DK0710227T3 - Vitamin D-analoger - Google Patents

Vitamin D-analoger

Info

Publication number: DK0710227T3
Authority: DK; Denmark
Prior art keywords: alpha; vitamin; azide; optionally substituted; group
Prior art date: 1993-07-23

Application number

DK94921070T

Other languages

Danish (da)

English (en)

Inventor

Robert Henry Hesse

Malathi Ramgopal

Gaddam Subba Reddy

Sundara Katugam Srinivas Setty

Original Assignee

Res Inst Medicine Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-23

Filing date

1994-07-22

Publication date

1999-06-28

1994-07-22 Application filed by Res Inst Medicine Chem filed Critical Res Inst Medicine Chem

1999-06-28 Application granted granted Critical

1999-06-28 Publication of DK0710227T3 publication Critical patent/DK0710227T3/da

Links

229930003316 Vitamin D Natural products 0.000 title abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
235000019166 vitamin D Nutrition 0.000 title abstract 2
239000011710 vitamin D Substances 0.000 title abstract 2
150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
229940046008 vitamin d Drugs 0.000 title abstract 2
150000001540 azides Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
-1 cyclohexylidene moiety Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Hematology (AREA)
Oncology (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

DK94921070T 1993-07-23 1994-07-22 Vitamin D-analoger DK0710227T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939315253A GB9315253D0 (en)	1993-07-23	1993-07-23	Chemical compounds
PCT/GB1994/001587 WO1995003273A1 (en)	1993-07-23	1994-07-22	Vitamin d analogues

Publications (1)

Publication Number	Publication Date
DK0710227T3 true DK0710227T3 (da)	1999-06-28

Family

ID=10739292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94921070T DK0710227T3 (da)	1993-07-23	1994-07-22	Vitamin D-analoger

Country Status (20)

