DK0612321T3 - Pyridopyridazinon- og pyridazinthionforbindelser med PDE IV inhiberende aktivitet - Google Patents

Pyridopyridazinon- og pyridazinthionforbindelser med PDE IV inhiberende aktivitet

Info

Publication number: DK0612321T3
Authority: DK; Denmark
Prior art keywords: pyridazinethione; pyridopyridazinone; pde; compounds; inhibitory activity
Prior art date: 1991-10-09

Application number

DK92922090T

Other languages

English (en)

Inventor

Robert Stephen Wilhelm

Bradley Earl Loe

Bruce Henry Devens

Michael Grant Martin

Robert Alvarez

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-09

Filing date

1992-10-08

Publication date

1999-12-13

1992-10-08 Application filed by Syntex Inc filed Critical Syntex Inc

1999-12-13 Application granted granted Critical

1999-12-13 Publication of DK0612321T3 publication Critical patent/DK0612321T3/da

Links

YQQSRZSUGBETRS-UHFFFAOYSA-N 1h-pyridazine-6-thione Chemical class SC1=CC=CN=N1 YQQSRZSUGBETRS-UHFFFAOYSA-N 0.000 title abstract 2
DYHGFTMEUMYPOC-UHFFFAOYSA-N 8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)pyrido[2,3-d]pyridazin-5-one Chemical compound [O-][N+](=O)C1=CC=CC(C=2C3=NC=CC=C3C(=O)N(CC=3C=CN=CC=3)N=2)=C1 DYHGFTMEUMYPOC-UHFFFAOYSA-N 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
KMUUDIJYIRNGRO-UHFFFAOYSA-N 2h-pyrido[3,2-c]pyridazin-3-one Chemical class N1=CC=CC2=NNC(=O)C=C21 KMUUDIJYIRNGRO-UHFFFAOYSA-N 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
150000001266 acyl halides Chemical class 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK92922090T 1991-10-09 1992-10-08 Pyridopyridazinon- og pyridazinthionforbindelser med PDE IV inhiberende aktivitet DK0612321T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US77567991A	1991-10-09	1991-10-09
PCT/US1992/008398 WO1993007146A1 (en)	1991-10-09	1992-10-08	Benzo and pyrido pyridazinone and pyridazinthione compounds with pde iv inhibiting activity

Publications (1)

Publication Number	Publication Date
DK0612321T3 true DK0612321T3 (da)	1999-12-13

Family

ID=25105161

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92922090T DK0612321T3 (da)	1991-10-09	1992-10-08	Pyridopyridazinon- og pyridazinthionforbindelser med PDE IV inhiberende aktivitet

Country Status (20)

Country	Link
EP (1)	EP0612321B1 (da)
JP (1)	JP3245165B2 (da)
KR (1)	KR100263494B1 (da)
AT (1)	ATE183745T1 (da)
AU (1)	AU670544B2 (da)
CA (1)	CA2117059C (da)
DE (1)	DE69229874T2 (da)
DK (1)	DK0612321T3 (da)
ES (2)	ES2105920B1 (da)
FI (1)	FI108229B (da)
GR (1)	GR3030969T3 (da)
HU (2)	HUT66969A (da)
IL (1)	IL103388A (da)
MX (1)	MX9205794A (da)
NO (1)	NO302888B1 (da)
NZ (1)	NZ244660A (da)
PT (1)	PT100938B (da)
TW (1)	TW365606B (da)
WO (1)	WO1993007146A1 (da)
ZA (1)	ZA927755B (da)

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JP2005538140A (ja)	2002-08-10	2005-12-15	アルタナ　ファルマ　アクチエンゲゼルシャフト	Ｐｄｅ４インヒビターとしてのピペリジン−ピリダゾン及びフタラゾン
HRP20050197A2 (en) *	2002-08-10	2006-06-30	Altana Pharma Ag	Piperidine-n-oxide-derivatives
ES2211344B1 (es)	2002-12-26	2005-10-01	Almirall Prodesfarma, S.A.	Nuevos derivados de piridazin-3(2h)-ona.
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EA200501548A1 (ru)	2003-04-01	2006-02-24	Апплайд Резеч Системз Арс Холдинг Н.В.	Ингибиторы фосфодиэстераз при бесплодии
AU2005210042B2 (en)	2004-02-04	2011-04-21	Takeda Gmbh	2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
ES2251866B1 (es)	2004-06-18	2007-06-16	Laboratorios Almirall S.A.	Nuevos derivados de piridazin-3(2h)-ona.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es)	2007-06-04	2010-02-15	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
PL383550A1 (pl) *	2007-10-15	2009-04-27	Uniwersytet Łódzki	Nowe pochodne benzeno- i pirydopirydazynonów
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CA2730603C (en)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
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JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EA201592263A1 (ru)	2013-06-05	2016-05-31	Синерджи Фармасьютикалз, Инк.	Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
KR20160042039A (ko)	2013-08-09	2016-04-18	알데릭스, 인코포레이티드	인산염 수송을 억제하기 위한 화합물 및 방법
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JP6837052B2 (ja) *	2016-03-09	2021-03-03	日本曹達株式会社	ピリジン化合物およびその用途
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1992
- 1992-10-08 JP JP50707893A patent/JP3245165B2/ja not_active Expired - Fee Related
- 1992-10-08 IL IL103388A patent/IL103388A/xx not_active IP Right Cessation
- 1992-10-08 MX MX9205794A patent/MX9205794A/es not_active IP Right Cessation
- 1992-10-08 NZ NZ244660A patent/NZ244660A/en unknown
- 1992-10-08 ES ES09201998A patent/ES2105920B1/es not_active Expired - Fee Related
- 1992-10-08 CA CA002117059A patent/CA2117059C/en not_active Expired - Fee Related
- 1992-10-08 TW TW081108015A patent/TW365606B/zh active
- 1992-10-08 HU HU9400949A patent/HUT66969A/hu unknown
- 1992-10-08 DK DK92922090T patent/DK0612321T3/da active
- 1992-10-08 WO PCT/US1992/008398 patent/WO1993007146A1/en not_active Ceased
- 1992-10-08 ZA ZA927755A patent/ZA927755B/xx unknown
- 1992-10-08 ES ES92922090T patent/ES2135416T3/es not_active Expired - Lifetime
- 1992-10-08 PT PT100938A patent/PT100938B/pt not_active IP Right Cessation
- 1992-10-08 AT AT92922090T patent/ATE183745T1/de not_active IP Right Cessation
- 1992-10-08 DE DE69229874T patent/DE69229874T2/de not_active Expired - Fee Related
- 1992-10-08 EP EP92922090A patent/EP0612321B1/en not_active Expired - Lifetime
- 1992-10-08 KR KR1019940701129A patent/KR100263494B1/ko not_active Expired - Fee Related
- 1992-10-08 AU AU27815/92A patent/AU670544B2/en not_active Ceased
1994
- 1994-04-05 NO NO941210A patent/NO302888B1/no not_active IP Right Cessation
- 1994-04-06 FI FI941567A patent/FI108229B/fi active
1995
- 1995-04-24 HU HU95P/P00113P patent/HU210814A9/hu unknown
1999
- 1999-08-26 GR GR990401632T patent/GR3030969T3/el unknown

