ATE188382T1 - Verfahren zum herstellen von microkugeln für die verzögerte verabreichung des lhrh-hormons und dessen analoga, microkugeln und so erhaltene zusammensetzungen - Google Patents

Verfahren zum herstellen von microkugeln für die verzögerte verabreichung des lhrh-hormons und dessen analoga, microkugeln und so erhaltene zusammensetzungen

Info

Publication number
ATE188382T1
ATE188382T1 AT93401874T AT93401874T ATE188382T1 AT E188382 T1 ATE188382 T1 AT E188382T1 AT 93401874 T AT93401874 T AT 93401874T AT 93401874 T AT93401874 T AT 93401874T AT E188382 T1 ATE188382 T1 AT E188382T1
Authority
AT
Austria
Prior art keywords
microspheres
micro spheres
hormone
analogues
lhrh
Prior art date
Application number
AT93401874T
Other languages
English (en)
Inventor
Genevieve Bernadette Billot
Marc Maurice Teichner
Original Assignee
Merial Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Sas filed Critical Merial Sas
Application granted granted Critical
Publication of ATE188382T1 publication Critical patent/ATE188382T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT93401874T 1992-07-27 1993-07-20 Verfahren zum herstellen von microkugeln für die verzögerte verabreichung des lhrh-hormons und dessen analoga, microkugeln und so erhaltene zusammensetzungen ATE188382T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR929209241A FR2693905B1 (fr) 1992-07-27 1992-07-27 Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.

Publications (1)

Publication Number Publication Date
ATE188382T1 true ATE188382T1 (de) 2000-01-15

Family

ID=9432294

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93401874T ATE188382T1 (de) 1992-07-27 1993-07-20 Verfahren zum herstellen von microkugeln für die verzögerte verabreichung des lhrh-hormons und dessen analoga, microkugeln und so erhaltene zusammensetzungen

Country Status (10)

Country Link
US (1) US5540937A (de)
EP (1) EP0585151B1 (de)
JP (1) JP3761591B2 (de)
AT (1) ATE188382T1 (de)
AU (1) AU675788B2 (de)
CA (1) CA2100925C (de)
DE (1) DE69327491T2 (de)
ES (1) ES2141756T3 (de)
FR (1) FR2693905B1 (de)
NZ (1) NZ248207A (de)

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US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
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GB2470378A (en) * 2009-05-20 2010-11-24 Univ Westminster A controlled release composition for intraocular delivery of a therapeutic agent
CN102665690A (zh) * 2009-12-22 2012-09-12 武田药品工业株式会社 缓释制剂
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Also Published As

Publication number Publication date
JPH0687758A (ja) 1994-03-29
JP3761591B2 (ja) 2006-03-29
CA2100925C (en) 2008-12-23
FR2693905A1 (fr) 1994-01-28
AU4202293A (en) 1994-02-10
EP0585151A1 (de) 1994-03-02
EP0585151B1 (de) 2000-01-05
US5540937A (en) 1996-07-30
FR2693905B1 (fr) 1994-09-02
AU675788B2 (en) 1997-02-20
DE69327491T2 (de) 2000-10-12
CA2100925A1 (en) 1994-01-28
NZ248207A (en) 1996-02-27
DE69327491D1 (de) 2000-02-10
ES2141756T3 (es) 2000-04-01

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