ATE175973T1 - Konjugate bdnf und nt-3 mit einem wasserlöslichen polymer - Google Patents

Konjugate bdnf und nt-3 mit einem wasserlöslichen polymer

Info

Publication number
ATE175973T1
ATE175973T1 AT95939123T AT95939123T ATE175973T1 AT E175973 T1 ATE175973 T1 AT E175973T1 AT 95939123 T AT95939123 T AT 95939123T AT 95939123 T AT95939123 T AT 95939123T AT E175973 T1 ATE175973 T1 AT E175973T1
Authority
AT
Austria
Prior art keywords
water soluble
soluble polymer
bdnf
conjugates
polypeptides
Prior art date
Application number
AT95939123T
Other languages
English (en)
Inventor
Olaf F Kinstler
Qiao Yan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE175973T1 publication Critical patent/ATE175973T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Treatment Of Sludge (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Detergent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT95939123T 1994-11-14 1995-11-13 Konjugate bdnf und nt-3 mit einem wasserlöslichen polymer ATE175973T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,131 US5770577A (en) 1994-11-14 1994-11-14 BDNF and NT-3 polypeptides selectively linked to polyethylene glycol

Publications (1)

Publication Number Publication Date
ATE175973T1 true ATE175973T1 (de) 1999-02-15

Family

ID=23332020

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95939123T ATE175973T1 (de) 1994-11-14 1995-11-13 Konjugate bdnf und nt-3 mit einem wasserlöslichen polymer

Country Status (22)