Also Published As

Publication number	Publication date
ES2105920B1 (es)	1998-07-01
NO941210L (no)	1994-04-05
IL103388A (en)	1997-09-30
KR100263494B1 (ko)	2000-08-01
WO1993007146A1 (en)	1993-04-15
DE69229874D1 (de)	1999-09-30
DE69229874T2 (de)	1999-12-09
NO941210D0 (no)	1994-04-05
HU9400949D0 (en)	1994-06-28
MX9205794A (es)	1993-04-01
HUT66969A (en)	1995-01-30
EP0612321A1 (en)	1994-08-31
CA2117059C (en)	2003-05-20
ES2135416T3 (es)	1999-11-01
JP3245165B2 (ja)	2002-01-07
PT100938B (pt)	1999-10-29
ATE183745T1 (de)	1999-09-15
TW365606B (en)	1999-08-01
AU2781592A (en)	1993-05-03
FI108229B (fi)	2001-12-14
PT100938A (pt)	1993-10-29
EP0612321B1 (en)	1999-08-25
AU670544B2 (en)	1996-07-25
FI941567L (fi)	1994-04-06
NZ244660A (en)	1995-05-26
ES2105920A1 (es)	1997-10-16
IL103388A0 (en)	1993-03-15
FI941567A0 (fi)	1994-04-06
JPH07500321A (ja)	1995-01-12
GR3030969T3 (en)	1999-11-30
NO302888B1 (no)	1998-05-04
ZA927755B (en)	1994-04-08
HU210814A9 (en)	1995-08-28
KR940702868A (ko)	1994-09-17
CA2117059A1 (en)	1993-04-15

Publication	Publication Date	Title
DE69229874D1 (de)	1999-09-30	Pyrido pyridazinon und pyridazinthionverbindungen mit pde iv inhibierender wirkung
CA2119572A1 (en)	1993-04-15	Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
FI953968A0 (fi)	1995-08-23	Antraniiliset happojohdannaiset
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
MA27626A1 (fr)	2005-11-01	Nouveaux derives de 2-pyridinecarboxamide
MXPA05003193A (es)	2005-06-08	Compuesto de adenina novedoso y uso del mismo.
RU95112848A (ru)	1997-03-20	Гетеробициклические производные сульфонамида и сульфонового эфира, способы получения, антиопухолевое средство, фармакологическая композиция, способ лечения
IE822310L (en)	1983-03-24	Triazoloquinazolone derivatives
DK0548680T3 (da)	1998-09-23	Beta-oxo-beta-benzenpropanthioamidderivater
KR940701253A (ko)	1994-05-28	면역조절제 아자스피란
TW360655B (en)	1999-06-11	Heterocyclyl-ergoline derivatives
FI89594C (fi)	1993-10-25	Foerfarande foer framstaellning av farmakologiskt vaerdefull pyrrolidinfoerening
DK0471856T3 (da)	1995-06-06	15-Deoxyprostaglandin-derivater
NO930844L (no)	1993-05-07	2-(2-substituerte pyrrolidinyltio)karbapenem-derivater
SE7713864L (sv)	1978-06-09	Nortropinkarbazatderivat och forfarande for framstellning av dem
DK0618917T3 (da)	1997-10-13	1Amino-2- (benzothiazolyl)methyl spiro isoquinolin-4(1h),3-pyrrolidin -1,2,3,5(2h)-tetroner og analoger deraf, der kan anvendes som aldosereduktaseinhibitorer.
TH19278A (th)	1996-06-21	อนุพันธ์ของ 5-อิมิโน-2-อิมิแดโซลีน ซึ่งมีฤทธิ์ฆ่าเชื้อรา
TH3055A (th)	1986-02-03	๒-ออกซ์อินโคล-๑-คาร์บอกซามิดที่ถูกแทนที่ทำแหน่ง?๓ ในฐานะสารแก้ปวดและต่อต้านการอักเสบ
TH861B (th)	1988-01-18	๒-ออกซ์อินโคล-๑-คาร์บอกซามิดที่ถูกแทนที่ทำแหน่ง?๓ ในฐานะสารแก้ปวดและต่อต้านการอักเสบ
KR970032864A (ko)	1997-07-22	골다공증 치료제