IL110415A - Vitamin D analogues and pharmaceutical compositions containing them - Google Patents

Vitamin D analogues and pharmaceutical compositions containing them

Info

Publication number: IL110415A
Authority: IL; Israel
Prior art keywords: alpha; vitamin; azide; optionally substituted; group
Prior art date: 1993-07-23

Application number

IL11041594A

Other languages

English (en)

Other versions

IL110415A0 (en

Original Assignee

Res Inst Medicine Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-23

Filing date

1994-07-22

Publication date

2000-01-31

1994-07-22 Application filed by Res Inst Medicine Chem filed Critical Res Inst Medicine Chem

1996-03-31 Publication of IL110415A0 publication Critical patent/IL110415A0/xx

2000-01-31 Publication of IL110415A publication Critical patent/IL110415A/xx

Links

229930003316 Vitamin D Natural products 0.000 title abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
235000019166 vitamin D Nutrition 0.000 title abstract 2
239000011710 vitamin D Substances 0.000 title abstract 2
150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
229940046008 vitamin d Drugs 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001540 azides Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
-1 cyclohexylidene moiety Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Transplantation (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

IL11041594A 1993-07-23 1994-07-22 Vitamin D analogues and pharmaceutical compositions containing them IL110415A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939315253A GB9315253D0 (en)	1993-07-23	1993-07-23	Chemical compounds

Publications (2)

Publication Number	Publication Date
IL110415A0 IL110415A0 (en)	1996-03-31
IL110415A true IL110415A (en)	2000-01-31

Family

ID=10739292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11041594A IL110415A (en)	1993-07-23	1994-07-22	Vitamin D analogues and pharmaceutical compositions containing them

Country Status (20)

Country	Link
US (2)	US5872140A (de)
EP (1)	EP0710227B1 (de)
JP (1)	JPH09500637A (de)
KR (1)	KR100321415B1 (de)
CN (1)	CN1043883C (de)
AT (1)	ATE172451T1 (de)
AU (1)	AU690565B2 (de)
CA (1)	CA2167837A1 (de)
CZ (1)	CZ20796A3 (de)
DE (1)	DE69414115T2 (de)
DK (1)	DK0710227T3 (de)
ES (1)	ES2125466T3 (de)
FI (1)	FI113535B (de)
GB (1)	GB9315253D0 (de)
HU (1)	HU221597B (de)
IL (1)	IL110415A (de)
NO (1)	NO314453B1 (de)
NZ (1)	NZ268659A (de)
WO (1)	WO1995003273A1 (de)
ZA (1)	ZA945427B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE19935771A1 (de) *	1999-07-23	2001-02-01	Schering Ag	Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE60019947T2 (de)	1999-09-29	2006-02-02	Colotech A/S	Prävention von kolorektalem Krebs
US6703380B2 (en)	1999-09-29	2004-03-09	Colotech A/S	Prevention of cancer
US6989377B2 (en)	1999-12-21	2006-01-24	Wisconsin Alumni Research Foundation	Treating vitamin D responsive diseases
US6358939B1 (en)	1999-12-21	2002-03-19	Northern Lights Pharmaceuticals, Llc	Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6555573B2 (en) *	2000-12-21	2003-04-29	The Quigley Corporation	Method and composition for the topical treatment of diabetic neuropathy
US20030105031A1 (en) *	2001-11-06	2003-06-05	Rosenbloom Richard A.	Methods for the treatment of skin disorders
US20030118536A1 (en) *	2001-11-06	2003-06-26	Rosenbloom Richard A.	Topical compositions and methods for treatment of adverse effects of ionizing radiation
US7435725B2 (en) *	2001-11-06	2008-10-14	The Quigly Corporation	Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105027A1 (en) *	2001-11-06	2003-06-05	Rosenbloom Richard A.	Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US6974592B2 (en) *	2002-04-11	2005-12-13	Ocean Nutrition Canada Limited	Encapsulated agglomeration of microcapsules and method for the preparation thereof
JP4833553B2 (ja) *	2002-11-04	2011-12-07	オーシャン・ニュートリション・カナダ・リミテッド	複数の殻を有するマイクロカプセル及びそれらの調製方法
US7083813B2 (en) *	2002-11-06	2006-08-01	The Quigley Corporation	Methods for the treatment of peripheral neural and vascular ailments
US8034450B2 (en) *	2005-01-21	2011-10-11	Ocean Nutrition Canada Limited	Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
EP1846355B1 (de) *	2005-01-27	2009-12-16	Ocean Nutrition Canada Limited	Fettsäure-benzenediol-derivate sowie herstellungs- und verwendungsverfahren dafür
US20080206316A1 (en) *	2005-01-27	2008-08-28	Colin Barrow	Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof
US9968120B2 (en) *	2006-05-17	2018-05-15	Dsm Nutritional Products Ag	Homogenized formulations containing microcapsules and methods of making and using thereof
CA2643662A1 (en) *	2006-04-07	2007-10-25	Ocean Nutrition Canada Ltd.	Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof
CA2654031C (en) *	2006-06-05	2016-05-24	Ocean Nutrition Canada Limited	Microcapsules with improved shells
WO2008085997A2 (en)	2007-01-10	2008-07-17	Ocean Nutrition Canada, Ltd.	Vegetarian microcapsules
US20090018151A1 (en) *	2007-02-23	2009-01-15	Ezekiel Fink	Topical Treatment of Peripheral diabetic complications
AU2010208323B2 (en)	2009-01-27	2016-03-10	Berg Llc	Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (de)	2009-08-14	2019-05-22	Berg LLC	Vitamin d3 und analoge davon zur behandlung von alopezie
WO2012158794A1 (en)	2011-05-17	2012-11-22	Wisconsin Alumni Research Foundation	N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN104926739B (zh) *	2015-06-09	2017-06-27	南京理工大学	基于氮杂环修饰的维生素d2衍生物、合成及应用
US10548908B2 (en) *	2016-09-15	2020-02-04	Nostopharma, LLC	Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL67153A (en) *	1981-11-02	1986-12-31	Res Inst Medicine Chem	Intermediates in the production of vitamin d analogues and method for their production
DE4141746A1 (de) *	1991-12-13	1993-06-17	Schering Ag	20-methyl-substituierte vitamin d-derivate
IL107185A (en) *	1992-10-06	1998-02-22	Schering Ag	Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US5446635A (en) *	1993-06-24	1995-08-29	Quarton, Inc.	Laser assembly for marking a line on a workpiece for guiding a cutting tool

1993
- 1993-07-23 GB GB939315253A patent/GB9315253D0/en active Pending
1994
- 1994-07-22 KR KR1019960700344A patent/KR100321415B1/ko not_active Expired - Fee Related
- 1994-07-22 CN CN94193108A patent/CN1043883C/zh not_active Expired - Fee Related
- 1994-07-22 WO PCT/GB1994/001587 patent/WO1995003273A1/en not_active Ceased
- 1994-07-22 AU AU71939/94A patent/AU690565B2/en not_active Ceased
- 1994-07-22 IL IL11041594A patent/IL110415A/xx not_active IP Right Cessation
- 1994-07-22 AT AT94921070T patent/ATE172451T1/de not_active IP Right Cessation
- 1994-07-22 ES ES94921070T patent/ES2125466T3/es not_active Expired - Lifetime
- 1994-07-22 ZA ZA945427A patent/ZA945427B/xx unknown
- 1994-07-22 JP JP7505021A patent/JPH09500637A/ja not_active Ceased
- 1994-07-22 US US08/537,869 patent/US5872140A/en not_active Expired - Fee Related
- 1994-07-22 HU HU9600136A patent/HU221597B/hu not_active IP Right Cessation
- 1994-07-22 CZ CZ96207A patent/CZ20796A3/cs unknown
- 1994-07-22 DE DE69414115T patent/DE69414115T2/de not_active Expired - Fee Related
- 1994-07-22 CA CA002167837A patent/CA2167837A1/en not_active Abandoned
- 1994-07-22 NZ NZ268659A patent/NZ268659A/en unknown
- 1994-07-22 DK DK94921070T patent/DK0710227T3/da active
- 1994-07-22 EP EP94921070A patent/EP0710227B1/de not_active Expired - Lifetime
1996
- 1996-01-22 NO NO19960251A patent/NO314453B1/no not_active IP Right Cessation
- 1996-01-22 FI FI960303A patent/FI113535B/fi not_active IP Right Cessation
1998
- 1998-10-20 US US09/175,311 patent/US6013814A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1043883C (zh)	1999-06-30
CA2167837A1 (en)	1995-02-02
HU9600136D0 (en)	1996-03-28
DK0710227T3 (da)	1999-06-28
FI960303L (fi)	1996-03-22
EP0710227A1 (de)	1996-05-08
ATE172451T1 (de)	1998-11-15
EP0710227B1 (de)	1998-10-21
IL110415A0 (en)	1996-03-31
NO960251L (no)	1996-03-22
NO960251D0 (no)	1996-01-22
US6013814A (en)	2000-01-11
NO314453B1 (no)	2003-03-24
ZA945427B (en)	1995-08-24
FI113535B (fi)	2004-05-14
US5872140A (en)	1999-02-16
ES2125466T3 (es)	1999-03-01
HUT73846A (en)	1996-09-30
DE69414115D1 (de)	1998-11-26
NZ268659A (en)	1996-09-25
GB9315253D0 (en)	1993-09-08
DE69414115T2 (de)	1999-04-08
CZ20796A3 (en)	1996-10-16
JPH09500637A (ja)	1997-01-21
AU7193994A (en)	1995-02-20
KR100321415B1 (ko)	2002-11-13
FI960303A0 (fi)	1996-01-22
WO1995003273A1 (en)	1995-02-02
CN1129441A (zh)	1996-08-21
HU221597B (hu)	2002-11-28
AU690565B2 (en)	1998-04-30

Legal Events

Date	Code	Title	Description
2000-06-29	FF	Patent granted
2005-07-25	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL110415A0 (en)	1996-03-31	Vitamin d analogues and pharmaceutical compositions containing them
AU564842B2 (en)	1987-08-27	Pyranyl (or cyclohexyl) methane sulfamates and their use as anticonvulsants
IL74497A (en)	1990-02-09	Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
DE3574014D1 (en)	1989-12-07	Novel biologically active compound having anti-prolyl endopeptidase activity
GEP20022709B (en)	2002-06-25	Pharmaceutical Compositions Having Appetite Suppressant Activity
DE69412476D1 (de)	1998-09-17	Vitamin-d-amid-derivate
IL98917A0 (en)	1992-07-15	Piperidyl ethers and thioethers and their use as inhibitors of cholesterol biosynthesis
IL113113A0 (en)	1995-06-29	Vitamin D analogues
GR3031118T3 (en)	1999-12-31	Novel seco-D steroids active in the cardiovascular system and pharmaceutical compositions containing same
HUT71523A (en)	1995-12-28	Gestagenically active 19,11-bridged 4-estrenes and pharmaceutical compositions containing the same
AU7037591A (en)	1991-07-18	Stabilization of t-pa pro
TW344650B (en)	1998-11-11	Fungicidal compositions and the process for the preparation thereof
YU23498A (sh)	2001-12-26	Herbicidni 3,5-difluoropiridini
IL114646A (en)	2000-02-29	Pharmaceutical compositions containing phenylurea derivatives for inhibiting leukotriene biosynthesis
MX9706826A (es)	1997-11-29	Esteres y amidas de 1,4-piperidina di-sustituida.
SU1086720A1 (ru)	1998-03-20	1,1,1-трихлор-2-окси-4-(4-нитрофенил)бутанон-4 в качестве промежуточного продукта в синтезе 1,1,1-трихлор-4-(4-нитрофенил)бутен-2-она-4 и 1,1,1-трихлор-4-(4-нитрофенил)бутен-2-он-4 в качестве фунгицида