ES2140178T3 - Sistema de composicion de imagenes de volumen continuo para microscopia explorativa. - Google Patents

Sistema de composicion de imagenes de volumen continuo para microscopia explorativa.

Info

Publication number
ES2140178T3
ES2140178T3 ES97120924T ES97120924T ES2140178T3 ES 2140178 T3 ES2140178 T3 ES 2140178T3 ES 97120924 T ES97120924 T ES 97120924T ES 97120924 T ES97120924 T ES 97120924T ES 2140178 T3 ES2140178 T3 ES 2140178T3
Authority
ES
Spain
Prior art keywords
image
microscopy
explorative
volume image
image composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97120924T
Other languages
English (en)
Inventor
Jeffrey H Price
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2140178T3 publication Critical patent/ES2140178T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/244—Devices for focusing using image analysis techniques
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microscoopes, Condenser (AREA)
  • Automatic Focus Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Eye Examination Apparatus (AREA)
  • Image Processing (AREA)
  • Focusing (AREA)
  • Closed-Circuit Television Systems (AREA)

Abstract

SE ESTABLECE UN APARATO PARA GENERAR UNA IMAGEN DE VOLUMEN, PARA SU INCORPORACION A UN SISTEMA DE AUTOENFOQUE PARA MICROSCOPIA DE EXPLORACION, QUE INCLUYE VARIOS DISPOSITIVOS DE FORMACION DE IMAGEN (436, 481) QUE SE ACOPLAN A UN APARATO DE FORMACION DE IMAGEN (437, 440, 481) Y SE UTILIZAN PARA FORMAR VARIAS REPRESENTACIONES DE IMAGENES ELECTRONICAS. EL ALMACENAMIENTO (443) Y PROCESAMIENTO (442) DE SUCESIVOS CONJUNTOS DE REPRESENTACIONES DE IMAGENES ELECTRONICAS, DONDE LOS CONJUNTOS DE REPRESENTACIONES DE IMAGENES ELECTRONICAS REPRESENTAN IMAGENES EN PLANOS DE IMAGEN RESPECTIVOS DE LOS CONJUNTOS DE PLANOS DE IMAGEN, PERMITE ADQUIRIR UNA IMAGEN DE VOLUMEN.
ES97120924T 1994-07-01 1995-06-30 Sistema de composicion de imagenes de volumen continuo para microscopia explorativa. Expired - Lifetime ES2140178T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27001794A 1994-07-01 1994-07-01

Publications (1)

Publication Number Publication Date
ES2140178T3 true ES2140178T3 (es) 2000-02-16

Family

ID=23029550

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95925491T Expired - Lifetime ES2131838T3 (es) 1994-07-01 1995-06-30 Sistema de autofoco para microscopia de exploracion.
ES97120924T Expired - Lifetime ES2140178T3 (es) 1994-07-01 1995-06-30 Sistema de composicion de imagenes de volumen continuo para microscopia explorativa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES95925491T Expired - Lifetime ES2131838T3 (es) 1994-07-01 1995-06-30 Sistema de autofoco para microscopia de exploracion.

Country Status (11)

