 1999-05-14 2008-06-10 Lipoxen Technologies Limited Liposomes
US6264996B1 (en) 1996-12-11 2001-07-24 A. Glenn Braswell Composition for inhibiting production of dihydrotestosterone to treat benign prostate hyperplasia
IT1289938B1 (it) * 1997-02-20 1998-10-19 Angelini Ricerche Spa Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e
CA2289702C (en) * 1997-05-14 2008-02-19 Inex Pharmaceuticals Corp. High efficiency encapsulation of charged therapeutic agents in lipid vesicles
AU752802C (en) * 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9813100D0 (en) * 1998-06-18 1998-08-19 Secr Defence Method of forming liposomes
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6911429B2 (en) 1999-04-01 2005-06-28 Transition Therapeutics Inc. Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US7129222B2 (en) * 2000-03-10 2006-10-31 Dynavax Technologies Corporation Immunomodulatory formulations and methods for use thereof
US20030129251A1 (en) 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
WO2002038128A1 (fr) * 2000-11-10 2002-05-16 Japan Science And Technology Corporation Procede de preparation d'une dispersion de microsome
WO2002087541A1 (en) * 2001-04-30 2002-11-07 Protiva Biotherapeutics Inc. Lipid-based formulations for gene transfer
US6676958B2 (en) * 2001-06-19 2004-01-13 Advanced Bioadjuvants, Llc Adjuvant composition for mucosal and injection delivered vaccines
WO2003039595A2 (en) * 2001-11-07 2003-05-15 Inex Pharmaceuticals Corporation Mucosal adjuvants comprising an oligonucleotide and a cationic lipid
US20040082521A1 (en) * 2002-03-29 2004-04-29 Azaya Therapeutics Inc. Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases
US20060093661A1 (en) 2002-05-07 2006-05-04 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US20030212046A1 (en) * 2002-05-07 2003-11-13 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same
WO2004032789A2 (en) * 2002-10-09 2004-04-22 The Azza Co., Ltd. Liposomal hgh composition and method for administration thereof
JP2006508126A (ja) * 2002-11-06 2006-03-09 アザヤ セラピューティクス インコーポレイティッド 薬学的製剤のタンパク質安定化されたリポソーム製剤
US20040092102A1 (en) * 2002-11-12 2004-05-13 Sachem, Inc. Chemical mechanical polishing composition and method
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
EP1643972A4 (de) * 2003-06-27 2010-01-20 Smithkline Beecham Corp Stabilisierte liposomale topotecan-zusammensetzung und verfahren
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US7943179B2 (en) 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
CA2542099A1 (en) * 2003-10-11 2005-04-21 Inex Pharmaceuticals Corporation Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
JP2005162702A (ja) * 2003-12-04 2005-06-23 Konica Minolta Medical & Graphic Inc リポソーム製剤の製造方法、リポソーム製剤およびその製造装置
US20050169978A1 (en) * 2004-01-29 2005-08-04 Shu-Wen Fu Wet-micro grinding
AU2005251691A1 (en) * 2004-05-17 2005-12-22 Tekmira Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
ES2798263T3 (es) 2005-12-08 2020-12-10 Insmed Inc Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8071127B2 (en) * 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8119156B2 (en) 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
AU2007329193A1 (en) * 2006-12-08 2008-06-12 Protech Research Pty Ltd Liposome production
US8415453B2 (en) * 2007-02-13 2013-04-09 Academia Sinica Lung cancer-targeted peptides and applications thereof
US8088887B2 (en) * 2007-02-13 2012-01-03 Academia Sinica Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US20080292663A1 (en) * 2007-05-22 2008-11-27 Gerber Jay D Adjuvant compositions and methods for delivering vaccines
US8541543B2 (en) * 2007-11-20 2013-09-24 Academia Sinica Peptides specific for hepatocellular carcinoma cells and applications thereof
EP2910637A1 (de) 2008-05-20 2015-08-26 University of Florida Research Foundation, Inc. Vektoren für die übertragung licht-empfindlicher proteine und deren verwendung
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
GB201116248D0 (en) * 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
CA3170184A1 (en) 2012-03-12 2013-09-19 Advanced Bioadjuvants, Llc Adjuvant and vaccine compositions
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
MX2016005232A (es) 2013-10-22 2017-01-19 Aradigm Corp Formulaciones liposomicas para inhalacion, modificadas con agente tensoactivo, que proveen un perfil de liberacion tanto inmediata como sostenida.
DK3138555T3 (da) * 2014-04-30 2020-12-14 Fujifilm Corp Liposomsammensætning og fremgangsmåde til fremstilling heraf
MX384843B (es) 2014-05-15 2025-03-14 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas.
IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
EP3362563A1 (de) 2015-10-14 2018-08-22 Bio-Path Holdings, Inc. P-ethoxy-nukleinsäuren für liposomale formulierung
CA3022698A1 (en) 2016-05-04 2017-11-09 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
SG11201901667TA (en) 2016-09-16 2019-03-28 Bio Path Holdings Inc Combination therapy with liposomal antisense oligonucleotides
US12234457B2 (en) 2017-04-19 2025-02-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for BCL2 inhibition
WO2018195249A1 (en) 2017-04-19 2018-10-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for stat3 inhibition
EP3773505B1 (de) 2018-03-30 2026-04-29 Insmed Incorporated Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten
EP3787602A4 (de) 2018-05-02 2022-03-23 Insmed Incorporated Verfahren zur herstellung von liposomalen arzneimittelformulierungen
FI3811949T3 (fi) 2018-06-20 2024-09-13 Fujifilm Corp Liposomikoostumukseen kapseloitua gemsitabiinia ja immuunitarkistuspistesalpaajaa käsittävä yhdistelmälääke
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12285419B2 (en) 2021-10-14 2025-04-29 Pacira Pharmaceuticals, Inc. Bupivacaine multivesicular liposome formulations and uses thereof
CN114916651B (zh) * 2022-05-19 2024-03-29 成都科建生物医药有限公司 一种芥末精油脂质体及其制备方法与应用
WO2025221243A1 (en) * 2024-04-16 2025-10-23 Esm Technologies, Llc Method of preparing stable, high-load, water-dispersible liposomal compositions that incorporate water-insoluble therapeutics
US12156940B1 (en) 2024-05-20 2024-12-03 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12280149B1 (en) 2024-05-20 2025-04-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
JPS5782311A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
JPH0753661B2 (ja) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
EP0172007B1 (de) * 1984-08-10 1991-05-22 Syntex (U.S.A.) Inc. Stabile Liposome mit wasserlöslichen Arzneimitteln
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US5104661A (en) * 1989-08-14 1992-04-14 Technology Unlimited, Inc. Reverse loading of liposomes

Also Published As

Publication number Publication date
US6355267B1 (en) 2002-03-12
WO1995012387A1 (en) 1995-05-11
JPH08505882A (ja) 1996-06-25
CA2153251C (en) 1998-09-01
AU683957B2 (en) 1997-11-27
DE69409361D1 (de) 1998-05-07
DE69409361T2 (de) 1998-11-12
DK0678017T3 (da) 1998-10-19
EP0678017B1 (de) 1998-04-01
ES2115343T3 (es) 1998-06-16
US5567433A (en) 1996-10-22
CA2153251A1 (en) 1995-05-11
AU8127394A (en) 1995-05-23
EP0678017A1 (de) 1995-10-25

Similar Documents

Publication Publication Date Title
DE69409361D1 (de) Herstellung von liposomen und verfahren zur substanzverkapselung
ES2110223T5 (es) Composicion resistente a la humedad.
TR27979A (tr) Laktam agartici aktivatör iceren parcaciklarin imal islemi.
IL91901A0 (en) Production of liposomes with improved stability during drying
GB2297907B (en) Liposomes containing particulate materials
DE60013773D1 (de) Methoden zur herstellung von therapeutische kalzium-phosphat partikeln
DE60229517D1 (de) Konservierung von biologischen materialien unter verwendung von faserbildungstechniken
DE69724257D1 (de) Verwendung von oxydierter zellulose und ihrer komplexen zur behandlung von chronischen wunden
NZ508960A (en) Method of forming liposomes
JP2000140088A5 (de)
ATE309326T1 (de) Verfahren zur konservierung eukariotischen zellen und dadurch hergestellte zusammensetzungen
WO2003000227A3 (en) A method for preparation of vesicles loaded with biological material and different uses thereof
DE60012693D1 (de) Verfahren zur kontrolle der liposomengrösse
ATE120231T1 (de) Verfahren zur herstellung von bleichmittelgranulaten.
DE69511117D1 (de) Verkapselte active materialien und verfahren zur ihrer herstellung
WO2003027232A3 (en) Method for producing biologically active products
EP0156924A4 (de) Chemisch aktive zusammensetzung ferro-ionen enthaltend.
ES2106230T3 (es) Tela no tejida de fibras naturales y usos de la misma.
JP2003155467A (ja) イオン発生体およびその製造方法
DE2964953D1 (en) Fragrance compositions
EP0320483A3 (en) Encapsulation method
ATE311447T1 (de) Herstellung von rekombinantem faktor viii in gegenwart von liposom-ähnliche verbindung- zusammensetzungen
DE60126815D1 (de) Herstellung von geschichteten und nach zelltyp geordneten geweben in vitro
WO1990007260A3 (en) 2,3-methanoproline
WO2002077347A3 (en) High superabsorbent content webs and a method for making them

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee