ATE178650T1 - D-enzymzusammensetzungen und verfahren zu deren verwendung - Google Patents

D-enzymzusammensetzungen und verfahren zu deren verwendung

Info

Publication number
ATE178650T1
ATE178650T1 AT93916447T AT93916447T ATE178650T1 AT E178650 T1 ATE178650 T1 AT E178650T1 AT 93916447 T AT93916447 T AT 93916447T AT 93916447 T AT93916447 T AT 93916447T AT E178650 T1 ATE178650 T1 AT E178650T1
Authority
AT
Austria
Prior art keywords
receptor
compound
contacting
modulate
amino acids
Prior art date
Application number
AT93916447T
Other languages
English (en)
Inventor
Stephen Brian Henry Kent
Saskia Charlotte Floren Milton
Raymond Cecil Delisle Milton
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25403558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE178650(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE178650T1 publication Critical patent/ATE178650T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
AT93916447T 1992-06-05 1993-06-07 D-enzymzusammensetzungen und verfahren zu deren verwendung ATE178650T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89481792A 1992-06-05 1992-06-05

Publications (1)

Publication Number Publication Date
ATE178650T1 true ATE178650T1 (de) 1999-04-15

Family

ID=25403558

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98108855T ATE366744T1 (de) 1992-06-05 1993-06-07 Verknüpftes d-protein und verfahren zur identifizierung von rezeptor aktivität modulierenden verbindungen
AT93916447T ATE178650T1 (de) 1992-06-05 1993-06-07 D-enzymzusammensetzungen und verfahren zu deren verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98108855T ATE366744T1 (de) 1992-06-05 1993-06-07 Verknüpftes d-protein und verfahren zur identifizierung von rezeptor aktivität modulierenden verbindungen

Country Status (9)

Country Link
US (5) US6548279B1 (de)
EP (2) EP0882737B1 (de)
JP (2) JPH08501207A (de)
AT (2) ATE366744T1 (de)
AU (2) AU678768B2 (de)
CA (1) CA2137378C (de)
DE (2) DE69324362T2 (de)
ES (1) ES2290976T3 (de)
WO (1) WO1993025667A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2290976T3 (es) * 1992-06-05 2008-02-16 The Scripps Research Institute D-proteina ligada y metodo para identificar compuestos que modulan la actividad de receptores.
US5780221A (en) * 1995-05-03 1998-07-14 Whitehead Institute For Biomedical Research Identification of enantiomeric ligands
ATE377006T1 (de) * 1995-11-28 2007-11-15 Cephalon Inc Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
US6277874B1 (en) * 1996-07-09 2001-08-21 University Of Cincinnati And Apologic, Incorporated Methods for the treatment of apolipoprotein E related diseases
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
WO2000052155A2 (en) 1999-03-05 2000-09-08 Maxygen, Inc. Recombination of insertion modified nucleic acids
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
EP1196548A2 (de) 1999-07-22 2002-04-17 The Procter & Gamble Company Proteasekonjugaten mit sterisch geschützten hydrolysierbaren stellen
JP2003505067A (ja) 1999-07-22 2003-02-12 ザ、プロクター、エンド、ギャンブル、カンパニー 特定のエピトープ領域にアミノ酸欠失及び置換を有するサブチリシンプロテアーゼの変異体
MXPA02000840A (es) 1999-07-22 2002-07-30 Procter & Gamble Variantes de proteasa de subtilisina que tienen substituciones de aminoacidos en regiones de epitopes definidas.
JP2003519495A (ja) * 2000-01-11 2003-06-24 マキシジェン， インコーポレイテッド 多様性生成およびスクリーニングのための一体化されたシステムおよび方法
US20030170846A1 (en) * 2000-04-24 2003-09-11 Weisgerber David John Enzyme variants having one or more D-amino acid substitutions
US20050181464A1 (en) * 2002-04-04 2005-08-18 Affinium Pharmaceuticals, Inc. Novel purified polypeptides from bacteria
US7618442B2 (en) * 2003-10-21 2009-11-17 Theken Spine, Llc Implant assembly and method for use in an internal structure stabilization system
US20100093624A1 (en) * 2008-07-30 2010-04-15 Cosmix Therapeutics Llc Peptide therapeutics that bind vegf and methods of use thereof
EP2638063A4 (de) 2010-11-12 2014-04-23 Reflexion Pharmaceuticals Inc Gb1-peptid-bibliotheken und -verbindungen sowie screening-verfahren dafür
US8465413B2 (en) 2010-11-25 2013-06-18 Coloplast A/S Method of treating Peyronie's disease
WO2013082531A2 (en) 2011-12-02 2013-06-06 Reflexion Pharmaceuticals Broad spectrum influenza a neutralizing vaccines and d-peptidic compounds, and methods for making and using the same
JP6170077B2 (ja) 2012-02-16 2017-07-26 エータイアー ファーマ， インコーポレイテッド 自己免疫および炎症疾患を処置するためのヒスチジルｔＲＮＡ合成酵素
EP2850095B1 (de) 2012-05-17 2019-10-09 RA Pharmaceuticals, Inc. Peptid- und peptidomimetische inhibitoren
WO2014140882A2 (en) 2013-03-14 2014-09-18 The Governing Council Of The University Of Toronto Scaffolded peptidic libraries and methods of making and screening the same
AU2016260274A1 (en) * 2015-05-11 2017-10-12 Shiseido Company, Ltd. Chiral analysis method and chiral analysis system for bound-type amino acid

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790240A (fr) 1971-10-19 1973-02-15 Sumitomo Chemical Co Procede de preparation de l'acide mixte (+)-cis, (+)-trans- chrysanthemique
US3963573A (en) 1975-03-03 1976-06-15 The Procter & Gamble Company Process for producing N-acyl-L-methionine
US4151198A (en) 1978-06-02 1979-04-24 American Cyanamid Company Resolution of N-acyl-DL (+)-phenylalanines
FR2443452A1 (fr) 1978-12-08 1980-07-04 Roussel Uclaf Nouveau procede de dedoublement de l'acide dl cis et dl trans chrysanthemique
US4262092A (en) 1979-05-08 1981-04-14 Ethyl Corporation Process for producing N-acyl-D-phenylalanine ester
US4290893A (en) 1979-05-08 1981-09-22 Yeda Research & Development Co. Ltd. Separation of amino acids by liquid chromatography using chiral eluants
US4423037A (en) * 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
US4454344A (en) 1982-08-23 1984-06-12 American Cyanamid Company Method for the resolution of racemic 2-(p-difluoromethoxyphenyl)-3-methylbutyric acid
US5157019A (en) * 1986-03-18 1992-10-20 Monsanto Company Serine protease inhibitors
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
US5098836A (en) * 1989-08-14 1992-03-24 Phillips Petroleum Company Deoxygenation in field preparation of polymers in aqueous solution
US5585353A (en) * 1990-02-02 1996-12-17 The Rockefeller University Antibiotic peptides containing D-amino acids
DK0558671T3 (da) * 1990-11-21 1999-09-13 Iterex Pharma Lp Syntese af ækvimolære multiple oligomerblandinger, især af oligopeptidblandinger
CA2133834C (en) * 1992-04-07 2009-07-21 Stephen B.H. Kent Process for preparing modified proteins
ES2290976T3 (es) * 1992-06-05 2008-02-16 The Scripps Research Institute D-proteina ligada y metodo para identificar compuestos que modulan la actividad de receptores.
US5589356A (en) * 1993-06-21 1996-12-31 Vanderbilt University Litigation of sidechain unprotected peptides via a masked glycoaldehyde ester and O,N-acyl rearrangement
AU2531397A (en) * 1996-03-21 1997-10-10 President And Fellows Of Harvard College Enantiomeric screening process, and compositions therefor

Also Published As

Publication number Publication date
CA2137378C (en) 2008-08-05
US6040133A (en) 2000-03-21
EP0882737B1 (de) 2007-07-11
EP0647266A1 (de) 1995-04-12
AU4599693A (en) 1994-01-04
ATE366744T1 (de) 2007-08-15
US5910437A (en) 1999-06-08
ES2290976T3 (es) 2008-02-16
AU678768B2 (en) 1997-06-12
CA2137378A1 (en) 1993-12-23
DE69324362T2 (de) 1999-08-26
DE69334152T2 (de) 2008-03-13
EP0647266B1 (de) 1999-04-07
DE69324362D1 (de) 1999-05-12
EP0882737A1 (de) 1998-12-09
US6548279B1 (en) 2003-04-15
WO1993025667A1 (en) 1993-12-23
US20030113881A1 (en) 2003-06-19
US7135279B2 (en) 2006-11-14
AU721228B2 (en) 2000-06-29
AU3756497A (en) 1997-12-18
US7118856B2 (en) 2006-10-10
US20040086988A1 (en) 2004-05-06
DE69334152D1 (de) 2007-08-23
JP4312615B2 (ja) 2009-08-12
JP2004275180A (ja) 2004-10-07
JPH08501207A (ja) 1996-02-13

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