NO941210L - Benzo- og pyrido-pyridazinonforbindelser og -pyridazintionforbindelser - Google Patents
Benzo- og pyrido-pyridazinonforbindelser og -pyridazintionforbindelserInfo
- Publication number
- NO941210L NO941210L NO941210A NO941210A NO941210L NO 941210 L NO941210 L NO 941210L NO 941210 A NO941210 A NO 941210A NO 941210 A NO941210 A NO 941210A NO 941210 L NO941210 L NO 941210L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- benzo
- pyridazinethione
- pyrido
- hydrogen
- Prior art date
Links
- YQQSRZSUGBETRS-UHFFFAOYSA-N 1h-pyridazine-6-thione Chemical class SC1=CC=CN=N1 YQQSRZSUGBETRS-UHFFFAOYSA-N 0.000 title abstract 2
- KMUUDIJYIRNGRO-UHFFFAOYSA-N 2h-pyrido[3,2-c]pyridazin-3-one Chemical class N1=CC=CC2=NNC(=O)C=C21 KMUUDIJYIRNGRO-UHFFFAOYSA-N 0.000 title abstract 2
- 125000005605 benzo group Chemical group 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001266 acyl halides Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77567991A | 1991-10-09 | 1991-10-09 | |
| PCT/US1992/008398 WO1993007146A1 (en) | 1991-10-09 | 1992-10-08 | Benzo and pyrido pyridazinone and pyridazinthione compounds with pde iv inhibiting activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO941210D0 NO941210D0 (no) | 1994-04-05 |
| NO941210L true NO941210L (no) | 1994-04-05 |
| NO302888B1 NO302888B1 (no) | 1998-05-04 |
Family
ID=25105161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO941210A NO302888B1 (no) | 1991-10-09 | 1994-04-05 | Benzo- og pyrido-pyridazinonforbindelser og -pyridazintionforbindelser |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0612321B1 (no) |
| JP (1) | JP3245165B2 (no) |
| KR (1) | KR100263494B1 (no) |
| AT (1) | ATE183745T1 (no) |
| AU (1) | AU670544B2 (no) |
| CA (1) | CA2117059C (no) |
| DE (1) | DE69229874T2 (no) |
| DK (1) | DK0612321T3 (no) |
| ES (2) | ES2105920B1 (no) |
| FI (1) | FI108229B (no) |
| GR (1) | GR3030969T3 (no) |
| HU (2) | HUT66969A (no) |
| IL (1) | IL103388A (no) |
| MX (1) | MX9205794A (no) |
| NO (1) | NO302888B1 (no) |
| NZ (1) | NZ244660A (no) |
| PT (1) | PT100938B (no) |
| TW (1) | TW365606B (no) |
| WO (1) | WO1993007146A1 (no) |
| ZA (1) | ZA927755B (no) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9200689D0 (en) * | 1992-01-14 | 1992-03-11 | Rhone Poulenc Agriculture | New compositions of matter |
| GB9314412D0 (en) * | 1993-07-13 | 1993-08-25 | Rhone Poulenc Agriculture | New compositions of matter |
| US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
| WO1996006843A1 (en) * | 1994-08-29 | 1996-03-07 | Yamanouchi Pharmaceutical Co., Ltd. | Novel naphthyridine derivative and medicinal composition thereof |
| US6069151A (en) * | 1996-11-06 | 2000-05-30 | Darwin Discovery, Ltd. | Quinolines and their therapeutic use |
| GB9712761D0 (en) * | 1997-06-17 | 1997-08-20 | Chiroscience Ltd | Quinolines and their therapeutic use |
| ES2137113B1 (es) * | 1997-07-29 | 2000-09-16 | Almirall Prodesfarma Sa | Nuevos derivados de triazolo-piridazinas heterociclicos. |
| US6380196B1 (en) | 1997-12-15 | 2002-04-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihydrobenzofurans |
| EP0934933A1 (en) * | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinones |
| IT1303272B1 (it) * | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
| JP3270834B2 (ja) | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
| UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| PL200923B1 (pl) | 1999-08-21 | 2009-02-27 | Nycomed Gmbh | Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu |
| NZ527424A (en) * | 2001-02-15 | 2005-02-25 | Altana Pharma Ag | Phthalayinone-piperidino-derivatives as PDE4 inhibitors |
| BR0209076A (pt) | 2001-04-25 | 2004-08-10 | Altana Pharma Ag | Derivados de piperazino e seu uso como inibidor de pde4 |
| EP1385848A2 (en) * | 2001-04-25 | 2004-02-04 | ALTANA Pharma AG | Phtalazinones derivatives useful as pde4/7 inhibitors |
| ES2195785B1 (es) | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| HRP20050198A2 (hr) | 2002-08-10 | 2006-04-30 | Altana Pharma Ag | Piperidin-piridazoni i ftalazoni kao inhibitori pde4 |
| US20060166995A1 (en) * | 2002-08-10 | 2006-07-27 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2006522151A (ja) | 2003-04-01 | 2006-09-28 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症におけるホスホジエステラーゼ阻害剤 |
| EP1716133B1 (en) | 2004-02-04 | 2008-03-26 | Nycomed GmbH | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors |
| ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| PL383550A1 (pl) * | 2007-10-15 | 2009-04-27 | Uniwersytet Łódzki | Nowe pochodne benzeno- i pirydopirydazynonów |
| ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
| US20130116241A1 (en) * | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
| EP2968323A4 (en) | 2013-03-13 | 2016-12-14 | Flatley Discovery Lab | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| PL3004138T3 (pl) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie |
| CA2920856C (en) | 2013-08-09 | 2026-03-03 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
| EP3265453B1 (en) * | 2015-03-05 | 2022-06-29 | Boehringer Ingelheim International GmbH | New pyridinones and isoquinolinones as inhibitors of the bromodomain brd9 |
| US10781177B2 (en) | 2016-03-09 | 2020-09-22 | Nippon Soda Co., Ltd. | Pyridine compound and use thereof |
| AU2017251537B2 (en) | 2016-04-15 | 2020-10-08 | Abbvie Inc. | Bromodomain inhibitors |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
| FR3105254B1 (fr) | 2019-12-19 | 2022-08-12 | Syctom Lagence Metropolitaine Des Dechets Menagers | Installation et procédé de gazéification hydrothermale de biomasse |
| US20260152484A1 (en) * | 2021-11-09 | 2026-06-04 | Vigil Neuroscience, Inc. | Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists |
| WO2025046523A1 (ko) * | 2023-08-31 | 2025-03-06 | 삼진제약주식회사 | 신규한 피리도 피리다진온 유도체 화합물 및 이를 포함하는 약학적 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2805344B2 (ja) * | 1989-07-11 | 1998-09-30 | 昭和電工株式会社 | オレフィン重合触媒の製造方法およびオレフィンの重合方法 |
| JP3120857B2 (ja) | 1990-02-19 | 2000-12-25 | 中外製薬株式会社 | 新規な縮合複素環化合物とこれを用いた抗喘息剤 |
-
1992
- 1992-10-08 JP JP50707893A patent/JP3245165B2/ja not_active Expired - Fee Related
- 1992-10-08 PT PT100938A patent/PT100938B/pt not_active IP Right Cessation
- 1992-10-08 NZ NZ244660A patent/NZ244660A/en unknown
- 1992-10-08 EP EP92922090A patent/EP0612321B1/en not_active Expired - Lifetime
- 1992-10-08 KR KR1019940701129A patent/KR100263494B1/ko not_active Expired - Fee Related
- 1992-10-08 TW TW081108015A patent/TW365606B/zh active
- 1992-10-08 ES ES09201998A patent/ES2105920B1/es not_active Expired - Fee Related
- 1992-10-08 ES ES92922090T patent/ES2135416T3/es not_active Expired - Lifetime
- 1992-10-08 DE DE69229874T patent/DE69229874T2/de not_active Expired - Fee Related
- 1992-10-08 DK DK92922090T patent/DK0612321T3/da active
- 1992-10-08 IL IL103388A patent/IL103388A/xx not_active IP Right Cessation
- 1992-10-08 AT AT92922090T patent/ATE183745T1/de not_active IP Right Cessation
- 1992-10-08 ZA ZA927755A patent/ZA927755B/xx unknown
- 1992-10-08 HU HU9400949A patent/HUT66969A/hu unknown
- 1992-10-08 WO PCT/US1992/008398 patent/WO1993007146A1/en not_active Ceased
- 1992-10-08 CA CA002117059A patent/CA2117059C/en not_active Expired - Fee Related