Country	Link
US (2)	US5872140A (de)
EP (1)	EP0710227B1 (de)
JP (1)	JPH09500637A (de)
KR (1)	KR100321415B1 (de)
CN (1)	CN1043883C (de)
AT (1)	ATE172451T1 (de)
AU (1)	AU690565B2 (de)
CA (1)	CA2167837A1 (de)
CZ (1)	CZ20796A3 (de)
DE (1)	DE69414115T2 (de)
DK (1)	DK0710227T3 (de)
ES (1)	ES2125466T3 (de)
FI (1)	FI113535B (de)
GB (1)	GB9315253D0 (de)
HU (1)	HU221597B (de)
IL (1)	IL110415A (de)
NO (1)	NO314453B1 (de)
NZ (1)	NZ268659A (de)
WO (1)	WO1995003273A1 (de)
ZA (1)	ZA945427B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE19935771A1 (de) *	1999-07-23	2001-02-01	Schering Ag	Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6703380B2 (en)	1999-09-29	2004-03-09	Colotech A/S	Prevention of cancer
ES2240159T3 (es)	1999-09-29	2005-10-16	Colotech A/S	Prevencion del cancer colorrectal.
US6358939B1 (en)	1999-12-21	2002-03-19	Northern Lights Pharmaceuticals, Llc	Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en)	1999-12-21	2006-01-24	Wisconsin Alumni Research Foundation	Treating vitamin D responsive diseases
US6555573B2 (en) *	2000-12-21	2003-04-29	The Quigley Corporation	Method and composition for the topical treatment of diabetic neuropathy
US7435725B2 (en) *	2001-11-06	2008-10-14	The Quigly Corporation	Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030118536A1 (en) *	2001-11-06	2003-06-26	Rosenbloom Richard A.	Topical compositions and methods for treatment of adverse effects of ionizing radiation
US20030105027A1 (en) *	2001-11-06	2003-06-05	Rosenbloom Richard A.	Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US20030105031A1 (en) *	2001-11-06	2003-06-05	Rosenbloom Richard A.	Methods for the treatment of skin disorders
US6974592B2 (en) *	2002-04-11	2005-12-13	Ocean Nutrition Canada Limited	Encapsulated agglomeration of microcapsules and method for the preparation thereof
JP4833553B2 (ja) *	2002-11-04	2011-12-07	オーシャン・ニュートリション・カナダ・リミテッド	複数の殻を有するマイクロカプセル及びそれらの調製方法
US7083813B2 (en) *	2002-11-06	2006-08-01	The Quigley Corporation	Methods for the treatment of peripheral neural and vascular ailments
US8034450B2 (en) *	2005-01-21	2011-10-11	Ocean Nutrition Canada Limited	Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
WO2006117675A1 (en) *	2005-01-27	2006-11-09	Ocean Nutrition Canada Ltd.	Fatty acid-benzenediol derivatives and methods of making and using thereof
US20080206316A1 (en) *	2005-01-27	2008-08-28	Colin Barrow	Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof
US9968120B2 (en) *	2006-05-17	2018-05-15	Dsm Nutritional Products Ag	Homogenized formulations containing microcapsules and methods of making and using thereof
EP2007224A2 (de) *	2006-04-07	2008-12-31	Ocean Nutrition Canada Limited	Emulsionen und mikrokapseln mit stoffen mit geringer grenzflächenspannung, herstellungsverfahren und verwendung
EP2040682B1 (de) *	2006-06-05	2017-07-26	DSM Nutritional Products AG	Mikrokapseln mit verbesserten ummantelungen
ES2604081T3 (es)	2007-01-10	2017-03-02	Dsm Nutritional Products Ag	Microcápsulas que incluyen proteína de guisante
US20090018151A1 (en) *	2007-02-23	2009-01-15	Ezekiel Fink	Topical Treatment of Peripheral diabetic complications
EA201691980A1 (ru)	2009-01-27	2017-07-31	БЕРГ ЭлЭлСи	Способы уменьшения побочных эффектов, связанных с химиотерапией
CN102655869B (zh)	2009-08-14	2016-08-10	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
US8987235B2 (en)	2011-05-17	2015-03-24	Wisconsin Alumni Research Foundation	N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses
WO2014194133A1 (en)	2013-05-29	2014-12-04	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN104926739B (zh) *	2015-06-09	2017-06-27	南京理工大学	基于氮杂环修饰的维生素d2衍生物、合成及应用
US10548908B2 (en) *	2016-09-15	2020-02-04	Nostopharma, LLC	Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL67153A (en) *	1981-11-02	1986-12-31	Res Inst Medicine Chem	Intermediates in the production of vitamin d analogues and method for their production
DE4141746A1 (de) *	1991-12-13	1993-06-17	Schering Ag	20-methyl-substituierte vitamin d-derivate
IL107185A (en) *	1992-10-06	1998-02-22	Schering Ag	Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US5446635A (en) *	1993-06-24	1995-08-29	Quarton, Inc.	Laser assembly for marking a line on a workpiece for guiding a cutting tool