Country Link
US (1) US5770577A (de)
EP (1) EP0792288B1 (de)
JP (1) JPH10508853A (de)
KR (1) KR100253762B1 (de)
CN (1) CN1173183A (de)
AT (1) ATE175973T1 (de)
AU (1) AU694589B2 (de)
CA (1) CA2204640C (de)
CZ (1) CZ137597A3 (de)
DE (1) DE69507507T2 (de)
DK (1) DK0792288T3 (de)
ES (1) ES2126331T3 (de)
GR (1) GR3029790T3 (de)
HU (1) HUT77747A (de)
IL (1) IL115965A (de)
MX (1) MX9703362A (de)
NO (1) NO972176L (de)
NZ (1) NZ296452A (de)
RU (1) RU2136694C1 (de)
SK (1) SK283083B6 (de)
WO (1) WO1996015146A1 (de)
ZA (1) ZA959653B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JPH10212241A (ja) * 1996-05-27 1998-08-11 Sumitomo Pharmaceut Co Ltd Ｂｄｎｆを安定に含有する製剤
NZ333650A (en) 1996-07-19 2000-02-28 Amgen Inc Analogs of cationic proteins like NT-3 (neurotrophin-3) and BDNF (brain derived neurotrophic factor) that are circulated more readily due to a lower isoelectric point and a lower protein charge relative to the native protein
WO2000024415A2 (en) * 1998-10-28 2000-05-04 Cornell Research Foundation, Inc. Methods for regulating angiogenesis and vascular integrity using trk receptor ligands
US6656474B1 (en) * 1999-01-15 2003-12-02 Regeneron Pharmaceuticals, Inc. Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders
RU2290411C2 (ru) * 2000-01-10 2006-12-27 Максиджен Холдингз Лтд Конъюгаты g-csf
US6800607B2 (en) * 2000-02-29 2004-10-05 Ltt Bio-Pharma Co., Ltd. Modified BDNF
US7514239B2 (en) * 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
JP4259868B2 (ja) * 2001-02-01 2009-04-30 バイオジェン・アイデック・エムエイ・インコーポレイテッド ニューブラスチンのポリマー結合体および同様の使用方法。
US7442370B2 (en) * 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
JP4279554B2 (ja) 2001-02-19 2009-06-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔ細胞エピトープの識別方法および低減された免疫原性を有する分子の製造方法
EP1234583A1 (de) * 2001-02-23 2002-08-28 F. Hoffmann-La Roche Ag PEG-Konjugate des HGF-NK4
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
RU2307126C2 (ru) * 2001-07-11 2007-09-27 Максиджен Холдингз Лтд. Конъюгаты g-csf
ATE344289T1 (de) * 2002-07-24 2006-11-15 Hoffmann La Roche Polyethylenglykol-aldehydderivate
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
RS20050501A (sr) * 2002-12-26 2007-08-03 Mountain View Pharmaceuticals Inc., Polimerni konjugati citokina,hemokina,faktora rasta, polipeptidnih hormona i njihovih antagonista sa očuvanom aktivnošću vezivanja receptora
GEP20084486B (en) * 2002-12-26 2008-09-25 Mountain View Pharmaceuticals Polymer conjugates of interferon-beta with enhanced biological potency
JP4742025B2 (ja) * 2003-01-31 2011-08-10 バイオジェン・アイデック・エムエイ・インコーポレイテッド 変異ニューブラスチンのポリマー結合体
PL1606409T3 (pl) 2003-03-19 2011-02-28 Biogen Ma Inc Białko wiążące receptor Nogo
EP1897552B1 (de) 2003-04-18 2009-06-17 Biogen Idec MA Inc. Polymerkonjugiertes glycosiliertes Neublastin
BRPI0506793A (pt) * 2004-02-20 2007-05-22 Rinat Neuroscience Corp métodos de tratamento de obesidade ou diabetes com o uso de nt-4/5
PT1776136E (pt) 2004-06-24 2012-12-05 Biogen Idec Inc Tratamento de estados que envolvem desmielinização
CN101043899B (zh) 2004-08-19 2011-03-30 比奥根艾迪克Ma公司 重折叠转化型生长因子beta家族蛋白
DK1786454T3 (da) * 2004-08-19 2010-09-06 Biogen Idec Inc Neublastinvarianter
MX2007015292A (es) 2005-06-06 2008-02-21 Wyeth Corp Anticuerpos monoclonales anti-trkb y sus usos.
SI1904104T1 (sl) 2005-07-08 2013-12-31 Biogen Idec Ma Inc. Protitelesa SP35 in njihova uporaba
ITRM20050447A1 (it) * 2005-08-19 2007-02-20 Anabasis S R L Uso del nerve growth factor in collirio nella terapia di patologie del sistema nervoso centrale, quali la malattia di alzheimer e il morbo di parkinson.
AU2007210862A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corp. Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist
JP2009525319A (ja) * 2006-02-02 2009-07-09 ライナット ニューロサイエンス コーポレイション ｔｒｋＢアンタゴニストを投与することにより肥満を治療する方法
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
US20100056440A1 (en) * 2006-03-01 2010-03-04 Biogen Idec Ma Inc. Compositions and methods for administering gdnf ligand family proteins
WO2007133811A2 (en) * 2006-05-15 2007-11-22 Viral Logic Systems Technology Corp. Cd47 related compositions and methods for treating immunological diseases and disorders
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
CA2672750A1 (en) * 2006-12-20 2008-07-03 Rinat Neuroscience Corporation Trkb agonists for treating autoimmune disorders
TWI445544B (zh) 2007-05-01 2014-07-21 Biogen Idec Inc 增進血管形成之組合物及方法
US20110135648A1 (en) * 2007-08-08 2011-06-09 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
CA2701189C (en) * 2007-10-11 2017-05-16 Biogen Idec Ma Inc. Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell survival via administration of lingo-1 antagonists and trkb agonists
WO2009061500A1 (en) * 2007-11-08 2009-05-14 Biogen Idec Ma Inc. Use of lingo-4 antagonists in the treatment of conditions involving demyelination
EP2315779A2 (de) 2008-07-09 2011-05-04 Biogen Idec MA Inc. Antikörper gegen lingo oder fragmente davon enthaltende zusammensetzungen
EP2588490B1 (de) 2010-07-02 2017-02-22 Angiochem Inc. Kurze und d-aminosäure-haltige polypeptide für therapeutische konjugate und ihre verwendungen
US9796780B2 (en) 2012-05-14 2017-10-24 Biogen Ma Inc. LINGO-2 antagonists for treatment of conditions involving motor neurons
CN102964442B (zh) * 2012-11-19 2015-04-29 未名生物医药有限公司 一种聚乙二醇同神经生长因子结合物的制备方法
WO2016112270A1 (en) 2015-01-08 2016-07-14 Biogen Ma Inc. Lingo-1 antagonists and uses for treatment of demyelinating disorders
CN116440252A (zh) * 2020-06-16 2023-07-18 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 神经营养因子3在制备提高睾丸中睾酮含量的药物中的应用
CN115025723A (zh) * 2022-05-10 2022-09-09 吉林大学 经神经生长因子及多巴胺改良的peg-plga微球