- 1992-10-08 MX MX9205794A patent/MX9205794A/es not_active IP Right Cessation
- 1992-10-08 AU AU27815/92A patent/AU670544B2/en not_active Ceased
-
1994
- 1994-04-05 NO NO941210A patent/NO302888B1/no not_active IP Right Cessation
- 1994-04-06 FI FI941567A patent/FI108229B/fi active
-
1995
- 1995-04-24 HU HU95P/P00113P patent/HU210814A9/hu unknown
-
1999
- 1999-08-26 GR GR990401632T patent/GR3030969T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO302888B1 (no) | 1998-05-04 |
| HU9400949D0 (en) | 1994-06-28 |
| JPH07500321A (ja) | 1995-01-12 |
| FI108229B (fi) | 2001-12-14 |
| DE69229874D1 (de) | 1999-09-30 |
| ES2105920B1 (es) | 1998-07-01 |
| WO1993007146A1 (en) | 1993-04-15 |
| AU2781592A (en) | 1993-05-03 |
| AU670544B2 (en) | 1996-07-25 |
| ES2105920A1 (es) | 1997-10-16 |
| CA2117059A1 (en) | 1993-04-15 |
| ZA927755B (en) | 1994-04-08 |
| DK0612321T3 (da) | 1999-12-13 |
| TW365606B (en) | 1999-08-01 |
| KR100263494B1 (ko) | 2000-08-01 |
| NZ244660A (en) | 1995-05-26 |
| ATE183745T1 (de) | 1999-09-15 |
| FI941567L (fi) | 1994-04-06 |
| HU210814A9 (en) | 1995-08-28 |
| CA2117059C (en) | 2003-05-20 |
| FI941567A0 (fi) | 1994-04-06 |
| EP0612321B1 (en) | 1999-08-25 |
| ES2135416T3 (es) | 1999-11-01 |
| HUT66969A (en) | 1995-01-30 |
| PT100938A (pt) | 1993-10-29 |
| DE69229874T2 (de) | 1999-12-09 |
| IL103388A0 (en) | 1993-03-15 |
| JP3245165B2 (ja) | 2002-01-07 |
| EP0612321A1 (en) | 1994-08-31 |
| IL103388A (en) | 1997-09-30 |
| MX9205794A (es) | 1993-04-01 |
| NO941210D0 (no) | 1994-04-05 |
| KR940702868A (ko) | 1994-09-17 |
| PT100938B (pt) | 1999-10-29 |
| GR3030969T3 (en) | 1999-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI941567A0 (fi) | Bentso- ja pyridopyridatsinoni- ja -pyridatsiinitioniyhdisteet | |
| CA2119572A1 (en) | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs | |
| LU91196I2 (fr) | Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO). | |
| ECSP941146A (es) | Derivados de benzofurano | |
| FI953968A0 (fi) | Antraniiliset happojohdannaiset | |
| DE3167757D1 (en) | Dibenz(b,f)(1,4)oxazepine derivatives, process for preparing the same, and pharmaceutical compositions comprising the same | |
| ATE169295T1 (de) | 2-phenylbenzo(b>furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische präparate | |
| LV5748B4 (lv) | Mikofenolskabes morfolinoetilesteris ta iegusana un pielietojums | |
| DE69535148D1 (de) | Aminotetrazolderivate als Stickstoffmonoxid-Synthaseinhibitoren | |
| DE69215694D1 (de) | Benzamid-derivate | |
| DK0548680T3 (da) | Beta-oxo-beta-benzenpropanthioamidderivater | |
| GB2108495B (en) | Triazoloquinazolone derivatives | |
| EP1172108A4 (en) | NEW IMMUNE SUPPRESSIVA | |
| FI883484A0 (fi) | Benzimidazolderivat, deras framstaellning och anvaendning vid terapi. | |
| TW360655B (en) | Heterocyclyl-ergoline derivatives | |
| NO914577L (no) | Fremgangsmaate for fremstilling av heterocyklisk substituerte piperazinoalkylbenzoksazin- og -tiazinforbindelser | |
| EP1197211A4 (en) | CANCER PREVENTION AND TREATMENT ACTIVE INGREDIENTS | |
| DK0471856T3 (da) | 15-Deoxyprostaglandin-derivater | |
| FI871253A0 (fi) | 1-/3-(2-dialkylaminoetoxi)-2 -tienyl/-3-fenyl-1-propanoner och deras syraadditionssalter, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska sammansaettningar. | |
| NO930844L (no) | 2-(2-substituerte pyrrolidinyltio)karbapenem-derivater | |
| SE7713864L (sv) | Nortropinkarbazatderivat och forfarande for framstellning av dem | |
| TH19278A (th) | อนุพันธ์ของ 5-อิมิโน-2-อิมิแดโซลีน ซึ่งมีฤทธิ์ฆ่าเชื้อรา |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |