ATE184113T1 - System zur kontinnierlichen räumlichen abbildung für abtastmikroskopie - Google Patents

System zur kontinnierlichen räumlichen abbildung für abtastmikroskopie

Info

Publication number
ATE184113T1
ATE184113T1 AT97120924T AT97120924T ATE184113T1 AT E184113 T1 ATE184113 T1 AT E184113T1 AT 97120924 T AT97120924 T AT 97120924T AT 97120924 T AT97120924 T AT 97120924T AT E184113 T1 ATE184113 T1 AT E184113T1
Authority
AT
Austria
Prior art keywords
image
scanning microscopy
imaging system
spatial imaging
continuous spatial
Prior art date
Application number
AT97120924T
Other languages
English (en)
Inventor
Jeffrey H Price
Original Assignee
Jeffrey H Price
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jeffrey H Price filed Critical Jeffrey H Price
Application granted granted Critical
Publication of ATE184113T1 publication Critical patent/ATE184113T1/de

Links

Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/24Base structure
    • G02B21/241Devices for focusing
    • G02B21/244Devices for focusing using image analysis techniques
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microscoopes, Condenser (AREA)
  • Automatic Focus Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Eye Examination Apparatus (AREA)
  • Closed-Circuit Television Systems (AREA)
  • Image Processing (AREA)
  • Focusing (AREA)
AT97120924T 1994-07-01 1995-06-30 System zur kontinnierlichen räumlichen abbildung für abtastmikroskopie ATE184113T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27001794A 1994-07-01 1994-07-01

Publications (1)

Publication Number Publication Date
ATE184113T1 true ATE184113T1 (de) 1999-09-15

Family

ID=23029550

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95925491T ATE177539T1 (de) 1994-07-01 1995-06-30 Autofokussystem für abtastmikroskopie
AT97120924T ATE184113T1 (de) 1994-07-01 1995-06-30 System zur kontinnierlichen räumlichen abbildung für abtastmikroskopie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT95925491T ATE177539T1 (de) 1994-07-01 1995-06-30 Autofokussystem für abtastmikroskopie

Country Status (11)