1993
- 1993-07-23 GB GB939315253A patent/GB9315253D0/en active Pending
1994
- 1994-07-22 AU AU71939/94A patent/AU690565B2/en not_active Ceased
- 1994-07-22 DK DK94921070T patent/DK0710227T3/da active
- 1994-07-22 CZ CZ96207A patent/CZ20796A3/cs unknown
- 1994-07-22 EP EP94921070A patent/EP0710227B1/de not_active Expired - Lifetime
- 1994-07-22 DE DE69414115T patent/DE69414115T2/de not_active Expired - Fee Related
- 1994-07-22 CA CA002167837A patent/CA2167837A1/en not_active Abandoned
- 1994-07-22 AT AT94921070T patent/ATE172451T1/de not_active IP Right Cessation
- 1994-07-22 WO PCT/GB1994/001587 patent/WO1995003273A1/en not_active Ceased
- 1994-07-22 KR KR1019960700344A patent/KR100321415B1/ko not_active Expired - Fee Related
- 1994-07-22 NZ NZ268659A patent/NZ268659A/en unknown
- 1994-07-22 CN CN94193108A patent/CN1043883C/zh not_active Expired - Fee Related
- 1994-07-22 US US08/537,869 patent/US5872140A/en not_active Expired - Fee Related
- 1994-07-22 ZA ZA945427A patent/ZA945427B/xx unknown
- 1994-07-22 HU HU9600136A patent/HU221597B/hu not_active IP Right Cessation
- 1994-07-22 JP JP7505021A patent/JPH09500637A/ja not_active Ceased
- 1994-07-22 ES ES94921070T patent/ES2125466T3/es not_active Expired - Lifetime
- 1994-07-22 IL IL11041594A patent/IL110415A/xx not_active IP Right Cessation
1996
- 1996-01-22 NO NO19960251A patent/NO314453B1/no not_active IP Right Cessation
- 1996-01-22 FI FI960303A patent/FI113535B/fi not_active IP Right Cessation
1998
- 1998-10-20 US US09/175,311 patent/US6013814A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HU9600136D0 (en)	1996-03-28
CN1043883C (zh)	1999-06-30
ES2125466T3 (es)	1999-03-01
AU690565B2 (en)	1998-04-30
NO314453B1 (no)	2003-03-24
US5872140A (en)	1999-02-16
FI113535B (fi)	2004-05-14
NO960251L (no)	1996-03-22
GB9315253D0 (en)	1993-09-08
DE69414115T2 (de)	1999-04-08
DE69414115D1 (de)	1998-11-26
CZ20796A3 (en)	1996-10-16
ZA945427B (en)	1995-08-24
ATE172451T1 (de)	1998-11-15
EP0710227A1 (de)	1996-05-08
FI960303A0 (fi)	1996-01-22
EP0710227B1 (de)	1998-10-21
AU7193994A (en)	1995-02-20
NZ268659A (en)	1996-09-25
JPH09500637A (ja)	1997-01-21
FI960303L (fi)	1996-03-22
CN1129441A (zh)	1996-08-21
NO960251D0 (no)	1996-01-22
IL110415A0 (en)	1996-03-31
HUT73846A (en)	1996-09-30
IL110415A (en)	2000-01-31
US6013814A (en)	2000-01-11
WO1995003273A1 (en)	1995-02-02
HU221597B (hu)	2002-11-28
KR100321415B1 (ko)	2002-11-13
CA2167837A1 (en)	1995-02-02

Publication	Publication Date	Title
DK0710227T3 (da)	1999-06-28	Vitamin D-analoger
ATE47711T1 (de)	1989-11-15	Biologisch aktive verbindung mit anti-prolyl endopeptidasewirkung.
NO995075L (no)	1994-04-29	Steroid-sulfataseinhibitorer
BG103805A (en)	2000-06-30	Trifluoromethylalkylaminotriazolopyrimidines with fungicidal effect
AU1026599A (en)	1999-04-23	Acylsulfamoyl benzoic acid amides, plant protection agents containing said acylsulfamoyl benzoic acid amides, and method for producing the same
IL74497A0 (en)	1985-06-30	Pharmaceutical compositions and phenyl carbamate derivatives
DK0696275T3 (da)	1998-11-09	Vitamin D-amid-derivater
TR200000272T2 (tr)	2000-09-21	Antitümör ve antimetastaz maddeleri olarak o-ikameli hidrosikumaranon türevleri.
NO981393D0 (no)	1998-03-27	Guanidinoproteasehemmere
FI963754A0 (fi)	1996-09-20	D-vitamiinijohdannaisia
DK0742214T3 (da)	1999-12-13	I hjerte-kar-systemet aktive, nye seco-D steroider samt farmaceutiske præparater indeholdende sådanne
DE69635990D1 (de)	2006-05-18	Bromierte hexahydroxybiphenylderivate
ITMI931808A1 (it)	1995-02-09	Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico
NO20053117L (no)	2005-06-24	Cyklopenta[c]isoksazol-3-aminer anvendt som materialbeskyttelsesmidler..