ATE174925T1 - Herstellung von fucosylierten kohlenhydraten durch enzymatische fucosylierungs-synthese der zuckernukleotide; und in situ regeneration von gdp-fucose - Google Patents

Herstellung von fucosylierten kohlenhydraten durch enzymatische fucosylierungs-synthese der zuckernukleotide; und in situ regeneration von gdp-fucose

Info

Publication number
ATE174925T1
ATE174925T1 AT92921939T AT92921939T ATE174925T1 AT E174925 T1 ATE174925 T1 AT E174925T1 AT 92921939 T AT92921939 T AT 92921939T AT 92921939 T AT92921939 T AT 92921939T AT E174925 T1 ATE174925 T1 AT E174925T1
Authority
AT
Austria
Prior art keywords
carbohydrates
production
gdp
fucose
synthesis
Prior art date
Application number
AT92921939T
Other languages
English (en)
Inventor
Chi-Huey Wong
Yoshitaka Ichikawa
Gwo-Jenn Shen
Kun-Chin Liu
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/961,076 external-priority patent/US6319695B1/en
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE174925T1 publication Critical patent/ATE174925T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT92921939T 1991-10-15 1992-10-15 Herstellung von fucosylierten kohlenhydraten durch enzymatische fucosylierungs-synthese der zuckernukleotide; und in situ regeneration von gdp-fucose ATE174925T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77766291A 1991-10-15 1991-10-15
US90126092A 1992-06-19 1992-06-19
US91061292A 1992-07-08 1992-07-08
US07/961,076 US6319695B1 (en) 1991-10-15 1992-10-14 Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose

Publications (1)

Publication Number Publication Date
ATE174925T1 true ATE174925T1 (de) 1999-01-15

Family

ID=27505746

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92921939T ATE174925T1 (de) 1991-10-15 1992-10-15 Herstellung von fucosylierten kohlenhydraten durch enzymatische fucosylierungs-synthese der zuckernukleotide; und in situ regeneration von gdp-fucose

Country Status (13)

Country Link
US (2) US6518418B1 (de)
EP (1) EP0642526B1 (de)
JP (1) JPH07500248A (de)
AT (1) ATE174925T1 (de)
AU (1) AU675209B2 (de)
BG (1) BG98713A (de)
CA (1) CA2121365C (de)
DE (1) DE69228005T2 (de)
ES (1) ES2129458T3 (de)
FI (1) FI941732A7 (de)
RO (1) RO118132B1 (de)
SK (1) SK42594A3 (de)
WO (1) WO1993008205A1 (de)

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AU675209B2 (en) 1991-10-15 1997-01-30 Scripps Research Institute, The Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
IT1268954B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
CA2237199A1 (en) * 1996-09-11 1998-03-19 Toshitada Noguchi Process for preparing sugar nucleotide
JP3545424B2 (ja) * 1996-11-19 2004-07-21 ヤマサ醤油株式会社 ヌクレオシド５’−トリリン酸の製造法及びその応用
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
DE19908712C2 (de) * 1999-03-01 2002-02-07 Forschungszentrum Juelich Gmbh Verfahren zur Herstellung eines ·1··8·F-markierten Glykosylierungsreagenz
CN102076865B (zh) 2008-05-02 2016-03-16 西雅图基因公司 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
EP3513794A3 (de) 2010-08-05 2019-10-16 Seattle Genetics, Inc. Fucose-analoga für in-vivo-hemmung einer protein-fucosylierung
CN103429604A (zh) * 2011-02-21 2013-12-04 格礼卡姆股份公司 寡糖前体的混合物的组合物的催化氢解及其用途
JP6000948B2 (ja) * 2011-06-09 2016-10-05 三洋化成工業株式会社 多糖の製造方法
US10350228B2 (en) 2012-08-23 2019-07-16 Seattle Genetics, Inc. Treatment of sickle cell disease and inflammatory conditions
CN104876977A (zh) * 2013-07-17 2015-09-02 张家港威胜生物医药有限公司 一种制备1-溴-2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖的方法
WO2018034877A1 (en) 2016-08-13 2018-02-22 Zymtronix, Llc Magnetically immobilized biocidal enzymes and biocidal chemicals
CN108251474A (zh) * 2018-01-15 2018-07-06 山东大学 Abh人血型抗原的合成方法
BR112021003156A2 (pt) 2018-08-23 2021-05-11 Seagen, Inc. composição, anticorpo que se liga ao tigit humano, formulação farmacêutica, polinucleotídeo isolado, vetor, célula hospedeira, métodos para a produção de um anticorpo que se liga ao tigit humano e de anticorpos afucosilados que se ligam a tigit e para o tratamento de um câncer, e, kit.
EP3719135A1 (de) * 2019-04-01 2020-10-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Enzymatisches verfahren zur herstellung von gdp-fucose
US20250361477A1 (en) * 2020-08-10 2025-11-27 Inbiose N.V. Production of an oligosaccharide mixture by a cell
CN112915565B (zh) * 2021-03-04 2022-04-08 安徽金禾实业股份有限公司 一种旋转式蔗糖-6-酯连续生产设备及生产方法
CN114990175B (zh) * 2021-10-22 2023-03-31 岩唐生物科技(杭州)有限责任公司 一种岩藻糖衍生物的合成方法
CN113960232B (zh) * 2021-10-28 2024-02-20 苏州大学 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用
EP4526315A1 (de) * 2022-05-18 2025-03-26 Glycomine, Inc. Durchflussverfahren zur herstellung von mannose-1-phosphat, polymorphe von mannose-1-phosphat sowie zusammensetzungen und verwendungen im zusammenhang damit
EP4526461A1 (de) * 2022-05-20 2025-03-26 ZYMtronix Catalytic Systems, Inc. Biologische herstellung von oligosacchariden und derivaten aus einfachen zuckern

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GB1544908A (en) * 1975-07-08 1979-04-25 Chembiomed Ltd Artificial oligosaccharide antigenic determinants
US4178210A (en) * 1977-03-07 1979-12-11 Massachusetts Institute Of Technology Accellular synthesis of cephalosporins
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US4973679A (en) * 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
FR2509313A1 (fr) * 1981-07-08 1983-01-14 Choay Sa Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques
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US4925796A (en) * 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
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DE3626915A1 (de) * 1986-08-08 1988-02-11 Hoechst Ag Verfahren zur enzymatischen synthese eines n-acetylneuraminsaeure-haltigen trisaccharids
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Also Published As

Publication number Publication date
RO118132B1 (ro) 2003-02-28
CA2121365A1 (en) 1993-04-29
SK42594A3 (en) 1994-10-05
FI941732A0 (fi) 1994-04-14
BG98713A (bg) 1995-05-31
US20020068331A1 (en) 2002-06-06
AU2785492A (en) 1993-05-21
EP0642526A1 (de) 1995-03-15
FI941732L (fi) 1994-06-14
WO1993008205A1 (en) 1993-04-29
US6518418B1 (en) 2003-02-11
AU675209B2 (en) 1997-01-30
EP0642526A4 (de) 1996-04-10
DE69228005T2 (de) 1999-07-15
FI941732A7 (fi) 1994-06-14
US7335500B2 (en) 2008-02-26
ES2129458T3 (es) 1999-06-16
EP0642526B1 (de) 1998-12-23
CA2121365C (en) 2000-11-28
JPH07500248A (ja) 1995-01-12
DE69228005D1 (de) 1999-02-04

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