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
DE3572982D1 (en) * 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
CA1340810C (en) * 1988-03-31 1999-11-02 Motoo Yamasaki Polypeptide derivatives of human granulocyte colony stimulating factor
EP0401384B1 (de) * 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemisch modifizierte granulocytenkolonie erregender faktor
IL95511A (en) * 1989-08-30 2000-10-31 Max Planck Gesellschaft Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5182107A (en) * 1989-09-07 1993-01-26 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates
JPH04218000A (ja) * 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
CA2092567C (en) * 1990-09-25 2007-07-03 Arnon Rosenthal Nt-4 neurotrophic factor
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
NZ244778A (en) * 1991-10-21 1994-03-25 Ortho Pharma Corp Peg imidates and protein derivatives thereof
US5260308A (en) * 1991-11-06 1993-11-09 Mayo Foundation For Medical Education And Research Method to increase permeability of the blood-nerve/brain barriers to proteins
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders

Also Published As

Publication number Publication date
AU694589B2 (en) 1998-07-23
DK0792288T3 (da) 1999-09-13
ZA959653B (en) 1997-08-26
KR100253762B1 (ko) 2000-05-01
AU4107196A (en) 1996-06-06
CA2204640C (en) 2001-01-09
CA2204640A1 (en) 1996-05-23
IL115965A0 (en) 1996-01-31
ES2126331T3 (es) 1999-03-16
DE69507507D1 (de) 1999-03-04
WO1996015146A1 (en) 1996-05-23
NO972176L (no) 1997-07-14
EP0792288A1 (de) 1997-09-03
CZ137597A3 (cs) 1998-10-14
NO972176D0 (no) 1997-05-12
DE69507507T2 (de) 1999-05-27
NZ296452A (en) 1999-01-28
CN1173183A (zh) 1998-02-11
US5770577A (en) 1998-06-23
EP0792288B1 (de) 1999-01-20
MX9703362A (es) 1997-08-30
SK57197A3 (en) 1999-02-11
RU2136694C1 (ru) 1999-09-10
SK283083B6 (sk) 2003-02-04
IL115965A (en) 2001-01-28
JPH10508853A (ja) 1998-09-02
HUT77747A (hu) 1998-07-28
GR3029790T3 (en) 1999-06-30

Similar Documents

Publication Publication Date Title
DE69507507D1 (de) Konjugate bdnf und nt-3 mit einem wasserlöslichen polymer
FI941434L (fi) Polymeerisäiliöitä, joilla on sulkuominaisuuksia
DE59208029D1 (de) Lösliche Katalysatorsysteme zur Herstellung von Polyalk-1-enen mit hohen Molmassen
DE59307460D1 (de) Biologisch abbaubare Polymermischung
DE59607712D1 (de) Vernetzbare, photoaktive Polymermaterialien
FI913259L (fi) Polymerblandning.
DE69726229D1 (de) Prothese mit Flansch
DE69401325D1 (de) Superabsorbierendes Polymer mit verbesserten Absorbiereigenschaften und Absorption unter Druck
ATE217325T1 (de) Cyclodextrinderivate mit erhöhter wasserlösichkeit und deren verwendung
NO891982D0 (no) Polymer-sammensetning.
NO902332D0 (no) Forsegling/tetningsring med spenningsavlastningsspor.
ZA979944B (en) Heat-sealing polymer films.
DE69717832D1 (de) Mit polymer verstärkte fluiddichtung
DE58903287D1 (de) Polymerblends mit guter alterungsstabilitaet.
ATE125556T1 (de) In wasser dispergierbare, elektrolytstabile polyetherester-modifizierte polyurethanionomere.
NO981833D0 (no) Vann-redispergerbar pulverformet, filmdannende polymerblanding
DE68911717D1 (de) Thermoplastische Polymerzusammensetzung.
SV1997000025A (es) Nuevos pirimido /1,2-a/ indoles ref. lea 31544-sv
DE69114425D1 (de) Elastomermischung mit ultrahohem Molekulargewicht.
DE69714358D1 (de) 9,10-disubstituierte campothecinderivate mit antitumoraktivität
DE69510093D1 (de) Polymermischung mit verbesserter anfärbbarkeit
DE3862372D1 (de) Polyphenylenaether, polyoctenylen und polyethylen enthaltende polymermischung.
DE68912740D1 (de) Azazyklische Derivate mit harntreibender Wirkung.
NO895187D0 (no) Polymerblanding.
DE59301365D1 (de) Lösliche Polymerisate

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee