ATE187717T1 - Pyrimidozykloalkanen als angiotensin ii antagonisten. - Google Patents

Pyrimidozykloalkanen als angiotensin ii antagonisten.

Info

Publication number: ATE187717T1
Authority: AT; Austria
Prior art keywords: alkyl; aralkyl; perfluoroalkyl; alkoxyalkyl; nconr12r13
Prior art date: 1991-10-24

Application number

AT92925019T

Other languages

English (en)

Inventor

John Laurent Primeau

Lloyd Michael Garrick

Timothy Donald Ocain

Richard Michael Soll

Paul Jeffrey Dollings

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-24

Filing date

1992-10-23

Publication date

2000-01-15

1992-10-23 Application filed by American Home Prod filed Critical American Home Prod

2000-01-15 Application granted granted Critical

2000-01-15 Publication of ATE187717T1 publication Critical patent/ATE187717T1/de

Links

229940123413 Angiotensin II antagonist Drugs 0.000 title 1
239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 10
125000003710 aryl alkyl group Chemical group 0.000 abstract 9
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 7
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 7
-1 alkyl-OH Chemical group 0.000 abstract 6
229910052731 fluorine Inorganic materials 0.000 abstract 5
229910052794 bromium Inorganic materials 0.000 abstract 4
229910052801 chlorine Inorganic materials 0.000 abstract 4
239000000460 chlorine Substances 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
229910052740 iodine Inorganic materials 0.000 abstract 2
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
210000002381 plasma Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT92925019T 1991-10-24 1992-10-23 Pyrimidozykloalkanen als angiotensin ii antagonisten. ATE187717T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/782,017 US5234936A (en)	1991-10-24	1991-10-24	Pyrimidocycloalkanes as a ii antagonists
PCT/US1992/008992 WO1993008171A1 (en)	1991-10-24	1992-10-23	Pyrimidocycloalkanes as angiotensin ii antagonists

Publications (1)

Publication Number	Publication Date
ATE187717T1 true ATE187717T1 (de)	2000-01-15

Family

ID=25124678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92925019T ATE187717T1 (de)	1991-10-24	1992-10-23	Pyrimidozykloalkanen als angiotensin ii antagonisten.

Country Status (9)

Country	Link
US (1)	US5234936A (de)
EP (1)	EP0610439B1 (de)
JP (1)	JPH07500345A (de)
AT (1)	ATE187717T1 (de)
AU (1)	AU3122893A (de)
CA (1)	CA2121814A1 (de)
DE (1)	DE69230442D1 (de)
PT (1)	PT100992B (de)
WO (1)	WO1993008171A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5283242A (en) *	1991-10-24	1994-02-01	American Home Products Corporation	Substituted benzimidazoles and quinazolines as antihypertensives
US5409926A (en) *	1993-07-19	1995-04-25	Merck & Co., Inc.	AT-2 antagonist inhibition of vascular restenosis
WO1997047601A1 (en) *	1996-06-11	1997-12-18	Yoshitomi Pharmaceutical Industries, Ltd.	Fused heterocyclic compounds and medicinal uses thereof
WO1999012534A1 (en) *	1997-09-10	1999-03-18	Ono Pharmaceutical Co., Ltd.	Peroxisome proliferator-activated receptor controllers
DE19939980A1 (de) *	1999-08-24	2001-03-01	Merck Patent Gmbh	Inhibitoren des Integrins alphavbeta¶3¶
US6605615B2 (en)	2000-03-01	2003-08-12	Tularik Inc.	Hydrazones and analogs as cholesterol lowering agents
ES2293317T3 (es) *	2003-08-12	2008-03-16	F. Hoffmann-La Roche Ag	Derivados de tetrahidroquinazolina com antagonistas de cfr.
US20070238740A1 (en) *	2003-08-28	2007-10-11	Nitromed, Inc.	Nitrosated And Nitrosylated Cardiovascular Compounds, Compositions And Methods Of Use
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101397277B (zh) *	2008-01-10	2012-04-18	联化科技股份有限公司	一种氨甲基联苯四氮唑及其盐的合成方法、及其中间体及中间体的合成方法
ES2522968T3 (es)	2008-06-04	2014-11-19	Synergy Pharmaceuticals Inc.	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
BR112015030326A2 (pt)	2013-06-05	2017-08-29	Synergy Pharmaceuticals Inc	Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
CA2946990A1 (en)	2014-04-28	2015-11-05	Pfizer Inc.	Heterocyclic compounds and their use as dopamine d1 ligands
KR102801643B1 (ko) *	2016-09-30	2025-04-30	(주)스파크바이오파마	신규한 피리미딘 유도체 화합물 또는 이의 약제학적으로 허용 가능한 염, 그 제조방법 및 이를 이용한 약학적 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5538325A (en) *	1978-09-11	1980-03-17	Sankyo Co Ltd	4-anilinoquinazoline derivative and its preparation
JPS57203072A (en) *	1981-06-05	1982-12-13	Sankyo Co Ltd	4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient
JPS6270A (ja) *	1985-03-07	1987-01-06	Sankyo Co Ltd	シクロペンタ〔ｄ〕ピリミジン誘導体
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
US5064825A (en) *	1989-06-01	1991-11-12	Merck & Co., Inc.	Angiotensin ii antagonists
CA2020073A1 (en) *	1989-07-03	1991-01-04	Eric E. Allen	Substituted quinazolinones as angiotensin ii antagonists
EP0412848B1 (de) *	1989-08-11	1995-01-18	Zeneca Limited	Chinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US5100897A (en) *	1989-08-28	1992-03-31	Merck & Co., Inc.	Substituted pyrimidinones as angiotensin ii antagonists
EP0424317A3 (en) *	1989-10-19	1991-09-25	Ciba-Geigy Ag	Pyrimidines

