PT100992A - Pirimidocicloalcanos e processo para a sua preparacao - Google Patents

Pirimidocicloalcanos e processo para a sua preparacao

Info

Publication number: PT100992A
Authority: PT; Portugal
Prior art keywords: alkyl; aralkyl; perfluoroalkyl; alkoxyalkyl; nconr12r13
Prior art date: 1991-10-24

Application number

PT100992A

Other languages

English (en)

Other versions

PT100992B (pt

Inventor

John Laurent Primeau

Lloyd Michael Garrick

Timothy Donald Ocain

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-24

Filing date

1992-10-22

Publication date

1994-02-28

1992-10-22 Application filed by American Home Prod filed Critical American Home Prod

1994-02-28 Publication of PT100992A publication Critical patent/PT100992A/pt

1999-07-30 Publication of PT100992B publication Critical patent/PT100992B/pt

Links

238000000034 method Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 10
125000003710 aryl alkyl group Chemical group 0.000 abstract 9
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 7
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 7
-1 alkyl-OH Chemical group 0.000 abstract 6
229910052731 fluorine Inorganic materials 0.000 abstract 5
229910052794 bromium Inorganic materials 0.000 abstract 4
229910052801 chlorine Inorganic materials 0.000 abstract 4
239000000460 chlorine Substances 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
229910052740 iodine Inorganic materials 0.000 abstract 2
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
210000002381 plasma Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT100992A 1991-10-24 1992-10-22 Pirimidocicloalcanos e processo para a sua preparacao PT100992B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/782,017 US5234936A (en)	1991-10-24	1991-10-24	Pyrimidocycloalkanes as a ii antagonists

Publications (2)

Publication Number	Publication Date
PT100992A true PT100992A (pt)	1994-02-28
PT100992B PT100992B (pt)	1999-07-30

Family

ID=25124678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT100992A PT100992B (pt)	1991-10-24	1992-10-22	Pirimidocicloalcanos e processo para a sua preparacao

Country Status (9)

Country	Link
US (1)	US5234936A (pt)
EP (1)	EP0610439B1 (pt)
JP (1)	JPH07500345A (pt)
AT (1)	ATE187717T1 (pt)
AU (1)	AU3122893A (pt)
CA (1)	CA2121814A1 (pt)
DE (1)	DE69230442D1 (pt)
PT (1)	PT100992B (pt)
WO (1)	WO1993008171A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5283242A (en) *	1991-10-24	1994-02-01	American Home Products Corporation	Substituted benzimidazoles and quinazolines as antihypertensives
US5409926A (en) *	1993-07-19	1995-04-25	Merck & Co., Inc.	AT-2 antagonist inhibition of vascular restenosis
WO1997047601A1 (en) *	1996-06-11	1997-12-18	Yoshitomi Pharmaceutical Industries, Ltd.	Fused heterocyclic compounds and medicinal uses thereof
AU8996698A (en) *	1997-09-10	1999-03-29	Ono Pharmaceutical Co. Ltd.	Peroxisome proliferator-activated receptor controllers
DE19939980A1 (de) *	1999-08-24	2001-03-01	Merck Patent Gmbh	Inhibitoren des Integrins alphavbeta¶3¶
AU2001245401A1 (en) *	2000-03-01	2001-09-12	Sumitomo Pharmaceuticals Company, Limited	Hydrazones and analogs as cholesterol lowering agents
CN100398524C (zh) *	2003-08-12	2008-07-02	弗·哈夫曼-拉罗切有限公司	作为crf拮抗剂的四氢喹唑啉衍生物
AU2004270161A1 (en) *	2003-08-28	2005-03-17	Nicox S.A.	Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101397277B (zh) *	2008-01-10	2012-04-18	联化科技股份有限公司	一种氨甲基联苯四氮唑及其盐的合成方法、及其中间体及中间体的合成方法
ES2627848T3 (es)	2008-06-04	2017-07-31	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
EP2968439A2 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
PL3004138T3 (pl)	2013-06-05	2024-07-29	Bausch Health Ireland Limited	Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
CA2946990A1 (en)	2014-04-28	2015-11-05	Pfizer Inc.	Heterocyclic compounds and their use as dopamine d1 ligands
KR102801643B1 (ko)	2016-09-30	2025-04-30	(주)스파크바이오파마	신규한 피리미딘 유도체 화합물 또는 이의 약제학적으로 허용 가능한 염, 그 제조방법 및 이를 이용한 약학적 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5538325A (en) *	1978-09-11	1980-03-17	Sankyo Co Ltd	4-anilinoquinazoline derivative and its preparation
JPS57203072A (en) *	1981-06-05	1982-12-13	Sankyo Co Ltd	4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient
JPS6270A (ja) *	1985-03-07	1987-01-06	Sankyo Co Ltd	シクロペンタ〔ｄ〕ピリミジン誘導体
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
US5064825A (en) *	1989-06-01	1991-11-12	Merck & Co., Inc.	Angiotensin ii antagonists
CA2020073A1 (en) *	1989-07-03	1991-01-04	Eric E. Allen	Substituted quinazolinones as angiotensin ii antagonists
ATE117294T1 (de) *	1989-08-11	1995-02-15	Ici Plc	Chinolin-derivate, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.
US5100897A (en) *	1989-08-28	1992-03-31	Merck & Co., Inc.	Substituted pyrimidinones as angiotensin ii antagonists
EP0424317A3 (en) *	1989-10-19	1991-09-25	Ciba-Geigy Ag	Pyrimidines

1991
- 1991-10-24 US US07/782,017 patent/US5234936A/en not_active Expired - Lifetime
1992
- 1992-10-22 PT PT100992A patent/PT100992B/pt not_active IP Right Cessation
- 1992-10-23 DE DE69230442T patent/DE69230442D1/de not_active Expired - Lifetime
- 1992-10-23 JP JP5507899A patent/JPH07500345A/ja active Pending
- 1992-10-23 WO PCT/US1992/008992 patent/WO1993008171A1/en not_active Ceased
- 1992-10-23 EP EP92925019A patent/EP0610439B1/en not_active Expired - Lifetime
- 1992-10-23 AU AU31228/93A patent/AU3122893A/en not_active Abandoned
- 1992-10-23 AT AT92925019T patent/ATE187717T1/de not_active IP Right Cessation
- 1992-10-23 CA CA002121814A patent/CA2121814A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69230442D1 (de)	2000-01-20
PT100992B (pt)	1999-07-30
US5234936A (en)	1993-08-10
EP0610439B1 (en)	1999-12-15
CA2121814A1 (en)	1993-04-29
EP0610439A1 (en)	1994-08-17
WO1993008171A1 (en)	1993-04-29
AU3122893A (en)	1993-05-21
ATE187717T1 (de)	2000-01-15
JPH07500345A (ja)	1995-01-12

Legal Events

Date

Code

Title

Description

1994-02-28

BB1A

Laying open of patent application

Effective date: 19930715

1999-07-30

FG3A

Patent granted, date of granting

Effective date: 19990416

2001-02-28

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20001031

Publication	Publication Date	Title
ATE187717T1 (de)	2000-01-15	Pyrimidozykloalkanen als angiotensin ii antagonisten.
DE60220890D1 (de)	2007-08-09	Benzoäfüisoindolderivate mit affinität zum ep4-rezeptor
HUT77372A (hu)	1998-03-30	Új benzil-pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
NZ336302A (en)	2000-08-25	Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia
NO954161D0 (no)	1995-10-18	10,11-metandibenzosuberanderivater for anvendelse som kjemosensibiliserende midler
DE3268225D1 (de)	1986-02-13	9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
GR3002065T3 (en)	1992-12-30	Quinazolinediones and pyridopyrimidinediones
PE20020599A1 (es)	2002-08-10	Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d
AR036204A1 (es)	2004-08-18	Proceso para la produccion de quinazolinas y compuestos utiles en dicho proceso
AU588656B2 (en)	1989-09-21	New fluorine-containing 1,4-dihydropyridines, process for their preparation and their use as medicaments
JPS6429367A (en)	1989-01-31	2-amino-5-hydroxy-4-pyrimidone
EP0849246A3 (en)	1998-09-23	Derivatives of 4-vinyl-4'-alpha-hydroxyethyl-biphenyl
NO840131L (no)	1984-07-16	Fremgangsmaate ved fremstilling av nye bicyklo (4.2.0)1,3,5-oktarienderivater
DK109285A (da)	1985-09-10	Laegemidler paa basis af piperidinderivater, piperidinderivater ogfremgangsmaade til deres fremstilling
EA200101050A1 (ru)	2002-04-25	Замещенные бензолактамные соединения
FI891031A0 (fi)	1989-03-03	Fastsaettning av plattor medelst plattlim.
NO164352C (no)	1990-09-26	Analogifremgangsmaate for fremstilling av farmasoeytisk aktive, antivirale, substituerte isoksazolderivater.
AU645253B2 (en)	1994-01-13	Leukotriene antagonists
DK0469837T3 (da)	1994-12-27	Anvendelse af en forbindelse til fremstilling af et lægemiddel til sænkning af blodets urinsyreindhold
ATE6652T1 (de)	1984-03-15	Clavulansaeurederivate, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE60008059D1 (de)	2004-03-11	Direktes Verfahren zur Herstellung von hoch reinen alpha-Fluor- beta-Dicarbonylverbindungen
FI803887L (fi)	1981-06-15	Nya substituerade 2-fenylamino-imidazoliner-(2) deras syraadditionssalter dessa innehaollande laekemedel och deras framstaellningsfoerfarande
HUP9800889A1 (hu)	2000-11-28	Új naftil-piperazin-származékok
FI874107A7 (fi)	1987-09-21	Foerfarande foer framstaellning av terapeutiskt anvaendbara piperidinderivat.
FI882421A0 (fi)	1988-05-23	5-fenyl-1,2,3a,4,5,9b-hexahydro-3h -benz(e)indol, deras framstaellning och anvoendning som laekemedel.