Country Link
EP (2) EP0834758B1 (es)
JP (1) JPH10502466A (es)
AT (2) ATE184113T1 (es)
AU (1) AU2960395A (es)
CA (1) CA2192986C (es)
DE (2) DE69511903T2 (es)
DK (2) DK0769159T3 (es)
ES (2) ES2131838T3 (es)
GR (1) GR3031737T3 (es)
MX (1) MX9606683A (es)
WO (1) WO1996001438A1 (es)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268611B1 (en) 1997-12-18 2001-07-31 Cellavision Ab Feature-free registration of dissimilar images using a robust similarity metric
US6640014B1 (en) 1999-01-22 2003-10-28 Jeffrey H. Price Automatic on-the-fly focusing for continuous image acquisition in high-resolution microscopy
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
DK1190271T3 (da) * 1999-06-04 2003-12-22 Janssen Pharmaceutica Nv Robust autofokussystem til mikroskop
AU6603100A (en) * 1999-08-10 2001-03-05 Cellavision Ab Methods and devices in an optical system
US6583865B2 (en) * 2000-08-25 2003-06-24 Amnis Corporation Alternative detector configuration and mode of operation of a time delay integration particle analyzer
EP2363828A1 (en) 2000-10-24 2011-09-07 Cyntellect, Inc. Device for selectively targeting cells within a three-dimensional specimen
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
WO2002063367A1 (en) 2001-02-02 2002-08-15 Cellomics, Inc. Method for estimating the best initial focus position
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
DE10115309A1 (de) * 2001-03-28 2002-10-02 Gnothis Holding Sa Ecublens Mikroskopanordnung zur Fluoreszenzspektorskopie, insbesondere Fluoreszenzkorrelationsspektroskopie
JP2005502907A (ja) * 2001-09-11 2005-01-27 ライカ ミクロジュステムス ヴェツラー ゲーエムベーハー 対象物の光学的検査をするための方法および装置
DE10234404B4 (de) 2002-07-29 2021-10-14 Leica Microsystems Cms Gmbh Verfahren, Anordnung und Software zur Überwachung und Kontrolle eines Mikroskops
DE10319182B4 (de) * 2003-04-29 2008-06-12 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur Bestimmung der Fokusposition bei der Abbildung einer Probe
DE10362244B4 (de) * 2003-04-29 2014-06-26 Carl Zeiss Microscopy Gmbh Verfahren zur Bestimmung der Fokusposition und der Verkippung der Fokusebene bei der Abbildung einer Probe
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
EP1646926A2 (en) 2003-07-18 2006-04-19 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7232221B2 (en) 2004-02-24 2007-06-19 Searete, Llc Volumetric imaging using “virtual” lenslets
US8169534B2 (en) 2004-02-24 2012-05-01 The Invention Science Fund I, Llc Volumetric imaging using “virtual” lenslets
JP4891232B2 (ja) * 2004-05-27 2012-03-07 アペリオ・テクノロジーズ・インコーポレイテッド 仮想スライドの画質を評価するシステム及び方法
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
US7417213B2 (en) 2005-06-22 2008-08-26 Tripath Imaging, Inc. Apparatus and method for rapid microscopic image focusing having a movable objective
US20070031056A1 (en) 2005-08-02 2007-02-08 Perz Cynthia B System for and method of focusing in automated microscope systems
CN101438147B (zh) 2006-05-31 2011-09-28 奥林巴斯株式会社 生物试样摄像方法及生物试样摄像装置
DE102006055987B4 (de) * 2006-11-24 2011-06-01 Pentacon Gmbh Foto- Und Feinwerktechnik Verfahren zur Fokussierung optischer Bilderfassungseinrichtungen
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
DE112008000363B4 (de) 2007-02-05 2021-12-02 Qiagen Sciences, LLC (n.d.Ges.d. Staates Delaware) Vorrichtung zur Detektion und ihre Verwendung
US20090185734A1 (en) * 2008-01-18 2009-07-23 Hemocue Ab Apparatus and method for analysis of particles in a liquid sample
DE102008015885A1 (de) * 2008-03-26 2009-10-01 Synentec Gmbh Vorrichtung und Verfahren zur Autofokussierung von optischen Geräten, insbesondere von Mikroskopen
DE102009045107A1 (de) * 2009-09-29 2011-03-31 Carl Zeiss Imaging Solutions Gmbh Automatisches Fokussierverfahren für ein optisches Instrument zum vergrößerten Betrachten eines Objektes
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
JP5938401B2 (ja) 2010-06-24 2016-06-22 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 差分測定に基づき顕微鏡検査をスキャンするためのオートフォーカス
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
DE102011007751B4 (de) 2011-04-20 2023-10-19 Carl Zeiss Microscopy Gmbh Weitfeldmikroskop und Verfahren zur Weitfeldmikroskopie
US20140125776A1 (en) * 2011-05-25 2014-05-08 Huron Technologies International Inc, 3d pathology slide scanner
US10640807B2 (en) 2011-12-29 2020-05-05 S.D. Sight Diagnostics Ltd Methods and systems for detecting a pathogen in a biological sample
EP2999988A4 (en) * 2013-05-23 2017-01-11 S.D. Sight Diagnostics Ltd. Method and system for imaging a cell sample
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for preparing a monolayer of cells, particularly suitable for diagnosis
WO2015029032A1 (en) * 2013-08-26 2015-03-05 Parasight Ltd. Digital microscopy systems, methods and computer program products
DE102014104430B4 (de) 2014-03-28 2015-10-29 Jenoptik Optical Systems Gmbh Objektiv mit axialem Verstellglied zur aktiven Verstellung von Objektivelementen
JP6219214B2 (ja) 2014-03-31 2017-10-25 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
US10482595B2 (en) 2014-08-27 2019-11-19 S.D. Sight Diagnostics Ltd. System and method for calculating focus variation for a digital microscope
US10488644B2 (en) 2015-09-17 2019-11-26 S.D. Sight Diagnostics Ltd. Methods and apparatus for detecting an entity in a bodily sample
US9939623B2 (en) * 2015-10-19 2018-04-10 Molecular Devices, Llc Microscope system with transillumination-based autofocusing for photoluminescence imaging
JP6578928B2 (ja) * 2015-12-16 2019-09-25 コニカミノルタ株式会社 蛍光画像の合焦位置特定システム、合焦位置特定方法および合焦位置特定プログラム
CA3018536A1 (en) 2016-03-30 2017-10-05 S.D. Sight Diagnostics Ltd Distinguishing between blood sample components
EP3455626B1 (en) 2016-05-11 2025-08-06 S.D. Sight Diagnostics Ltd. Performing optical measurements on a sample
WO2017195205A1 (en) 2016-05-11 2017-11-16 S.D. Sight Diagnostics Ltd Sample carrier for optical measurements
EP3545498B1 (en) * 2016-11-25 2024-08-28 Teledyne Dalsa B.V. Method for reconstructing a 2d image from a plurality of x-ray images
EP3351992B1 (en) * 2017-01-24 2019-10-23 Horiba France SAS Micro-spectrometry measurement method and system
EP3396430B1 (en) 2017-04-27 2023-08-16 Euroimmun Medizinische Labordiagnostika AG Optical scanning arrangement and method
CN111788471B (zh) 2017-11-14 2023-12-12 思迪赛特诊断有限公司 用于光学测量的样品载体
US11422349B2 (en) * 2017-11-28 2022-08-23 Leica Biosystems Imaging, Inc. Dual processor image processing
GB201907953D0 (en) 2019-06-04 2019-07-17 Smi Drug Discovery Ltd An optical microscope
AU2020370212B2 (en) 2019-10-22 2025-09-25 S.D. Sight Diagnostics Ltd Accounting for errors in optical measurements
CN114787625B (zh) 2019-12-12 2026-01-13 思迪赛特诊断有限公司 检测血液样品中的血小板
JP7677972B2 (ja) 2019-12-12 2025-05-15 エス．ディー．サイト ダイアグノスティックス リミテッド カラー血液スミア画像の人工的な生成
BR112022011312A2 (pt) 2019-12-12 2022-08-23 S D Sight Diagnostics Ltd Análise de um analito disposto dentro de um meio
US12301990B2 (en) 2020-08-07 2025-05-13 Nanotronics Imaging, Inc. Deep learning model for auto-focusing microscope systems
GB2600996A (en) 2020-11-17 2022-05-18 Ffei Ltd Image scanning apparatus and method
US20250245814A1 (en) * 2024-01-29 2025-07-31 Brightest Technology Taiwan Co., Ltd. Inspection apparatus and operation method of the same
CN120195855B (zh) * 2025-03-25 2026-02-06 华南师范大学 一种自适应聚焦显微镜设备

