DK0594857T3 - Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf - Google Patents

Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf

Info

Publication number
DK0594857T3
DK0594857T3 DK92918702T DK92918702T DK0594857T3 DK 0594857 T3 DK0594857 T3 DK 0594857T3 DK 92918702 T DK92918702 T DK 92918702T DK 92918702 T DK92918702 T DK 92918702T DK 0594857 T3 DK0594857 T3 DK 0594857T3
Authority
DK
Denmark
Prior art keywords
alkyl
preparation
methanediphosphonic acid
acid derivatives
medical use
Prior art date
Application number
DK92918702T
Other languages
Danish (da)
English (en)
Inventor
Norio Kawabe
Hiromi Uchiro
Teruo Nakadate
Masahiko Tanahashi
Masatoshi Ito
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of DK0594857T3 publication Critical patent/DK0594857T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK92918702T 1991-09-05 1992-09-07 Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf DK0594857T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22617591 1991-09-05
JP17980292 1992-07-07
PCT/JP1992/001140 WO1993005052A1 (en) 1991-09-05 1992-09-07 Methanediphosphonic acid derivative, production thereof and medicinal use thereof

Publications (1)

Publication Number Publication Date
DK0594857T3 true DK0594857T3 (da) 1998-10-07

Family

ID=26499539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92918702T DK0594857T3 (da) 1991-09-05 1992-09-07 Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf

Country Status (9)

Country Link
US (2) US5527940A (de)
EP (1) EP0594857B1 (de)
JP (1) JPH0826048B2 (de)
AT (1) ATE165603T1 (de)
CA (1) CA2095128C (de)
DE (1) DE69225325T2 (de)
DK (1) DK0594857T3 (de)
ES (1) ES2114946T3 (de)
WO (1) WO1993005052A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0642519T3 (da) * 1992-05-29 2000-09-18 Procter & Gamble Pharma Svovlholdige phosphonatforbindelser til behandling af unormal calcium- og phosphatmetabolisme
JPH06135976A (ja) * 1992-10-30 1994-05-17 Toray Ind Inc メタンジホスホン酸誘導体、その製造方法およびその医薬用途
DE69529975T2 (de) * 1994-12-22 2004-01-08 Toray Industries, Inc. Verfahren zur herstellung von bis(4-alkylthiophenyl)disulfid
EP0998934A4 (de) * 1997-12-25 2005-09-14 Toray Industries Heilmittel gegen intramedullare krankheiten
DE19828450A1 (de) * 1998-06-26 1999-12-30 Hassan Jomaa Bisphosphonsäuren und deren Derivate enthaltende Arzneimittel zur Prophylaxe und zur Behandlung von Autoimmunkrankheiten sowie von Allergien
EP1057488A4 (de) * 1998-12-25 2003-10-22 Toray Industries Inhibitoren der interleukin-6 produktion
ES2337545T3 (es) * 1999-07-19 2010-04-27 Toray Industries, Inc. Farmacos para enfermedades periodontales.
US6692758B1 (en) * 1999-08-02 2004-02-17 Toray Industries, Inc. Insertion stabilizers for implants
JP2001181191A (ja) * 1999-12-24 2001-07-03 Cci Corp 慢性関節リウマチ疾患予防および治療剤
US6548042B2 (en) 2000-08-07 2003-04-15 Arstad Erik Bis-phosphonate compounds
US20060040899A1 (en) * 2000-12-15 2006-02-23 Hassan Jomaa Medicaments containing bisphosphonic acids and derivatives thereof for preventing and treating diseases and allergies
EP1506208A4 (de) * 2002-05-11 2006-05-24 Ilex Products Inc 1,1- und 1,2-bisphosphonate als modulatoren von apolipoprotein e
EP2340841B1 (de) * 2008-09-03 2016-11-09 Tohoku University Osteogenesepromoter mit [4-(methylthio)phenylthio]methanbisphosphonsäure oder pharmazeutisch akzeptablem salz daraus als wirkstoff
JP7076798B2 (ja) * 2015-09-09 2022-05-30 清華大学 効果的なワクチンアジュバントとするメバロン酸経路の阻害剤
JP2024169831A (ja) * 2023-05-26 2024-12-06 公立大学法人福島県立医科大学 抗酸化剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3609075A (en) * 1968-06-25 1971-09-28 Procter & Gamble Cleaning and softening detergent compositions
DE3365492D1 (en) * 1982-01-27 1986-10-02 Schering Ag Diphosphonic acid derivatives and pharmaceutical preparations containing them
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
CH675422A5 (de) * 1988-03-31 1990-09-28 Symphar Sa
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
DE69023844T2 (de) * 1989-09-06 1996-06-20 Merck & Co Inc Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
US5256808A (en) * 1992-12-04 1993-10-26 The University Of Tennessee Research Corp. Synthesis of tetraalkyl vinylidene diphosphonate monomer

Also Published As

Publication number Publication date
DE69225325D1 (de) 1998-06-04
ES2114946T3 (es) 1998-06-16
US5683992A (en) 1997-11-04
EP0594857A4 (en) 1994-05-18
WO1993005052A1 (en) 1993-03-18
JPH06500489A (ja) 1994-01-20
CA2095128A1 (en) 1993-03-06
JPH0826048B2 (ja) 1996-03-13
EP0594857B1 (de) 1998-04-29
DE69225325T2 (de) 1998-08-27
EP0594857A1 (de) 1994-05-04
US5527940A (en) 1996-06-18
ATE165603T1 (de) 1998-05-15
CA2095128C (en) 1998-01-06

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