Country Link
EP (2) EP0834758B1 (de)
JP (1) JPH10502466A (de)
AT (2) ATE177539T1 (de)
AU (1) AU2960395A (de)
CA (1) CA2192986C (de)
DE (2) DE69511903T2 (de)
DK (2) DK0834758T3 (de)
ES (2) ES2131838T3 (de)
GR (1) GR3031737T3 (de)
MX (1) MX9606683A (de)
WO (1) WO1996001438A1 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6341180B1 (en) 1997-12-18 2002-01-22 Cellavision Ab Image content autofocus for microscopy using a noise-insensitive focus filter
US6640014B1 (en) * 1999-01-22 2003-10-28 Jeffrey H. Price Automatic on-the-fly focusing for continuous image acquisition in high-resolution microscopy
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
DE60005007T2 (de) * 1999-06-04 2004-07-08 Janssen Pharmaceutica N.V. Robustes autofokussystem für mikroskop
WO2001011407A2 (en) * 1999-08-10 2001-02-15 Cellavision Ab A method and device for autofocusing
US6583865B2 (en) * 2000-08-25 2003-06-24 Amnis Corporation Alternative detector configuration and mode of operation of a time delay integration particle analyzer
EP1344181B1 (de) 2000-10-24 2013-12-11 Intrexon Corporation Verfahren und einrichtung zum selektiven abzielen auf zellen in einer dreidimensionalen probe
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
DE60212343T2 (de) 2001-02-02 2007-06-14 Cellomics, Inc. Verfahren zur schätzung der besten anfangsfokussierung
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
DE10115309A1 (de) * 2001-03-28 2002-10-02 Gnothis Holding Sa Ecublens Mikroskopanordnung zur Fluoreszenzspektorskopie, insbesondere Fluoreszenzkorrelationsspektroskopie
WO2003023482A1 (de) * 2001-09-11 2003-03-20 Leica Microsystems Wetzlar Gmbh Verfahren und vorrichtung zur optischen untersuchung eines objektes
DE10234404B4 (de) 2002-07-29 2021-10-14 Leica Microsystems Cms Gmbh Verfahren, Anordnung und Software zur Überwachung und Kontrolle eines Mikroskops
DE10319182B4 (de) * 2003-04-29 2008-06-12 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur Bestimmung der Fokusposition bei der Abbildung einer Probe
DE10362244B4 (de) * 2003-04-29 2014-06-26 Carl Zeiss Microscopy Gmbh Verfahren zur Bestimmung der Fokusposition und der Verkippung der Fokusebene bei der Abbildung einer Probe
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
GB2423988A (en) 2003-07-18 2006-09-13 Cytokinetics Inc Characterizing biological stimuli by response curves
US7232221B2 (en) 2004-02-24 2007-06-19 Searete, Llc Volumetric imaging using “virtual” lenslets
US8169534B2 (en) 2004-02-24 2012-05-01 The Invention Science Fund I, Llc Volumetric imaging using “virtual” lenslets
WO2005119325A2 (en) * 2004-05-27 2005-12-15 Aperio Technologies, Inc. System and method for assessing virtual slide image quality
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
US7417213B2 (en) 2005-06-22 2008-08-26 Tripath Imaging, Inc. Apparatus and method for rapid microscopic image focusing having a movable objective
US20070031056A1 (en) 2005-08-02 2007-02-08 Perz Cynthia B System for and method of focusing in automated microscope systems
EP2023127B1 (de) 2006-05-31 2017-12-20 Olympus Corporation Verfahren und vorrichtung zur abbildung einer biologischen probe
DE102006055987B4 (de) * 2006-11-24 2011-06-01 Pentacon Gmbh Foto- Und Feinwerktechnik Verfahren zur Fokussierung optischer Bilderfassungseinrichtungen
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
WO2008097455A1 (en) 2007-02-05 2008-08-14 Intelligent Bio-Systems, Inc. Detection device and methods of use
US20090185734A1 (en) * 2008-01-18 2009-07-23 Hemocue Ab Apparatus and method for analysis of particles in a liquid sample
DE102008015885A1 (de) * 2008-03-26 2009-10-01 Synentec Gmbh Vorrichtung und Verfahren zur Autofokussierung von optischen Geräten, insbesondere von Mikroskopen
DE102009045107A1 (de) 2009-09-29 2011-03-31 Carl Zeiss Imaging Solutions Gmbh Automatisches Fokussierverfahren für ein optisches Instrument zum vergrößerten Betrachten eines Objektes
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
JP5938401B2 (ja) * 2010-06-24 2016-06-22 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. 差分測定に基づき顕微鏡検査をスキャンするためのオートフォーカス
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
DE102011007751B4 (de) * 2011-04-20 2023-10-19 Carl Zeiss Microscopy Gmbh Weitfeldmikroskop und Verfahren zur Weitfeldmikroskopie
CA2837226A1 (en) * 2011-05-25 2012-11-29 Huron Technologies International Inc. 3d pathology slide scanner
BR112014016072B1 (pt) 2011-12-29 2021-01-12 Sight Diagnostics Ltd. método e sistema para detectar uma infecção por plasmodium em uma amostra de sangue
EP2999988A4 (de) 2013-05-23 2017-01-11 S.D. Sight Diagnostics Ltd. Verfahren und system zur bildgebung einer zellprobe
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for preparing a monolayer of cells, particularly suitable for diagnosis
EP3039477B1 (de) 2013-08-26 2021-10-20 S.D. Sight Diagnostics Ltd. Digitale mikroskopiesysteme, verfahren und computerprogrammprodukte
DE102014104430B4 (de) 2014-03-28 2015-10-29 Jenoptik Optical Systems Gmbh Objektiv mit axialem Verstellglied zur aktiven Verstellung von Objektivelementen
JP6219214B2 (ja) * 2014-03-31 2017-10-25 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
EP3186778B1 (de) 2014-08-27 2023-01-11 S.D. Sight Diagnostics Ltd. System und verfahren zur berechnung der fokusvariation für ein digitales mikroskop
CN108474934B (zh) 2015-09-17 2022-01-18 思迪赛特诊断有限公司 用于检测身体样本中实体的方法和设备
US9939623B2 (en) * 2015-10-19 2018-04-10 Molecular Devices, Llc Microscope system with transillumination-based autofocusing for photoluminescence imaging
JP6578928B2 (ja) * 2015-12-16 2019-09-25 コニカミノルタ株式会社 蛍光画像の合焦位置特定システム、合焦位置特定方法および合焦位置特定プログラム
EP3436864B1 (de) 2016-03-30 2021-04-28 S.D. Sight Diagnostics Ltd. Bildverarbeitungsgerät zur blutparasiten identifikation
CN109564209B (zh) 2016-05-11 2022-05-31 思迪赛特诊断有限公司 对样品实施的光学测量
EP3455610B1 (de) 2016-05-11 2023-01-04 S.D. Sight Diagnostics Ltd. Probenträger für optische messungen
KR102662878B1 (ko) * 2016-11-25 2024-05-07 텔레다인 달사 비.브이. 복수의 엑스선 영상들로부터 2d 영상을 재구성하기 위한 방법
EP3351992B1 (de) * 2017-01-24 2019-10-23 Horiba France SAS Mikrospektrometriemessverfahren und -system
EP3396430B1 (de) 2017-04-27 2023-08-16 Euroimmun Medizinische Labordiagnostika AG Optische abtastanordnung und verfahren
EP3710810B1 (de) 2017-11-14 2023-09-06 S.D. Sight Diagnostics Ltd. Probenträger für optische messungen
JP6945737B2 (ja) * 2017-11-28 2021-10-06 ライカ バイオシステムズ イメージング インコーポレイテッドLeica Biosystems Imaging, Inc. デュアルプロセッサ画像処理
GB201907953D0 (en) 2019-06-04 2019-07-17 Smi Drug Discovery Ltd An optical microscope
BR112022007712A2 (pt) 2019-10-22 2022-07-12 S D Sight Diagnostics Ltd Contabilização de erros em medições ópticas
MX2022007123A (es) 2019-12-12 2022-07-11 S D Sight Diagnostics Ltd Analisis de un analito dispuesto dentro de un medio.
BR112022011354A2 (pt) 2019-12-12 2022-08-23 S D Sight Diagnostics Ltd Geração artificial de uma imagem colorida de esfregaço sanguíneo
MX2022007119A (es) 2019-12-12 2022-07-11 S D Sight Diagnostics Ltd Deteccion de plaquetas en una muestra de sangre.
WO2022032126A1 (en) 2020-08-07 2022-02-10 Nanotronics Imaging, Inc. Deep learning model for auto-focusing microscope systems
GB2600996A (en) 2020-11-17 2022-05-18 Ffei Ltd Image scanning apparatus and method
US20250245814A1 (en) * 2024-01-29 2025-07-31 Brightest Technology Taiwan Co., Ltd. Inspection apparatus and operation method of the same
CN120195855B (zh) * 2025-03-25 2026-02-06 华南师范大学 一种自适应聚焦显微镜设备

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51112114A (en) * 1975-03-27 1976-10-04 Matsushita Electric Ind Co Ltd Record reproduction method
DE2615841C3 (de) * 1976-04-10 1978-10-19 Fa. Carl Zeiss, 7920 Heidenheim Verfahren zum automatischen Nachführen der Scharfeinstellung eines mit einer Fernsehkamera ausgerüsteten Mikroskops
US4342905A (en) * 1979-08-31 1982-08-03 Nippon Kogaku K.K. Automatic focusing device of a microscope
JPS5635111A (en) * 1979-08-31 1981-04-07 Nippon Kogaku Kk <Nikon> Focus detector of phase contrast microscope
DE3584314D1 (de) * 1984-04-16 1991-11-14 Image Recognition Systems Ltd Automatische fokussiereinrichtung.
JPS61112114A (ja) * 1984-11-06 1986-05-30 Mitsubishi Rayon Co Ltd 自動焦点調節方法
JPS63127148A (ja) * 1986-11-17 1988-05-31 Kanzaki Paper Mfg Co Ltd 表面検査装置
JPS6454408A (en) * 1987-08-25 1989-03-01 Hitachi Ltd Automatic focusing method
JPH0237313A (ja) * 1988-07-27 1990-02-07 Hitachi Ltd 自動焦点位置検出方法
DE3828381C2 (de) * 1988-08-20 1997-09-11 Zeiss Carl Fa Verfahren und Einrichtung zur automatischen Fokussierung eines optischen Systems
JPH02276363A (ja) * 1989-04-18 1990-11-13 Canon Inc 画像読取装置
US5239178A (en) 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
JP3267984B2 (ja) * 1991-04-17 2002-03-25 株式会社三協精機製作所 自動合焦装置及び自動合焦装置における合焦調整方法
US5239170A (en) * 1991-10-23 1993-08-24 Karl Suss America, Incorporated Autofocus method and apparatus for imaging microscopy using a predetermined visual imaging feature
JPH05210042A (ja) * 1992-01-23 1993-08-20 Asahi Optical Co Ltd 自動焦点調節装置
DE4226523B4 (de) * 1992-08-11 2005-01-05 Universität Stuttgart Verfahren und Vorrichtung zum automatischen Fokussieren auf Objekte
DE19502472A1 (de) * 1995-01-27 1996-08-01 Fraunhofer Ges Forschung Verfahren und Vorrichtung zum Aufnehmen eines Objektes

Also Published As

Publication number Publication date
ATE177539T1 (de) 1999-03-15
DE69511903D1 (de) 1999-10-07
CA2192986A1 (en) 1996-01-18
EP0834758B1 (de) 1999-09-01
DK0769159T3 (da) 1999-09-27
MX9606683A (es) 1997-12-31
EP0769159A1 (de) 1997-04-23
CA2192986C (en) 2002-01-22
EP0834758A2 (de) 1998-04-08
DE69511903T2 (de) 2000-04-20
DE69508248T2 (de) 1999-11-04
WO1996001438A1 (en) 1996-01-18
JPH10502466A (ja) 1998-03-03
ES2131838T3 (es) 1999-08-01
DK0834758T3 (da) 1999-12-13
AU2960395A (en) 1996-01-25
GR3031737T3 (en) 2000-02-29
ES2140178T3 (es) 2000-02-16
EP0834758A3 (de) 1998-05-06
EP0769159B1 (de) 1999-03-10
DE69508248D1 (de) 1999-04-15

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