ATE172451T1 - Vitamin d analoge - Google Patents

Vitamin d analoge

Info

Publication number: ATE172451T1
Authority: AT; Austria
Prior art keywords: alpha; vitamin; azide; optionally substituted; group
Prior art date: 1993-07-23

Application number

AT94921070T

Other languages

English (en)

Inventor

Robert Henry Hesse

Malathi Ramgopal

Gaddam Subba Reddy

Sundara Katugam Srinivas Setty

Original Assignee

Res Inst Medicine Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-23

Filing date

1994-07-22

Publication date

1998-11-15

1994-07-22 Application filed by Res Inst Medicine Chem filed Critical Res Inst Medicine Chem

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE172451T1 publication Critical patent/ATE172451T1/de

Links

229940088594 vitamin Drugs 0.000 title 1
229930003231 vitamin Natural products 0.000 title 1
235000013343 vitamin Nutrition 0.000 title 1
239000011782 vitamin Substances 0.000 title 1
150000003722 vitamin derivatives Chemical class 0.000 title 1
150000001540 azides Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
229930003316 Vitamin D Natural products 0.000 abstract 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
-1 cyclohexylidene moiety Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1
235000019166 vitamin D Nutrition 0.000 abstract 1
239000011710 vitamin D Substances 0.000 abstract 1
150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
229940046008 vitamin d Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

AT94921070T 1993-07-23 1994-07-22 Vitamin d analoge ATE172451T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939315253A GB9315253D0 (en)	1993-07-23	1993-07-23	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE172451T1 true ATE172451T1 (de)	1998-11-15

Family

ID=10739292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94921070T ATE172451T1 (de)	1993-07-23	1994-07-22	Vitamin d analoge

Country Status (20)

Country	Link
US (2)	US5872140A (de)
EP (1)	EP0710227B1 (de)
JP (1)	JPH09500637A (de)
KR (1)	KR100321415B1 (de)
CN (1)	CN1043883C (de)
AT (1)	ATE172451T1 (de)
AU (1)	AU690565B2 (de)
CA (1)	CA2167837A1 (de)
CZ (1)	CZ20796A3 (de)
DE (1)	DE69414115T2 (de)
DK (1)	DK0710227T3 (de)
ES (1)	ES2125466T3 (de)
FI (1)	FI113535B (de)
GB (1)	GB9315253D0 (de)
HU (1)	HU221597B (de)
IL (1)	IL110415A (de)
NO (1)	NO314453B1 (de)
NZ (1)	NZ268659A (de)
WO (1)	WO1995003273A1 (de)
ZA (1)	ZA945427B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE19935771A1 (de)	1999-07-23	2001-02-01	Schering Ag	Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6703380B2 (en)	1999-09-29	2004-03-09	Colotech A/S	Prevention of cancer
DK1220676T3 (da)	1999-09-29	2005-09-05	Colotech As	Forebyggelse af colorektal cancer
US6358939B1 (en)	1999-12-21	2002-03-19	Northern Lights Pharmaceuticals, Llc	Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en)	1999-12-21	2006-01-24	Wisconsin Alumni Research Foundation	Treating vitamin D responsive diseases
US6555573B2 (en) *	2000-12-21	2003-04-29	The Quigley Corporation	Method and composition for the topical treatment of diabetic neuropathy
US20030118536A1 (en) *	2001-11-06	2003-06-26	Rosenbloom Richard A.	Topical compositions and methods for treatment of adverse effects of ionizing radiation
US7435725B2 (en) *	2001-11-06	2008-10-14	The Quigly Corporation	Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105031A1 (en) *	2001-11-06	2003-06-05	Rosenbloom Richard A.	Methods for the treatment of skin disorders
US20030105027A1 (en) *	2001-11-06	2003-06-05	Rosenbloom Richard A.	Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US6974592B2 (en) *	2002-04-11	2005-12-13	Ocean Nutrition Canada Limited	Encapsulated agglomeration of microcapsules and method for the preparation thereof
BRPI0315977B8 (pt) *	2002-11-04	2021-05-25	Dsm Nutritional Products Ag	microcápsulas possuindo múltiplas cascas e método para preparação destas
US7083813B2 (en) *	2002-11-06	2006-08-01	The Quigley Corporation	Methods for the treatment of peripheral neural and vascular ailments
US8034450B2 (en) *	2005-01-21	2011-10-11	Ocean Nutrition Canada Limited	Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
EP1848729A2 (de) *	2005-01-27	2007-10-31	Ocean Nutrition Canada Limited	Chrom-fettsäureverbindungen und verfahren zu ihrer herstellung und verwendung
CA2596023A1 (en) *	2005-01-27	2006-11-09	Ocean Nutrition Canada Ltd.	Fatty acid-benzenediol derivatives and methods of making and using thereof
US9968120B2 (en) *	2006-05-17	2018-05-15	Dsm Nutritional Products Ag	Homogenized formulations containing microcapsules and methods of making and using thereof
MX292905B (es) *	2006-04-07	2011-12-01	Ocean Nutrition Canada Ltd	Emulsiones y microcapsulas con sustancias que tienen baja tension interfacial y metodos para fabricar y usar las mismas.
KR20090046773A (ko) *	2006-06-05	2009-05-11	오션 뉴트리션 캐나다 리미티드	개선된 쉘을 가지는 마이크로캡슐
US10166196B2 (en)	2007-01-10	2019-01-01	Dsm Nutritional Products Ag	Vegetarian microcapsules
US20090018151A1 (en) *	2007-02-23	2009-01-15	Ezekiel Fink	Topical Treatment of Peripheral diabetic complications
SG173119A1 (en) *	2009-01-27	2011-08-29	Berg Biosystems Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es)	2009-08-14	2019-06-27	Berg Llc	Vitamina d3 y analogos de la misma para tratar alopecia.
US8987235B2 (en)	2011-05-17	2015-03-24	Wisconsin Alumni Research Foundation	N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN104926739B (zh) *	2015-06-09	2017-06-27	南京理工大学	基于氮杂环修饰的维生素d2衍生物、合成及应用
US10548908B2 (en) *	2016-09-15	2020-02-04	Nostopharma, LLC	Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL67153A (en) *	1981-11-02	1986-12-31	Res Inst Medicine Chem	Intermediates in the production of vitamin d analogues and method for their production
DE4141746A1 (de) *	1991-12-13	1993-06-17	Schering Ag	20-methyl-substituierte vitamin d-derivate
IL107185A (en) *	1992-10-06	1998-02-22	Schering Ag	Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US5446635A (en) *	1993-06-24	1995-08-29	Quarton, Inc.	Laser assembly for marking a line on a workpiece for guiding a cutting tool

1993
- 1993-07-23 GB GB939315253A patent/GB9315253D0/en active Pending
1994
- 1994-07-22 AU AU71939/94A patent/AU690565B2/en not_active Ceased
- 1994-07-22 WO PCT/GB1994/001587 patent/WO1995003273A1/en not_active Ceased
- 1994-07-22 CA CA002167837A patent/CA2167837A1/en not_active Abandoned
- 1994-07-22 JP JP7505021A patent/JPH09500637A/ja not_active Ceased
- 1994-07-22 US US08/537,869 patent/US5872140A/en not_active Expired - Fee Related
- 1994-07-22 NZ NZ268659A patent/NZ268659A/en unknown
- 1994-07-22 ZA ZA945427A patent/ZA945427B/xx unknown
- 1994-07-22 HU HU9600136A patent/HU221597B/hu not_active IP Right Cessation
- 1994-07-22 EP EP94921070A patent/EP0710227B1/de not_active Expired - Lifetime
- 1994-07-22 CN CN94193108A patent/CN1043883C/zh not_active Expired - Fee Related
- 1994-07-22 KR KR1019960700344A patent/KR100321415B1/ko not_active Expired - Fee Related
- 1994-07-22 IL IL11041594A patent/IL110415A/xx not_active IP Right Cessation
- 1994-07-22 DK DK94921070T patent/DK0710227T3/da active
- 1994-07-22 DE DE69414115T patent/DE69414115T2/de not_active Expired - Fee Related
- 1994-07-22 ES ES94921070T patent/ES2125466T3/es not_active Expired - Lifetime
- 1994-07-22 CZ CZ96207A patent/CZ20796A3/cs unknown
- 1994-07-22 AT AT94921070T patent/ATE172451T1/de not_active IP Right Cessation
1996
- 1996-01-22 FI FI960303A patent/FI113535B/fi not_active IP Right Cessation
- 1996-01-22 NO NO19960251A patent/NO314453B1/no not_active IP Right Cessation
1998
- 1998-10-20 US US09/175,311 patent/US6013814A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI113535B (fi)	2004-05-14
CN1129441A (zh)	1996-08-21
CA2167837A1 (en)	1995-02-02
EP0710227A1 (de)	1996-05-08
FI960303L (fi)	1996-03-22
KR100321415B1 (ko)	2002-11-13
NO314453B1 (no)	2003-03-24
WO1995003273A1 (en)	1995-02-02
NZ268659A (en)	1996-09-25
DE69414115T2 (de)	1999-04-08
JPH09500637A (ja)	1997-01-21
DK0710227T3 (da)	1999-06-28
NO960251D0 (no)	1996-01-22
HU9600136D0 (en)	1996-03-28
AU690565B2 (en)	1998-04-30
GB9315253D0 (en)	1993-09-08
NO960251L (no)	1996-03-22
HUT73846A (en)	1996-09-30
CZ20796A3 (en)	1996-10-16
US5872140A (en)	1999-02-16
ES2125466T3 (es)	1999-03-01
US6013814A (en)	2000-01-11
HU221597B (hu)	2002-11-28
AU7193994A (en)	1995-02-20
IL110415A0 (en)	1996-03-31
CN1043883C (zh)	1999-06-30
EP0710227B1 (de)	1998-10-21
ZA945427B (en)	1995-08-24
DE69414115D1 (de)	1998-11-26
IL110415A (en)	2000-01-31
FI960303A0 (fi)	1996-01-22

Legal Events

Date	Code	Title	Description
1999-11-15	UEP	Publication of translation of european patent specification
2005-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69414115D1 (de)	1998-11-26	Vitamin d analoge
BG103805A (en)	2000-06-30	Trifluoromethylalkylaminotriazolopyrimidines with fungicidal effect
DE3574014D1 (en)	1989-12-07	Novel biologically active compound having anti-prolyl endopeptidase activity
AU1026599A (en)	1999-04-23	Acylsulfamoyl benzoic acid amides, plant protection agents containing said acylsulfamoyl benzoic acid amides, and method for producing the same
AU5428486A (en)	1986-09-11	Phenyl carbamates
MY132115A (en)	2007-09-28	Novel thrombin inhibitors
AU6576898A (en)	1998-11-11	Fungicidal trifluorophenyl-triazolopyrimidines
PT831837E (pt)	2003-09-30	Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe
NO995075D0 (no)	1999-10-18	Steroid-sulfataseinhibitorer
DK0515544T3 (da)	1996-02-12	Steroidsulfataseinhibitorer
TR200000272T2 (tr)	2000-09-21	Antitümör ve antimetastaz maddeleri olarak o-ikameli hidrosikumaranon türevleri.
AU4387296A (en)	1996-07-19	Diastereomerically pure 3-oxo and 3-thioxo-4-aza-androstan derivatives and the use thereof as antiandrogens
ES2148593T3 (es)	2000-10-16	Compuestos retinoides trienoicos novedosos y metodos.
ES2191208T3 (es)	2003-09-01	Oxiimino-pregnano-carbolactonas.
DK0696278T3 (da)	1999-04-26	Herbicidtvirkende substituerede 1-phenyl- eller 1-pyridinylbenzotriazoler
NO981393D0 (no)	1998-03-27	Guanidinoproteasehemmere
FI963754A0 (fi)	1996-09-20	D-vitamiinijohdannaisia
GB2324091A (en)	1998-10-14	Metalloproteinase inhibitors
GR3031118T3 (en)	1999-12-31	Novel seco-D steroids active in the cardiovascular system and pharmaceutical compositions containing same
DE59307133D1 (de)	1997-09-18	Gestagen wirksame 19,11-überbrückte 4-estrene
AU6722498A (en)	1998-09-22	Disubstituted biphenyloxazolines
DK0713485T3 (da)	1998-12-07	Thiocarbamoylforbindelser som mikrobicider
TR199800958A2 (xx)	1998-12-21	Herbisidal 3,5-Difloropridinleri.
ITMI931808A1 (it)	1995-02-09	Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico
NO20053117L (no)	2005-06-24	Cyklopenta[c]isoksazol-3-aminer anvendt som materialbeskyttelsesmidler..