ATE189528T1 - Methode zur auswahl von superagonisten, antagonisten und superantagonisten von interleukin 6 - Google Patents
Methode zur auswahl von superagonisten, antagonisten und superantagonisten von interleukin 6Info
- Publication number
- ATE189528T1 ATE189528T1 AT94920582T AT94920582T ATE189528T1 AT E189528 T1 ATE189528 T1 AT E189528T1 AT 94920582 T AT94920582 T AT 94920582T AT 94920582 T AT94920582 T AT 94920582T AT E189528 T1 ATE189528 T1 AT E189528T1
- Authority
- AT
- Austria
- Prior art keywords
- interleukin
- site
- superantagonists
- antagonists
- superagonists
- Prior art date
Links
- 102000004889 Interleukin-6 Human genes 0.000 title abstract 4
- 108090001005 Interleukin-6 Proteins 0.000 title abstract 4
- 229940100601 interleukin-6 Drugs 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 2
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 abstract 2
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 abstract 2
- 102000003815 Interleukin-11 Human genes 0.000 abstract 2
- 108090000177 Interleukin-11 Proteins 0.000 abstract 2
- 102000004058 Leukemia inhibitory factor Human genes 0.000 abstract 2
- 108090000581 Leukemia inhibitory factor Proteins 0.000 abstract 2
- 102000004140 Oncostatin M Human genes 0.000 abstract 2
- 108090000630 Oncostatin M Proteins 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 229940074383 interleukin-11 Drugs 0.000 abstract 2
- 101100338243 Caenorhabditis elegans hil-6 gene Proteins 0.000 abstract 1
- YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 abstract 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000002483 superagonistic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM930409A IT1261787B (it) | 1993-06-23 | 1993-06-23 | Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130. |
| PCT/IT1994/000095 WO1995000852A2 (en) | 1993-06-23 | 1994-06-23 | A methodology for selecting superagonists, antagonists and superantagonists of hormones whose receptor complex includes gp 130 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE189528T1 true ATE189528T1 (de) | 2000-02-15 |
Family
ID=11401818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94920582T ATE189528T1 (de) | 1993-06-23 | 1994-06-23 | Methode zur auswahl von superagonisten, antagonisten und superantagonisten von interleukin 6 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0656117B1 (de) |
| JP (1) | JP2643604B2 (de) |
| CN (2) | CN1249439C (de) |
| AT (1) | ATE189528T1 (de) |
| AU (1) | AU687416B2 (de) |
| CA (1) | CA2142973C (de) |
| DE (1) | DE69422893T2 (de) |
| DK (1) | DK0656117T3 (de) |
| ES (1) | ES2144524T3 (de) |
| GR (1) | GR3033111T3 (de) |
| IT (1) | IT1261787B (de) |
| PT (1) | PT656117E (de) |
| WO (1) | WO1995000852A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1276555B1 (it) * | 1995-04-28 | 1997-11-03 | Angeletti P Ist Richerche Bio | Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni |
| IT1277926B1 (it) * | 1995-09-01 | 1997-11-12 | Angeletti P Ist Richerche Bio | Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire |
| US5849293A (en) * | 1996-01-11 | 1998-12-15 | Cornell Research Foundation, Inc. | Use of human transferrin in controlling insulin levels |
| IT1285790B1 (it) * | 1996-09-24 | 1998-06-24 | Angeletti P Ist Richerche Bio | Adenovirus difettivi ricombinanti che codificano per mutanti di interleuchina 6 umana (hil-6) con attivita' antagonista o |
| EP2011514B1 (de) | 1997-03-21 | 2012-02-29 | Chugai Seiyaku Kabushiki Kaisha | Präventives oder therapeutisches Mittel mit einem IL-6-Antagonisten als Wirkstoff für durch sensibilisierte T-Zellen vermittelte Erkrankungen |
| GB9806530D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
