ATE182148T1 - Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden - Google Patents

Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden

Info

Publication number
ATE182148T1
ATE182148T1 AT96913989T AT96913989T ATE182148T1 AT E182148 T1 ATE182148 T1 AT E182148T1 AT 96913989 T AT96913989 T AT 96913989T AT 96913989 T AT96913989 T AT 96913989T AT E182148 T1 ATE182148 T1 AT E182148T1
Authority
AT
Austria
Prior art keywords
new
crf1
specific ligands
deazapurine derivatives
class
Prior art date
Application number
AT96913989T
Other languages
English (en)
Inventor
Jun Yuan
Alan Hutchison
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/439,874 external-priority patent/US5644057A/en
Priority claimed from US08/476,689 external-priority patent/US5804685A/en
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of ATE182148T1 publication Critical patent/ATE182148T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96913989T 1995-05-12 1996-05-09 Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden ATE182148T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/439,874 US5644057A (en) 1995-05-12 1995-05-12 Deazapurine derivatives; a new class of CRF1 specific ligands
US08/476,689 US5804685A (en) 1995-06-07 1995-06-07 Deazapurine derivatives: a new class of CRF1 specific ligands

Publications (1)

Publication Number Publication Date
ATE182148T1 true ATE182148T1 (de) 1999-07-15

Family

ID=27032200

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96913989T ATE182148T1 (de) 1995-05-12 1996-05-09 Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden

Country Status (9)

Country Link
US (3) US6020492A (de)
EP (1) EP0770080B1 (de)
JP (1) JPH10506126A (de)
KR (1) KR100256707B1 (de)
AT (1) ATE182148T1 (de)
AU (1) AU716993B2 (de)
CA (1) CA2194756A1 (de)
DE (1) DE69603240T2 (de)
WO (1) WO1996035689A1 (de)

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US7557113B2 (en) * 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
BRPI0414087A (pt) * 2003-09-05 2006-10-31 Neurogen Corp composto, métodos para tratar um distúrbio, para demostrar a presença de receptores de crf em amostras de célula ou tecido, e para inibir a ligação de crf a um receptor de crf1, composição farmacêutica, e, embalagem
MX2013003184A (es) 2010-09-22 2013-06-07 Arena Pharm Inc Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo.
US8853213B2 (en) 2011-01-03 2014-10-07 Hanmi Pharm. Co., Ltd Bicyclic compound for modulating G protein-coupled receptors
KR102061743B1 (ko) 2011-03-04 2020-01-03 뉴젠 세러퓨틱스 인코포레이티드 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
KR101420097B1 (ko) * 2011-12-28 2014-07-17 주식회사 두산 유기발광 화합물 및 이를 이용한 유기 전계 발광 소자
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KR102571296B1 (ko) 2016-09-07 2023-08-28 더 리전트 오브 더 유니버시티 오브 캘리포니아 P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제
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Also Published As

Publication number Publication date
KR100256707B1 (ko) 2000-05-15
AU716993B2 (en) 2000-03-16
CA2194756A1 (en) 1996-11-14
US6495688B2 (en) 2002-12-17
US6281220B1 (en) 2001-08-28
WO1996035689A1 (en) 1996-11-14
DE69603240T2 (de) 2000-01-05
US20020065290A1 (en) 2002-05-30
EP0770080A1 (de) 1997-05-02
JPH10506126A (ja) 1998-06-16
EP0770080B1 (de) 1999-07-14
US6020492A (en) 2000-02-01
AU5679096A (en) 1996-11-29
DE69603240D1 (de) 1999-08-19

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