ATE167400T1 - Lys-plasminogen in der verhütung und behandlung von ischämie und reperfusionschäden - Google Patents

Lys-plasminogen in der verhütung und behandlung von ischämie und reperfusionschäden

Info

Publication number
ATE167400T1
ATE167400T1 AT94110267T AT94110267T ATE167400T1 AT E167400 T1 ATE167400 T1 AT E167400T1 AT 94110267 T AT94110267 T AT 94110267T AT 94110267 T AT94110267 T AT 94110267T AT E167400 T1 ATE167400 T1 AT E167400T1
Authority
AT
Austria
Prior art keywords
plasminogen
lys
ischemia
treatment
reperfusion
Prior art date
Application number
AT94110267T
Other languages
English (en)
Inventor
Johann Dr Eibl
Ludwig Prof Pichler
Hans-Peter Schwarz
Original Assignee
Immuno Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno Ag filed Critical Immuno Ag
Application granted granted Critical
Publication of ATE167400T1 publication Critical patent/ATE167400T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Electrotherapy Devices (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT94110267T 1993-07-02 1994-07-01 Lys-plasminogen in der verhütung und behandlung von ischämie und reperfusionschäden ATE167400T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8803393A 1993-07-02 1993-07-02

Publications (1)

Publication Number Publication Date
ATE167400T1 true ATE167400T1 (de) 1998-07-15

Family

ID=22208925

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94110267T ATE167400T1 (de) 1993-07-02 1994-07-01 Lys-plasminogen in der verhütung und behandlung von ischämie und reperfusionschäden
AT0131094A AT407706B (de) 1993-07-02 1994-07-01 Prevention und behandlung ischemischer vorfälle und hieraus resultierender perfusionsverletzungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT0131094A AT407706B (de) 1993-07-02 1994-07-01 Prevention und behandlung ischemischer vorfälle und hieraus resultierender perfusionsverletzungen

Country Status (19)

Country Link
US (2) US5520912A (de)
EP (1) EP0631786B1 (de)
JP (1) JP2784146B2 (de)
AT (2) ATE167400T1 (de)
AU (1) AU680492B2 (de)
CA (1) CA2127199C (de)
CZ (1) CZ283352B6 (de)
DE (1) DE69411084T2 (de)
DK (1) DK0631786T3 (de)
ES (1) ES2119934T3 (de)
GR (1) GR3027778T3 (de)
HR (1) HRP940381B1 (de)
HU (1) HU217961B (de)
NO (1) NO942367L (de)
PL (1) PL304061A1 (de)
RU (1) RU2153353C2 (de)
SI (1) SI0631786T1 (de)
SK (1) SK281472B6 (de)
ZA (1) ZA944522B (de)

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DE4411143C2 (de) * 1994-03-30 1996-08-01 Immuno Ag Thrombosemittel
WO2000018436A1 (en) * 1998-09-29 2000-04-06 Leuven Research & Development Vzw Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke
EP1062953A1 (de) * 1999-06-22 2000-12-27 Leuven Research & Development vzw Verwendung von Verbindungen, die Alpha2-Antiplasmin in vivo reduzieren, zur Herstellung einer Zusammensetzung zur Behandlung ischämischer Schlaganfälle
US7184963B1 (en) 1999-01-19 2007-02-27 Bristol-Myers Squibb Company Method for determining care and prevention pathways for clinical management of wounds
WO2000041714A1 (en) * 1999-01-19 2000-07-20 Bristol-Myers Squibb Company Method for determining care and prevention pathways for clinical management of wounds
WO2001058476A2 (en) * 2000-02-11 2001-08-16 The European Molecular Biology Laboratory Methods and compositions for treatment of alzheimer's disease by enhancing plasmin or plasmin-like activity
US20050124036A1 (en) * 2002-02-06 2005-06-09 Rudy Susilo Method for producing recombinant proteins in micro-organisms
US7479270B2 (en) * 2002-07-23 2009-01-20 Vegenics Limited Methods and compositions for activating VEGF-D and VEGF-C
PE20050438A1 (es) * 2003-10-20 2005-06-14 Esperion Therapeutics Inc Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos
RU2341256C1 (ru) * 2007-03-26 2008-12-20 Государственное Образовательное Учреждение Высшего Профессионального Образования Амурская Государственная Медицинская Академия Росздрава Способ профилактики реперфузионных осложнений у пациентов, оперированных по поводу хронической ишемии нижних конечностей
RU2411911C1 (ru) * 2009-07-02 2011-02-20 Клиника государственного образовательного учреждения высшего профессионального образования "Челябинская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию"(Клиника ГОУ ВПО ЧелГМА Роздрава) Способ прогнозирования характера течения реперфузионного синдрома после поэтапного хирургического лечения сонных артерий у пациентов с симптомными бикаротидными стенозами
EP2451835A1 (de) 2009-07-10 2012-05-16 ThromboGenics N.V. Varianten von plasminogen und plasmin
ES2534911T3 (es) 2009-08-28 2015-04-30 Thrombogenics N.V. Uso de plasmina para el tratamiento de fallo de filtración después de trabeculectomía
RU2604807C2 (ru) 2011-01-05 2016-12-10 ТромбоДженикс НВ Варианты плазминогена и плазмина
JP6000353B2 (ja) 2011-08-12 2016-09-28 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
TW201822805A (zh) 2016-12-15 2018-07-01 深圳瑞健生命科學硏究院有限公司 一種預防和治療脂肪異常沉積導致的組織損傷的方法
TW201829448A (zh) 2016-12-15 2018-08-16 大陸商深圳瑞健生命科學硏究院有限公司 纖溶酶原在製備預防或治療肥胖症及疾病倂發的肥胖的藥物中的用途
EP3556385A4 (de) * 2016-12-15 2020-12-30 Talengen International Limited Verfahren zur verringerung von herzerkrankungen
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
RU2729788C2 (ru) * 2018-09-04 2020-08-12 Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр "Пущинский научный центр биологических исследований Российской академии наук" Средство, его применение и способ повышения устойчивости организма млекопитающих к ишемически-реперфузионному поражению тонкого кишечника
EP3914288A1 (de) 2019-01-24 2021-12-01 PreviPharma Consulting GmbH Plasminogen zur behandlung und vorbeugung von mikrothrombose
IL287036B2 (en) * 2019-04-12 2025-07-01 Uglk Science Ab Method and apparatus for reconditioning kidneys
MX2021012242A (es) * 2019-04-12 2021-12-10 Uglx Res Ab Metodo y aparato para reacondicionar organos.
CN114642722A (zh) * 2020-12-18 2022-06-21 四川大学华西医院 纤溶酶原用于制备促进血管新生的药物中的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028489B1 (de) * 1979-11-05 1983-10-05 Beecham Group Plc Enzym-Derivate und ihre Herstellung
JPH0680015B2 (ja) * 1986-05-12 1994-10-12 ザ ウエルカム ファウンデーション リミテッド 医薬組成物
JP2764264B2 (ja) * 1987-10-01 1998-06-11 株式会社ミドリ十字 線溶活性増強剤
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
US5256642A (en) * 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
AT390801B (de) * 1988-07-28 1990-07-10 Immuno Ag Verfahren zur herstellung von lys-plasminogen
US5358936A (en) * 1990-08-03 1994-10-25 Paul Gordon Anionic furanose derivatives, methods of making and using the same
AT402367B (de) * 1990-10-11 1997-04-25 Immuno Ag Pharmazeutische zubereitung auf basis von lys-plasminogen

Also Published As

Publication number Publication date
EP0631786A1 (de) 1995-01-04
SK281472B6 (sk) 2001-04-09
RU94022754A (ru) 1996-08-10
JP2784146B2 (ja) 1998-08-06
US5520912A (en) 1996-05-28
AT407706B (de) 2001-05-25
HRP940381A2 (en) 1997-04-30
JPH07145076A (ja) 1995-06-06
HU9401983D0 (en) 1994-09-28
RU2153353C2 (ru) 2000-07-27
CA2127199C (en) 2000-11-28
DK0631786T3 (da) 1999-04-06
GR3027778T3 (en) 1998-11-30
CA2127199A1 (en) 1995-01-03
CZ283352B6 (cs) 1998-03-18
HU217961B (hu) 2000-05-28
PL304061A1 (en) 1995-01-09
CZ161394A3 (en) 1995-01-18
AU6485494A (en) 1995-01-12
NO942367L (no) 1995-01-03
HRP940381B1 (en) 1999-06-30
US5597800A (en) 1997-01-28
ES2119934T3 (es) 1998-10-16
DE69411084D1 (de) 1998-07-23
HUT67225A (en) 1995-03-28
EP0631786B1 (de) 1998-06-17
SK79894A3 (en) 1995-05-10
ZA944522B (en) 1995-02-23
SI0631786T1 (en) 1998-10-31
DE69411084T2 (de) 1998-12-03
ATA131094A (de) 2000-10-15
NO942367D0 (de) 1994-06-21
AU680492B2 (en) 1997-07-31

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Legal Events

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