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51112114A (en) * 1975-03-27 1976-10-04 Matsushita Electric Ind Co Ltd Record reproduction method
DE2615841C3 (de) * 1976-04-10 1978-10-19 Fa. Carl Zeiss, 7920 Heidenheim Verfahren zum automatischen Nachführen der Scharfeinstellung eines mit einer Fernsehkamera ausgerüsteten Mikroskops
JPS5635111A (en) * 1979-08-31 1981-04-07 Nippon Kogaku Kk <Nikon> Focus detector of phase contrast microscope
US4342905A (en) * 1979-08-31 1982-08-03 Nippon Kogaku K.K. Automatic focusing device of a microscope
EP0163394B1 (en) * 1984-04-16 1991-10-09 Image Recognition Systems, Ltd. An automatic focussing device
JPS61112114A (ja) * 1984-11-06 1986-05-30 Mitsubishi Rayon Co Ltd 自動焦点調節方法
JPS63127148A (ja) * 1986-11-17 1988-05-31 Kanzaki Paper Mfg Co Ltd 表面検査装置
JPS6454408A (en) * 1987-08-25 1989-03-01 Hitachi Ltd Automatic focusing method
JPH0237313A (ja) * 1988-07-27 1990-02-07 Hitachi Ltd 自動焦点位置検出方法
DE3828381C2 (de) * 1988-08-20 1997-09-11 Zeiss Carl Fa Verfahren und Einrichtung zur automatischen Fokussierung eines optischen Systems
JPH02276363A (ja) * 1989-04-18 1990-11-13 Canon Inc 画像読取装置
US5239178A (en) 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
JP3267984B2 (ja) * 1991-04-17 2002-03-25 株式会社三協精機製作所 自動合焦装置及び自動合焦装置における合焦調整方法
US5239170A (en) * 1991-10-23 1993-08-24 Karl Suss America, Incorporated Autofocus method and apparatus for imaging microscopy using a predetermined visual imaging feature
JPH05210042A (ja) * 1992-01-23 1993-08-20 Asahi Optical Co Ltd 自動焦点調節装置
DE4226523B4 (de) * 1992-08-11 2005-01-05 Universität Stuttgart Verfahren und Vorrichtung zum automatischen Fokussieren auf Objekte
DE19502472A1 (de) * 1995-01-27 1996-08-01 Fraunhofer Ges Forschung Verfahren und Vorrichtung zum Aufnehmen eines Objektes

Also Published As

Publication number Publication date
EP0834758A2 (en) 1998-04-08
DE69511903D1 (de) 1999-10-07
CA2192986A1 (en) 1996-01-18
MX9606683A (es) 1997-12-31
EP0834758A3 (en) 1998-05-06
DK0834758T3 (da) 1999-12-13
DE69511903T2 (de) 2000-04-20
DE69508248T2 (de) 1999-11-04
ES2131838T3 (es) 1999-08-01
EP0769159A1 (en) 1997-04-23
EP0769159B1 (en) 1999-03-10
CA2192986C (en) 2002-01-22
DK0769159T3 (da) 1999-09-27
JPH10502466A (ja) 1998-03-03
EP0834758B1 (en) 1999-09-01
ATE184113T1 (de) 1999-09-15
GR3031737T3 (en) 2000-02-29
AU2960395A (en) 1996-01-25
DE69508248D1 (de) 1999-04-15
ATE177539T1 (de) 1999-03-15
WO1996001438A1 (en) 1996-01-18

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