1991
- 1991-10-24 US US07/782,017 patent/US5234936A/en not_active Expired - Lifetime
1992
- 1992-10-22 PT PT100992A patent/PT100992B/pt not_active IP Right Cessation
- 1992-10-23 AT AT92925019T patent/ATE187717T1/de not_active IP Right Cessation
- 1992-10-23 EP EP92925019A patent/EP0610439B1/de not_active Expired - Lifetime
- 1992-10-23 DE DE69230442T patent/DE69230442D1/de not_active Expired - Lifetime
- 1992-10-23 AU AU31228/93A patent/AU3122893A/en not_active Abandoned
- 1992-10-23 JP JP5507899A patent/JPH07500345A/ja active Pending
- 1992-10-23 CA CA002121814A patent/CA2121814A1/en not_active Abandoned
- 1992-10-23 WO PCT/US1992/008992 patent/WO1993008171A1/en not_active Ceased

Also Published As

Publication number	Publication date
JPH07500345A (ja)	1995-01-12
AU3122893A (en)	1993-05-21
DE69230442D1 (de)	2000-01-20
PT100992B (pt)	1999-07-30
US5234936A (en)	1993-08-10
CA2121814A1 (en)	1993-04-29
EP0610439B1 (de)	1999-12-15
EP0610439A1 (de)	1994-08-17
PT100992A (pt)	1994-02-28
WO1993008171A1 (en)	1993-04-29

Legal Events

Date	Code	Title	Description
2000-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE187717T1 (de)	2000-01-15	Pyrimidozykloalkanen als angiotensin ii antagonisten.
NZ336302A (en)	2000-08-25	Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia
DE60220890D1 (de)	2007-08-09	Benzoäfüisoindolderivate mit affinität zum ep4-rezeptor
NO954161L (no)	1995-12-05	10,11-metandibenzosuberanderivater for anvendelse som kjemosensibiliserende midler
YU85001A (sh)	2004-09-03	Derivati 5-fenil-pirimidina
CO5611127A2 (es)	2006-02-28	Derivados de indolilmaleimida
EA200100755A1 (ru)	2001-12-24	4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
ATE172460T1 (de)	1998-11-15	3-benzoylbenzofuran-derivate als thyroidhormonantagonisten
DE3268225D1 (de)	1986-02-13	9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
ATE159524T1 (de)	1997-11-15	Substituierte indole als angiotensin ii antagonisten
ATE24494T1 (de)	1987-01-15	Substituierte phenylaether.
AR045824A1 (es)	2005-11-16	Derivados de 4 aminoquinolina 3 carboxamida como inhibidores de pde4
PE20020599A1 (es)	2002-08-10	Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d
ES2190809T3 (es)	2003-08-16	Compuestos de quinolina y quinazolina utiles en terapia.
YU84901A (sh)	2004-09-03	Derivati 4-fenil-pirimidina
AR036204A1 (es)	2004-08-18	Proceso para la produccion de quinazolinas y compuestos utiles en dicho proceso
CO5251424A1 (es)	2003-02-28	Oxazinquinolonas utiles en el tratamiento de infecciones virales
DE59206593D1 (de)	1996-07-25	Verwendung von 2-Iminothiazolidin-4-onderivaten als neuartige Arzneimittelwirkstoffe
FI955386A0 (fi)	1995-11-08	4-p-fluoribentsoyyli-1-piperidinyyli-propoksi-kromen-4-onijohdannaiset, niiden valmistus ja käyttö psykoosin ja skitsofrenian hoidossa
FI883285A0 (fi)	1988-07-08	2-amino-5 -hydroxi-4-pyrimidoner.
FI891031A0 (fi)	1989-03-03	Fastsaettning av plattor medelst plattlim.
DK109285A (da)	1985-09-10	Laegemidler paa basis af piperidinderivater, piperidinderivater ogfremgangsmaade til deres fremstilling
ATE203022T1 (de)	2001-07-15	4-(6-fluor-1,2-benzisoxazolyl)-1-piperidinyl- propoxy-chromen-4-on-derivate,ihre herstellung und ihre verwendung in der behandlung von psychosen, schizophrenie und angstzuständen
AU588656B2 (en)	1989-09-21	New fluorine-containing 1,4-dihydropyridines, process for their preparation and their use as medicaments
DK0469837T3 (da)	1994-12-27	Anvendelse af en forbindelse til fremstilling af et lægemiddel til sænkning af blodets urinsyreindhold