DK0656117T3 - Fremgangsmåde til udvælgelse af superagonister, antagonister og superantagonister for interleukin 6 - Google Patents

Fremgangsmåde til udvælgelse af superagonister, antagonister og superantagonister for interleukin 6

Info

Publication number
DK0656117T3
DK0656117T3 DK94920582T DK94920582T DK0656117T3 DK 0656117 T3 DK0656117 T3 DK 0656117T3 DK 94920582 T DK94920582 T DK 94920582T DK 94920582 T DK94920582 T DK 94920582T DK 0656117 T3 DK0656117 T3 DK 0656117T3
Authority
DK
Denmark
Prior art keywords
interleukin
antagonists
site
superantagonists
superagonists
Prior art date
Application number
DK94920582T
Other languages
English (en)
Inventor
Rocco Savino
Armin Lahm
Gennaro Ciliberto
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Application granted granted Critical
Publication of DK0656117T3 publication Critical patent/DK0656117T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK94920582T 1993-06-23 1994-06-23 Fremgangsmåde til udvælgelse af superagonister, antagonister og superantagonister for interleukin 6 DK0656117T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM930409A IT1261787B (it) 1993-06-23 1993-06-23 Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130.
PCT/IT1994/000095 WO1995000852A2 (en) 1993-06-23 1994-06-23 A methodology for selecting superagonists, antagonists and superantagonists of hormones whose receptor complex includes gp 130

Publications (1)

Publication Number Publication Date
DK0656117T3 true DK0656117T3 (da) 2000-07-24

Family

ID=11401818

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94920582T DK0656117T3 (da) 1993-06-23 1994-06-23 Fremgangsmåde til udvælgelse af superagonister, antagonister og superantagonister for interleukin 6

Country Status (13)

Country Link
EP (1) EP0656117B1 (da)
JP (1) JP2643604B2 (da)
CN (2) CN1249439C (da)
AT (1) ATE189528T1 (da)
AU (1) AU687416B2 (da)
CA (1) CA2142973C (da)
DE (1) DE69422893T2 (da)
DK (1) DK0656117T3 (da)
ES (1) ES2144524T3 (da)
GR (1) GR3033111T3 (da)
IT (1) IT1261787B (da)
PT (1) PT656117E (da)
WO (1) WO1995000852A2 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276555B1 (it) * 1995-04-28 1997-11-03 Angeletti P Ist Richerche Bio Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni
IT1277926B1 (it) * 1995-09-01 1997-11-12 Angeletti P Ist Richerche Bio Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire
US5849293A (en) * 1996-01-11 1998-12-15 Cornell Research Foundation, Inc. Use of human transferrin in controlling insulin levels
IT1285790B1 (it) * 1996-09-24 1998-06-24 Angeletti P Ist Richerche Bio Adenovirus difettivi ricombinanti che codificano per mutanti di interleuchina 6 umana (hil-6) con attivita' antagonista o
AU736282B2 (en) 1997-03-21 2001-07-26 Chugai Seiyaku Kabushiki Kaisha A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient
GB9806530D0 (en) 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
YU29804A (sh) * 2001-10-11 2006-08-17 Applied Research Systems Ars Holding N.V. Upotreba aktivatora gp-130 u dijabetskoj neuropatiji
FR2833011B1 (fr) * 2001-12-04 2004-10-29 Univ Claude Bernard Lyon Nouvelle proteine a activite inhibitrice de l'il-6
IL161673A0 (en) 2004-04-29 2004-09-27 Applied Research Systems Compositions and methods for therapy of chemotherapy-induced neuropathy
CN101246160B (zh) * 2007-09-06 2012-11-21 三峡大学 在体外用ELISA方法建立的IL-6/sIL-6R结合的分子模型
DE102011104822A1 (de) * 2011-06-18 2012-12-20 Christian-Albrechts-Universität Zu Kiel Ciliary-Neutrophic-Factor-Varianten
JP6280031B2 (ja) 2012-03-29 2018-02-14 中外製薬株式会社 抗ｌａｍｐ５抗体およびその利用
HUE065402T2 (hu) * 2017-08-11 2024-05-28 Solvay Specialty Polymers It Eljárás fluorozott polimerek vizes diszperzióinak stabilizálására

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0397834B1 (en) * 1988-10-28 2000-02-02 Genentech, Inc. Method for identifying active domains and amino acid residues in polypeptides and hormone variants
JP2898064B2 (ja) * 1989-08-03 1999-05-31 忠三 岸本 ヒトｇｐ１３０蛋白質
JP2898040B2 (ja) * 1990-01-26 1999-05-31 忠三 岸本 ｇｐ１３０蛋白質に対する抗体
US5210075A (en) * 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
JP3417558B2 (ja) * 1991-05-10 2003-06-16 ジェネンテク，インコーポレイテッド 配位子作用薬および拮抗薬の選択
CA2147466A1 (en) * 1992-10-20 1994-04-28 Just P. J. Brakenhoff Interleukin-6 receptor antagonists
US5470952A (en) * 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
EP0749980A4 (en) * 1993-12-29 1999-09-29 Sumitomo Pharma NEW CELLAR FACTOR FROM HUMAN

Also Published As

Publication number Publication date
AU687416B2 (en) 1998-02-26
HK1011081A1 (en) 1999-07-02
WO1995000852A2 (en) 1995-01-05
ES2144524T3 (es) 2000-06-16
DE69422893T2 (de) 2000-08-17
DE69422893D1 (de) 2000-03-09
EP0656117A1 (en) 1995-06-07
CA2142973C (en) 2004-10-26
GR3033111T3 (en) 2000-08-31
CN1112795A (zh) 1995-11-29
JP2643604B2 (ja) 1997-08-20
WO1995000852A3 (en) 1995-03-30
ITRM930409A1 (it) 1994-12-23
ITRM930409A0 (it) 1993-06-23
IT1261787B (it) 1996-06-03
CN1538176A (zh) 2004-10-20
CN1249439C (zh) 2006-04-05
CN1101937C (zh) 2003-02-19
CA2142973A1 (en) 1995-01-05
ATE189528T1 (de) 2000-02-15
JPH07509571A (ja) 1995-10-19
PT656117E (pt) 2000-07-31
EP0656117B1 (en) 2000-02-02
AU7132494A (en) 1995-01-17

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