ATE183745T1 - Pyrido pyridazinon und pyridazinthionverbindungen mit pde iv inhibierender wirkung - Google Patents
Pyrido pyridazinon und pyridazinthionverbindungen mit pde iv inhibierender wirkungInfo
- Publication number
- ATE183745T1 ATE183745T1 AT92922090T AT92922090T ATE183745T1 AT E183745 T1 ATE183745 T1 AT E183745T1 AT 92922090 T AT92922090 T AT 92922090T AT 92922090 T AT92922090 T AT 92922090T AT E183745 T1 ATE183745 T1 AT E183745T1
- Authority
- AT
- Austria
- Prior art keywords
- pde
- inhibiting effect
- hydrogen
- carbon
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77567991A | 1991-10-09 | 1991-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE183745T1 true ATE183745T1 (de) | 1999-09-15 |
Family
ID=25105161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92922090T ATE183745T1 (de) | 1991-10-09 | 1992-10-08 | Pyrido pyridazinon und pyridazinthionverbindungen mit pde iv inhibierender wirkung |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0612321B1 (de) |
| JP (1) | JP3245165B2 (de) |
| KR (1) | KR100263494B1 (de) |
| AT (1) | ATE183745T1 (de) |
| AU (1) | AU670544B2 (de) |
| CA (1) | CA2117059C (de) |
| DE (1) | DE69229874T2 (de) |
| DK (1) | DK0612321T3 (de) |
| ES (2) | ES2105920B1 (de) |
| FI (1) | FI108229B (de) |
| GR (1) | GR3030969T3 (de) |
| HU (2) | HUT66969A (de) |
| IL (1) | IL103388A (de) |
| MX (1) | MX9205794A (de) |
| NO (1) | NO302888B1 (de) |
| NZ (1) | NZ244660A (de) |
| PT (1) | PT100938B (de) |
| TW (1) | TW365606B (de) |
| WO (1) | WO1993007146A1 (de) |
| ZA (1) | ZA927755B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9200689D0 (en) * | 1992-01-14 | 1992-03-11 | Rhone Poulenc Agriculture | New compositions of matter |
| GB9314412D0 (en) * | 1993-07-13 | 1993-08-25 | Rhone Poulenc Agriculture | New compositions of matter |
| US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
| WO1996006843A1 (en) * | 1994-08-29 | 1996-03-07 | Yamanouchi Pharmaceutical Co., Ltd. | Novel naphthyridine derivative and medicinal composition thereof |
| US6069151A (en) * | 1996-11-06 | 2000-05-30 | Darwin Discovery, Ltd. | Quinolines and their therapeutic use |
| GB9712761D0 (en) * | 1997-06-17 | 1997-08-20 | Chiroscience Ltd | Quinolines and their therapeutic use |
| ES2137113B1 (es) * | 1997-07-29 | 2000-09-16 | Almirall Prodesfarma Sa | Nuevos derivados de triazolo-piridazinas heterociclicos. |
| WO1999031090A1 (en) * | 1997-12-15 | 1999-06-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihydrobenzofurans |
| EP0934933A1 (de) * | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinone |
| IT1303272B1 (it) * | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
| JP3270834B2 (ja) | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
| UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
| CZ20032491A3 (cs) | 2001-02-15 | 2004-01-14 | Altana Pharma Ag | Ftalazinonpiperidinové deriváty |
| BR0209076A (pt) | 2001-04-25 | 2004-08-10 | Altana Pharma Ag | Derivados de piperazino e seu uso como inibidor de pde4 |
| EP1385848A2 (de) * | 2001-04-25 | 2004-02-04 | ALTANA Pharma AG | Phtalazinone derivate verwendbar als pde4/7 inhibitoren |
| ES2195785B1 (es) | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| US20060166995A1 (en) * | 2002-08-10 | 2006-07-27 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| BR0313330A (pt) | 2002-08-10 | 2005-06-14 | Altana Pharma Ag | Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4 |
| ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7153824B2 (en) | 2003-04-01 | 2006-12-26 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| DE602005005638T2 (de) | 2004-02-04 | 2009-05-14 | Nycomed Gmbh | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-on-derivate als pde4-inhibitoren |
| ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| PL383550A1 (pl) * | 2007-10-15 | 2009-04-27 | Uniwersytet Łódzki | Nowe pochodne benzeno- i pirydopirydazynonów |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| DK2681236T3 (en) | 2011-03-01 | 2018-04-16 | Synergy Pharmaceuticals Inc | PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS |
| US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| WO2014131024A2 (en) | 2013-02-25 | 2014-08-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| EP2968323A4 (de) | 2013-03-13 | 2016-12-14 | Flatley Discovery Lab | Pyridazinonverbindungen und verfahren zur behandlung von zystischer fibrose |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
| AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| US11319318B2 (en) * | 2015-03-05 | 2022-05-03 | Boehringer Ingelheim International Gmbh | Pyridinones and isoquinolinones as inhibitors of the bromodomain BRD9 |
| EP3428151A4 (de) * | 2016-03-09 | 2020-02-19 | Nippon Soda Co., Ltd. | Pyridinverbindung und verwendung davon |
| PT3442972T (pt) | 2016-04-15 | 2020-05-29 | Abbvie Inc | Inibidores de bromodomínio |
| EP4706758A3 (de) | 2019-05-21 | 2026-05-06 | Ardelyx, Inc. | Verfahren zur hemmung des phosphattransports |
| FR3105254B1 (fr) | 2019-12-19 | 2022-08-12 | Syctom Lagence Metropolitaine Des Dechets Menagers | Installation et procédé de gazéification hydrothermale de biomasse |
| AR127621A1 (es) * | 2021-11-09 | 2024-02-14 | Vigil Neuroscience Inc | Compuestos heterocíclicos como agonistas del receptor activador expresado en células mieloides 2 y métodos de uso |
| KR20250033093A (ko) * | 2023-08-31 | 2025-03-07 | 삼진제약주식회사 | 신규한 피리도 피리다진온 유도체 화합물 및 이를 포함하는 약학적 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2805344B2 (ja) * | 1989-07-11 | 1998-09-30 | 昭和電工株式会社 | オレフィン重合触媒の製造方法およびオレフィンの重合方法 |
| JP3120857B2 (ja) * | 1990-02-19 | 2000-12-25 | 中外製薬株式会社 | 新規な縮合複素環化合物とこれを用いた抗喘息剤 |
-
1992
- 1992-10-08 ZA ZA927755A patent/ZA927755B/xx unknown
- 1992-10-08 DE DE69229874T patent/DE69229874T2/de not_active Expired - Fee Related
- 1992-10-08 ES ES09201998A patent/ES2105920B1/es not_active Expired - Fee Related
- 1992-10-08 DK DK92922090T patent/DK0612321T3/da active
- 1992-10-08 ES ES92922090T patent/ES2135416T3/es not_active Expired - Lifetime
- 1992-10-08 TW TW081108015A patent/TW365606B/zh active
- 1992-10-08 KR KR1019940701129A patent/KR100263494B1/ko not_active Expired - Fee Related
- 1992-10-08 EP EP92922090A patent/EP0612321B1/de not_active Expired - Lifetime
- 1992-10-08 IL IL103388A patent/IL103388A/xx not_active IP Right Cessation
- 1992-10-08 WO PCT/US1992/008398 patent/WO1993007146A1/en not_active Ceased
- 1992-10-08 JP JP50707893A patent/JP3245165B2/ja not_active Expired - Fee Related
- 1992-10-08 AT AT92922090T patent/ATE183745T1/de not_active IP Right Cessation
- 1992-10-08 HU HU9400949A patent/HUT66969A/hu unknown
- 1992-10-08 CA CA002117059A patent/CA2117059C/en not_active Expired - Fee Related
- 1992-10-08 NZ NZ244660A patent/NZ244660A/en unknown
- 1992-10-08 AU AU27815/92A patent/AU670544B2/en not_active Ceased
- 1992-10-08 MX MX9205794A patent/MX9205794A/es not_active IP Right Cessation
- 1992-10-08 PT PT100938A patent/PT100938B/pt not_active IP Right Cessation
-
1994
- 1994-04-05 NO NO941210A patent/NO302888B1/no not_active IP Right Cessation
- 1994-04-06 FI FI941567A patent/FI108229B/fi active
-
1995
- 1995-04-24 HU HU95P/P00113P patent/HU210814A9/hu unknown
-
1999
- 1999-08-26 GR GR990401632T patent/GR3030969T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO941210L (no) | 1994-04-05 |
| JPH07500321A (ja) | 1995-01-12 |
| MX9205794A (es) | 1993-04-01 |
| EP0612321B1 (de) | 1999-08-25 |
| PT100938A (pt) | 1993-10-29 |
| ZA927755B (en) | 1994-04-08 |
| ES2105920A1 (es) | 1997-10-16 |
| AU2781592A (en) | 1993-05-03 |
| KR940702868A (ko) | 1994-09-17 |
| CA2117059A1 (en) | 1993-04-15 |
| DE69229874T2 (de) | 1999-12-09 |
| DK0612321T3 (da) | 1999-12-13 |
| CA2117059C (en) | 2003-05-20 |
| JP3245165B2 (ja) | 2002-01-07 |
| NO941210D0 (no) | 1994-04-05 |
| GR3030969T3 (en) | 1999-11-30 |
| ES2135416T3 (es) | 1999-11-01 |
| FI108229B (fi) | 2001-12-14 |
| HU210814A9 (en) | 1995-08-28 |
| HU9400949D0 (en) | 1994-06-28 |
| IL103388A (en) | 1997-09-30 |
| AU670544B2 (en) | 1996-07-25 |
| DE69229874D1 (de) | 1999-09-30 |
| KR100263494B1 (ko) | 2000-08-01 |
| FI941567L (fi) | 1994-04-06 |
| NZ244660A (en) | 1995-05-26 |
| NO302888B1 (no) | 1998-05-04 |
| PT100938B (pt) | 1999-10-29 |
| ES2105920B1 (es) | 1998-07-01 |
| HUT66969A (en) | 1995-01-30 |
| IL103388A0 (en) | 1993-03-15 |
| FI941567A0 (fi) | 1994-04-06 |
| TW365606B (en) | 1999-08-01 |
| WO1993007146A1 (en) | 1993-04-15 |
| EP0612321A1 (de) | 1994-08-31 |
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