| WO2003033015A1 (en) | 2001-10-11 | 2003-04-24 | Applied Research Systems Ars Holding N.V. | USE OF gp130 ACTIVATORS IN DIABETIC NEUROPATHY |
| FR2833011B1 (fr) * | 2001-12-04 | 2004-10-29 | Univ Claude Bernard Lyon | Nouvelle proteine a activite inhibitrice de l'il-6 |
| IL161673A0 (en) | 2004-04-29 | 2004-09-27 | Applied Research Systems | Compositions and methods for therapy of chemotherapy-induced neuropathy |
| CN101246160B (zh) * | 2007-09-06 | 2012-11-21 | 三峡大学 | 在体外用ELISA方法建立的IL-6/sIL-6R结合的分子模型 |
| DE102011104822A1 (de) | 2011-06-18 | 2012-12-20 | Christian-Albrechts-Universität Zu Kiel | Ciliary-Neutrophic-Factor-Varianten |
| WO2013147153A1 (ja) | 2012-03-29 | 2013-10-03 | 株式会社未来創薬研究所 | 抗ｌａｍｐ５抗体およびその利用 |
| WO2018104564A2 (en) * | 2017-08-11 | 2018-06-14 | Solvay Specialty Polymers Italy S.P.A. | Method for stabilizing aqueous dispersions of fluorinated polymers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990004788A1 (en) * | 1988-10-28 | 1990-05-03 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| JP2898064B2 (ja) * | 1989-08-03 | 1999-05-31 | 忠三 岸本 | ヒトｇｐ１３０蛋白質 |
| JP2898040B2 (ja) * | 1990-01-26 | 1999-05-31 | 忠三 岸本 | ｇｐ１３０蛋白質に対する抗体 |
| US5210075A (en) * | 1990-02-16 | 1993-05-11 | Tanabe Seiyaku Co., Ltd. | Interleukin 6 antagonist peptides |
| ATE196548T1 (de) * | 1991-05-10 | 2000-10-15 | Genentech Inc | Auswählen von agonisten und antagonisten von liganden |
| AU687763B2 (en) * | 1992-10-20 | 1998-03-05 | Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service | Interleukin-6 receptor antagonists |
| US5470952A (en) * | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
| US5939534A (en) * | 1993-12-29 | 1999-08-17 | Sumitomo Pharmaceuticals Company, Limited | Factors mutated in the D1 cap region |
-
1993
- 1993-06-23 IT ITRM930409A patent/IT1261787B/it active IP Right Grant
-
1994
- 1994-06-23 JP JP7502633A patent/JP2643604B2/ja not_active Expired - Lifetime
- 1994-06-23 PT PT94920582T patent/PT656117E/pt unknown
- 1994-06-23 WO PCT/IT1994/000095 patent/WO1995000852A2/en not_active Ceased
- 1994-06-23 DE DE69422893T patent/DE69422893T2/de not_active Expired - Fee Related
- 1994-06-23 CN CN02107480.1A patent/CN1249439C/zh not_active Expired - Fee Related
- 1994-06-23 AT AT94920582T patent/ATE189528T1/de not_active IP Right Cessation
- 1994-06-23 ES ES94920582T patent/ES2144524T3/es not_active Expired - Lifetime
- 1994-06-23 CN CN94190533.0A patent/CN1101937C/zh not_active Expired - Fee Related
- 1994-06-23 CA CA002142973A patent/CA2142973C/en not_active Expired - Fee Related
- 1994-06-23 AU AU71324/94A patent/AU687416B2/en not_active Ceased
- 1994-06-23 EP EP94920582A patent/EP0656117B1/de not_active Expired - Lifetime
- 1994-06-23 DK DK94920582T patent/DK0656117T3/da active
-
2000
- 2000-03-29 GR GR20000400800T patent/GR3033111T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995000852A3 (en) | 1995-03-30 |
| DE69422893D1 (de) | 2000-03-09 |
| DE69422893T2 (de) | 2000-08-17 |
| ES2144524T3 (es) | 2000-06-16 |
| ITRM930409A1 (it) | 1994-12-23 |
| IT1261787B (it) | 1996-06-03 |
| EP0656117B1 (de) | 2000-02-02 |
| JPH07509571A (ja) | 1995-10-19 |
| HK1011081A1 (en) | 1999-07-02 |
| CN1538176A (zh) | 2004-10-20 |
| AU687416B2 (en) | 1998-02-26 |
| CA2142973A1 (en) | 1995-01-05 |
| DK0656117T3 (da) | 2000-07-24 |
| ITRM930409A0 (it) | 1993-06-23 |
| GR3033111T3 (en) | 2000-08-31 |
| CN1101937C (zh) | 2003-02-19 |
| PT656117E (pt) | 2000-07-31 |
| CN1249439C (zh) | 2006-04-05 |
| CA2142973C (en) | 2004-10-26 |
| AU7132494A (en) | 1995-01-17 |
| EP0656117A1 (de) | 1995-06-07 |
| JP2643604B2 (ja) | 1997-08-20 |
| CN1112795A (zh) | 1995-11-29 |
| WO1995000852A2 (en) | 1995-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |